MK-8353_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-8353 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-8353_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.197414
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.12218
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.100932
SOX5 SRY (sex determining region Y)-box 5 0.0860716
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0770222
COL5A2 collagen, type V, alpha 2 0.0761674
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0757166
CDH18 cadherin 18, type 2 0.0739364
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0724876
USP9X ubiquitin specific peptidase 9, X-linked 0.0701967
JMJD1C jumonji domain containing 1C 0.0692986
DST dystonin 0.0664776
ENO1 enolase 1, (alpha) 0.0609063
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0606374
ZNF608 zinc finger protein 608 0.0592001
ZNF292 zinc finger protein 292 0.0583331
KMT2C lysine (K)-specific methyltransferase 2C 0.0581261
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0576008
WLS wntless Wnt ligand secretion mediator 0.0570583
NFIA nuclear factor I/A 0.056564
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0560337
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0532264
SLIT2 slit homolog 2 (Drosophila) 0.0520724
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0520117
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0517421
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0516217
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0501433
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0492247
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0486545
PCM1 pericentriolar material 1 0.0479905
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0474883
HELZ helicase with zinc finger 0.0472896
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0466493
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0451431
ANKRD12 ankyrin repeat domain 12 0.0449033
NBEAL1 neurobeachin-like 1 0.0446125
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0444128
ZNF638 zinc finger protein 638 0.0431383
PCBP2 poly(rC) binding protein 2 0.0431218
USP34 ubiquitin specific peptidase 34 0.043077
WAC WW domain containing adaptor with coiled-coil 0.0423369
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0421665
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0416714
BBX bobby sox homolog (Drosophila) 0.0412998
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0405664
PDIA3 protein disulfide isomerase family A, member 3 0.0404194
TPM3 tropomyosin 3 0.0400073
SPATS2 spermatogenesis associated, serine-rich 2 0.0396554
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0396551
KTN1 kinectin 1 (kinesin receptor) 0.0393537
CCSER1 coiled-coil serine-rich protein 1 0.0393212
RPL4 ribosomal protein L4 0.0390917
VMP1 vacuole membrane protein 1 0.0390336
SIK3 SIK family kinase 3 0.038986
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0384443
BPTF bromodomain PHD finger transcription factor 0.0383903
GNAS GNAS complex locus 0.0383332
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0382622
ERBB4 erb-b2 receptor tyrosine kinase 4 0.038179
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0380856
ASPH aspartate beta-hydroxylase 0.0377866
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0376706
TAOK1 TAO kinase 1 0.0374158
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0373199
SERTAD2 SERTA domain containing 2 0.0364457
CCDC88A coiled-coil domain containing 88A 0.0363644
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0359504
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0357428
CENPF centromere protein F, 350/400kDa 0.0355574
KDM2A lysine (K)-specific demethylase 2A 0.0352397
XPO1 exportin 1 0.0352284
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0350942
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0350834
NGLY1 N-glycanase 1 0.0348534
DSCAM Down syndrome cell adhesion molecule 0.0346079
JARID2 jumonji, AT rich interactive domain 2 0.0345905
CLTC clathrin, heavy chain (Hc) 0.0344396
APLP2 amyloid beta (A4) precursor-like protein 2 0.0343363
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0342706
AUTS2 autism susceptibility candidate 2 0.0342207
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0340251
NIPBL Nipped-B homolog (Drosophila) 0.0339896
AKAP9 A kinase (PRKA) anchor protein 9 0.0339462
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0334087
KMT2E lysine (K)-specific methyltransferase 2E 0.0332539
NFIB nuclear factor I/B 0.0332507
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0332
CHD7 chromodomain helicase DNA binding protein 7 0.0328356
TPM4 tropomyosin 4 0.0318516
USP37 ubiquitin specific peptidase 37 0.0316321
SBF2 SET binding factor 2 0.031595
FXR1 fragile X mental retardation, autosomal homolog 1 0.0314449
AGTPBP1 ATP/GTP binding protein 1 0.0311754
ASCC3 activating signal cointegrator 1 complex subunit 3 0.031076
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.030594
