| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.152652 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.142869 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.133936 |
| AHNAK | AHNAK nucleoprotein | 0.110525 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.108536 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.101234 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0986024 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0860427 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0831973 |
| CANX | calnexin | 0.0685655 |
| ANXA2 | annexin A2 | 0.0664237 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0642303 |
| DST | dystonin | 0.0626755 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0607326 |
| LOX | lysyl oxidase | 0.0595535 |
| UBC | ubiquitin C | 0.0582392 |
| B2M | beta-2-microglobulin | 0.0563596 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0554667 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.055243 |
| LDHA | lactate dehydrogenase A | 0.0535153 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0521056 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0507709 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0495443 |
| SQSTM1 | sequestosome 1 | 0.0481693 |
| TPM3 | tropomyosin 3 | 0.0480599 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0473288 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.046791 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0464841 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.046074 |
| COL3A1 | collagen, type III, alpha 1 | 0.0450157 |
| FBN1 | fibrillin 1 | 0.0449872 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0428838 |
| CD44 | CD44 molecule (Indian blood group) | 0.0393086 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.038896 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0362511 |
| FLNB | filamin B, beta | 0.0358978 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0358069 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0357093 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0347722 |
| TMSB4X | thymosin beta 4, X-linked | 0.0346765 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0345589 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0340219 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0338615 |
| OGA | O-GlcNAcase | 0.0337774 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0337774 |
| SPAG9 | sperm associated antigen 9 | 0.0336745 |
| RUNX1 | runt-related transcription factor 1 | 0.0336395 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.033564 |
| HDAC9 | histone deacetylase 9 | 0.0331453 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0328623 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0327066 |
| CALR | calreticulin | 0.032611 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0324942 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0311616 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0311316 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0307836 |
| RAI1 | retinoic acid induced 1 | 0.0300357 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0300233 |
| ZNF292 | zinc finger protein 292 | 0.0299747 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0298549 |
| HELZ | helicase with zinc finger | 0.0297513 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0296152 |
| RIGI | RNA sensor RIG-I | 0.0294476 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0293675 |
| XPO1 | exportin 1 | 0.0293105 |
| RTN4 | reticulon 4 | 0.0292776 |
| MXI1 | MAX interactor 1, dimerization protein | 0.029238 |
| MB21D2 | Mab-21 domain containing 2 | 0.0292221 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0290573 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0289698 |
| STC1 | stanniocalcin 1 | 0.0289273 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0288294 |
| MYOF | myoferlin | 0.0287091 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.028646 |
| LOXL2 | lysyl oxidase-like 2 | 0.0285139 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0284939 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.02843 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0282274 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0280374 |
| TPM4 | tropomyosin 4 | 0.0280344 |
| RND3 | Rho family GTPase 3 | 0.0278842 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0277169 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.027542 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0274429 |
| APP | amyloid beta (A4) precursor protein | 0.0274039 |
| MT2A | metallothionein 2A | 0.0273935 |
| RNF24 | ring finger protein 24 | 0.0273135 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0268744 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0265715 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0264772 |
| THBS2 | thrombospondin 2 | 0.0257355 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0256261 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0256245 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.025558 |
| ENO1 | enolase 1, (alpha) | 0.025373 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0252558 |
| ZNF207 | zinc finger protein 207 | 0.0251544 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0250267 |
| ADM | adrenomedullin | 0.0249357 |
