MK-8353_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-8353 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-8353_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.178109
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.163239
KYNU kynureninase 0.117524
ARHGAP26 Rho GTPase activating protein 26 0.112386
ZSWIM6 zinc finger, SWIM-type containing 6 0.0988441
FNDC3B fibronectin type III domain containing 3B 0.089104
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0876761
ALCAM activated leukocyte cell adhesion molecule 0.0860206
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0749551
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0748453
VCL vinculin 0.0708056
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0676128
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0674688
RPS2 ribosomal protein S2 0.0656566
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0652881
PDLIM5 PDZ and LIM domain 5 0.0595471
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0594161
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0586732
EXT1 exostosin glycosyltransferase 1 0.0585777
VMP1 vacuole membrane protein 1 0.0566954
ASPH aspartate beta-hydroxylase 0.0549564
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0545395
GLS2 glutaminase 2 (liver, mitochondrial) 0.0517472
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0499322
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0479028
ECT2 epithelial cell transforming 2 0.0474407
FAM107B family with sequence similarity 107, member B 0.0469943
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0465581
AKAP13 A kinase (PRKA) anchor protein 13 0.0462385
CXCL8 chemokine (C-X-C motif) ligand 8 0.045407
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.042111
STC1 stanniocalcin 1 0.0418371
RPL4 ribosomal protein L4 0.0409652
RND3 Rho family GTPase 3 0.040489
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0403023
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0401429
GPATCH2L G patch domain containing 2-like 0.039452
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0390388
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0385558
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.038488
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0379758
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0376501
SPAG9 sperm associated antigen 9 0.0376225
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.036508
MSN moesin 0.0362687
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0361214
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0359152
SAMD4A sterile alpha motif domain containing 4A 0.0346891
MCTP1 multiple C2 domains, transmembrane 1 0.0346305
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0343522
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0333055
AADAC arylacetamide deacetylase 0.0330491
MBNL1 muscleblind-like splicing regulator 1 0.0326123
INTS6 integrator complex subunit 6 0.0325471
KTN1 kinectin 1 (kinesin receptor) 0.0322379
SLC38A2 solute carrier family 38, member 2 0.0319066
TM4SF1 transmembrane 4 L six family member 1 0.0317005
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0315902
PKM pyruvate kinase, muscle 0.0313631
PICALM phosphatidylinositol binding clathrin assembly protein 0.031058
CD44 CD44 molecule (Indian blood group) 0.0310203
IPO7 importin 7 0.0307664
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.030401
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0302534
TXNRD1 thioredoxin reductase 1 0.0301215
TRIO trio Rho guanine nucleotide exchange factor 0.0300031
USP34 ubiquitin specific peptidase 34 0.0294033
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.028902
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0288001
SOD2 superoxide dismutase 2, mitochondrial 0.0287779
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0284944
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0284269
ELL2 elongation factor, RNA polymerase II, 2 0.0280835
TPM3 tropomyosin 3 0.0279976
MYO10 myosin X 0.0279275
RPL23 ribosomal protein L23 0.0278635
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0278402
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0275893
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0275097
MED13 mediator complex subunit 13 0.027393
UBASH3B ubiquitin associated and SH3 domain containing B 0.0273734
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.027359
USP47 ubiquitin specific peptidase 47 0.0270361
BIRC3 baculoviral IAP repeat containing 3 0.0270176
NRIP1 nuclear receptor interacting protein 1 0.0269276
DSCAM Down syndrome cell adhesion molecule 0.0263431
SET SET nuclear proto-oncogene 0.026266
SMYD3 SET and MYND domain containing 3 0.0262658
RASA2 RAS p21 protein activator 2 0.0262402
MYO1B myosin IB 0.0258712
RNF145 ring finger protein 145 0.0258247
CORO1C coronin, actin binding protein, 1C 0.0252822
NAP1L1 nucleosome assembly protein 1-like 1 0.0252122
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0252111
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0250394
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0246482
