| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.366458 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.191007 |
| COL6A3 | collagen, type VI, alpha 3 | 0.112215 |
| CANX | calnexin | 0.111957 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.110344 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.108712 |
| B2M | beta-2-microglobulin | 0.10397 |
| AHNAK | AHNAK nucleoprotein | 0.0956828 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0891188 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0852423 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0785624 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0768807 |
| FAM13A | family with sequence similarity 13, member A | 0.0752598 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0740174 |
| VIM | vimentin | 0.0710831 |
| KYNU | kynureninase | 0.0701031 |
| ENO1 | enolase 1, (alpha) | 0.0688492 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.066215 |
| TPM4 | tropomyosin 4 | 0.0657766 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0593995 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0588819 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0563429 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0561493 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0552389 |
| MMP12 | matrix metallopeptidase 12 | 0.0544837 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0539524 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0509585 |
| CD44 | CD44 molecule (Indian blood group) | 0.0502486 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0486033 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0482907 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0480632 |
| CALR | calreticulin | 0.0473688 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0460319 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0451815 |
| ZNF395 | zinc finger protein 395 | 0.0445151 |
| SQSTM1 | sequestosome 1 | 0.0440341 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0435804 |
| LOXL2 | lysyl oxidase-like 2 | 0.0432168 |
| LOX | lysyl oxidase | 0.0422786 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0421567 |
| ASPH | aspartate beta-hydroxylase | 0.0420205 |
| DST | dystonin | 0.0419516 |
| CENPF | centromere protein F, 350/400kDa | 0.0417838 |
| MKI67 | marker of proliferation Ki-67 | 0.0403392 |
| OSMR | oncostatin M receptor | 0.0395214 |
| CALU | calumenin | 0.0388857 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0384996 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0384906 |
| PGK1 | phosphoglycerate kinase 1 | 0.038423 |
| APP | amyloid beta (A4) precursor protein | 0.0384005 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0376716 |
| MORF4L2 | mortality factor 4 like 2 | 0.0376433 |
| ANLN | anillin, actin binding protein | 0.0357546 |
| NAV2 | neuron navigator 2 | 0.0357092 |
| LDHA | lactate dehydrogenase A | 0.0348824 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0345604 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0343433 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0340453 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.034024 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0338706 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0338277 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0337706 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.0336576 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0331279 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0328696 |
| SPAG9 | sperm associated antigen 9 | 0.0326388 |
| TNS3 | tensin 3 | 0.0321063 |
| HLA-B | major histocompatibility complex, class I, B | 0.0319246 |
| FNIP1 | folliculin interacting protein 1 | 0.0313346 |
| GOLGB1 | golgin B1 | 0.0310989 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.031091 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0306273 |
| MYO1B | myosin IB | 0.0304756 |
| SRP54 | signal recognition particle 54kDa | 0.0299547 |
| YEATS2 | YEATS domain containing 2 | 0.0296092 |
| IL6ST | interleukin 6 signal transducer | 0.0295506 |
| MYO10 | myosin X | 0.0294786 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0293237 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0293028 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0292374 |
| MAP1B | microtubule-associated protein 1B | 0.0288532 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0285762 |
| ANXA2 | annexin A2 | 0.028571 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0285235 |
| JUN | jun proto-oncogene | 0.0285155 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0280486 |
| HDAC9 | histone deacetylase 9 | 0.027982 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0279595 |
| CADM1 | cell adhesion molecule 1 | 0.0276407 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0275409 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0273676 |
| HIP1 | huntingtin interacting protein 1 | 0.0271835 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0270579 |
| UBC | ubiquitin C | 0.0268696 |
| STC1 | stanniocalcin 1 | 0.0267546 |
| MYLK | myosin light chain kinase | 0.0266601 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0264372 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0263102 |
| TMEM41B | transmembrane protein 41B | 0.0261465 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0259741 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.119183 |
