MK-3903_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the MK-3903_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.192063
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.158545
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.125391
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0875125
EXT1 exostosin glycosyltransferase 1 0.0825012
GMDS GDP-mannose 4,6-dehydratase 0.0729538
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0709732
ASPH aspartate beta-hydroxylase 0.0676996
LMO7 LIM domain 7 0.0627765
ZSWIM6 zinc finger, SWIM-type containing 6 0.0536961
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0486781
SLC38A2 solute carrier family 38, member 2 0.046285
TRIM2 tripartite motif containing 2 0.0460788
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0453923
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0447283
TXNIP thioredoxin interacting protein 0.0435783
HSPA8 heat shock 70kDa protein 8 0.0424482
MBNL1 muscleblind-like splicing regulator 1 0.0415089
EPS8 epidermal growth factor receptor pathway substrate 8 0.0402791
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0387001
ERRFI1 ERBB receptor feedback inhibitor 1 0.0370894
TPM3 tropomyosin 3 0.0366495
PDZD8 PDZ domain containing 8 0.0362497
GOLGA4 golgin A4 0.0360276
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0355983
CEMIP2 cell migration inducing hyaluronidase 2 0.0355518
FTL ferritin, light polypeptide 0.0354171
CALR calreticulin 0.0351885
CLTC clathrin, heavy chain (Hc) 0.0342826
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0341101
LDHA lactate dehydrogenase A 0.0339177
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0335995
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0331238
PDIA3 protein disulfide isomerase family A, member 3 0.0330941
AFF1 AF4/FMR2 family, member 1 0.0326515
MED13 mediator complex subunit 13 0.0316042
VMP1 vacuole membrane protein 1 0.030884
BRD2 bromodomain containing 2 0.0304816
PDIA4 protein disulfide isomerase family A, member 4 0.030469
PELI1 pellino E3 ubiquitin protein ligase 1 0.0293232
LOC102724023 ES1 protein homolog, mitochondrial 0.0288198
RPL3 ribosomal protein L3 0.0285691
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0277646
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0276402
PAPOLA poly(A) polymerase alpha 0.0273012
INTS6 integrator complex subunit 6 0.0271183
PDIA6 protein disulfide isomerase family A, member 6 0.0262847
SIK3 SIK family kinase 3 0.0256244
AREG amphiregulin 0.025426
DSTN destrin (actin depolymerizing factor) 0.0249951
NCEH1 neutral cholesterol ester hydrolase 1 0.0244714
MARCHF3 membrane associated ring-CH-type finger 3 0.0242147
UNC13B unc-13 homolog B (C. elegans) 0.0240714
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0238625
CENPF centromere protein F, 350/400kDa 0.0238159
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0236939
APLP2 amyloid beta (A4) precursor-like protein 2 0.0235998
RNF145 ring finger protein 145 0.023297
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0231862
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0230274
VEGFA vascular endothelial growth factor A 0.0228309
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.022434
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0223673
P4HB prolyl 4-hydroxylase, beta polypeptide 0.022336
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0222372
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0221218
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0220492
CLCN3 chloride channel, voltage-sensitive 3 0.0213951
CANX calnexin 0.021246
TSC22D2 TSC22 domain family, member 2 0.0211839
SOX9 SRY (sex determining region Y)-box 9 0.020796
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0205016
HYOU1 hypoxia up-regulated 1 0.0204121
CHD1 chromodomain helicase DNA binding protein 1 0.0199212
SPDYA speedy/RINGO cell cycle regulator family member A 0.0198319
USP9X ubiquitin specific peptidase 9, X-linked 0.0197678
TGFBR3 transforming growth factor, beta receptor III 0.0197202
MBNL2 muscleblind-like splicing regulator 2 0.0196423
TTC3 tetratricopeptide repeat domain 3 0.0196037
GLS2 glutaminase 2 (liver, mitochondrial) 0.0195647
CATSPERB catsper channel auxiliary subunit beta 0.0195281
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0194871
USP53 ubiquitin specific peptidase 53 0.0193385
SON SON DNA binding protein 0.0192559
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.019066
DSG2 desmoglein 2 0.01896
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0189503
LIMA1 LIM domain and actin binding 1 0.0188611
SRRM1 serine/arginine repetitive matrix 1 0.0187706
TSC22D1 TSC22 domain family, member 1 0.0187667
TMF1 TATA element modulatory factor 1 0.0186521
NDFIP2 Nedd4 family interacting protein 2 0.0186501
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0185791
AKAP13 A kinase (PRKA) anchor protein 13 0.0184279
PDE10A phosphodiesterase 10A 0.0183852
