| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.111262 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0826704 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0803354 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0772923 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0770356 |
| PTK2 | protein tyrosine kinase 2 | 0.0622282 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0603162 |
| SDC4 | syndecan 4 | 0.0578578 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0569369 |
| MT2A | metallothionein 2A | 0.0568453 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0562101 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0546346 |
| FMNL2 | formin-like 2 | 0.0540616 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0488011 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0472911 |
| RPLP1 | ribosomal protein, large, P1 | 0.0471001 |
| GOLGB1 | golgin B1 | 0.0462144 |
| B2M | beta-2-microglobulin | 0.0457098 |
| SQSTM1 | sequestosome 1 | 0.0450029 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0430765 |
| PRRC2C | proline-rich coiled-coil 2C | 0.04271 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0412505 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0405685 |
| CD44 | CD44 molecule (Indian blood group) | 0.0405008 |
| NAV2 | neuron navigator 2 | 0.0394792 |
| RPS12 | ribosomal protein S12 | 0.0388681 |
| FNDC3B | fibronectin type III domain containing 3B | 0.038852 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0385572 |
| MYO9B | myosin IXB | 0.0382887 |
| NGLY1 | N-glycanase 1 | 0.0382722 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0380483 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0374378 |
| IER3 | immediate early response 3 | 0.0364495 |
| SON | SON DNA binding protein | 0.0359955 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0359736 |
| TXNIP | thioredoxin interacting protein | 0.0355897 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.035527 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0354878 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.035486 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0348874 |
| YAP1 | Yes-associated protein 1 | 0.0347834 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0347522 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.033716 |
| MAP1B | microtubule-associated protein 1B | 0.0330521 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0327661 |
| SVIL | supervillin | 0.032527 |
| ANGPTL4 | angiopoietin-like 4 | 0.0316722 |
| CCNH | cyclin H | 0.0314559 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0307156 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0307076 |
| HLA-B | major histocompatibility complex, class I, B | 0.0305235 |
| TPM3 | tropomyosin 3 | 0.030481 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0303165 |
| TTC1 | tetratricopeptide repeat domain 1 | 0.0301173 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0301039 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0296288 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.029601 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0292509 |
| MSN | moesin | 0.0292194 |
| RIGI | RNA sensor RIG-I | 0.0291167 |
| GPHN | gephyrin | 0.0290574 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0289998 |
| PFN1 | profilin 1 | 0.0289181 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0284599 |
| SEPTIN7 | septin 7 | 0.0284404 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0281572 |
| TXNRD1 | thioredoxin reductase 1 | 0.0281241 |
| PNN | pinin, desmosome associated protein | 0.0274703 |
| HLA-A | major histocompatibility complex, class I, A | 0.0273473 |
| ANO6 | anoctamin 6 | 0.0272357 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0268664 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.026762 |
| RPL36 | ribosomal protein L36 | 0.0261005 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0259184 |
| R3HDM1 | R3H domain containing 1 | 0.0256926 |
| YBX3 | Y box binding protein 3 | 0.0255534 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.025433 |
| ANXA2 | annexin A2 | 0.0251829 |
| GOLIM4 | golgi integral membrane protein 4 | 0.0250624 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0249645 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0249318 |
| SMAD3 | SMAD family member 3 | 0.0249279 |
| PHF20 | PHD finger protein 20 | 0.0243778 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0243082 |
| RBM25 | RNA binding motif protein 25 | 0.0242056 |
| DIAPH1 | diaphanous-related formin 1 | 0.0240353 |
| KIF2A | kinesin heavy chain member 2A | 0.023971 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0237914 |
| TUBB | tubulin, beta class I | 0.023726 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.023575 |
| DSTN | destrin (actin depolymerizing factor) | 0.0235281 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0234811 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0234695 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0233885 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | 0.0233607 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0232 |
| CWF19L2 | CWF19-like 2, cell cycle control (S. pombe) | 0.0231747 |
| CBFB | core-binding factor, beta subunit | 0.0230973 |
| CENPF | centromere protein F, 350/400kDa | 0.0230467 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0229178 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0781204 |
| ATM | ATM serine/threonine kinase | -0.0602399 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0578371 |
| AHNAK | AHNAK nucleoprotein | -0.0578186 |
| VCL | vinculin | -0.0489041 |
| FMN1 | formin 1 | -0.0436905 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0427055 |
| OSMR | oncostatin M receptor | -0.0393901 |
| UBC | ubiquitin C | -0.0389567 |
| ATXN1 | ataxin 1 | -0.0382458 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0376127 |
| DST | dystonin | -0.0368825 |
| CANX | calnexin | -0.0366266 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0364199 |
| PHF3 | PHD finger protein 3 | -0.0358818 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0355071 |
| ATG7 | autophagy related 7 | -0.0353018 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0352905 |
| PTMA | prothymosin, alpha | -0.0347676 |
| DENND1A | DENN/MADD domain containing 1A | -0.033926 |
| HMGA2 | high mobility group AT-hook 2 | -0.0336086 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0335166 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0332703 |
| LDHA | lactate dehydrogenase A | -0.0331034 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0329624 |
| GNAS | GNAS complex locus | -0.0324567 |
| FLNA | filamin A, alpha | -0.0316027 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0312599 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.030842 |
| CALU | calumenin | -0.0306738 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0306587 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0306037 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0305564 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0303577 |
| TMSB10 | thymosin beta 10 | -0.0303407 |
| RNF213 | ring finger protein 213 | -0.0301965 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0298806 |
| PCNX4 | pecanex 4 | -0.0296238 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0295551 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0290506 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0288524 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.02858 |
| POTEF | POTE ankyrin domain family, member F | -0.0283483 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0277535 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0276122 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0274193 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0271001 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0269477 |
| RBM39 | RNA binding motif protein 39 | -0.0269438 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0267538 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0265812 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0264584 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0264571 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.026421 |
| DENND5B | DENN/MADD domain containing 5B | -0.0261099 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0260525 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0259626 |
| TMEM263 | transmembrane protein 263 | -0.0252083 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0251434 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0250582 |
| CLINT1 | clathrin interactor 1 | -0.0246629 |
| FBXO34 | F-box protein 34 | -0.0246588 |
| MCL1 | myeloid cell leukemia 1 | -0.024564 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.024332 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0242852 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0242079 |
| TPM4 | tropomyosin 4 | -0.0240066 |
| USP22 | ubiquitin specific peptidase 22 | -0.0238258 |
| CFH | complement factor H | -0.0237454 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0237009 |
| FUS | FUS RNA binding protein | -0.0236696 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0236261 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0235653 |
| CALR | calreticulin | -0.0233318 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.023233 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0228525 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0227785 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0227654 |
| RORA | RAR-related orphan receptor A | -0.022689 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0225132 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0224324 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0222962 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0222654 |
| NUP58 | nucleoporin 58 | -0.022202 |
| PRELID2 | PRELI domain containing 2 | -0.0221136 |
| USP53 | ubiquitin specific peptidase 53 | -0.021988 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.021891 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0217003 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0216975 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0215709 |
| ATF7IP | activating transcription factor 7 interacting protein | -0.0215542 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0214176 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0212518 |
| GPR75-ASB3 | GPR75-ASB3 readthrough | -0.0212026 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0211545 |
| MRTFA | myocardin related transcription factor A | -0.0211491 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0211391 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | -0.0210441 |
| PCBP2 | poly(rC) binding protein 2 | -0.0210412 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0208681 |
