MK-3903_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.159097
ERRFI1 ERBB receptor feedback inhibitor 1 0.138993
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.085594
DST dystonin 0.0796279
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.056891
CAPRIN2 caprin family member 2 0.0464966
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0450595
EHBP1 EH domain binding protein 1 0.0411371
CXCL8 chemokine (C-X-C motif) ligand 8 0.0407362
MACF1 microtubule-actin crosslinking factor 1 0.0406408
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0373555
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0367418
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0364127
ZSWIM6 zinc finger, SWIM-type containing 6 0.0362642
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0346942
CADM2 cell adhesion molecule 2 0.03404
HOMER1 homer scaffolding protein 1 0.0327095
TXNIP thioredoxin interacting protein 0.0323177
PSD3 pleckstrin and Sec7 domain containing 3 0.0316971
PDE10A phosphodiesterase 10A 0.0306332
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0301288
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0294263
TRIP12 thyroid hormone receptor interactor 12 0.0292526
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0290573
SPAG9 sperm associated antigen 9 0.028704
FMNL2 formin-like 2 0.0286712
CFAP299 cilia and flagella associated protein 299 0.0278824
OSBPL8 oxysterol binding protein-like 8 0.0278011
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0276296
SDC4 syndecan 4 0.0269731
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0263457
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0256138
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.024606
CLTC clathrin, heavy chain (Hc) 0.0244361
SON SON DNA binding protein 0.0242166
SDCCAG8 serologically defined colon cancer antigen 8 0.0237996
BIRC3 baculoviral IAP repeat containing 3 0.0237645
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0237045
TMSB4X thymosin beta 4, X-linked 0.0236454
MCTP1 multiple C2 domains, transmembrane 1 0.0229733
TPM3 tropomyosin 3 0.0228778
EREG epiregulin 0.0228502
SEC24A SEC24 family member A 0.0228489
JUN jun proto-oncogene 0.022684
ZBTB38 zinc finger and BTB domain containing 38 0.0226653
SRRM2 serine/arginine repetitive matrix 2 0.0224068
HDLBP high density lipoprotein binding protein 0.0223175
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0222702
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0221063
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0220812
PAPOLA poly(A) polymerase alpha 0.0218487
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218249
WWTR1 WW domain containing transcription regulator 1 0.0214522
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0211618
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0211407
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0210563
CSMD3 CUB and Sushi multiple domains 3 0.0210513
GLS2 glutaminase 2 (liver, mitochondrial) 0.0208732
ADGRG6 adhesion G protein-coupled receptor G6 0.0207783
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0207247
ADARB1 adenosine deaminase, RNA-specific, B1 0.0206139
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0204588
PLK2 polo-like kinase 2 0.0193214
SMC4 structural maintenance of chromosomes 4 0.0191799
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0191305
ENO1 enolase 1, (alpha) 0.0185779
ZEB1 zinc finger E-box binding homeobox 1 0.018532
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0185027
HSPH1 heat shock 105kDa/110kDa protein 1 0.0183658
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0183116
PRELID2 PRELI domain containing 2 0.0183078
ZC3H11A zinc finger CCCH-type containing 11A 0.0182615
GOLGB1 golgin B1 0.0182048
HSPA8 heat shock 70kDa protein 8 0.0180822
BICD1 bicaudal D homolog 1 (Drosophila) 0.0178335
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0177841
SOX9 SRY (sex determining region Y)-box 9 0.0177782
GPHN gephyrin 0.0174486
TTC3 tetratricopeptide repeat domain 3 0.017445
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0172718
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0170128
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.01698
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.016875
MB21D2 Mab-21 domain containing 2 0.0168237
INTS6 integrator complex subunit 6 0.0167364
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0167322
TRIM55 tripartite motif containing 55 0.0164352
BRD2 bromodomain containing 2 0.0163285
IARS1 isoleucyl-tRNA synthetase 1 0.0162782
CDK6 cyclin-dependent kinase 6 0.016153
ARHGAP5 Rho GTPase activating protein 5 0.0160968
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0160314
LDHA lactate dehydrogenase A 0.0155523
NPAS2 neuronal PAS domain protein 2 0.015551
NEK10 NIMA-related kinase 10 0.0154649
