| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-3903_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0985475 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0866257 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0785157 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0695282 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0637829 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0619907 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0561105 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0498413 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0446221 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0445752 |
| TRIM2 | tripartite motif containing 2 | 0.0440207 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0436333 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0426979 |
| VMP1 | vacuole membrane protein 1 | 0.041509 |
| SON | SON DNA binding protein | 0.040851 |
| RPS12 | ribosomal protein S12 | 0.0393775 |
| YAP1 | Yes-associated protein 1 | 0.0385479 |
| BRD2 | bromodomain containing 2 | 0.036293 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0358824 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0355013 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0351344 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0349761 |
| RPL3 | ribosomal protein L3 | 0.034594 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.034449 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0327138 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0326713 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0323748 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0314307 |
| NBAS | neuroblastoma amplified sequence | 0.0312813 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0308748 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0308327 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0307546 |
| DIAPH1 | diaphanous-related formin 1 | 0.03051 |
| PTK2 | protein tyrosine kinase 2 | 0.030488 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0304491 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.030374 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0301404 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0296291 |
| YBX1 | Y box binding protein 1 | 0.0295576 |
| TPM3 | tropomyosin 3 | 0.0294638 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0292975 |
| GPHN | gephyrin | 0.0288252 |
| PCBP2 | poly(rC) binding protein 2 | 0.0282433 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0276011 |
| INTS6 | integrator complex subunit 6 | 0.0275668 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0275017 |
| MYO5B | myosin VB | 0.0268845 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0266388 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.026498 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0262316 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0262005 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0260057 |
| PNN | pinin, desmosome associated protein | 0.0254396 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0252839 |
| CENPF | centromere protein F, 350/400kDa | 0.0252237 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0249545 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0249372 |
| USP24 | ubiquitin specific peptidase 24 | 0.0249031 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0248064 |
| CRY1 | cryptochrome circadian clock 1 | 0.0247838 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0247799 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.024586 |
| RPL21 | ribosomal protein L21 | 0.0242162 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0238575 |
| LIMA1 | LIM domain and actin binding 1 | 0.0238252 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0232859 |
| PAPOLA | poly(A) polymerase alpha | 0.0232215 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0228553 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0227123 |
| ATL2 | atlastin GTPase 2 | 0.022616 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0225463 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0225301 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0224595 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.02239 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0221364 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.0221345 |
| MEF2A | myocyte enhancer factor 2A | 0.0220713 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0219331 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0218536 |
| NCKAP1 | NCK-associated protein 1 | 0.0216785 |
| OLA1 | Obg-like ATPase 1 | 0.0216012 |
| SIK3 | SIK family kinase 3 | 0.0214537 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0214433 |
| ASPH | aspartate beta-hydroxylase | 0.0213762 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0213333 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0212446 |
| ECT2 | epithelial cell transforming 2 | 0.0212346 |
| LRRC58 | leucine rich repeat containing 58 | 0.0211792 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0211251 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0209528 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0208599 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0207771 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0207657 |
| RYBP | RING1 and YY1 binding protein | 0.0205615 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0205451 |
| RPS17 | ribosomal protein S17 | 0.0205292 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0205284 |
| CUL3 | cullin 3 | 0.0205089 |
| MCU | mitochondrial calcium uniporter | 0.0204976 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0204036 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.289447 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.124576 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.122252 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.101449 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.101163 |
| TMSB10 | thymosin beta 10 | -0.0991602 |
| RPL35A | ribosomal protein L35a | -0.098379 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0894513 |
| AHNAK | AHNAK nucleoprotein | -0.0826428 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0790969 |
| IER3 | immediate early response 3 | -0.077434 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0768753 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0701522 |
| GNAS | GNAS complex locus | -0.0691736 |
| ACTN4 | actinin, alpha 4 | -0.0684069 |
| KRT18 | keratin 18, type I | -0.0647703 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.063856 |
| BCL2L1 | BCL2-like 1 | -0.0619595 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.061776 |
| TMEM123 | transmembrane protein 123 | -0.0557299 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0557017 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0542523 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0530329 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0526346 |
| TPM4 | tropomyosin 4 | -0.0521596 |
| RPLP1 | ribosomal protein, large, P1 | -0.0519054 |
| EZR | ezrin | -0.0515942 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0508799 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0486755 |
| S100A6 | S100 calcium binding protein A6 | -0.0475625 |
| LOC112694756 | uncharaterized LOC112694756 | -0.047511 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0469657 |
| CUX1 | cut-like homeobox 1 | -0.0462042 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.045742 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.044816 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0424597 |
| VCL | vinculin | -0.0423833 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0422216 |
| CTSD | cathepsin D | -0.0420966 |
| RPS21 | ribosomal protein S21 | -0.04138 |
| OGA | O-GlcNAcase | -0.0412187 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0409562 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0405934 |
| NDRG1 | N-myc downstream regulated 1 | -0.0402007 |
| CD2AP | CD2-associated protein | -0.0396128 |
| PERP | PERP, TP53 apoptosis effector | -0.0382976 |
| HLA-B | major histocompatibility complex, class I, B | -0.0379801 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0376105 |
| ZNF217 | zinc finger protein 217 | -0.036526 |
| CCND1 | cyclin D1 | -0.0353238 |
| RPL38 | ribosomal protein L38 | -0.0349106 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0342337 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0341547 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0340876 |
| EPCAM | epithelial cell adhesion molecule | -0.0338346 |
| RNF213 | ring finger protein 213 | -0.0337378 |
| ITGB4 | integrin, beta 4 | -0.0336749 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0332511 |
| LAMB3 | laminin, beta 3 | -0.0332482 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0332251 |
| MX2 | MX dynamin-like GTPase 2 | -0.0330561 |
| MYOF | myoferlin | -0.0330357 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0327469 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0326429 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0324305 |
| RPS27A | ribosomal protein S27a | -0.0322837 |
| H1-0 | H1.0 linker histone | -0.0319625 |
| RPS6 | ribosomal protein S6 | -0.0311979 |
| CDK13 | cyclin-dependent kinase 13 | -0.0310813 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0309062 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0308491 |
| ARF1 | ADP-ribosylation factor 1 | -0.0306628 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.030506 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0305044 |
| TRIM56 | tripartite motif containing 56 | -0.030312 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0301421 |
| ACTG1 | actin gamma 1 | -0.0301089 |
| ONECUT3 | one cut homeobox 3 | -0.0299708 |
| KRT19 | keratin 19, type I | -0.0297318 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0296204 |
| SERINC5 | serine incorporator 5 | -0.0295106 |
| PRPF6 | pre-mRNA processing factor 6 | -0.0294822 |
| RBM39 | RNA binding motif protein 39 | -0.0294179 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0291667 |
| RPS24 | ribosomal protein S24 | -0.0291347 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0289524 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0289344 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0289129 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0288397 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0288032 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0285988 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0284654 |
| PGK1 | phosphoglycerate kinase 1 | -0.0284533 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.028208 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0282012 |
| CANX | calnexin | -0.0281438 |
| S100A2 | S100 calcium binding protein A2 | -0.0279799 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0279314 |
| EDN1 | endothelin 1 | -0.0278161 |
| MAP4 | microtubule-associated protein 4 | -0.0277396 |
