| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0708833 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0573032 |
| TXNRD1 | thioredoxin reductase 1 | 0.037059 |
| RPS2 | ribosomal protein S2 | 0.0340491 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0274811 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0268427 |
| RPS8 | ribosomal protein S8 | 0.0249232 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0230076 |
| FTL | ferritin, light polypeptide | 0.0229982 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0226709 |
| KIF5B | kinesin family member 5B | 0.0224852 |
| TPM3 | tropomyosin 3 | 0.0223615 |
| AREG | amphiregulin | 0.0202126 |
| PCM1 | pericentriolar material 1 | 0.0198759 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0190759 |
| CPOX | coproporphyrinogen oxidase | 0.0182587 |
| SQSTM1 | sequestosome 1 | 0.0179 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.017335 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0173142 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.017077 |
| KLHL24 | kelch-like family member 24 | 0.0169285 |
| YBX1 | Y box binding protein 1 | 0.0167041 |
| ARRDC3 | arrestin domain containing 3 | 0.0163531 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0162198 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0160118 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0158217 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0149756 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0149244 |
| RPS19 | ribosomal protein S19 | 0.0147218 |
| TMEM41B | transmembrane protein 41B | 0.0145845 |
| SET | SET nuclear proto-oncogene | 0.0143552 |
| MED13 | mediator complex subunit 13 | 0.0142089 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0140877 |
| DSPP | dentin sialophosphoprotein | 0.0140212 |
| RPS12 | ribosomal protein S12 | 0.0139675 |
| TNPO1 | transportin 1 | 0.0139561 |
| CCNL1 | cyclin L1 | 0.0136692 |
| TBK1 | TANK-binding kinase 1 | 0.0135075 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0129677 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0127741 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.012687 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0125732 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0122764 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0121588 |
| NEK7 | NIMA-related kinase 7 | 0.012128 |
| RPS6 | ribosomal protein S6 | 0.0120713 |
| SON | SON DNA binding protein | 0.0119511 |
| SMC6 | structural maintenance of chromosomes 6 | 0.0117853 |
| YBX3 | Y box binding protein 3 | 0.0117702 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0115495 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0113901 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0113612 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.011164 |
| SPAG9 | sperm associated antigen 9 | 0.0109746 |
| OGA | O-GlcNAcase | 0.0109685 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0108129 |
| DENND4A | DENN/MADD domain containing 4A | 0.0107828 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0106813 |
| PREPL | prolyl endopeptidase-like | 0.0106317 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.010433 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0103239 |
| ATF6 | activating transcription factor 6 | 0.010201 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0101672 |
| BRD2 | bromodomain containing 2 | 0.0100879 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0100637 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.00998762 |
| PEG10 | paternally expressed 10 | 0.00997014 |
| NUP58 | nucleoporin 58 | 0.00994707 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.00981502 |
| RAB5A | RAB5A, member RAS oncogene family | 0.00980334 |
| PCBP2 | poly(rC) binding protein 2 | 0.00979598 |
| NRDC | nardilysin convertase | 0.00977954 |
| WDR26 | WD repeat domain 26 | 0.00977012 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.00975185 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.00970764 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00970266 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00966917 |
| GOLGB1 | golgin B1 | 0.00939457 |
| ADIPOR2 | adiponectin receptor 2 | 0.00936188 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.00929905 |
| HBP1 | HMG-box transcription factor 1 | 0.00926777 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.00924228 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.00908324 |
| B2M | beta-2-microglobulin | 0.0090485 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.00898515 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.00891161 |
| DSCAM | Down syndrome cell adhesion molecule | 0.00886361 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0088605 |
| XPC | xeroderma pigmentosum, complementation group C | 0.008786 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.00866899 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00853204 |
| SFPQ | splicing factor proline/glutamine-rich | 0.00842916 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.00839991 |
| AFTPH | aftiphilin | 0.0083818 |
| NKTR | natural killer cell triggering receptor | 0.00837327 |
| TFG | TRK-fused gene | 0.00828224 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.00824692 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.00824204 |
| HSPA4 | heat shock 70kDa protein 4 | 0.00823834 |
| RPL23 | ribosomal protein L23 | 0.00818695 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | -0.212621 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.131446 |
| PCDH7 | protocadherin 7 | -0.0741116 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0730676 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0729041 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0706425 |
| RASAL2 | RAS protein activator like 2 | -0.0667893 |
| TMSB10 | thymosin beta 10 | -0.0622364 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0604941 |
| NHSL1 | NHS-like 1 | -0.0597971 |
| ZNF804A | zinc finger protein 804A | -0.0584299 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0567289 |
| HMGA2 | high mobility group AT-hook 2 | -0.0564578 |
| EHBP1 | EH domain binding protein 1 | -0.0553591 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0545284 |
| ACTG1 | actin gamma 1 | -0.052671 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0521867 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0517804 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0458585 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0443154 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0417532 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0406484 |
| CMIP | c-Maf inducing protein | -0.0393539 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0386969 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0382989 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.036928 |
| DST | dystonin | -0.0365505 |
| SYT1 | synaptotagmin I | -0.0347918 |
| MGAT4C | MGAT4 family, member C | -0.0344651 |
| DTNA | dystrobrevin, alpha | -0.0337655 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0336105 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0328475 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0326427 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0316303 |
| VIM | vimentin | -0.0314987 |
| TENM3 | teneurin transmembrane protein 3 | -0.0313331 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0308148 |
| PTMA | prothymosin, alpha | -0.0295275 |
| BCHE | butyrylcholinesterase | -0.0294051 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0293144 |
| ASPH | aspartate beta-hydroxylase | -0.0292411 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0289531 |
| MKI67 | marker of proliferation Ki-67 | -0.0288712 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0288098 |
| CCN2 | cellular communication network factor 2 | -0.0283927 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0282377 |
| HMGA1 | high mobility group AT-hook 1 | -0.0280471 |
| NEBL | nebulette | -0.0277122 |
| CUX1 | cut-like homeobox 1 | -0.0272956 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0269525 |
| CLDN1 | claudin 1 | -0.026762 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0267582 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0265583 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0265315 |
| PDGFC | platelet derived growth factor C | -0.026436 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0261899 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0261191 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0259498 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0257311 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0256095 |
| NF1 | neurofibromin 1 | -0.0254913 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0253363 |
| ANXA1 | annexin A1 | -0.0248755 |
| MYPN | myopalladin | -0.0247576 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0246018 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0243146 |
| EXOC4 | exocyst complex component 4 | -0.0242939 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0242767 |
| TGM2 | transglutaminase 2 | -0.0240144 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0239751 |
| NAV3 | neuron navigator 3 | -0.0235879 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0232684 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0229212 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0225479 |
| TUBB | tubulin, beta class I | -0.0224072 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0222455 |
| MMP12 | matrix metallopeptidase 12 | -0.0221034 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0219634 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0218354 |
| EGR1 | early growth response 1 | -0.0218099 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0217652 |
| EGFR | epidermal growth factor receptor | -0.0216231 |
| DIAPH3 | diaphanous-related formin 3 | -0.0215412 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0215009 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0211508 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0211384 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0211268 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0210745 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | -0.0208071 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0206788 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0206618 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0206557 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0204661 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0199495 |
| COMMD10 | COMM domain containing 10 | -0.0198214 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0193336 |
| LMO7 | LIM domain 7 | -0.0191435 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0189915 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0188799 |
| AK1 | adenylate kinase 1 | -0.0186162 |
