MK-6892 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/135416394
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Genes

198 proteins with high or low expression in MK-6892 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PEX7 peroxisomal biogenesis factor 7 1.87
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.15
ENO1 enolase 1, (alpha) 0.87
NEK2 NIMA-related kinase 2 0.63
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.6
HDAC5 histone deacetylase 5 0.59
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.57
SPC24 SPC24, NDC80 kinetochore complex component 0.57
RPLP1 ribosomal protein, large, P1 0.55
BMP4 bone morphogenetic protein 4 0.55
LGALSL lectin, galactoside-binding-like 0.54
ODC1 ornithine decarboxylase 1 0.54
ZNF652 zinc finger protein 652 0.52
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 0.51
MDM1 Mdm1 nuclear protein homolog (mouse) 0.49
RPL27A ribosomal protein L27a 0.49
RPS26 ribosomal protein S26 0.48
NCAM1 neural cell adhesion molecule 1 0.47
ALMS1 Alstrom syndrome protein 1 0.47
GM2A GM2 ganglioside activator 0.46
RPL34 ribosomal protein L34 0.46
DOHH deoxyhypusine hydroxylase/monooxygenase 0.46
PRR3 proline rich 3 0.46
GOLGA4 golgin A4 0.45
DDT D-dopachrome tautomerase 0.44
HBA1 hemoglobin, alpha 1 0.44
RGPD8 RANBP2-like and GRIP domain containing 8 0.44
TMEM41B transmembrane protein 41B 0.43
UBQLN1 ubiquilin 1 0.42
CCDC91 coiled-coil domain containing 91 0.41
RPE ribulose-5-phosphate-3-epimerase 0.41
DIXDC1 DIX domain containing 1 0.4
RPL32 ribosomal protein L32 0.39
ISCA2 iron-sulfur cluster assembly 2 0.39
CEP44 centrosomal protein 44kDa 0.39
TMSB10 thymosin beta 10 0.39
RGN regucalcin 0.38
MFSD14B major facilitator superfamily domain containing 14B 0.38
RPL36 ribosomal protein L36 0.38
RPS23 ribosomal protein S23 0.37
VAV1 vav 1 guanine nucleotide exchange factor 0.37
RNF138 ring finger protein 138, E3 ubiquitin protein ligase 0.37
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.37
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.36
ZNF697 zinc finger protein 697 0.36
BOK BCL2-related ovarian killer 0.36
LYST lysosomal trafficking regulator 0.36
TEC tec protein tyrosine kinase 0.36
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.35
TFCP2L1 transcription factor CP2-like 1 0.35
NAV2 neuron navigator 2 0.35
C6ORF62 chromosome 6 open reading frame 62 0.34
TP73 tumor protein p73 0.34
ATP5F1D ATP synthase F1 subunit delta 0.34
PAQR4 progestin and adipoQ receptor family member IV 0.33
SYBU syntabulin (syntaxin-interacting) 0.33
NOP16 NOP16 nucleolar protein 0.33
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 0.33
ADCK1 aarF domain containing kinase 1 0.32
CENPP centromere protein P 0.32
IVNS1ABP influenza virus NS1A binding protein 0.32
TCF19 transcription factor 19 0.32
RAB30 RAB30, member RAS oncogene family 0.32
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.32
BOLA2 bolA family member 2 0.32
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.31
ZFAND6 zinc finger, AN1-type domain 6 0.31
NFE2L1 nuclear factor, erythroid 2-like 1 0.31
NAGS N-acetylglutamate synthase 0.31
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 0.31
MRPL34 mitochondrial ribosomal protein L34 0.3
TMEM106C transmembrane protein 106C 0.3
LGALS1 lectin, galactoside-binding, soluble, 1 0.3
FBF1 Fas (TNFRSF6) binding factor 1 0.3
MRPL57 mitochondrial ribosomal protein L57 0.3
TRIM8 tripartite motif containing 8 0.3
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.29
SUMO2 small ubiquitin-like modifier 2 0.29
ZNRD2 zinc ribbon domain containing 2 0.29
NOS3 nitric oxide synthase 3 (endothelial cell) 0.29
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.29
RPL24 ribosomal protein L24 0.29
ZNF184 zinc finger protein 184 0.29
CCNE1 cyclin E1 0.29
NIN ninein (GSK3B interacting protein) 0.29
GPBP1 GC-rich promoter binding protein 1 0.28
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 0.28
NUCB1 nucleobindin 1 0.28
RNASEH2C ribonuclease H2, subunit C 0.28
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa 0.28
SZT2 seizure threshold 2 homolog (mouse) 0.28
ZNF410 zinc finger protein 410 0.27
RNF145 ring finger protein 145 0.27
BAIAP2 BAI1-associated protein 2 0.27
PEG10 paternally expressed 10 0.27
S100A2 S100 calcium binding protein A2 0.27
TRIM46 tripartite motif containing 46 0.27
ATAD5 ATPase family, AAA domain containing 5 0.27
ZCCHC10 zinc finger, CCHC domain containing 10 0.27
ZNF100 zinc finger protein 100 0.27

