| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.203892 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0959441 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.093208 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0913326 |
| INTS6 | integrator complex subunit 6 | 0.089766 |
| SMAD3 | SMAD family member 3 | 0.0802005 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.077093 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0718647 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.068807 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0669824 |
| RNF213 | ring finger protein 213 | 0.0592801 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0588582 |
| ERBIN | erbb2 interacting protein | 0.0574606 |
| ANXA2 | annexin A2 | 0.0547826 |
| SP100 | SP100 nuclear antigen | 0.054101 |
| MYO1E | myosin IE | 0.0528867 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.052267 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0518752 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0499035 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0498195 |
| MCU | mitochondrial calcium uniporter | 0.0497476 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.047697 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0475081 |
| MX1 | MX dynamin-like GTPase 1 | 0.0469906 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0469328 |
| RIGI | RNA sensor RIG-I | 0.0467223 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0464255 |
| TJP1 | tight junction protein 1 | 0.0460812 |
| MACC1 | metastasis associated in colon cancer 1 | 0.045954 |
| VCL | vinculin | 0.0437686 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0428421 |
| TMC5 | transmembrane channel-like 5 | 0.0425092 |
| MAP7 | microtubule-associated protein 7 | 0.0423614 |
| EFNB2 | ephrin-B2 | 0.0413219 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0413177 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0409501 |
| LAMA4 | laminin, alpha 4 | 0.0398958 |
| DST | dystonin | 0.0395747 |
| AREG | amphiregulin | 0.0393932 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0392528 |
| ASPH | aspartate beta-hydroxylase | 0.0387351 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0364232 |
| MX2 | MX dynamin-like GTPase 2 | 0.0360003 |
| KYNU | kynureninase | 0.0357098 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0357027 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0348578 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0344578 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0340084 |
| PLSCR2 | phospholipid scramblase 2 | 0.0338393 |
| HKDC1 | hexokinase domain containing 1 | 0.033819 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0336668 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0335234 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.033495 |
| MYO5B | myosin VB | 0.0334193 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0333461 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0326719 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.031622 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0307486 |
| RBM47 | RNA binding motif protein 47 | 0.0305286 |
| ETV6 | ets variant 6 | 0.0303937 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0303012 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0293884 |
| ZNF292 | zinc finger protein 292 | 0.0293274 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0291211 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0289941 |
| LCN2 | lipocalin 2 | 0.0281991 |
| SIK3 | SIK family kinase 3 | 0.0277225 |
| UBAP2 | ubiquitin associated protein 2 | 0.0273669 |
| DIAPH1 | diaphanous-related formin 1 | 0.027036 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0268261 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0265572 |
| SERINC5 | serine incorporator 5 | 0.026186 |
| PERP | PERP, TP53 apoptosis effector | 0.0259633 |
| FNIP2 | folliculin interacting protein 2 | 0.0258343 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0255463 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0252409 |
| SEPTIN9 | septin 9 | 0.025084 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0250734 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.025049 |
| RAB10 | RAB10, member RAS oncogene family | 0.0242934 |
| BCL2L1 | BCL2-like 1 | 0.0242693 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.024246 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0240416 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0240171 |
| VMP1 | vacuole membrane protein 1 | 0.0233726 |
| PHF3 | PHD finger protein 3 | 0.0231162 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0228704 |
| MCL1 | myeloid cell leukemia 1 | 0.0228332 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0227571 |
| PDZD8 | PDZ domain containing 8 | 0.0226923 |
| PRKCA | protein kinase C, alpha | 0.0225594 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0224756 |
| NABP1 | nucleic acid binding protein 1 | 0.0224188 |
| LIMA1 | LIM domain and actin binding 1 | 0.0223657 |
| POF1B | premature ovarian failure, 1B | 0.022258 |
| TMEM65 | transmembrane protein 65 | 0.0221549 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0221439 |
| TOX3 | TOX high mobility group box family member 3 | 0.0220953 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0220065 |
| LYZ | lysozyme | 0.0219701 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.143379 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111624 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0738028 |
