| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | 0.249033 |
| LSAMP | limbic system-associated membrane protein | 0.145727 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.129907 |
| NRG1 | neuregulin 1 | 0.129705 |
| TLE4 | transducin-like enhancer of split 4 | 0.112256 |
| FMN1 | formin 1 | 0.110236 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.100819 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0970079 |
| MEIS2 | Meis homeobox 2 | 0.0967451 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0917971 |
| EXT1 | exostosin glycosyltransferase 1 | 0.091162 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0835054 |
| RNF213 | ring finger protein 213 | 0.0765189 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0744928 |
| PLAT | plasminogen activator, tissue | 0.0744008 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.068039 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0677698 |
| BPTF | bromodomain PHD finger transcription factor | 0.0674804 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0674402 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0614376 |
| MED13 | mediator complex subunit 13 | 0.0613604 |
| FAM107B | family with sequence similarity 107, member B | 0.0597288 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0579109 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0576317 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0554189 |
| MCL1 | myeloid cell leukemia 1 | 0.0552835 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0536706 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0530668 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0514889 |
| PRKCA | protein kinase C, alpha | 0.0510744 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0506928 |
| TPM1 | tropomyosin 1 (alpha) | 0.0490931 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0488784 |
| VMP1 | vacuole membrane protein 1 | 0.048863 |
| RIGI | RNA sensor RIG-I | 0.048807 |
| PLPP1 | phospholipid phosphatase 1 | 0.0481367 |
| SYT1 | synaptotagmin I | 0.048063 |
| SP100 | SP100 nuclear antigen | 0.0478329 |
| FRMD4A | FERM domain containing 4A | 0.0465761 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.046388 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.045918 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0455456 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0454613 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0453682 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0453566 |
| ACTG1 | actin gamma 1 | 0.0444655 |
| KLHL13 | kelch-like family member 13 | 0.0442451 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0437515 |
| LPIN1 | lipin 1 | 0.0436884 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | 0.0435605 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.042204 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.041426 |
| SIK2 | salt-inducible kinase 2 | 0.0412562 |
| ENO1 | enolase 1, (alpha) | 0.0410424 |
| MRTFA | myocardin related transcription factor A | 0.0408611 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0392986 |
| AHR | aryl hydrocarbon receptor | 0.0391311 |
| TPM4 | tropomyosin 4 | 0.0388978 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0387235 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0386973 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0385194 |
| RAD51B | RAD51 paralog B | 0.038501 |
| MYO1E | myosin IE | 0.0384734 |
| MSI2 | musashi RNA-binding protein 2 | 0.0378857 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.0377604 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0374784 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0372166 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0371538 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0371538 |
| STK38L | serine/threonine kinase 38 like | 0.0371447 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0362875 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0361768 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0360857 |
| NBEA | neurobeachin | 0.0357547 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0354321 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0352946 |
| GLCCI1 | glucocorticoid induced 1 | 0.0347824 |
| FERMT2 | fermitin family member 2 | 0.0346457 |
| MBTD1 | mbt domain containing 1 | 0.0345428 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 0.0345245 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0344495 |
| CANX | calnexin | 0.0344176 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0340594 |
| CUX1 | cut-like homeobox 1 | 0.0338261 |
| PDE8A | phosphodiesterase 8A | 0.0336186 |
| FNBP1 | formin binding protein 1 | 0.0335094 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0334956 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.0332395 |
| RAB1A | RAB1A, member RAS oncogene family | 0.033176 |
| AUTS2 | autism susceptibility candidate 2 | 0.0330915 |
| DNM3 | dynamin 3 | 0.0328205 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0326351 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0325909 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0323505 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0322719 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0322512 |
| FAM13B | family with sequence similarity 13, member B | 0.0317646 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.031358 |
| ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 0.0311648 |
