| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.181828 |
| HDAC9 | histone deacetylase 9 | 0.113322 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0993761 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.087045 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.08428 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0822086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0778574 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0669702 |
| CADM1 | cell adhesion molecule 1 | 0.0646027 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0644047 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0630402 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0581604 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0557449 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0554843 |
| ARRDC3 | arrestin domain containing 3 | 0.0523399 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0508019 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0465729 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0461774 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0457663 |
| RUNX1 | runt-related transcription factor 1 | 0.0454274 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.045161 |
| GOLGB1 | golgin B1 | 0.0448178 |
| ASPH | aspartate beta-hydroxylase | 0.0447814 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.042741 |
| CLTC | clathrin, heavy chain (Hc) | 0.0410154 |
| TXNRD1 | thioredoxin reductase 1 | 0.0406684 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0406645 |
| MORF4L2 | mortality factor 4 like 2 | 0.0402599 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0401375 |
| CANX | calnexin | 0.0395554 |
| LDHA | lactate dehydrogenase A | 0.0387732 |
| SDC4 | syndecan 4 | 0.0385153 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0372535 |
| PGK1 | phosphoglycerate kinase 1 | 0.0365434 |
| GOLGA4 | golgin A4 | 0.0362422 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0362195 |
| MKI67 | marker of proliferation Ki-67 | 0.0358166 |
| TPM3 | tropomyosin 3 | 0.0352736 |
| YBX1 | Y box binding protein 1 | 0.0351554 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0351051 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0347887 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0345958 |
| CD44 | CD44 molecule (Indian blood group) | 0.0345652 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0345332 |
| PRELID2 | PRELI domain containing 2 | 0.0344977 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.03395 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0337081 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0336799 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0335748 |
| PGM3 | phosphoglucomutase 3 | 0.0335662 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0331209 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0328413 |
| SMAD3 | SMAD family member 3 | 0.0327548 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0317045 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0311412 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.030674 |
| SPAG9 | sperm associated antigen 9 | 0.030208 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0300039 |
| CREB5 | cAMP responsive element binding protein 5 | 0.029466 |
| SNX9 | sorting nexin 9 | 0.0292861 |
| NAV2 | neuron navigator 2 | 0.0291303 |
| RPL4 | ribosomal protein L4 | 0.0289035 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0277503 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0277264 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0277222 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.027579 |
| IRF1 | interferon regulatory factor 1 | 0.0272981 |
| PDE10A | phosphodiesterase 10A | 0.0271613 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0270555 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.027021 |
| RYBP | RING1 and YY1 binding protein | 0.0269178 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0268714 |
| IPO7 | importin 7 | 0.0261105 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0260912 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0259164 |
| KIAA1217 | KIAA1217 | 0.0258575 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0256461 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0252693 |
| AHNAK | AHNAK nucleoprotein | 0.0252312 |
| CALR | calreticulin | 0.0252256 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0252005 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0248446 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0248063 |
| MT2A | metallothionein 2A | 0.0247822 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0247197 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0246267 |
| ATF3 | activating transcription factor 3 | 0.0244276 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0237762 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0227729 |
| ARFGEF3 | ARFGEF family member 3 | 0.0226687 |
| FRMD5 | FERM domain containing 5 | 0.022562 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.022517 |
| TLN1 | talin 1 | 0.0224466 |
| IL6ST | interleukin 6 signal transducer | 0.0223055 |
| ANXA2 | annexin A2 | 0.022198 |
| BRD2 | bromodomain containing 2 | 0.0221667 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0221373 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.0221101 |