| UBC | ubiquitin C | -0.0663584 |
| NDRG1 | N-myc downstream regulated 1 | -0.0545488 |
| PTMA | prothymosin, alpha | -0.0455766 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0441976 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0441491 |
| RNF43 | ring finger protein 43 | -0.0438813 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0412415 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0381751 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0373226 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0365891 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.03635 |
| CALR | calreticulin | -0.0359265 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0335461 |
| HLA-B | major histocompatibility complex, class I, B | -0.0335147 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0317428 |
| CANX | calnexin | -0.0312102 |
| H1-0 | H1.0 linker histone | -0.0311895 |
| RNF149 | ring finger protein 149 | -0.0308048 |
| TXNIP | thioredoxin interacting protein | -0.0307929 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0305728 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0305671 |
| PTEN | phosphatase and tensin homolog | -0.0285884 |
| RUNX1 | runt-related transcription factor 1 | -0.0283993 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.028116 |
| DIAPH3 | diaphanous-related formin 3 | -0.0274663 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0272441 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0258765 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0254551 |
| HDLBP | high density lipoprotein binding protein | -0.0253675 |
| MKI67 | marker of proliferation Ki-67 | -0.0252206 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0249392 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0246976 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.024683 |
| RRBP1 | ribosome binding protein 1 | -0.0243271 |
| TMSB10 | thymosin beta 10 | -0.0242962 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0241551 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0236695 |
| OGA | O-GlcNAcase | -0.0224247 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0223144 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0222715 |
| CALU | calumenin | -0.02223 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0220031 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0216546 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0214564 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.021278 |
| GNAS | GNAS complex locus | -0.0212075 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0211471 |
| PRELID2 | PRELI domain containing 2 | -0.0207478 |
| AHI1 | Abelson helper integration site 1 | -0.020455 |
| SBF2 | SET binding factor 2 | -0.0204337 |
| USP3 | ubiquitin specific peptidase 3 | -0.0203228 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0200379 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0196178 |
| EPCAM | epithelial cell adhesion molecule | -0.019457 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0193303 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0192565 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0190626 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0190477 |
| TMEM263 | transmembrane protein 263 | -0.0188763 |
| SEC24D | SEC24 family member D | -0.0187353 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0184428 |
| HLA-C | major histocompatibility complex, class I, C | -0.0183849 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0181019 |
| GOLGA4 | golgin A4 | -0.0178624 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0178493 |
| WDR45B | WD repeat domain 45B | -0.0177828 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.017734 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.017732 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0176918 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0175385 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0174546 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0174429 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0173988 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0173423 |
| FDPS | farnesyl diphosphate synthase | -0.0172603 |
| BRCA2 | breast cancer 2, early onset | -0.017255 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.017194 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0171736 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0171682 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0169794 |
| JUN | jun proto-oncogene | -0.0168747 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0167955 |
| RBM39 | RNA binding motif protein 39 | -0.0166202 |
| UBAC2 | UBA domain containing 2 | -0.0164995 |
| LDHA | lactate dehydrogenase A | -0.0164889 |
| RPL12 | ribosomal protein L12 | -0.0164861 |
| GRAMD2B | GRAM domain containing 2B | -0.0162912 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0162467 |
| EHF | ets homologous factor | -0.016237 |
| AHNAK | AHNAK nucleoprotein | -0.0161676 |
| TMEM62 | transmembrane protein 62 | -0.0161428 |
| RPS6 | ribosomal protein S6 | -0.016125 |
| PCBP2 | poly(rC) binding protein 2 | -0.0160926 |
| HLA-E | major histocompatibility complex, class I, E | -0.0159586 |
| NUCB2 | nucleobindin 2 | -0.0156021 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0155971 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0154167 |
