MK-3903_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 0.154606
ZSWIM6 zinc finger, SWIM-type containing 6 0.147042
HMGA2 high mobility group AT-hook 2 0.131019
ASPH aspartate beta-hydroxylase 0.0873761
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0838678
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0730742
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0714549
EFNA5 ephrin-A5 0.0706421
RAI14 retinoic acid induced 14 0.0686751
ERRFI1 ERBB receptor feedback inhibitor 1 0.0639746
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0627252
LIMCH1 LIM and calponin homology domains 1 0.0614295
STC2 stanniocalcin 2 0.060804
HIPK2 homeodomain interacting protein kinase 2 0.0601093
EXT1 exostosin glycosyltransferase 1 0.058677
AKAP12 A kinase (PRKA) anchor protein 12 0.0580446
CXCL8 chemokine (C-X-C motif) ligand 8 0.0579498
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0498958
MRPS6 mitochondrial ribosomal protein S6 0.0488184
GPATCH2L G patch domain containing 2-like 0.048042
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0471091
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0462707
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0457528
GRB10 growth factor receptor-bound protein 10 0.0440241
INTS6 integrator complex subunit 6 0.0436466
OXR1 oxidation resistance 1 0.0427223
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0421808
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0418752
LOC102724023 ES1 protein homolog, mitochondrial 0.0415791
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0404168
ATF6 activating transcription factor 6 0.0398703
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0396756
ZCCHC7 zinc finger, CCHC domain containing 7 0.0394412
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0393008
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0388096
RASAL2 RAS protein activator like 2 0.0378447
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0374459
MBNL1 muscleblind-like splicing regulator 1 0.0368551
SLC35F3 solute carrier family 35, member F3 0.0365263
AEBP2 AE binding protein 2 0.036236
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0362288
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0361094
EGFR epidermal growth factor receptor 0.035965
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0356387
FAT1 FAT atypical cadherin 1 0.0356299
DOCK5 dedicator of cytokinesis 5 0.0355735
LOXL2 lysyl oxidase-like 2 0.0355396
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.03413
ZFP36L1 ZFP36 ring finger protein-like 1 0.0335134
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0333407
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0332714
GPC6 glypican 6 0.0330899
SEPTIN9 septin 9 0.0327119
DUSP6 dual specificity phosphatase 6 0.0326199
MYOF myoferlin 0.0324542
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0324105
MCL1 myeloid cell leukemia 1 0.0319164
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0319029
RAB10 RAB10, member RAS oncogene family 0.0311156
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.031056
PDLIM5 PDZ and LIM domain 5 0.0310196
ENO2 enolase 2 (gamma, neuronal) 0.0309695
ESYT2 extended synaptotagmin-like protein 2 0.0308133
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0307187
PDE4D phosphodiesterase 4D, cAMP-specific 0.030602
MAP1B microtubule-associated protein 1B 0.030545
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0304009
LYST lysosomal trafficking regulator 0.030347
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0303004
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0302206
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0300728
TTC19 tetratricopeptide repeat domain 19 0.0299175
TRIO trio Rho guanine nucleotide exchange factor 0.0296637
CTBP2 C-terminal binding protein 2 0.029477
VEGFA vascular endothelial growth factor A 0.0289478
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0287351
CLIP2 CAP-GLY domain containing linker protein 2 0.0286886
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0283055
PRKCA protein kinase C, alpha 0.0279907
GOLGB1 golgin B1 0.0277019
SHB Src homology 2 domain containing adaptor protein B 0.0274664
TTC3 tetratricopeptide repeat domain 3 0.0272125
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0270352
CCDC138 coiled-coil domain containing 138 0.026941
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0268725
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.026646
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0263823
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0261881
RND3 Rho family GTPase 3 0.0261136
PTK2 protein tyrosine kinase 2 0.0258092
SYT1 synaptotagmin I 0.0257641
FAM13A family with sequence similarity 13, member A 0.025257
TFPI2 tissue factor pathway inhibitor 2 0.0251157
CRY1 cryptochrome circadian clock 1 0.0241858
MACF1 microtubule-actin crosslinking factor 1 0.0241787
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0240202