KIF1B kinesin family member 1B 0.0302352
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0301766
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0301352
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.030061
UBE4B ubiquitination factor E4B 0.0299421

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.110518
PTMA prothymosin, alpha -0.0947985
TENM3 teneurin transmembrane protein 3 -0.0742006
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0648741
RPL37A ribosomal protein L37a -0.0633958
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0609645
MCTP1 multiple C2 domains, transmembrane 1 -0.0454108
RPL35A ribosomal protein L35a -0.0424455
RPL26 ribosomal protein L26 -0.0399712
PDE4D phosphodiesterase 4D, cAMP-specific -0.0392526
NAP1L1 nucleosome assembly protein 1-like 1 -0.0375662
SOX2 SRY (sex determining region Y)-box 2 -0.0372793
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0356556
RPL13A ribosomal protein L13a -0.0345363
OSBPL10 oxysterol binding protein-like 10 -0.0344429
ACTG1 actin gamma 1 -0.0328785
RPL11 ribosomal protein L11 -0.0314184
RPL38 ribosomal protein L38 -0.0312713
RPS23 ribosomal protein S23 -0.0311133
RPS29 ribosomal protein S29 -0.0302706
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0286124
TPT1 tumor protein, translationally-controlled 1 -0.0276137
EGR1 early growth response 1 -0.0275647
NOP56 NOP56 ribonucleoprotein -0.0265551
RPS24 ribosomal protein S24 -0.0263956
EMP1 epithelial membrane protein 1 -0.0257692
RPS21 ribosomal protein S21 -0.0253703
RPS3 ribosomal protein S3 -0.025217
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0250116
CAVIN1 caveolae associated protein 1 -0.0249252
DNMBP dynamin binding protein -0.0245199
RSL1D1 ribosomal L1 domain containing 1 -0.0242541
RPS12 ribosomal protein S12 -0.024137
RPS27A ribosomal protein S27a -0.0235656
SHROOM3 shroom family member 3 -0.0217475
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0214038
CELF1 CUGBP, Elav-like family member 1 -0.0213323
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0210054
RPL34 ribosomal protein L34 -0.020804
MYL12B myosin, light chain 12B, regulatory -0.0207686
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0203231
NOL8 nucleolar protein 8 -0.0202617
DNAH14 dynein, axonemal, heavy chain 14 -0.020085
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0200781
RPL12 ribosomal protein L12 -0.020047
RPLP2 ribosomal protein, large, P2 -0.0199599
PA2G4 proliferation-associated 2G4, 38kDa -0.0198721
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -0.0198011
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -0.0197621
RPS2 ribosomal protein S2 -0.0197117
FASN fatty acid synthase -0.0193745
CDV3 CDV3 homolog (mouse) -0.0191994
RPL36 ribosomal protein L36 -0.0191289
RPL8 ribosomal protein L8 -0.0189625
ATXN10 ataxin 10 -0.0188463
GJA1 gap junction protein, alpha 1, 43kDa -0.0185794
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0184779
TRAP1 TNF receptor-associated protein 1 -0.0184688
PRRC2B proline-rich coiled-coil 2B -0.018461
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0184288
ZNF33A zinc finger protein 33A -0.0183592
VIM vimentin -0.018282
TFPI2 tissue factor pathway inhibitor 2 -0.0181562
RPL9 ribosomal protein L9 -0.0180865
RPL7L1 ribosomal protein L7-like 1 -0.0180832
ZNF544 zinc finger protein 544 -0.0180252
RPS11 ribosomal protein S11 -0.017873
FBXO22 F-box protein 22 -0.0177928
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0176368
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0176329
KDM3A lysine (K)-specific demethylase 3A -0.0174816
RPL31 ribosomal protein L31 -0.0174283
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 -0.0173195
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0170232
RPS14 ribosomal protein S14 -0.0169081
LARP1 La ribonucleoprotein domain family, member 1 -0.01665
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0165129
HHIP hedgehog interacting protein -0.0164778
TNPO2 transportin 2 -0.0164516
SLC39A11 solute carrier family 39, member 11 -0.0163965
FRMD5 FERM domain containing 5 -0.0163957
PCDH11X protocadherin 11 X-linked -0.0163555
EIF5B eukaryotic translation initiation factor 5B -0.0162833
RPL19 ribosomal protein L19 -0.0162671
ZSCAN5A zinc finger and SCAN domain containing 5A -0.0161801
E2F3 E2F transcription factor 3 -0.0160915
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0155876
EFNA5 ephrin-A5 -0.015538
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -0.0154842
FKBP10 FK506 binding protein 10, 65 kDa -0.0153035
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0152041
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.015185
KIAA0825 KIAA0825 -0.0151262
RPL18 ribosomal protein L18 -0.0149967
C1ORF159 chromosome 1 open reading frame 159 -0.0149924
RPL7A ribosomal protein L7a -0.0148673
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0144756
MTAP methylthioadenosine phosphorylase -0.0144471
DIDO1 death inducer-obliterator 1 -0.014425
RPL41 ribosomal protein L41 -0.0143701