MK-3903_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.154744
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0891737
ERRFI1 ERBB receptor feedback inhibitor 1 0.0870602
NRXN3 neurexin 3 0.0860405
STC1 stanniocalcin 1 0.0839086
PSD3 pleckstrin and Sec7 domain containing 3 0.0734705
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.069524
ELL2 elongation factor, RNA polymerase II, 2 0.0693177
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0665866
ZSWIM6 zinc finger, SWIM-type containing 6 0.059877
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0567976
GOLGB1 golgin B1 0.0560274
COG5 component of oligomeric golgi complex 5 0.0532958
FNIP1 folliculin interacting protein 1 0.0530646
TENT5A terminal nucleotidyltransferase 5A 0.0518019
CD44 CD44 molecule (Indian blood group) 0.0513147
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0510207
TTC3 tetratricopeptide repeat domain 3 0.050895
EFNA5 ephrin-A5 0.050027
CANX calnexin 0.0462511
RUNX1 runt-related transcription factor 1 0.0444218
DLG1 discs, large homolog 1 (Drosophila) 0.0431937
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0405235
TGFBI transforming growth factor, beta-induced, 68kDa 0.0403436
SEC24A SEC24 family member A 0.0385596
RAI14 retinoic acid induced 14 0.038465
EGFR epidermal growth factor receptor 0.0379912
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0369725
GLIS3 GLIS family zinc finger 3 0.0359174
FAM13A family with sequence similarity 13, member A 0.0354521
MEF2A myocyte enhancer factor 2A 0.0354188
TIMP3 TIMP metallopeptidase inhibitor 3 0.0346021
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.034425
LIMS1 LIM and senescent cell antigen-like domains 1 0.0342512
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0341733
ASPH aspartate beta-hydroxylase 0.0337946
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0337817
AKAP12 A kinase (PRKA) anchor protein 12 0.0334373
MBD5 methyl-CpG binding domain protein 5 0.0333988
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0328453
VEGFA vascular endothelial growth factor A 0.0328385
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0318466
MYH9 myosin, heavy chain 9, non-muscle 0.0314029
SUCO SUN domain containing ossification factor 0.0313895
CLINT1 clathrin interactor 1 0.0306743
EXT1 exostosin glycosyltransferase 1 0.0300476
ESYT2 extended synaptotagmin-like protein 2 0.0298603
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0294481
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0292164
KYNU kynureninase 0.0288076
SETBP1 SET binding protein 1 0.0285193
RICTOR RPTOR independent companion of MTOR, complex 2 0.0283663
AKAP9 A kinase (PRKA) anchor protein 9 0.0279886
JARID2 jumonji, AT rich interactive domain 2 0.0279757
SP100 SP100 nuclear antigen 0.0276902
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0272225
HMGA2 high mobility group AT-hook 2 0.0270099
EPAS1 endothelial PAS domain protein 1 0.0268861
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0263986
MORF4L2 mortality factor 4 like 2 0.0263187
TENT2 terminal nucleotidyltransferase 2 0.0261364
INTS6 integrator complex subunit 6 0.0259742
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.025849
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0254499
CDH13 cadherin 13 0.0252431
ZNF133 zinc finger protein 133 0.0251344
NCOA3 nuclear receptor coactivator 3 0.0245732
CA12 carbonic anhydrase XII 0.0239899
LAMB1 laminin, beta 1 0.0239646
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0239352
PRELID2 PRELI domain containing 2 0.0238435
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0237598
HLA-B major histocompatibility complex, class I, B 0.023437
CADM1 cell adhesion molecule 1 0.0234251
SOX5 SRY (sex determining region Y)-box 5 0.0234194
MAP1B microtubule-associated protein 1B 0.0233465
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0232447
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0231509
VCL vinculin 0.0230587
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230538
CSNK1A1 casein kinase 1, alpha 1 0.0230268
SND1 staphylococcal nuclease and tudor domain containing 1 0.0229866
ZBTB20 zinc finger and BTB domain containing 20 0.0229492
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0229235
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0226897
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0226756
HLA-A major histocompatibility complex, class I, A 0.0224975
RAB31 RAB31, member RAS oncogene family 0.0224531
BLTP1 bridge-like lipid transfer protein family member 1 0.0222471
WASL Wiskott-Aldrich syndrome-like 0.022166
TPI1 triosephosphate isomerase 1 0.0219592
EIF1 eukaryotic translation initiation factor 1 0.0219554
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0217237
TRIP12 thyroid hormone receptor interactor 12 0.0214583
PTGES2 prostaglandin E synthase 2 0.0213262
ZMIZ1 zinc finger, MIZ-type containing 1 0.0213043
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0212065
