MK-3903_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-3903 perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-3903_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.213632
PTMA prothymosin, alpha 0.108482
VIM vimentin 0.091312
TPT1 tumor protein, translationally-controlled 1 0.0903944
RPS8 ribosomal protein S8 0.0817313
ASPH aspartate beta-hydroxylase 0.0758104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0757935
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0705839
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0644246
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.062807
CCND1 cyclin D1 0.0624047
RPL35A ribosomal protein L35a 0.0623476
CDK6 cyclin-dependent kinase 6 0.0611417
AKAP12 A kinase (PRKA) anchor protein 12 0.0610791
FTL ferritin, light polypeptide 0.0577807
RPS12 ribosomal protein S12 0.0558164
MT2A metallothionein 2A 0.054912
RPL23 ribosomal protein L23 0.0541491
RPS6 ribosomal protein S6 0.0539652
INTS6 integrator complex subunit 6 0.0537225
ANXA2 annexin A2 0.053279
HSPH1 heat shock 105kDa/110kDa protein 1 0.0505455
RPS19 ribosomal protein S19 0.0502186
RPL37A ribosomal protein L37a 0.047145
RPS17 ribosomal protein S17 0.0467225
SQSTM1 sequestosome 1 0.0459151
SERINC5 serine incorporator 5 0.0458816
ENO1 enolase 1, (alpha) 0.0457496
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0448429
RPL31 ribosomal protein L31 0.044465
RPL12 ribosomal protein L12 0.0435471
TMSB10 thymosin beta 10 0.0424711
RPL4 ribosomal protein L4 0.0395676
YBX1 Y box binding protein 1 0.0391944
RPL19 ribosomal protein L19 0.0384455
RPS25 ribosomal protein S25 0.0378028
RPS23 ribosomal protein S23 0.0377484
CD44 CD44 molecule (Indian blood group) 0.0373732
RPLP1 ribosomal protein, large, P1 0.0370916
WWOX WW domain containing oxidoreductase 0.0359173
VCL vinculin 0.0354059
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0353147
RPS13 ribosomal protein S13 0.0351919
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0350922
SLC38A2 solute carrier family 38, member 2 0.0337189
LOC102724023 ES1 protein homolog, mitochondrial 0.0335619
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0335553
ZFP36L1 ZFP36 ring finger protein-like 1 0.0332379
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0331648
FTH1 ferritin, heavy polypeptide 1 0.0331301
HSPA8 heat shock 70kDa protein 8 0.0330262
RPL26 ribosomal protein L26 0.0330007
FRMD5 FERM domain containing 5 0.0326092
MRPS6 mitochondrial ribosomal protein S6 0.0320775
RPS27A ribosomal protein S27a 0.0317453
RACK1 receptor for activated C kinase 1 0.0314998
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0311788
RPS14 ribosomal protein S14 0.0308013
SPATA13 spermatogenesis associated 13 0.0299719
RPL34 ribosomal protein L34 0.0297421
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0296974
B2M beta-2-microglobulin 0.0291792
RPS3 ribosomal protein S3 0.0290236
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0289789
SDC4 syndecan 4 0.0286513
IPO7 importin 7 0.0285018
EGFR epidermal growth factor receptor 0.0281552
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.028152
LDHA lactate dehydrogenase A 0.0280881
LIMS1 LIM and senescent cell antigen-like domains 1 0.0280368
TPM4 tropomyosin 4 0.0279309
CANX calnexin 0.0279306
BACE2 beta-site APP-cleaving enzyme 2 0.0279299
RPL37 ribosomal protein L37 0.0278981
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0278607
PA2G4 proliferation-associated 2G4, 38kDa 0.0275707
SAMD4A sterile alpha motif domain containing 4A 0.0275623
RPS5 ribosomal protein S5 0.0275076
RPL35 ribosomal protein L35 0.0271018
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0270122
TMSB4X thymosin beta 4, X-linked 0.026886
RPL5 ribosomal protein L5 0.0266594
GOLGB1 golgin B1 0.0263898
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0263317
EXT1 exostosin glycosyltransferase 1 0.026077
PTPRK protein tyrosine phosphatase, receptor type, K 0.0259186
RPS16 ribosomal protein S16 0.0255709
ZSWIM6 zinc finger, SWIM-type containing 6 0.0250895
MYOF myoferlin 0.0249396
FHIT fragile histidine triad 0.0248174
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0245722
COBL cordon-bleu WH2 repeat protein 0.0241934
ACTG1 actin gamma 1 0.024168
IGFBP3 insulin-like growth factor binding protein 3 0.0241003
LRMDA leucine rich melanocyte differentiation associated 0.0237693
RPL11 ribosomal protein L11 0.0233318
EZR ezrin 0.0232034
FNIP1 folliculin interacting protein 1 0.0231487
GSPT1 G1 to S phase transition 1 0.0231169
RPL36 ribosomal protein L36 0.0231074

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.115038
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0878612
RBM39 RNA binding motif protein 39 -0.0781099
PROX1 prospero homeobox 1 -0.0703521