| FNIP1 | folliculin interacting protein 1 | 0.0220532 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0220228 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.19816 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.114559 |
| BICC1 | BicC family RNA binding protein 1 | -0.0912729 |
| HLA-B | major histocompatibility complex, class I, B | -0.0894204 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0871454 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0867944 |
| CTSD | cathepsin D | -0.0706313 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0699286 |
| FBXO32 | F-box protein 32 | -0.0696372 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0628573 |
| FTL | ferritin, light polypeptide | -0.0625928 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0577171 |
| VCL | vinculin | -0.0570768 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0551253 |
| TMSB10 | thymosin beta 10 | -0.0532765 |
| NDRG1 | N-myc downstream regulated 1 | -0.0523962 |
| CTSB | cathepsin B | -0.0515329 |
| C3 | complement component 3 | -0.0482272 |
| GLIS3 | GLIS family zinc finger 3 | -0.0479977 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.047223 |
| RPL35A | ribosomal protein L35a | -0.0455069 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.045172 |
| FN1 | fibronectin 1 | -0.0435119 |
| HLA-A | major histocompatibility complex, class I, A | -0.0430732 |
| FRMD4A | FERM domain containing 4A | -0.0427067 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0419264 |
| RAI14 | retinoic acid induced 14 | -0.0408063 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0403575 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0400432 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0380544 |
| RPL37A | ribosomal protein L37a | -0.0372728 |
| ADM | adrenomedullin | -0.0364463 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0360002 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0358403 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0357908 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0354513 |
| RPL23 | ribosomal protein L23 | -0.0349192 |
| ACTG1 | actin gamma 1 | -0.0336985 |
| PTMA | prothymosin, alpha | -0.0332366 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0327926 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0319958 |
| CDH13 | cadherin 13 | -0.0308671 |
| GPC6 | glypican 6 | -0.0305939 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0305677 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0305369 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0301189 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0295738 |
| RPLP2 | ribosomal protein, large, P2 | -0.0292584 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0288314 |
| CPPED1 | calcineurin-like phosphoesterase domain containing 1 | -0.0284913 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0283822 |
| GNAS | GNAS complex locus | -0.0283447 |
| KLHL24 | kelch-like family member 24 | -0.0278596 |
| RPS13 | ribosomal protein S13 | -0.0276619 |
| RPL9 | ribosomal protein L9 | -0.027538 |
| RPS21 | ribosomal protein S21 | -0.0271284 |
| COL1A1 | collagen, type I, alpha 1 | -0.0269592 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0267374 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0263311 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0262566 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0262385 |
| PLIN2 | perilipin 2 | -0.0260023 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.025955 |
| CALD1 | caldesmon 1 | -0.0254587 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0252499 |
| TNRC6B | trinucleotide repeat containing 6B | -0.024858 |
| HLA-E | major histocompatibility complex, class I, E | -0.0247513 |
| GDF15 | growth differentiation factor 15 | -0.0246908 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0246781 |
| RPL31 | ribosomal protein L31 | -0.02462 |
| TPM4 | tropomyosin 4 | -0.024492 |
| INSR | insulin receptor | -0.0238461 |
| RPS29 | ribosomal protein S29 | -0.0237816 |
| MMP12 | matrix metallopeptidase 12 | -0.0236962 |
| KLHL5 | kelch-like family member 5 | -0.0235505 |
| NAV1 | neuron navigator 1 | -0.0230769 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0229916 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0225991 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.022517 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.022492 |
| EGFR | epidermal growth factor receptor | -0.0223561 |
| NABP1 | nucleic acid binding protein 1 | -0.0221017 |
| RAD51B | RAD51 paralog B | -0.0220601 |
| CTSA | cathepsin A | -0.0217128 |
| DIAPH2 | diaphanous-related formin 2 | -0.0216673 |
| FBXO11 | F-box protein 11 | -0.0215742 |
| HMGA2 | high mobility group AT-hook 2 | -0.0214298 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0212258 |
| SLC38A1 | solute carrier family 38, member 1 | -0.021137 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0211332 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0211201 |
| S100A9 | S100 calcium binding protein A9 | -0.0210829 |
| RPL38 | ribosomal protein L38 | -0.0209743 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.020898 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0206974 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0206563 |
| DENND5B | DENN/MADD domain containing 5B | -0.0203405 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0203383 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0203199 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0203087 |
