MK-8353_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-8353 perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-8353_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.316026
FRMD4A FERM domain containing 4A 0.215843
VIM vimentin 0.125866
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.10806
GPC6 glypican 6 0.103083
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0999694
EXT1 exostosin glycosyltransferase 1 0.0973663
B2M beta-2-microglobulin 0.0906013
RND3 Rho family GTPase 3 0.082799
ZSWIM6 zinc finger, SWIM-type containing 6 0.0775108
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0723774
GOLGB1 golgin B1 0.0719774
TPM3 tropomyosin 3 0.0719364
RIGI RNA sensor RIG-I 0.0694576
ASPH aspartate beta-hydroxylase 0.0655719
AHNAK AHNAK nucleoprotein 0.0655387
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0654598
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0652803
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0651576
CREB5 cAMP responsive element binding protein 5 0.0612363
SP100 SP100 nuclear antigen 0.0587467
VCL vinculin 0.0573353
KYNU kynureninase 0.0570485
EGFR epidermal growth factor receptor 0.054544
RAI14 retinoic acid induced 14 0.0544751
AKAP9 A kinase (PRKA) anchor protein 9 0.0531015
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0508319
PDIA3 protein disulfide isomerase family A, member 3 0.0505884
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0472404
FAM107B family with sequence similarity 107, member B 0.0471854
SFTPA2 surfactant protein A2 0.0469654
ZBTB20 zinc finger and BTB domain containing 20 0.0468043
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0465615
RNF213 ring finger protein 213 0.0465048
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0464546
HDAC9 histone deacetylase 9 0.0457385
CRY1 cryptochrome circadian clock 1 0.0448428
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0448314
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0438686
EHBP1 EH domain binding protein 1 0.0437704
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0432352
DST dystonin 0.0425744
SEC31A SEC31 homolog A (S. cerevisiae) 0.0416518
ZCCHC7 zinc finger, CCHC domain containing 7 0.0415874
NAV2 neuron navigator 2 0.0413235
MX1 MX dynamin-like GTPase 1 0.0410297
IFI44L interferon-induced protein 44-like 0.0408956
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0401277
ATF3 activating transcription factor 3 0.0397504
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.039255
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0389641
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0388947
SPDYA speedy/RINGO cell cycle regulator family member A 0.0386003
INTS6 integrator complex subunit 6 0.0385635
TPM4 tropomyosin 4 0.038535
PDLIM5 PDZ and LIM domain 5 0.0384364
MYADM myeloid-associated differentiation marker 0.0383589
ESYT2 extended synaptotagmin-like protein 2 0.0372652
CALR calreticulin 0.037061
PALLD palladin, cytoskeletal associated protein 0.036926
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0367384
KPNB1 karyopherin (importin) beta 1 0.0366241
CANX calnexin 0.0363404
PDIA6 protein disulfide isomerase family A, member 6 0.035907
CUX1 cut-like homeobox 1 0.0359015
UBAP2 ubiquitin associated protein 2 0.0357993
MSR1 macrophage scavenger receptor 1 0.035626
ALCAM activated leukocyte cell adhesion molecule 0.0355424
TSHZ2 teashirt zinc finger homeobox 2 0.0353224
MYO1E myosin IE 0.0345359
CSNK1A1 casein kinase 1, alpha 1 0.034477
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0342498
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0340611
SAMD9 sterile alpha motif domain containing 9 0.0336128
BLZF1 basic leucine zipper nuclear factor 1 0.0334388
MLF1 myeloid leukemia factor 1 0.0332534
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0331436
LPP LIM domain containing preferred translocation partner in lipoma 0.0331366
PDE4D phosphodiesterase 4D, cAMP-specific 0.0331091
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.032898
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0326899
CTBP2 C-terminal binding protein 2 0.0326389
GPC5 glypican 5 0.0324749
IFIH1 interferon induced with helicase C domain 1 0.0323892
HM13 histocompatibility (minor) 13 0.0323143
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0318216
OSMR oncostatin M receptor 0.0306568
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0306274
GPR176 G protein-coupled receptor 176 0.0303522
ENO1 enolase 1, (alpha) 0.0303483
IFI16 interferon, gamma-inducible protein 16 0.0301648
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0301242
TXNRD1 thioredoxin reductase 1 0.0296526
ATF6 activating transcription factor 6 0.0294928
APOL1 apolipoprotein L, 1 0.0285974
PLIN2 perilipin 2 0.0285665
IFITM3 interferon induced transmembrane protein 3 0.0285211
ADIPOR2 adiponectin receptor 2 0.0284875
PDIA4 protein disulfide isomerase family A, member 4 0.0283317
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0282861

decreased expression

Symbol Name Standardized Value
CSF1 colony stimulating factor 1 (macrophage) -0.101285
CCL2 chemokine (C-C motif) ligand 2 -0.0813454
