| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD109 | CD109 molecule | 0.120847 |
| VIM | vimentin | 0.106235 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0946779 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.089437 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.087507 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0860689 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0810773 |
| SFTPA2 | surfactant protein A2 | 0.0796593 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.078721 |
| ENO1 | enolase 1, (alpha) | 0.0786265 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0780042 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0640492 |
| CENPF | centromere protein F, 350/400kDa | 0.0635856 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0603701 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0588568 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0562685 |
| ASPH | aspartate beta-hydroxylase | 0.0513475 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0506473 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0494029 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0491901 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0490823 |
| AHNAK | AHNAK nucleoprotein | 0.0482661 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0472406 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0468127 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.045702 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0455253 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0452249 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0451468 |
| PHF21A | PHD finger protein 21A | 0.0450195 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0435738 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0431792 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0430002 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0427305 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0419151 |
| CDC73 | cell division cycle 73 | 0.0417051 |
| RTN4 | reticulon 4 | 0.0416463 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0410113 |
| ZNF292 | zinc finger protein 292 | 0.0406095 |
| NAV2 | neuron navigator 2 | 0.0404111 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0386801 |
| RYBP | RING1 and YY1 binding protein | 0.0384285 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0381366 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0380479 |
| COG5 | component of oligomeric golgi complex 5 | 0.0379907 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0369831 |
| COPA | coatomer protein complex, subunit alpha | 0.0363656 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0358866 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0355001 |
| ARRDC3 | arrestin domain containing 3 | 0.0352369 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0351566 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0349252 |
| HELZ | helicase with zinc finger | 0.0348802 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0347801 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0346661 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0343826 |
| LDHA | lactate dehydrogenase A | 0.0338421 |
| XPO1 | exportin 1 | 0.0333527 |
| TAGLN2 | transgelin 2 | 0.0332365 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0318311 |
| KLF10 | Kruppel-like factor 10 | 0.0315393 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.031358 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0311476 |
| MTPN | myotrophin | 0.0308509 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0302138 |
| TMEM178B | transmembrane protein 178B | 0.0294973 |
| MRTFA | myocardin related transcription factor A | 0.0292137 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0290689 |
| EMP1 | epithelial membrane protein 1 | 0.029027 |
| SRPK2 | SRSF protein kinase 2 | 0.0289647 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0289069 |
| ANXA5 | annexin A5 | 0.0286361 |
| JMJD1C | jumonji domain containing 1C | 0.0283675 |
| MEF2A | myocyte enhancer factor 2A | 0.028159 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.027877 |
| AFDN | afadin, adherens junction formation factor | 0.027385 |
| VMP1 | vacuole membrane protein 1 | 0.0271911 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0270735 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.027047 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0269761 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0267224 |
| NUP58 | nucleoporin 58 | 0.0266736 |
| RHEB | Ras homolog enriched in brain | 0.0265396 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0261782 |
| MKRN1 | makorin ring finger protein 1 | 0.025861 |
| B2M | beta-2-microglobulin | 0.0257592 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.025594 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0255725 |
| TXNIP | thioredoxin interacting protein | 0.0255078 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0254747 |
| USP37 | ubiquitin specific peptidase 37 | 0.0252211 |
| LRRC58 | leucine rich repeat containing 58 | 0.02516 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0250074 |
| APP | amyloid beta (A4) precursor protein | 0.0247995 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0247376 |
| VCL | vinculin | 0.024732 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0247028 |
| IL6ST | interleukin 6 signal transducer | 0.0242247 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | 0.0242091 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0241255 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.02397 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VGF | VGF nerve growth factor inducible | -0.248118 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.175832 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.134325 |
| MACROD2 | MACRO domain containing 2 | -0.0887027 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0882057 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0727244 |
| HMCN1 | hemicentin 1 | -0.072292 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0693113 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0688682 |
| GPC6 | glypican 6 | -0.0643715 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0625208 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0624864 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0623058 |
| NLGN1 | neuroligin 1 | -0.060449 |
| CDK14 | cyclin-dependent kinase 14 | -0.0603555 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0597284 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0572716 |
| EGR1 | early growth response 1 | -0.0550335 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0546223 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.053033 |
| HLA-B | major histocompatibility complex, class I, B | -0.052456 |
| PTCHD4 | patched domain containing 4 | -0.0497797 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0490263 |
| SCFD2 | sec1 family domain containing 2 | -0.0471088 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0433837 |
| FMN1 | formin 1 | -0.043237 |
| FRMD4A | FERM domain containing 4A | -0.0425877 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.042542 |
| RPL37A | ribosomal protein L37a | -0.0419799 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0413645 |
| NAV3 | neuron navigator 3 | -0.0408062 |
| LSAMP | limbic system-associated membrane protein | -0.0401627 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0393299 |
| EHBP1 | EH domain binding protein 1 | -0.0388929 |
| NEGR1 | neuronal growth regulator 1 | -0.0388313 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0387757 |
| MT2A | metallothionein 2A | -0.0386507 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0377742 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0352891 |
| HMGA2 | high mobility group AT-hook 2 | -0.0350684 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | -0.0336857 |
| FHIT | fragile histidine triad | -0.0334836 |
| JAZF1 | JAZF zinc finger 1 | -0.0333517 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0330136 |
| LRAT | lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) | -0.0328781 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0327973 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0326914 |
| ADAM19 | ADAM metallopeptidase domain 19 | -0.0317924 |
| TNNC1 | troponin C type 1 (slow) | -0.031778 |
| RPS12 | ribosomal protein S12 | -0.0315432 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0314911 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0308176 |
| PKM | pyruvate kinase, muscle | -0.0307069 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0294588 |
| TMSB10 | thymosin beta 10 | -0.0291887 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0288816 |
| RPL35A | ribosomal protein L35a | -0.0288546 |
| GSN | gelsolin | -0.027744 |
| AEBP2 | AE binding protein 2 | -0.0268169 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0268065 |
| EBF1 | early B-cell factor 1 | -0.026767 |
| CUX1 | cut-like homeobox 1 | -0.0255534 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0254345 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | -0.0253816 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0253215 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.025308 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0249952 |
| RPS8 | ribosomal protein S8 | -0.0247099 |
| NDRG1 | N-myc downstream regulated 1 | -0.0245859 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | -0.024485 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.024286 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0242161 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0240236 |
| GHR | growth hormone receptor | -0.0236446 |
| EXOC4 | exocyst complex component 4 | -0.0235167 |
| FN1 | fibronectin 1 | -0.0234733 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0233147 |
| PTK2 | protein tyrosine kinase 2 | -0.0231382 |
| RASA3 | RAS p21 protein activator 3 | -0.0226874 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0225158 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0225139 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0224893 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.022267 |
| RPS29 | ribosomal protein S29 | -0.0222094 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0221717 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0220623 |
| FLNA | filamin A, alpha | -0.0220309 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0218394 |
| CFAP20DC | CFAP20 domain containing | -0.02171 |
| PDE10A | phosphodiesterase 10A | -0.0213884 |
| AGMO | alkylglycerol monooxygenase | -0.0213847 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0212853 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0207742 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0207742 |
| SEM1 | SEM1 26S proteasome subunit | -0.0207301 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0206781 |
| RPS3 | ribosomal protein S3 | -0.0205447 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0204807 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.0204072 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.0201644 |