PNN pinin, desmosome associated protein 0.018225
RPL21 ribosomal protein L21 0.0179932
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0174988
WNK1 WNK lysine deficient protein kinase 1 0.0172868
PLS1 plastin 1 0.0172481

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.251217
PTMA prothymosin, alpha -0.162902
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.156561
NALF1 NALCN channel auxiliary factor 1 -0.152769
TPT1 tumor protein, translationally-controlled 1 -0.144386
TMSB10 thymosin beta 10 -0.131492
PTPRR protein tyrosine phosphatase, receptor type, R -0.11921
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0992969
GCC2 GRIP and coiled-coil domain containing 2 -0.0868353
ONECUT3 one cut homeobox 3 -0.0853382
ANXA2 annexin A2 -0.0835595
FLNB filamin B, beta -0.0795034
TNS4 tensin 4 -0.0791095
RPS6 ribosomal protein S6 -0.0709528
S100A6 S100 calcium binding protein A6 -0.068873
CEMIP cell migration inducing protein, hyaluronan binding -0.0656133
RPL35A ribosomal protein L35a -0.0652222
ACTN4 actinin, alpha 4 -0.0624245
PPARG peroxisome proliferator-activated receptor gamma -0.057553
ACTG1 actin gamma 1 -0.0567813
ITGB4 integrin, beta 4 -0.0547358
FERMT1 fermitin family member 1 -0.053757
RPLP1 ribosomal protein, large, P1 -0.0498408
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0494994
EZR ezrin -0.0489774
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0468734
FOXP1 forkhead box P1 -0.0465224
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0457866
IER3 immediate early response 3 -0.0450293
BACE2 beta-site APP-cleaving enzyme 2 -0.044343
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0439324
ANTXR2 anthrax toxin receptor 2 -0.0433214
RIN2 Ras and Rab interactor 2 -0.0431455
ALCAM activated leukocyte cell adhesion molecule -0.0430241
SOX4 SRY (sex determining region Y)-box 4 -0.0424175
PRSS3 protease, serine, 3 -0.0421404
SH3D19 SH3 domain containing 19 -0.0418464
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0416272
ITGA6 integrin, alpha 6 -0.0415314
GTF2IRD1 GTF2I repeat domain containing 1 -0.0413063
RNF217 ring finger protein 217 -0.0408425
KLK10 kallikrein-related peptidase 10 -0.0405241
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0396319
FOXO1 forkhead box O1 -0.0391105
RPS24 ribosomal protein S24 -0.0381513
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0380833
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0377459
GNAS GNAS complex locus -0.0375124
MAML3 mastermind-like 3 (Drosophila) -0.037506
TPM4 tropomyosin 4 -0.0370378
KLF3 Kruppel-like factor 3 (basic) -0.0370179
CCSER1 coiled-coil serine-rich protein 1 -0.0368697
AHNAK AHNAK nucleoprotein -0.0365202
MAML2 mastermind-like 2 (Drosophila) -0.0361745
SLC35F3 solute carrier family 35, member F3 -0.0354235
EPCAM epithelial cell adhesion molecule -0.035074
ESYT2 extended synaptotagmin-like protein 2 -0.0349432
GREB1L growth regulation by estrogen in breast cancer-like -0.0341291
CCND1 cyclin D1 -0.0337076
ABHD2 abhydrolase domain containing 2 -0.0329166
ZMYND8 zinc finger, MYND-type containing 8 -0.0327658
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0323502
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0322561
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) -0.0320502
MUC17 mucin 17, cell surface associated -0.0320421
ZNF33A zinc finger protein 33A -0.0317857
NDRG1 N-myc downstream regulated 1 -0.0316875
KPNB1 karyopherin (importin) beta 1 -0.0315392
RPL34 ribosomal protein L34 -0.0310999
LAMB3 laminin, beta 3 -0.0308787
RNF43 ring finger protein 43 -0.0307422
TFF3 trefoil factor 3 (intestinal) -0.0306094
KRT18 keratin 18, type I -0.0303762
BTG1 B-cell translocation gene 1, anti-proliferative -0.0300286
CALB1 calbindin 1, 28kDa -0.029958
PLAUR plasminogen activator, urokinase receptor -0.0298392
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0296284
FHL2 four and a half LIM domains 2 -0.0293474
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0290694
KIAA1217 KIAA1217 -0.0289194
RPL31 ribosomal protein L31 -0.0288263
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0286438
FNBP1L formin binding protein 1-like -0.02833
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0283299
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0282849
TMEM45B transmembrane protein 45B -0.0281162
DIAPH2 diaphanous-related formin 2 -0.0279169
SREBF2 sterol regulatory element binding transcription factor 2 -0.0276326
VCL vinculin -0.0275841
BCL2L1 BCL2-like 1 -0.0275652
MYO1D myosin ID -0.0269702
MECOM MDS1 and EVI1 complex locus -0.026669
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0266029
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0262804
FOXP2 forkhead box P2 -0.0262008
RAD51B RAD51 paralog B -0.0260952
AGR2 anterior gradient 2 -0.0259767
TMCC1 transmembrane and coiled-coil domain family 1 -0.0259231
MSI2 musashi RNA-binding protein 2 -0.0256431
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0256429