| FTL | ferritin, light polypeptide | -0.0790676 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0499568 |
| RPL37A | ribosomal protein L37a | -0.0455207 |
| RPS3 | ribosomal protein S3 | -0.0445123 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0444427 |
| TMSB10 | thymosin beta 10 | -0.0346345 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0325386 |
| RPLP2 | ribosomal protein, large, P2 | -0.0313417 |
| RPL9 | ribosomal protein L9 | -0.0306076 |
| RPS16 | ribosomal protein S16 | -0.0297862 |
| RPS19 | ribosomal protein S19 | -0.0287389 |
| RPS12 | ribosomal protein S12 | -0.0274443 |
| RPS23 | ribosomal protein S23 | -0.0273231 |
| BRD4 | bromodomain containing 4 | -0.0251029 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0242769 |
| MCL1 | myeloid cell leukemia 1 | -0.0233666 |
| RPL13A | ribosomal protein L13a | -0.0230763 |
| RPL36 | ribosomal protein L36 | -0.0229225 |
| CDK14 | cyclin-dependent kinase 14 | -0.0228786 |
| RPL35A | ribosomal protein L35a | -0.0218321 |
| CDK13 | cyclin-dependent kinase 13 | -0.0217647 |
| FLNA | filamin A, alpha | -0.021629 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0214745 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.021285 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0210624 |
| RPS27A | ribosomal protein S27a | -0.0210593 |
| INTS6 | integrator complex subunit 6 | -0.0210136 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.020834 |
| TJP1 | tight junction protein 1 | -0.0208146 |
| RPL19 | ribosomal protein L19 | -0.0203468 |
| GANAB | glucosidase, alpha; neutral AB | -0.0203056 |
| UBAP2 | ubiquitin associated protein 2 | -0.0199111 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0197951 |
| USP34 | ubiquitin specific peptidase 34 | -0.0197241 |
| R3HDM2 | R3H domain containing 2 | -0.0195783 |
| PTMA | prothymosin, alpha | -0.0195144 |
| RPS11 | ribosomal protein S11 | -0.0194864 |
| RPS21 | ribosomal protein S21 | -0.0193982 |
| RPL28 | ribosomal protein L28 | -0.0193947 |
| RPL11 | ribosomal protein L11 | -0.0193805 |
| PHIP | pleckstrin homology domain interacting protein | -0.0193593 |
| RPL26 | ribosomal protein L26 | -0.0193349 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0192741 |
| FHL2 | four and a half LIM domains 2 | -0.0191112 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.019066 |
| PFN1 | profilin 1 | -0.0188509 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0187843 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0184632 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0183317 |
| RPS20 | ribosomal protein S20 | -0.0182497 |
| RPS8 | ribosomal protein S8 | -0.0178445 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.017453 |
| RPS10 | ribosomal protein S10 | -0.0173135 |
| RPS13 | ribosomal protein S13 | -0.0172334 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0172111 |
| PHF14 | PHD finger protein 14 | -0.0170612 |
| VCL | vinculin | -0.0167376 |
| TTYH3 | tweety family member 3 | -0.0167092 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0162704 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0162428 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0161747 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0160903 |
| SYT1 | synaptotagmin I | -0.0160302 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0160203 |
| RPL37 | ribosomal protein L37 | -0.0155958 |
| KLHL29 | kelch-like family member 29 | -0.01543 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0153339 |
| RPS29 | ribosomal protein S29 | -0.0152526 |
| PCNT | pericentrin | -0.0152072 |
| RPS5 | ribosomal protein S5 | -0.0151974 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0148462 |
| PDHX | pyruvate dehydrogenase complex, component X | -0.0148172 |
| TBCA | tubulin folding cofactor A | -0.0148151 |
| METTL15 | methyltransferase like 15 | -0.0147176 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.014716 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0146649 |
| RNF216 | ring finger protein 216 | -0.0143826 |
| RPL27A | ribosomal protein L27a | -0.0143057 |
| MT1X | metallothionein 1X | -0.0141874 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0140992 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0140766 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0140341 |
| ALMS1 | Alstrom syndrome protein 1 | -0.0140096 |
| NPTN | neuroplastin | -0.0138988 |
| COX6B1 | cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) | -0.0138763 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | -0.0138748 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0136528 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.01359 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0134837 |
| PTK2 | protein tyrosine kinase 2 | -0.0134685 |
| HMGA1 | high mobility group AT-hook 1 | -0.013401 |
| RBM25 | RNA binding motif protein 25 | -0.0133817 |
| NEK11 | NIMA-related kinase 11 | -0.0133435 |
| RPL38 | ribosomal protein L38 | -0.0133196 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0132975 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0132648 |
| RPS15 | ribosomal protein S15 | -0.0132201 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.013136 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0130933 |
