| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-3903 perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the MK-3903_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.16442 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0853344 |
| HMGA2 | high mobility group AT-hook 2 | 0.0702631 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0562972 |
| LAMA4 | laminin, alpha 4 | 0.0549808 |
| RCOR1 | REST corepressor 1 | 0.0535246 |
| IER3 | immediate early response 3 | 0.0530301 |
| SGMS2 | sphingomyelin synthase 2 | 0.052614 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.0503592 |
| ACTG1 | actin gamma 1 | 0.0498162 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.04474 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0426008 |
| LAMC2 | laminin, gamma 2 | 0.041192 |
| SNX9 | sorting nexin 9 | 0.0410633 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0409877 |
| SEPTIN9 | septin 9 | 0.0387394 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0387114 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0377205 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0368707 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0352672 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0344503 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0339194 |
| ABR | active BCR-related | 0.0311838 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0294502 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.029414 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0291071 |
| NUP50 | nucleoporin 50kDa | 0.0284947 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0280106 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0278719 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.027706 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0274551 |
| EGR1 | early growth response 1 | 0.0272905 |
| MYO5B | myosin VB | 0.0269598 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0259122 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.0257693 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0256786 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0253319 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0249982 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0249815 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0246183 |
| RPL4 | ribosomal protein L4 | 0.0245367 |
| LAMB3 | laminin, beta 3 | 0.0242538 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0236415 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0232056 |
| ANXA2 | annexin A2 | 0.0226472 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0222642 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0220281 |
| EFNB2 | ephrin-B2 | 0.02191 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0216611 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.021389 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0213351 |
| GPHN | gephyrin | 0.0213287 |
| DST | dystonin | 0.0213279 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0207256 |
| ITGA6 | integrin, alpha 6 | 0.0204613 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0202513 |
| SMAD3 | SMAD family member 3 | 0.0200171 |
| SDC4 | syndecan 4 | 0.0198968 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0197139 |
| SERTAD2 | SERTA domain containing 2 | 0.0194696 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0191401 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0190222 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0187982 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0186918 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0184425 |
| FAM107B | family with sequence similarity 107, member B | 0.01824 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0178564 |
| CDCP1 | CUB domain containing protein 1 | 0.0176689 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.017542 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0171355 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0171104 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0170622 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.01701 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0169415 |
| CD44 | CD44 molecule (Indian blood group) | 0.0168566 |
| GPC5 | glypican 5 | 0.0167838 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0167431 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0166716 |
| DSG2 | desmoglein 2 | 0.0166651 |
| EGFR | epidermal growth factor receptor | 0.0166285 |
| HOMER1 | homer scaffolding protein 1 | 0.0164779 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0163398 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0163051 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | 0.0162035 |
| TPM3 | tropomyosin 3 | 0.0155582 |
| BRD2 | bromodomain containing 2 | 0.0153549 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0153547 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0149 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0148118 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0148099 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0146937 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0146259 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0144244 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0143935 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0143896 |
| GPATCH2L | G patch domain containing 2-like | 0.0141653 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0138564 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0138372 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0138254 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0136337 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD36 | CD36 molecule (thrombospondin receptor) | -0.193422 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.12756 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.117518 |
| OXR1 | oxidation resistance 1 | -0.0854321 |
| LMO7 | LIM domain 7 | -0.0628948 |
| PTMA | prothymosin, alpha | -0.0600454 |
| HDAC2 | histone deacetylase 2 | -0.0597851 |
| RNF43 | ring finger protein 43 | -0.0560676 |
| RUNX2 | runt-related transcription factor 2 | -0.0515608 |
| ANXA1 | annexin A1 | -0.0480173 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.04538 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0440639 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.040759 |
| SERINC5 | serine incorporator 5 | -0.0390936 |
| PCBP2 | poly(rC) binding protein 2 | -0.0380422 |
| RAD51B | RAD51 paralog B | -0.0372169 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0347069 |
| RBM25 | RNA binding motif protein 25 | -0.0339389 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0321742 |
| EZR | ezrin | -0.0309976 |
| AREG | amphiregulin | -0.0308959 |
| RPS3 | ribosomal protein S3 | -0.0307997 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0303572 |
| GNAT3 | guanine nucleotide binding protein, alpha transducing 3 | -0.0291127 |
| EREG | epiregulin | -0.02874 |
| FAT1 | FAT atypical cadherin 1 | -0.0283574 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.027932 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0277343 |
| UBC | ubiquitin C | -0.0272264 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0267694 |
| AXIN2 | axin 2 | -0.0261833 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0259014 |
| CENPF | centromere protein F, 350/400kDa | -0.0254714 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.024771 |
| NEMF | nuclear export mediator factor | -0.0244983 |
| RPS6 | ribosomal protein S6 | -0.0244117 |
| ACTN4 | actinin, alpha 4 | -0.0240174 |
| NEK7 | NIMA-related kinase 7 | -0.0238195 |
| GDF15 | growth differentiation factor 15 | -0.0236338 |
| CUX1 | cut-like homeobox 1 | -0.0230945 |
| KITLG | KIT ligand | -0.0230441 |
| RPS27A | ribosomal protein S27a | -0.0225938 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0224915 |
| AOPEP | aminopeptidase O (putative) | -0.022456 |
| CEP152 | centrosomal protein 152kDa | -0.0219553 |
| RPL23 | ribosomal protein L23 | -0.0217702 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0210613 |
| MSI2 | musashi RNA-binding protein 2 | -0.020944 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0207412 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0206754 |
| TXNIP | thioredoxin interacting protein | -0.0205881 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0205339 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0205069 |
| FAR1 | fatty acyl CoA reductase 1 | -0.0203742 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0200939 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0198239 |
| ANLN | anillin, actin binding protein | -0.0197875 |
| RBM39 | RNA binding motif protein 39 | -0.0197306 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0195164 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0192145 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0191946 |
| RPS29 | ribosomal protein S29 | -0.0191744 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0190048 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0187228 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.018569 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0185225 |
| OGA | O-GlcNAcase | -0.0183729 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0182536 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0182309 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0180725 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0180374 |
| PCNX1 | pecanex 1 | -0.0179302 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0175096 |
| RPL31 | ribosomal protein L31 | -0.0174249 |
| COG5 | component of oligomeric golgi complex 5 | -0.0169291 |
| PERP | PERP, TP53 apoptosis effector | -0.0169242 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0169185 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0167217 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0166335 |
| FAM3C | family with sequence similarity 3, member C | -0.0165356 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0162647 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0161733 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0161569 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0161327 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0160216 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0158859 |
| GOLGA4 | golgin A4 | -0.0158676 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0157964 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0154329 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0154147 |
| TNS3 | tensin 3 | -0.0154112 |
| LDHA | lactate dehydrogenase A | -0.0153868 |
| RPL26 | ribosomal protein L26 | -0.0153793 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0149932 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | -0.0147346 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0147165 |
| NCKAP1 | NCK-associated protein 1 | -0.0147093 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0146142 |
| PHIP | pleckstrin homology domain interacting protein | -0.0146084 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0144114 |