UBASH3B ubiquitin associated and SH3 domain containing B 0.0236482
KDM4C lysine (K)-specific demethylase 4C 0.0234895
WNK1 WNK lysine deficient protein kinase 1 0.0234799
SUCO SUN domain containing ossification factor 0.0233161

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.154745
NAMPT nicotinamide phosphoribosyltransferase -0.138878
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.136487
SQSTM1 sequestosome 1 -0.10054
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0965154
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0689614
FN1 fibronectin 1 -0.06236
RBM39 RNA binding motif protein 39 -0.0607569
TPT1 tumor protein, translationally-controlled 1 -0.0606207
HLA-B major histocompatibility complex, class I, B -0.0593908
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0583415
OGA O-GlcNAcase -0.0565417
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0553777
RPL35A ribosomal protein L35a -0.0511496
RPS6 ribosomal protein S6 -0.0506157
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0456339
MT2A metallothionein 2A -0.0441887
NAP1L1 nucleosome assembly protein 1-like 1 -0.0433584
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0429181
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0420317
RPL26 ribosomal protein L26 -0.0414481
OSMR oncostatin M receptor -0.0401933
RPS24 ribosomal protein S24 -0.0394225
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0390075
FNBP1 formin binding protein 1 -0.0385041
NEK7 NIMA-related kinase 7 -0.0381263
SMOX spermine oxidase -0.0381148
RPLP1 ribosomal protein, large, P1 -0.0367348
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0359511
WSB1 WD repeat and SOCS box containing 1 -0.0359189
FBXO32 F-box protein 32 -0.0356849
NPC1 Niemann-Pick disease, type C1 -0.0352628
PELO pelota homolog (Drosophila) -0.0350032
RPL38 ribosomal protein L38 -0.0347437
CAB39 calcium binding protein 39 -0.0343649
ARF1 ADP-ribosylation factor 1 -0.0342942
PNISR PNN-interacting serine/arginine-rich protein -0.0339397
RPS21 ribosomal protein S21 -0.0339391
S100A6 S100 calcium binding protein A6 -0.0337536
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0332533
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0332036
RPL12 ribosomal protein L12 -0.0331519
RPL9 ribosomal protein L9 -0.0325861
VIM vimentin -0.0318581
PTMA prothymosin, alpha -0.031822
ACTN4 actinin, alpha 4 -0.0317938
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0314546
RAD21 RAD21 homolog (S. pombe) -0.0314429
ETV1 ets variant 1 -0.0313846
MARCHF6 membrane associated ring-CH-type finger 6 -0.0313827
RPS20 ribosomal protein S20 -0.0311265
MIS18BP1 MIS18 binding protein 1 -0.0307685
RPL23 ribosomal protein L23 -0.0303379
GNAS GNAS complex locus -0.0297177
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0295914
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0295131
CENPF centromere protein F, 350/400kDa -0.0293099
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0290651
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0290084
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0289544
RPS29 ribosomal protein S29 -0.0287072
FOXP1 forkhead box P1 -0.028628
CANX calnexin -0.0283137
RPL31 ribosomal protein L31 -0.0281094
ACBD3 acyl-CoA binding domain containing 3 -0.0277405
IFI16 interferon, gamma-inducible protein 16 -0.0275227
WDR45B WD repeat domain 45B -0.0275
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0274105
MKI67 marker of proliferation Ki-67 -0.027065
SEPTIN7 septin 7 -0.0266336
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0262904
ZMYND8 zinc finger, MYND-type containing 8 -0.0259953
RPS27A ribosomal protein S27a -0.0259505
KIF5B kinesin family member 5B -0.0257662
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0255697
UGCG UDP-glucose ceramide glucosyltransferase -0.0254982
RPL37A ribosomal protein L37a -0.0252155
EIF1 eukaryotic translation initiation factor 1 -0.0252014
LOC112694756 uncharaterized LOC112694756 -0.025151
EWSR1 EWS RNA-binding protein 1 -0.0249442
RPL13A ribosomal protein L13a -0.0245504
KLHL5 kelch-like family member 5 -0.024354
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0240585
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0239378
ZFR zinc finger RNA binding protein -0.0239281
RPL30 ribosomal protein L30 -0.023778
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0237692
FTL ferritin, light polypeptide -0.0235134
NRIP1 nuclear receptor interacting protein 1 -0.0234123
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0233408
RPS11 ribosomal protein S11 -0.0232179
RHEB Ras homolog enriched in brain -0.0231787
ZNF292 zinc finger protein 292 -0.0231589
RPS5 ribosomal protein S5 -0.0229837
RPL11 ribosomal protein L11 -0.0229515
KDM3A lysine (K)-specific demethylase 3A -0.0227168
RPS25 ribosomal protein S25 -0.0227047
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0224067
RRBP1 ribosome binding protein 1 -0.0220608
GANAB glucosidase, alpha; neutral AB -0.0220393