RAB27B RAB27B, member RAS oncogene family 0.0154117
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0151873
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0151815
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0151806
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0151482

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.161676
MT2A metallothionein 2A -0.105131
RPL35A ribosomal protein L35a -0.0814377
TMSB10 thymosin beta 10 -0.0792534
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0791114
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0719664
RPS6 ribosomal protein S6 -0.0647548
TPT1 tumor protein, translationally-controlled 1 -0.0515179
POTEF POTE ankyrin domain family, member F -0.0489322
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0441469
RPLP1 ribosomal protein, large, P1 -0.0432913
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0422208
RPL31 ribosomal protein L31 -0.0408952
ZMYND8 zinc finger, MYND-type containing 8 -0.0401537
RPL37A ribosomal protein L37a -0.0394919
ACTG1 actin gamma 1 -0.0391886
RPS8 ribosomal protein S8 -0.0391783
MT1X metallothionein 1X -0.0383932
RPL26 ribosomal protein L26 -0.0383565
RPS29 ribosomal protein S29 -0.0375199
HMGA1 high mobility group AT-hook 1 -0.0372828
FTL ferritin, light polypeptide -0.0367377
WSB1 WD repeat and SOCS box containing 1 -0.0362109
RPL38 ribosomal protein L38 -0.0336517
EPHA4 EPH receptor A4 -0.0329684
RPLP2 ribosomal protein, large, P2 -0.0316672
RPS19 ribosomal protein S19 -0.0315739
RPL23 ribosomal protein L23 -0.0296514
PTMA prothymosin, alpha -0.0296195
RPS23 ribosomal protein S23 -0.0295309
TSC22D1 TSC22 domain family, member 1 -0.029453
RPS14 ribosomal protein S14 -0.0273818
RPS16 ribosomal protein S16 -0.0272669
RPLP0 ribosomal protein, large, P0 -0.0270625
RPS27A ribosomal protein S27a -0.0270425
EFNA5 ephrin-A5 -0.026101
RPS25 ribosomal protein S25 -0.0259392
RPL34 ribosomal protein L34 -0.0256634
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0255609
RPL8 ribosomal protein L8 -0.0248309
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0245543
RPS13 ribosomal protein S13 -0.0242694
RPL9 ribosomal protein L9 -0.0242395
RAI1 retinoic acid induced 1 -0.0240308
RPL36 ribosomal protein L36 -0.023526
RPL36A ribosomal protein L36a -0.0235036
ANKRD12 ankyrin repeat domain 12 -0.0234962
MT1E metallothionein 1E -0.0233625
PNISR PNN-interacting serine/arginine-rich protein -0.0232012
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0228133
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0222041
RPS21 ribosomal protein S21 -0.0221405
S100A9 S100 calcium binding protein A9 -0.0220956
KLHL24 kelch-like family member 24 -0.0220163
RPS10 ribosomal protein S10 -0.021848
RPS24 ribosomal protein S24 -0.0216172
RPS3 ribosomal protein S3 -0.0215926
RPS17 ribosomal protein S17 -0.021384
RPL37 ribosomal protein L37 -0.0212913
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0212833
EZR ezrin -0.021241
RPS11 ribosomal protein S11 -0.021156
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0210989
RPL12 ribosomal protein L12 -0.0203532
KPNB1 karyopherin (importin) beta 1 -0.0201781
TNS3 tensin 3 -0.0198434
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0193626
CD44 CD44 molecule (Indian blood group) -0.0189999
FTH1 ferritin, heavy polypeptide 1 -0.0188799
RPS27 ribosomal protein S27 -0.0186375
S100A6 S100 calcium binding protein A6 -0.0185674
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0185301
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0184795
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0183875
MYOF myoferlin -0.0183872
RPL27 ribosomal protein L27 -0.0181533
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0179247
RPL13A ribosomal protein L13a -0.0178043
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0174305
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0173003
RPL5 ribosomal protein L5 -0.0169018
CLIP2 CAP-GLY domain containing linker protein 2 -0.016786
ANKRD28 ankyrin repeat domain 28 -0.0164799
CELF1 CUGBP, Elav-like family member 1 -0.0163785
GCC2 GRIP and coiled-coil domain containing 2 -0.0160064
RPL27A ribosomal protein L27a -0.0159903
RPL35 ribosomal protein L35 -0.0159423
BRWD1 bromodomain and WD repeat domain containing 1 -0.0158962
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0158287
RPS20 ribosomal protein S20 -0.0157903
EIF1 eukaryotic translation initiation factor 1 -0.0157412
RPS28 ribosomal protein S28 -0.0156324
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0153457
FOXK1 forkhead box K1 -0.0152814
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.014899
KLF6 Kruppel-like factor 6 -0.0148725
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0148336
HLA-E major histocompatibility complex, class I, E -0.014826
RTN4 reticulon 4 -0.014789
RPL7A ribosomal protein L7a -0.0147453