| PGK1 | phosphoglycerate kinase 1 | 0.0248087 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.244991 |
| VIM | vimentin | -0.105421 |
| PODXL | podocalyxin-like | -0.100155 |
| PLAT | plasminogen activator, tissue | -0.078783 |
| TMSB10 | thymosin beta 10 | -0.0682015 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0646002 |
| NAV1 | neuron navigator 1 | -0.0563551 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0457331 |
| COL5A1 | collagen, type V, alpha 1 | -0.0441208 |
| SUCNR1 | succinate receptor 1 | -0.0406487 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0380764 |
| POTEF | POTE ankyrin domain family, member F | -0.0362103 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.029877 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0270261 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.026659 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0259285 |
| HLA-B | major histocompatibility complex, class I, B | -0.0258089 |
| RPL35A | ribosomal protein L35a | -0.0247698 |
| RPL37A | ribosomal protein L37a | -0.0242434 |
| FN1 | fibronectin 1 | -0.0220553 |
| MCL1 | myeloid cell leukemia 1 | -0.021832 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0216265 |
| CD81 | CD81 molecule | -0.020431 |
| FTL | ferritin, light polypeptide | -0.020325 |
| KRT81 | keratin 81, type II | -0.0200044 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0197649 |
| CDH13 | cadherin 13 | -0.0194121 |
| RPL31 | ribosomal protein L31 | -0.0184563 |
| FRMD4A | FERM domain containing 4A | -0.0182465 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0181122 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0177936 |
| PTMA | prothymosin, alpha | -0.0175774 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0170262 |
| CCND1 | cyclin D1 | -0.0168538 |
| FLNA | filamin A, alpha | -0.0161174 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0159902 |
| RPS23 | ribosomal protein S23 | -0.0158861 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.0156466 |
| NCOR2 | nuclear receptor corepressor 2 | -0.015188 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | -0.0149267 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0146783 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.014673 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0146068 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0144536 |
| RPLP2 | ribosomal protein, large, P2 | -0.0143427 |
| HLA-C | major histocompatibility complex, class I, C | -0.0141033 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | -0.0140681 |
| S100A11 | S100 calcium binding protein A11 | -0.0139375 |
| COL1A1 | collagen, type I, alpha 1 | -0.0137543 |
| INTS6 | integrator complex subunit 6 | -0.0135216 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0134086 |
| EGFR | epidermal growth factor receptor | -0.0133756 |
| RPS14 | ribosomal protein S14 | -0.0133005 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0132716 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0131756 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0131686 |
| CMIP | c-Maf inducing protein | -0.0128385 |
| RPLP1 | ribosomal protein, large, P1 | -0.012619 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0125455 |
| CCM2 | cerebral cavernous malformation 2 | -0.0125415 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0123956 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0123896 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.012332 |
| ECM1 | extracellular matrix protein 1 | -0.0123133 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0122779 |
| RPL9 | ribosomal protein L9 | -0.0121538 |
| TNS3 | tensin 3 | -0.0120872 |
| HLA-A | major histocompatibility complex, class I, A | -0.0118917 |
| CYTH3 | cytohesin 3 | -0.0117987 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0112122 |
| RPL38 | ribosomal protein L38 | -0.0112107 |
| RPS29 | ribosomal protein S29 | -0.0111735 |
| CTSD | cathepsin D | -0.0111371 |
| MRC2 | mannose receptor, C type 2 | -0.0109497 |
| CSPG4 | chondroitin sulfate proteoglycan 4 | -0.01093 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0109087 |
| PDCD5 | programmed cell death 5 | -0.0108021 |
| RPS25 | ribosomal protein S25 | -0.0107995 |
| S100A6 | S100 calcium binding protein A6 | -0.0107666 |
| TPM1 | tropomyosin 1 (alpha) | -0.0106973 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0105649 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0104379 |
| RPL37 | ribosomal protein L37 | -0.0103922 |
| LAMA5 | laminin, alpha 5 | -0.0103264 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0102711 |
| SRGN | serglycin | -0.0102507 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0101977 |
| AEBP2 | AE binding protein 2 | -0.0101724 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0101007 |
| PLEC | plectin | -0.0100997 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | -0.0100666 |
| RPS15 | ribosomal protein S15 | -0.0100346 |
| LMNA | lamin A/C | -0.00993875 |
| CD59 | CD59 molecule, complement regulatory protein | -0.00993763 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | -0.00992645 |
| TOX | thymocyte selection-associated high mobility group box | -0.00991165 |
| TBCA | tubulin folding cofactor A | -0.00980208 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0097997 |
| AGRN | agrin | -0.00970726 |
| IL32 | interleukin 32 | -0.00946643 |
