MK-3903_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.254082
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.125783
MBNL2 muscleblind-like splicing regulator 2 0.0997342
FTL ferritin, light polypeptide 0.0923963
LCN2 lipocalin 2 0.0902949
DSTN destrin (actin depolymerizing factor) 0.0758653
RPS3 ribosomal protein S3 0.0694758
RPS6 ribosomal protein S6 0.0682569
RPS12 ribosomal protein S12 0.067206
LOC102724023 ES1 protein homolog, mitochondrial 0.0646464
ASPH aspartate beta-hydroxylase 0.0601612
RPS8 ribosomal protein S8 0.0591889
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0582708
B2M beta-2-microglobulin 0.0581587
DSPP dentin sialophosphoprotein 0.0551479
GDA guanine deaminase 0.0545424
APLP2 amyloid beta (A4) precursor-like protein 2 0.0531743
ENO1 enolase 1, (alpha) 0.0460744
ANXA1 annexin A1 0.0458768
RPL19 ribosomal protein L19 0.0457194
MYH9 myosin, heavy chain 9, non-muscle 0.0453118
RPS17 ribosomal protein S17 0.0442555
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0441208
DST dystonin 0.0435792
FNDC3B fibronectin type III domain containing 3B 0.0429928
ZSWIM6 zinc finger, SWIM-type containing 6 0.0410341
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0403483
RPS19 ribosomal protein S19 0.0402266
MAML2 mastermind-like 2 (Drosophila) 0.0402225
GOLGB1 golgin B1 0.0400563
AKAP13 A kinase (PRKA) anchor protein 13 0.0388619
MBNL1 muscleblind-like splicing regulator 1 0.0385613
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0383035
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0382389
EZR ezrin 0.0382141
SET SET nuclear proto-oncogene 0.0375087
RPL23 ribosomal protein L23 0.0370365
RPL37A ribosomal protein L37a 0.0370065
VEGFA vascular endothelial growth factor A 0.0369491
LMO7 LIM domain 7 0.0366729
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0365683
LIMA1 LIM domain and actin binding 1 0.0357786
CDK6 cyclin-dependent kinase 6 0.0357043
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0352619
KLF5 Kruppel-like factor 5 (intestinal) 0.0349999
HDAC9 histone deacetylase 9 0.0347601
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0347505
PTMA prothymosin, alpha 0.0345455
TPM3 tropomyosin 3 0.033383
MACC1 metastasis associated in colon cancer 1 0.0329161
AREG amphiregulin 0.0326829
HSPA8 heat shock 70kDa protein 8 0.0317364
ERRFI1 ERBB receptor feedback inhibitor 1 0.0317077
TXNIP thioredoxin interacting protein 0.031189
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0310288
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.03069
KTN1 kinectin 1 (kinesin receptor) 0.0306803
RPL26 ribosomal protein L26 0.0306313
RPS25 ribosomal protein S25 0.0304813
FNIP1 folliculin interacting protein 1 0.0300533
VMP1 vacuole membrane protein 1 0.0299395
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0290764
PTPRK protein tyrosine phosphatase, receptor type, K 0.0288497
AGR3 anterior gradient 3 0.0287205
SRRM2 serine/arginine repetitive matrix 2 0.0285428
EEF2 eukaryotic translation elongation factor 2 0.028375
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0279349
MYOF myoferlin 0.0278131
BRD2 bromodomain containing 2 0.0275294
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0272079
RPS27 ribosomal protein S27 0.0270465
RPL7A ribosomal protein L7a 0.027009
RPS29 ribosomal protein S29 0.0269337
ATXN1 ataxin 1 0.0263709
TXNRD1 thioredoxin reductase 1 0.0263346
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.02581
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0257024
RPS10 ribosomal protein S10 0.0254349
PKM pyruvate kinase, muscle 0.0252273
MT2A metallothionein 2A 0.0249846
FAM107B family with sequence similarity 107, member B 0.0249076
RPS23 ribosomal protein S23 0.0248506
DSG2 desmoglein 2 0.0248039
RPL12 ribosomal protein L12 0.0247049
TMF1 TATA element modulatory factor 1 0.0245897
PDLIM5 PDZ and LIM domain 5 0.0245769
ARHGAP29 Rho GTPase activating protein 29 0.0244932
GOLGA4 golgin A4 0.0244626
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0243492
RPL21 ribosomal protein L21 0.0243318
RPL18 ribosomal protein L18 0.0242975
PGM3 phosphoglucomutase 3 0.0242146
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0240198
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0235739
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.023539
IFI6 interferon, alpha-inducible protein 6 0.0233073
HSPH1 heat shock 105kDa/110kDa protein 1 0.0232067
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0228148
S100P S100 calcium binding protein P 0.0226848
EFNA5 ephrin-A5 0.022469

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.219414
FGFR2 fibroblast growth factor receptor 2 -0.184592
NPSR1 neuropeptide S receptor 1 -0.101798
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0941387
GMDS GDP-mannose 4,6-dehydratase -0.0855798
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0775204