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0245855
FNIP1 folliculin interacting protein 1 0.0245812
EEF1G eukaryotic translation elongation factor 1 gamma 0.0245086
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0244687

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.214574
NDRG1 N-myc downstream regulated 1 -0.147431
IGFBP3 insulin-like growth factor binding protein 3 -0.127304
TPT1 tumor protein, translationally-controlled 1 -0.0845605
CA12 carbonic anhydrase XII -0.0810112
IGFBP4 insulin-like growth factor binding protein 4 -0.0652942
ACTG1 actin gamma 1 -0.0647962
AKAP12 A kinase (PRKA) anchor protein 12 -0.0640438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0626129
S100A6 S100 calcium binding protein A6 -0.0622348
VIM vimentin -0.0596549
ANXA4 annexin A4 -0.0534775
RRBP1 ribosome binding protein 1 -0.051214
RIN2 Ras and Rab interactor 2 -0.0500699
ZMYND8 zinc finger, MYND-type containing 8 -0.0500428
PTMA prothymosin, alpha -0.0490168
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.046594
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0459276
MT1X metallothionein 1X -0.0434515
RPLP1 ribosomal protein, large, P1 -0.0405649
AHNAK2 AHNAK nucleoprotein 2 -0.0395008
RNF213 ring finger protein 213 -0.0384431
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0371492
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0351545
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0346588
BTG1 B-cell translocation gene 1, anti-proliferative -0.0338987
EFNA5 ephrin-A5 -0.0335955
OSMR oncostatin M receptor -0.0332079
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0331565
GRB10 growth factor receptor-bound protein 10 -0.0329053
HLA-B major histocompatibility complex, class I, B -0.0326685
TNS3 tensin 3 -0.0326362
LAMB3 laminin, beta 3 -0.0319894
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0319072
FLNB filamin B, beta -0.0308966
FTH1 ferritin, heavy polypeptide 1 -0.0300382
ADM adrenomedullin -0.0298828
KDM3A lysine (K)-specific demethylase 3A -0.0298151
AKR1C2 aldo-keto reductase family 1, member C2 -0.029741
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0289216
BASP1 brain abundant, membrane attached signal protein 1 -0.0287415
LOXL2 lysyl oxidase-like 2 -0.0286663
RAI14 retinoic acid induced 14 -0.0281757
RPS24 ribosomal protein S24 -0.0277883
CAVIN1 caveolae associated protein 1 -0.0277457
CP ceruloplasmin (ferroxidase) -0.0268568
ZFHX3 zinc finger homeobox 3 -0.0268124
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0264824
PYGL phosphorylase, glycogen, liver -0.0264675
RPS19 ribosomal protein S19 -0.0261699
WSB1 WD repeat and SOCS box containing 1 -0.0260285
AOPEP aminopeptidase O (putative) -0.0252906
EHBP1 EH domain binding protein 1 -0.0250144
RPL38 ribosomal protein L38 -0.0248455
IER3 immediate early response 3 -0.0247881
DAPK1 death-associated protein kinase 1 -0.0247871
HLA-E major histocompatibility complex, class I, E -0.0244583
KRT81 keratin 81, type II -0.0244014
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0236946
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0235516
SLC38A1 solute carrier family 38, member 1 -0.023381
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0231493
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0230321
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0228266
FTL ferritin, light polypeptide -0.0223013
TMSB4X thymosin beta 4, X-linked -0.0221613
GNAS GNAS complex locus -0.0220068
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0216935
RPH3AL rabphilin 3A-like (without C2 domains) -0.0214184
PLEC plectin -0.0210947
CD99 CD99 molecule -0.0209083
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0208838
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.020744
NPEPPS aminopeptidase puromycin sensitive -0.020575
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0204141
LTBP4 latent transforming growth factor beta binding protein 4 -0.0202346
RPL37 ribosomal protein L37 -0.0201272
GCC2 GRIP and coiled-coil domain containing 2 -0.0200216
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0199538
ARL4C ADP-ribosylation factor-like 4C -0.0198123
FA2H fatty acid 2-hydroxylase -0.0196651
RPS29 ribosomal protein S29 -0.0195339
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0193887
PGK1 phosphoglycerate kinase 1 -0.0192328
KPNB1 karyopherin (importin) beta 1 -0.019132
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.019075
PTPRF protein tyrosine phosphatase, receptor type, F -0.0190582
H1-0 H1.0 linker histone -0.0188783
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0188452
NPAS2 neuronal PAS domain protein 2 -0.0186873
EIF1 eukaryotic translation initiation factor 1 -0.018392
RPL36A ribosomal protein L36a -0.0183837
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0183077
DENND4C DENN/MADD domain containing 4C -0.0182253
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0181561
RPL35A ribosomal protein L35a -0.017868
RPL34 ribosomal protein L34 -0.0177912
ZCCHC2 zinc finger, CCHC domain containing 2 -0.0177589
FLNA filamin A, alpha -0.017446
NCOA7 nuclear receptor coactivator 7 -0.0173024