| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the MK-8353_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.155099 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.14396 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.126731 |
| ASPH | aspartate beta-hydroxylase | 0.119276 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.102425 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0977806 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0965407 |
| PRELID2 | PRELI domain containing 2 | 0.0955717 |
| RAD51B | RAD51 paralog B | 0.0842354 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0789996 |
| ECT2 | epithelial cell transforming 2 | 0.0785702 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.074536 |
| TPM4 | tropomyosin 4 | 0.0714566 |
| GOLGB1 | golgin B1 | 0.0678465 |
| FHIT | fragile histidine triad | 0.0678217 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0674138 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0654813 |
| ANXA1 | annexin A1 | 0.0647524 |
| RUNX1 | runt-related transcription factor 1 | 0.0613264 |
| RPS2 | ribosomal protein S2 | 0.0610524 |
| SVIL | supervillin | 0.0606916 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0600252 |
| ENO1 | enolase 1, (alpha) | 0.0595246 |
| MACROD2 | MACRO domain containing 2 | 0.058333 |
| WWOX | WW domain containing oxidoreductase | 0.0580754 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0569359 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0546443 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.054111 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.054007 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0531042 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0527738 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0520321 |
| VCL | vinculin | 0.0516783 |
| BBX | bobby sox homolog (Drosophila) | 0.050861 |
| CD44 | CD44 molecule (Indian blood group) | 0.0497047 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0495678 |
| LAMA4 | laminin, alpha 4 | 0.0487576 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0464961 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0461053 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0457597 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0452652 |
| ATXN1 | ataxin 1 | 0.0439149 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0437726 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0430973 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0428928 |
| HMGA2 | high mobility group AT-hook 2 | 0.0425468 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0422176 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0420001 |
| EGFR | epidermal growth factor receptor | 0.0418635 |
| DSPP | dentin sialophosphoprotein | 0.0409922 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0409162 |
| ITGA6 | integrin, alpha 6 | 0.0408785 |
| BPTF | bromodomain PHD finger transcription factor | 0.0406831 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0403788 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0403276 |
| RND3 | Rho family GTPase 3 | 0.0401874 |
| MYO1E | myosin IE | 0.039714 |
| DIAPH3 | diaphanous-related formin 3 | 0.0392377 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0390387 |
| TJP1 | tight junction protein 1 | 0.0389223 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0388653 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.038757 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0386118 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0380703 |
| LAMC2 | laminin, gamma 2 | 0.037295 |
| SGMS2 | sphingomyelin synthase 2 | 0.0368259 |
| FNIP1 | folliculin interacting protein 1 | 0.0366956 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0364799 |
| EXOC4 | exocyst complex component 4 | 0.0364602 |
| SSH2 | slingshot protein phosphatase 2 | 0.0364585 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.036336 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0359969 |
| TPM3 | tropomyosin 3 | 0.0353531 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0347915 |
| MT2A | metallothionein 2A | 0.0347897 |
| VCAN | versican | 0.0346181 |
| SMYD3 | SET and MYND domain containing 3 | 0.0344987 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0344473 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0340132 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0338025 |
| POTEF | POTE ankyrin domain family, member F | 0.0329191 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0324832 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0324462 |
| MYOF | myoferlin | 0.0324395 |
| SET | SET nuclear proto-oncogene | 0.0323827 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0323426 |
| ANO6 | anoctamin 6 | 0.0323075 |
| DIAPH2 | diaphanous-related formin 2 | 0.0321631 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0319806 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0319527 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0315405 |
| CDK13 | cyclin-dependent kinase 13 | 0.0311825 |
| TES | testin LIM domain protein | 0.0310488 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0309315 |
| TXNRD1 | thioredoxin reductase 1 | 0.0308188 |
| VMP1 | vacuole membrane protein 1 | 0.0305617 |