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0210645
IL6 interleukin 6 0.0209974
LOXL2 lysyl oxidase-like 2 0.0207571

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.150874
VIM vimentin -0.127722
COL1A2 collagen, type I, alpha 2 -0.0958997
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0849498
COL6A3 collagen, type VI, alpha 3 -0.0799254
POTEF POTE ankyrin domain family, member F -0.0765948
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0762105
COL1A1 collagen, type I, alpha 1 -0.0707462
UBC ubiquitin C -0.0689306
ENO1 enolase 1, (alpha) -0.0579383
SPAG9 sperm associated antigen 9 -0.05621
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0549573
MT2A metallothionein 2A -0.0536887
FN1 fibronectin 1 -0.0535392
GRB10 growth factor receptor-bound protein 10 -0.0526035
TXNIP thioredoxin interacting protein -0.0462949
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0448974
CCNI cyclin I -0.044774
GANAB glucosidase, alpha; neutral AB -0.0434896
ACTG1 actin gamma 1 -0.0411663
PDIA3 protein disulfide isomerase family A, member 3 -0.040591
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0405462
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0398696
MT1X metallothionein 1X -0.0397035
AHNAK AHNAK nucleoprotein -0.039694
PTMA prothymosin, alpha -0.0373515
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0366598
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0364302
THOC2 THO complex 2 -0.0359188
WSB1 WD repeat and SOCS box containing 1 -0.0357068
SRPK2 SRSF protein kinase 2 -0.0356192
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0354757
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.035443
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0332425
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0324835
EEF2 eukaryotic translation elongation factor 2 -0.0319512
SEPTIN7 septin 7 -0.0318653
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0316104
RTN4 reticulon 4 -0.0315716
LDHA lactate dehydrogenase A -0.0313277
ZNF207 zinc finger protein 207 -0.0305198
FLNB filamin B, beta -0.0303061
COL4A2 collagen, type IV, alpha 2 -0.0302789
ZNF292 zinc finger protein 292 -0.0298124
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0296549
H3-3B H3.3 histone B -0.0296265
RPL37A ribosomal protein L37a -0.0294394
SMAD3 SMAD family member 3 -0.0294251
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0292779
AFAP1 actin filament associated protein 1 -0.0288746
S100A9 S100 calcium binding protein A9 -0.0286973
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0286947
LOX lysyl oxidase -0.0286421
RIGI RNA sensor RIG-I -0.0284124
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0276257
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.027604
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0274887
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0274237
NAV2 neuron navigator 2 -0.027256
RAB8B RAB8B, member RAS oncogene family -0.0271142
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0269143
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.026798
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0265925
LONP2 lon peptidase 2, peroxisomal -0.0263153
WDFY2 WD repeat and FYVE domain containing 2 -0.0263041
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0255506
PLCB4 phospholipase C, beta 4 -0.0246779
COL5A2 collagen, type V, alpha 2 -0.024509
RPS13 ribosomal protein S13 -0.0243288
RPL23 ribosomal protein L23 -0.0243105
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0242652
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0240033
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0239729
ANXA5 annexin A5 -0.0237973
RUNX2 runt-related transcription factor 2 -0.0233126
KMT2E lysine (K)-specific methyltransferase 2E -0.0230155
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0229622
FNDC3B fibronectin type III domain containing 3B -0.0228646
AFDN afadin, adherens junction formation factor -0.0228618
SOS2 son of sevenless homolog 2 (Drosophila) -0.0228508
ITM2B integral membrane protein 2B -0.0224281
ABI1 abl-interactor 1 -0.0222173
RPLP1 ribosomal protein, large, P1 -0.0222113
PCYOX1 prenylcysteine oxidase 1 -0.0222029
ZNF609 zinc finger protein 609 -0.0221281
RPS11 ribosomal protein S11 -0.0220577
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0219154
GRN granulin -0.021906
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0218921
TNS3 tensin 3 -0.0216756
SCARB2 scavenger receptor class B, member 2 -0.0214397
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0214241
LMNA lamin A/C -0.0214168
F3 coagulation factor III (thromboplastin, tissue factor) -0.0210699
CSDE1 cold shock domain containing E1, RNA-binding -0.0209789
FAM20C family with sequence similarity 20, member C -0.0209067
HMGB2 high mobility group box 2 -0.0208893
UGCG UDP-glucose ceramide glucosyltransferase -0.0208805
IARS1 isoleucyl-tRNA synthetase 1 -0.0207796
SERINC3 serine incorporator 3 -0.0207424