| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.454076 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.126757 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.117152 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0861024 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0761949 |
| TPM3 | tropomyosin 3 | 0.0738713 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0705164 |
| GOLGB1 | golgin B1 | 0.0662145 |
| YBX3 | Y box binding protein 3 | 0.0643258 |
| MCL1 | myeloid cell leukemia 1 | 0.0637732 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0636641 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0611629 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0610841 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0606383 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0558538 |
| DST | dystonin | 0.0555094 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0553019 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0544244 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0536302 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0534471 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0517032 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0512142 |
| INTS6 | integrator complex subunit 6 | 0.0505768 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.049055 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0481801 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0467841 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0465963 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.045711 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0456833 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0439251 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0428271 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0425775 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0410598 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0403323 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0402336 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0393258 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0381658 |
| CANX | calnexin | 0.0371754 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0363162 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0361786 |
| AEBP2 | AE binding protein 2 | 0.0357899 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0353895 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0350871 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0348963 |
| VMP1 | vacuole membrane protein 1 | 0.0348402 |
| ATXN1 | ataxin 1 | 0.0348307 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0346096 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0341334 |
| DSPP | dentin sialophosphoprotein | 0.033974 |
| EXOC4 | exocyst complex component 4 | 0.0338191 |
| GPHN | gephyrin | 0.0332372 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0321512 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0318462 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | 0.0317452 |
| PTK2 | protein tyrosine kinase 2 | 0.0317039 |
| ATF6 | activating transcription factor 6 | 0.0314803 |
| PRELID2 | PRELI domain containing 2 | 0.0310805 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0310721 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0308789 |
| GRAMD1B | GRAM domain containing 1B | 0.0308583 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0300006 |
| VCP | valosin containing protein | 0.0299219 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0297285 |
| WWOX | WW domain containing oxidoreductase | 0.0296482 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.029298 |
| ANO6 | anoctamin 6 | 0.0291539 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0288609 |
| HOMER1 | homer scaffolding protein 1 | 0.0287917 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0286116 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0280921 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0280404 |
| FMNL2 | formin-like 2 | 0.0273897 |
| COPA | coatomer protein complex, subunit alpha | 0.0272084 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0269997 |
| HDLBP | high density lipoprotein binding protein | 0.026888 |
| ASPH | aspartate beta-hydroxylase | 0.0266767 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0266302 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0265715 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0263723 |
| GPATCH2L | G patch domain containing 2-like | 0.0260129 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0259944 |
| PRKCE | protein kinase C, epsilon | 0.0255949 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0254815 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0254212 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0254146 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0252838 |
| SIK3 | SIK family kinase 3 | 0.0252182 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0250462 |
| SVIL | supervillin | 0.0249542 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0249322 |
| AHNAK | AHNAK nucleoprotein | 0.0249272 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.024673 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0244397 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0242726 |
| TLN1 | talin 1 | 0.0242228 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0240577 |
| NF1 | neurofibromin 1 | 0.0238019 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0236791 |
| PDE10A | phosphodiesterase 10A | 0.0235865 |
| YBX1 | Y box binding protein 1 | 0.0234968 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0871323 |
| TXNRD1 | thioredoxin reductase 1 | -0.0588476 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0545815 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0510296 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.049294 |
| EGR1 | early growth response 1 | -0.0485659 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0472625 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0437635 |
| RTN4 | reticulon 4 | -0.0405756 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0376441 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.036455 |
| PHIP | pleckstrin homology domain interacting protein | -0.0363967 |
| PFN1 | profilin 1 | -0.0359899 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0347001 |
| LATS2 | large tumor suppressor kinase 2 | -0.0345665 |
| CCNL1 | cyclin L1 | -0.0337674 |
| TMEM165 | transmembrane protein 165 | -0.0337557 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.03243 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0314907 |
| POTEF | POTE ankyrin domain family, member F | -0.031155 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0294948 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.028168 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0281519 |
| XPO1 | exportin 1 | -0.0280177 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0277883 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0273455 |
| RPLP0 | ribosomal protein, large, P0 | -0.0272428 |
| RPL35A | ribosomal protein L35a | -0.025489 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0242657 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0241593 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0241226 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0236679 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0231409 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0230407 |
| HMGA1 | high mobility group AT-hook 1 | -0.0230141 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0226929 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0222337 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0221813 |
| RNF38 | ring finger protein 38 | -0.0221585 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0214417 |
| RNF145 | ring finger protein 145 | -0.0213848 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0203731 |
| BBX | bobby sox homolog (Drosophila) | -0.019586 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0195537 |
| GPSM2 | G-protein signaling modulator 2 | -0.0194696 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0194169 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0193903 |
| PRR11 | proline rich 11 | -0.0193422 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0190722 |
| SEPTIN7 | septin 7 | -0.0190197 |
| ATXN2 | ataxin 2 | -0.0188557 |
| TNPO3 | transportin 3 | -0.0186877 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0185909 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0184509 |
| PCNX1 | pecanex 1 | -0.018436 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0183964 |
| FBXO34 | F-box protein 34 | -0.0183714 |
| CDK19 | cyclin-dependent kinase 19 | -0.0182015 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0180173 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0179573 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | -0.0177439 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0176954 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0176656 |
| PCBP2 | poly(rC) binding protein 2 | -0.0176531 |
| ZFR | zinc finger RNA binding protein | -0.0175753 |
| FHL2 | four and a half LIM domains 2 | -0.0175665 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0175546 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0174564 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0172517 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0172472 |
| NEK7 | NIMA-related kinase 7 | -0.017204 |
| WASF2 | WAS protein family, member 2 | -0.0171633 |
| MT1X | metallothionein 1X | -0.0171303 |
| ANKRD36B | ankyrin repeat domain 36B | -0.0171301 |
| RPL23 | ribosomal protein L23 | -0.0169806 |
| TMPO | thymopoietin | -0.0169357 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0168925 |
| BRD8 | bromodomain containing 8 | -0.016822 |
| SGO2 | shugoshin 2 | -0.0167635 |
| STIL | SCL/TAL1 interrupting locus | -0.0167208 |
| ZNF292 | zinc finger protein 292 | -0.0166949 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0166395 |
| CDC27 | cell division cycle 27 | -0.0165543 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0164841 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0164752 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.0164734 |
| OGA | O-GlcNAcase | -0.0164358 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0163899 |
| NEMF | nuclear export mediator factor | -0.0163395 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.016004 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.015944 |
| KIF18B | kinesin family member 18B | -0.0159249 |
| LDHB | lactate dehydrogenase B | -0.0158635 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.015831 |
| POGZ | pogo transposable element with ZNF domain | -0.0157731 |
| IGF2 | insulin-like growth factor 2 | -0.0157513 |
| KIF2C | kinesin family member 2C | -0.0156944 |
| SRPK2 | SRSF protein kinase 2 | -0.0156372 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0156072 |
| ETNK1 | ethanolamine kinase 1 | -0.0154221 |