| SMYD3 | SET and MYND domain containing 3 | 0.0311514 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0724971 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0460895 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0455256 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0387651 |
| NUP58 | nucleoporin 58 | -0.0360022 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0320007 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0317921 |
| FAM13A | family with sequence similarity 13, member A | -0.0311165 |
| DTNA | dystrobrevin, alpha | -0.0272112 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0265044 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0263702 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0249387 |
| WDR45B | WD repeat domain 45B | -0.0241284 |
| OGA | O-GlcNAcase | -0.0237557 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0237354 |
| RPL27 | ribosomal protein L27 | -0.0237326 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0237254 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0236752 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0233478 |
| PCDH9 | protocadherin 9 | -0.0233403 |
| FAM162A | family with sequence similarity 162, member A | -0.0231476 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0230686 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.022922 |
| RPS24 | ribosomal protein S24 | -0.0228569 |
| PTK2 | protein tyrosine kinase 2 | -0.0226264 |
| IPO7 | importin 7 | -0.0225178 |
| RPL38 | ribosomal protein L38 | -0.0222773 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0222633 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0222033 |
| QKI | QKI, KH domain containing, RNA binding | -0.0217697 |
| NDRG1 | N-myc downstream regulated 1 | -0.0210103 |
| TUBB | tubulin, beta class I | -0.0209597 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0207012 |
| MEF2A | myocyte enhancer factor 2A | -0.0203261 |
| SEPTIN2 | septin 2 | -0.0199241 |
| RLF | rearranged L-myc fusion | -0.0196451 |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | -0.0196101 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0195771 |
| RAD21 | RAD21 homolog (S. pombe) | -0.019394 |
| FTL | ferritin, light polypeptide | -0.0193095 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0192496 |
| XPO1 | exportin 1 | -0.0190889 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.0190381 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0190168 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0189166 |
| RPS11 | ribosomal protein S11 | -0.0188482 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0182042 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0180434 |
| RPL35A | ribosomal protein L35a | -0.0179192 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0178967 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0178824 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0177833 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0174315 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0173498 |
| NKTR | natural killer cell triggering receptor | -0.0172647 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0170326 |
| SRPK2 | SRSF protein kinase 2 | -0.0167814 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0167183 |
| MMP12 | matrix metallopeptidase 12 | -0.016364 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0163467 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0162825 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0162578 |
| RIOK3 | RIO kinase 3 | -0.0160152 |
| RBM39 | RNA binding motif protein 39 | -0.01587 |
| RPLP2 | ribosomal protein, large, P2 | -0.0158198 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0157486 |
| HELZ | helicase with zinc finger | -0.0156918 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0156904 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0156424 |
| HMGB1 | high mobility group box 1 | -0.0156045 |
| ZNF148 | zinc finger protein 148 | -0.0155896 |
| TRAM1 | translocation associated membrane protein 1 | -0.0155818 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0155772 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0155727 |
| ZCCHC8 | zinc finger, CCHC domain containing 8 | -0.0155324 |
| OTUD7B | OTU deubiquitinase 7B | -0.0155208 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0154552 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0154496 |
| TENT4A | terminal nucleotidyltransferase 4A | -0.0154392 |
| URB1 | URB1 ribosome biogenesis 1 homolog (S. cerevisiae) | -0.0154153 |
| RNF145 | ring finger protein 145 | -0.0153207 |
| YAP1 | Yes-associated protein 1 | -0.0152116 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.015195 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0151361 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0150994 |
| RPL31 | ribosomal protein L31 | -0.0150787 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0150112 |
| RPS5 | ribosomal protein S5 | -0.014975 |
| RPS3 | ribosomal protein S3 | -0.0149416 |
| OLA1 | Obg-like ATPase 1 | -0.0148808 |
| CASC3 | cancer susceptibility candidate 3 | -0.0147558 |
| DENND4C | DENN/MADD domain containing 4C | -0.0146594 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0145917 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.0145902 |
| C1ORF21 | chromosome 1 open reading frame 21 | -0.0145847 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0145698 |
| USP3 | ubiquitin specific peptidase 3 | -0.0145314 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0144739 |
| SRSF7 | serine/arginine-rich splicing factor 7 | -0.0144045 |
| IPO5 | importin 5 | -0.0143583 |