NAMPT nicotinamide phosphoribosyltransferase -0.0803814
PTBP3 polypyrimidine tract binding protein 3 -0.0712336
GLS2 glutaminase 2 (liver, mitochondrial) -0.0633257
NRIP1 nuclear receptor interacting protein 1 -0.0609779
ICAM1 intercellular adhesion molecule 1 -0.0606926
UGCG UDP-glucose ceramide glucosyltransferase -0.0591547
G0S2 G0/G1 switch 2 -0.0584594
NRP2 neuropilin 2 -0.058444
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0577849
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0577518
DDIT4 DNA-damage-inducible transcript 4 -0.0566748
DENND2B DENN domain containing 2B -0.0563387
OSBPL3 oxysterol binding protein-like 3 -0.0536003
ANKRD33B ankyrin repeat domain 33B -0.053208
RTN4 reticulon 4 -0.0503021
MARCHF6 membrane associated ring-CH-type finger 6 -0.0496393
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0473799
KMT2E lysine (K)-specific methyltransferase 2E -0.0463641
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0457266
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0455511
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0433502
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.042831
MYH9 myosin, heavy chain 9, non-muscle -0.042645
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0421867
RHEB Ras homolog enriched in brain -0.0409156
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0407071
ANKRD10 ankyrin repeat domain 10 -0.0406703
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0399219
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0390492
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0389536
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0383893
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0380564
USP3 ubiquitin specific peptidase 3 -0.0378818
SP3 Sp3 transcription factor -0.0375161
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0373339
EML4 echinoderm microtubule associated protein like 4 -0.0370438
WAC WW domain containing adaptor with coiled-coil -0.0366632
APP amyloid beta (A4) precursor protein -0.0360989
CXCL3 chemokine (C-X-C motif) ligand 3 -0.0354557
XPO1 exportin 1 -0.0337299
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0325564
AGFG1 ArfGAP with FG repeats 1 -0.0325011
VCAM1 vascular cell adhesion molecule 1 -0.0323417
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0321789
RNF145 ring finger protein 145 -0.0321541
POTEF POTE ankyrin domain family, member F -0.032042
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0318182
WDR43 WD repeat domain 43 -0.0314368
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0309849
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0309724
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0305168
LITAF lipopolysaccharide-induced TNF factor -0.0303538
TGFBI transforming growth factor, beta-induced, 68kDa -0.0301154
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0300386
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0296416
CADM1 cell adhesion molecule 1 -0.0292143
SLMAP sarcolemma associated protein -0.0291582
NPEPPS aminopeptidase puromycin sensitive -0.0285872
CD70 CD70 molecule -0.0285701
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0284796
STOM stomatin -0.0283942
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0279863
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0279086
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0279003
FLNA filamin A, alpha -0.0278537
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0278246
PKM pyruvate kinase, muscle -0.0277147
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0276956
CELF1 CUGBP, Elav-like family member 1 -0.0275273
PTMA prothymosin, alpha -0.0273229
HPCAL1 hippocalcin-like 1 -0.0270801
PLPP3 phospholipid phosphatase 3 -0.0270662
QKI QKI, KH domain containing, RNA binding -0.0270254
TM9SF2 transmembrane 9 superfamily member 2 -0.0269897
ANLN anillin, actin binding protein -0.0268311
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0268215
TFG TRK-fused gene -0.0266214
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0265751
NAP1L1 nucleosome assembly protein 1-like 1 -0.0261451
EEF2 eukaryotic translation elongation factor 2 -0.025814
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.025734
PRRC1 proline-rich coiled-coil 1 -0.0256695
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0256635
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.025616
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0254692
INSIG1 insulin induced gene 1 -0.0254392
FOSL2 FOS-like antigen 2 -0.0251573
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0250925
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0250594
NDRG1 N-myc downstream regulated 1 -0.0247536
OLA1 Obg-like ATPase 1 -0.0245814
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0244248
AZIN1 antizyme inhibitor 1 -0.024302
PNISR PNN-interacting serine/arginine-rich protein -0.0242475
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0241697
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.024061
SRPK2 SRSF protein kinase 2 -0.0239279
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.023927