low expression

Symbol Name Standardized Value
AKR1C3 aldo-keto reductase family 1, member C3 -1.27
BID BH3 interacting domain death agonist -1.26
TRIM29 tripartite motif containing 29 -0.87
RPL37 ribosomal protein L37 -0.73
TTLL4 tubulin tyrosine ligase-like family member 4 -0.73
RPL29 ribosomal protein L29 -0.72
KIAA1958 KIAA1958 -0.72
CFAP57 cilia and flagella associated protein 57 -0.71
HIST1H1T histone cluster 1, H1t -0.71
FAM171A1 family with sequence similarity 171, member A1 -0.7
C12ORF60 chromosome 12 open reading frame 60 -0.68
ANKRD10 ankyrin repeat domain 10 -0.66
FAM171A2 family with sequence similarity 171, member A2 -0.64
DOP1A DOP1 leucine zipper like protein A -0.63
LLPH LLP homolog, long-term synaptic facilitation (Aplysia) -0.62
CMC4 C-x(9)-C motif containing 4 -0.6
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.58
TCTN2 tectonic family member 2 -0.57
FRMPD1 FERM and PDZ domain containing 1 -0.56
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 -0.54
DOCK4 dedicator of cytokinesis 4 -0.53
MED31 mediator complex subunit 31 -0.53
MFF mitochondrial fission factor -0.52
PLK2 polo-like kinase 2 -0.52
CCDC32 coiled-coil domain containing 32 -0.52
DCTPP1 dCTP pyrophosphatase 1 -0.51
ADPRHL1 ADP-ribosylhydrolase like 1 -0.51
KMT2B lysine (K)-specific methyltransferase 2B -0.49
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.48
CDC37L1 cell division cycle 37-like 1 -0.47
SLC45A4 solute carrier family 45, member 4 -0.47
ANKRD18B ankyrin repeat domain 18B -0.46
FTL ferritin, light polypeptide -0.46
PGK2 phosphoglycerate kinase 2 -0.45
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.45
TMEM160 transmembrane protein 160 -0.44
MYH16 myosin, heavy chain 16 pseudogene -0.44
MIS12 MIS12 kinetochore complex component -0.44
PPP1R3D protein phosphatase 1, regulatory subunit 3D -0.43
MED12L mediator complex subunit 12-like -0.43
RNF130 ring finger protein 130 -0.42
PRG4 proteoglycan 4 -0.42
CMC2 C-x(9)-C motif containing 2 -0.41
RNF17 ring finger protein 17 -0.41
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -0.41
ANKRD46 ankyrin repeat domain 46 -0.41
GDF15 growth differentiation factor 15 -0.4
NAXE NAD(P)HX epimerase -0.4
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -0.4
RNF185 ring finger protein 185 -0.39
CDA cytidine deaminase -0.39
KLHL5 kelch-like family member 5 -0.39
DENND6A DENN/MADD domain containing 6A -0.39
ZNF362 zinc finger protein 362 -0.38
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -0.38
B2M beta-2-microglobulin -0.37
UBE2N ubiquitin-conjugating enzyme E2N -0.37
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.37
PPCDC phosphopantothenoylcysteine decarboxylase -0.37
PSIP1 PC4 and SFRS1 interacting protein 1 -0.36
NAP1L1 nucleosome assembly protein 1-like 1 -0.36
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) -0.36
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 -0.36
TTC3 tetratricopeptide repeat domain 3 -0.36
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.36
APLF aprataxin and PNKP like factor -0.35
MGST3 microsomal glutathione S-transferase 3 -0.35
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.35
MT-ND4 NADH dehydrogenase, subunit 4 (complex I) -0.34
FBXL2 F-box and leucine-rich repeat protein 2 -0.34
BCL2L13 BCL2-like 13 (apoptosis facilitator) -0.34
LNX2 ligand of numb-protein X 2 -0.34
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.34
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.34
C19ORF25 chromosome 19 open reading frame 25 -0.34
FKBP1A FK506 binding protein 1A, 12kDa -0.33
PPP1R2B PPP1R2 family member B -0.33
COQ9 coenzyme Q9 -0.33
ITM2B integral membrane protein 2B -0.33
NOP10 NOP10 ribonucleoprotein -0.32
NF1 neurofibromin 1 -0.32
ZBTB46 zinc finger and BTB domain containing 46 -0.32
FZD2 frizzled class receptor 2 -0.32
ROGDI rogdi homolog (Drosophila) -0.32
ACTN4 actinin, alpha 4 -0.31
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -0.31
FBXL15 F-box and leucine-rich repeat protein 15 -0.31
TTC19 tetratricopeptide repeat domain 19 -0.31
NBPF20 neuroblastoma breakpoint family, member 20 -0.3
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.3
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -0.3
ATXN7L1 ataxin 7-like 1 -0.3
PDCD5 programmed cell death 5 -0.29
MT-ND5 NADH dehydrogenase, subunit 5 (complex I) -0.29
MRPS24 mitochondrial ribosomal protein S24 -0.29
FGGY FGGY carbohydrate kinase domain containing -0.29
MPV17L2 MPV17 mitochondrial membrane protein-like 2 -0.29
PBLD phenazine biosynthesis-like protein domain containing -0.29