| EHBP1 | EH domain binding protein 1 | 0.0303534 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0302645 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0302424 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0300574 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.130097 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.108604 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.105075 |
| UBC | ubiquitin C | -0.0879158 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0838186 |
| PTMA | prothymosin, alpha | -0.0750476 |
| RPS27A | ribosomal protein S27a | -0.0708751 |
| APP | amyloid beta (A4) precursor protein | -0.0700007 |
| FLNA | filamin A, alpha | -0.0642477 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0641015 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0557054 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0533624 |
| OGA | O-GlcNAcase | -0.0495525 |
| MATR3 | matrin 3 | -0.0430003 |
| RPL23 | ribosomal protein L23 | -0.0417288 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0415417 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0401734 |
| FTL | ferritin, light polypeptide | -0.0371466 |
| PCBP2 | poly(rC) binding protein 2 | -0.0370733 |
| RPS24 | ribosomal protein S24 | -0.0368216 |
| RNF145 | ring finger protein 145 | -0.0354509 |
| RLF | rearranged L-myc fusion | -0.034345 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0337208 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0336996 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0333854 |
| YTHDC1 | YTH domain containing 1 | -0.0332237 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0330425 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0320289 |
| RPL26 | ribosomal protein L26 | -0.0316034 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0310257 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0309124 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0308197 |
| LDHA | lactate dehydrogenase A | -0.0306901 |
| H3-3B | H3.3 histone B | -0.0302836 |
| ZNF292 | zinc finger protein 292 | -0.029641 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0295918 |
| RBM27 | RNA binding motif protein 27 | -0.0294444 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0294272 |
| RPLP1 | ribosomal protein, large, P1 | -0.0286348 |
| RBM25 | RNA binding motif protein 25 | -0.0284832 |
| PLEC | plectin | -0.0283259 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0277032 |
| RPL9 | ribosomal protein L9 | -0.0273922 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0270639 |
| RPS29 | ribosomal protein S29 | -0.0269935 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0268851 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0267037 |
| WDR45B | WD repeat domain 45B | -0.0263995 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0260749 |
| RPL13A | ribosomal protein L13a | -0.0260535 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0260494 |
| TMSB4X | thymosin beta 4, X-linked | -0.0253142 |
| CLINT1 | clathrin interactor 1 | -0.0251229 |
| RPLP2 | ribosomal protein, large, P2 | -0.0251225 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0250729 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0250412 |
| S100A6 | S100 calcium binding protein A6 | -0.0249333 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0248024 |
| RPL34 | ribosomal protein L34 | -0.0246826 |
| RPS19 | ribosomal protein S19 | -0.0245197 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0244507 |
| RPL19 | ribosomal protein L19 | -0.0242615 |
| RPS5 | ribosomal protein S5 | -0.0238748 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0236005 |
| RPL32 | ribosomal protein L32 | -0.0235622 |
| RPL31 | ribosomal protein L31 | -0.0235496 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0233367 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.0232866 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0231141 |
| CDC73 | cell division cycle 73 | -0.0230026 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0229782 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0228343 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0225279 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.0224997 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.02249 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0224826 |
| RAD21 | RAD21 homolog (S. pombe) | -0.022141 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0219559 |
| SNX4 | sorting nexin 4 | -0.021877 |
| RASA3 | RAS p21 protein activator 3 | -0.0217761 |
| PHIP | pleckstrin homology domain interacting protein | -0.0216678 |
| POU5F1 | POU class 5 homeobox 1 | -0.021119 |
| GRB2 | growth factor receptor-bound protein 2 | -0.0208741 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0207911 |
| USP3 | ubiquitin specific peptidase 3 | -0.0206574 |
| RPS11 | ribosomal protein S11 | -0.0205199 |
| URI1 | URI1, prefoldin-like chaperone | -0.020311 |
| GNAS | GNAS complex locus | -0.0202912 |
| ACTG1 | actin gamma 1 | -0.0201187 |
| RTN4 | reticulon 4 | -0.0201064 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0200753 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0197791 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0196998 |
| RPL36A | ribosomal protein L36a | -0.0196976 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0196504 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0195429 |
| CCNI | cyclin I | -0.0195234 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0193919 |
| SEC24B | SEC24 family member B | -0.0193523 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0193415 |