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0664351
RUNX1 runt-related transcription factor 1 -0.0659582
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0631896
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0623055
ANLN anillin, actin binding protein -0.0596905
OXR1 oxidation resistance 1 -0.0590654
DIAPH3 diaphanous-related formin 3 -0.0585668
ATXN1 ataxin 1 -0.0562086
OGA O-GlcNAcase -0.056078
ETNK1 ethanolamine kinase 1 -0.0557671
BRWD3 bromodomain and WD repeat domain containing 3 -0.0516402
HDAC4 histone deacetylase 4 -0.0514698
VGLL4 vestigial-like family member 4 -0.0498315
KMT2C lysine (K)-specific methyltransferase 2C -0.047043
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0462983
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0453613
SBF2 SET binding factor 2 -0.0447789
CEMIP2 cell migration inducing hyaluronidase 2 -0.044644
XPO1 exportin 1 -0.043968
THOC2 THO complex 2 -0.0433838
ESYT2 extended synaptotagmin-like protein 2 -0.0426524
WDFY2 WD repeat and FYVE domain containing 2 -0.0421119
ABHD2 abhydrolase domain containing 2 -0.041559
USP34 ubiquitin specific peptidase 34 -0.0409718
NKTR natural killer cell triggering receptor -0.0405643
AOPEP aminopeptidase O (putative) -0.0398423
CD46 CD46 molecule, complement regulatory protein -0.0396329
ZMYM2 zinc finger, MYM-type 2 -0.0392477
SETD5 SET domain containing 5 -0.0392284
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0390118
BCL2L1 BCL2-like 1 -0.0389338
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0388706
ARGLU1 arginine and glutamate rich 1 -0.0377978
PCBP2 poly(rC) binding protein 2 -0.0372086
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0367804
GARS1 glycyl-tRNA synthetase 1 -0.0363284
KIZ kizuna centrosomal protein -0.0359724
RBM26 RNA binding motif protein 26 -0.03593
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0358316
TRA2B transformer 2 beta homolog (Drosophila) -0.0357322
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0356063
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0353535
MKI67 marker of proliferation Ki-67 -0.0346621
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0344429
MIS18BP1 MIS18 binding protein 1 -0.034345
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0342182
CDK8 cyclin-dependent kinase 8 -0.0342107
ZNF292 zinc finger protein 292 -0.0338717
CCDC82 coiled-coil domain containing 82 -0.0337638
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0337582
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0332579
TNS4 tensin 4 -0.0330007
GLG1 golgi glycoprotein 1 -0.0328887
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0324889
RNF43 ring finger protein 43 -0.0323133
PCCA propionyl CoA carboxylase, alpha polypeptide -0.032164
TBC1D22A TBC1 domain family, member 22A -0.0320391
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0318829
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0318502
MARCHF6 membrane associated ring-CH-type finger 6 -0.0318335
CEP95 centrosomal protein 95kDa -0.031755
YEATS2 YEATS domain containing 2 -0.0315762
NF1 neurofibromin 1 -0.0314622
ZFAND3 zinc finger, AN1-type domain 3 -0.0312321
BIRC6 baculoviral IAP repeat containing 6 -0.0310768
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0309122
PDE8A phosphodiesterase 8A -0.0307881
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0307685
KDM7A lysine (K)-specific demethylase 7A -0.0307261
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0306932
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0306525
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0305624
MORF4L2 mortality factor 4 like 2 -0.0304741
MYH9 myosin, heavy chain 9, non-muscle -0.0299865
CEP192 centrosomal protein 192kDa -0.0297789
ZDHHC20 zinc finger, DHHC-type containing 20 -0.029628
EFNB2 ephrin-B2 -0.0291936
UTRN utrophin -0.0291624
HELZ helicase with zinc finger -0.0290635
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0290352
KMT2E lysine (K)-specific methyltransferase 2E -0.0290245
ZFC3H1 zinc finger, C3H1-type containing -0.0287026
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0276768
STAG2 stromal antigen 2 -0.0274959
PCM1 pericentriolar material 1 -0.0274783
FANCL Fanconi anemia, complementation group L -0.027443
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0273956
ACTN4 actinin, alpha 4 -0.0273889
PTEN phosphatase and tensin homolog -0.0273594
JMJD1C jumonji domain containing 1C -0.0273303
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0271577
PHF21A PHD finger protein 21A -0.0270581
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0269302
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0269285
NUP58 nucleoporin 58 -0.0268247
RPS2 ribosomal protein S2 -0.0268112