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0759307
H1-0 H1.0 linker histone -0.071257
CEMIP cell migration inducing protein, hyaluronan binding -0.0687588
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0659029
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0655226
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0627779
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0608889
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0580861
CD2AP CD2-associated protein -0.0517496
ACTN4 actinin, alpha 4 -0.0511698
LOC112694756 uncharaterized LOC112694756 -0.0499014
S100A6 S100 calcium binding protein A6 -0.0466386
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0464899
NF1 neurofibromin 1 -0.0451432
HLA-C major histocompatibility complex, class I, C -0.0450266
RRBP1 ribosome binding protein 1 -0.0450101
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0445459
ANXA2 annexin A2 -0.0436433
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0427583
EMP1 epithelial membrane protein 1 -0.0422635
GPX2 glutathione peroxidase 2 -0.0417779
HLA-E major histocompatibility complex, class I, E -0.0412668
RNF213 ring finger protein 213 -0.0410536
WDR45B WD repeat domain 45B -0.0403019
MUC17 mucin 17, cell surface associated -0.0394839
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0393096
RBM39 RNA binding motif protein 39 -0.0391386
BIRC6 baculoviral IAP repeat containing 6 -0.0390855
AGR2 anterior gradient 2 -0.0387065
PDIA4 protein disulfide isomerase family A, member 4 -0.0384712
ACACA acetyl-CoA carboxylase alpha -0.0384633
WARS1 tryptophanyl-tRNA synthetase 1 -0.0373952
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0357917
MSI2 musashi RNA-binding protein 2 -0.0344877
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0343043
INSIG1 insulin induced gene 1 -0.0341898
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0337857
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0335207
IARS1 isoleucyl-tRNA synthetase 1 -0.0333611
SHROOM3 shroom family member 3 -0.0329239
PDIA3 protein disulfide isomerase family A, member 3 -0.0328229
KDM3A lysine (K)-specific demethylase 3A -0.0320952
ALDOC aldolase C, fructose-bisphosphate -0.0316352
GARS1 glycyl-tRNA synthetase 1 -0.0315699
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0314824
DLG1 discs, large homolog 1 (Drosophila) -0.031434
GNAS GNAS complex locus -0.0313193
PRSS3 protease, serine, 3 -0.0310782
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0310422
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0305107
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0297144
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0296835
MECOM MDS1 and EVI1 complex locus -0.029668
ARF1 ADP-ribosylation factor 1 -0.0292878
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0292472
RAB1A RAB1A, member RAS oncogene family -0.0292214
TMEM45B transmembrane protein 45B -0.0290726
NECTIN2 nectin cell adhesion molecule 2 -0.0282587
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0280818
TMEM123 transmembrane protein 123 -0.0280552
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0278264
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0278209
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0277599
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0277394
SULF2 sulfatase 2 -0.0273302
TASP1 taspase, threonine aspartase, 1 -0.0273292
EPCAM epithelial cell adhesion molecule -0.0271558
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0270887
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0268562
MUC13 mucin 13, cell surface associated -0.0268557
ZFAND3 zinc finger, AN1-type domain 3 -0.0268245
GRB2 growth factor receptor-bound protein 2 -0.0264903
NPC1 Niemann-Pick disease, type C1 -0.0264341
NCOA7 nuclear receptor coactivator 7 -0.0259771
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0258999
TC2N tandem C2 domains, nuclear -0.0254186
ITGB4 integrin, beta 4 -0.0249181
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0248097
PRKCA protein kinase C, alpha -0.0247628
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0246139
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0245503
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0244521
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0243794
CUX1 cut-like homeobox 1 -0.0243266
PLSCR1 phospholipid scramblase 1 -0.0241979
LMAN1 lectin, mannose-binding, 1 -0.0239087
PRRC2B proline-rich coiled-coil 2B -0.0238775
SREBF2 sterol regulatory element binding transcription factor 2 -0.023848
STK24 serine/threonine kinase 24 -0.023796
GAK cyclin G associated kinase -0.0237893
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0235332
CAMKMT calmodulin-lysine N-methyltransferase -0.023502
NT5C2 5'-nucleotidase, cytosolic II -0.0234403
ETV6 ets variant 6 -0.0231226