MK-8353_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-8353 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-8353_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SVIL supervillin 0.160067
ERRFI1 ERBB receptor feedback inhibitor 1 0.143706
ENO1 enolase 1, (alpha) 0.143568
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.125692
IGFBP1 insulin-like growth factor binding protein 1 0.122063
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.104437
PDLIM5 PDZ and LIM domain 5 0.100666
AKAP12 A kinase (PRKA) anchor protein 12 0.0921995
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0874045
SAMD4A sterile alpha motif domain containing 4A 0.0839131
FAM107B family with sequence similarity 107, member B 0.0826725
MBNL2 muscleblind-like splicing regulator 2 0.08181
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0812391
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0782706
DSPP dentin sialophosphoprotein 0.0765665
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0762962
CRY1 cryptochrome circadian clock 1 0.0747203
MBNL1 muscleblind-like splicing regulator 1 0.0729061
FOXP1 forkhead box P1 0.0725706
AHSG alpha-2-HS-glycoprotein 0.0690071
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0649533
EXT1 exostosin glycosyltransferase 1 0.0621848
RPS8 ribosomal protein S8 0.0617853
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0578691
TF transferrin 0.0568572
PAWR PRKC, apoptosis, WT1, regulator 0.05335
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0503337
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0502776
AFF1 AF4/FMR2 family, member 1 0.0500778
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0484413
ASPH aspartate beta-hydroxylase 0.0473881
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0470355
STK17A serine/threonine kinase 17a 0.0446249
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0437634
RPS12 ribosomal protein S12 0.0437321
CCL20 chemokine (C-C motif) ligand 20 0.0429897
PDIA6 protein disulfide isomerase family A, member 6 0.0408537
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0408178
PALLD palladin, cytoskeletal associated protein 0.0403754
TXNRD1 thioredoxin reductase 1 0.0395713
CPE carboxypeptidase E 0.0395549
RPS6 ribosomal protein S6 0.0392731
B2M beta-2-microglobulin 0.0392496
SIK3 SIK family kinase 3 0.0390515
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0388764
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0363966
MYO1E myosin IE 0.036323
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0363134
PDIA3 protein disulfide isomerase family A, member 3 0.0363027
PLIN2 perilipin 2 0.0361374
LIMS1 LIM and senescent cell antigen-like domains 1 0.0359524
DSTN destrin (actin depolymerizing factor) 0.0356135
KIF21A kinesin family member 21A 0.0351988
ATXN1 ataxin 1 0.0349532
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0348979
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0348201
APLP2 amyloid beta (A4) precursor-like protein 2 0.0347245
EPS8 epidermal growth factor receptor pathway substrate 8 0.0346561
SIK2 salt-inducible kinase 2 0.0344177
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.034148
RPL4 ribosomal protein L4 0.03411
NAP1L1 nucleosome assembly protein 1-like 1 0.0340128
CLIC4 chloride intracellular channel 4 0.0339587
KYNU kynureninase 0.0328735
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0324433
FAM13A family with sequence similarity 13, member A 0.032342
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0321288
JMJD1C jumonji domain containing 1C 0.0320178
EIF1 eukaryotic translation initiation factor 1 0.0318875
RPS3 ribosomal protein S3 0.0318516
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0316103
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0315085
ITGAV integrin, alpha V 0.0311641
RPL23 ribosomal protein L23 0.0310689
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0307856
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0306208
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.029827
INTS6 integrator complex subunit 6 0.0297746
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0297688
HM13 histocompatibility (minor) 13 0.0295856
FAT1 FAT atypical cadherin 1 0.0292276
GOLGB1 golgin B1 0.0292181
GCLC glutamate-cysteine ligase, catalytic subunit 0.0291635
FTL ferritin, light polypeptide 0.0288994
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0285555
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0282212
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0281453
EEF1G eukaryotic translation elongation factor 1 gamma 0.0281336
BIRC3 baculoviral IAP repeat containing 3 0.027864
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0277854
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0276523
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0276147
PEAK1 pseudopodium-enriched atypical kinase 1 0.0275657
SLC38A2 solute carrier family 38, member 2 0.0274104
AHR aryl hydrocarbon receptor 0.0272461
TLE4 transducin-like enhancer of split 4 0.0271831
FERMT2 fermitin family member 2 0.0271624
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0268212
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0266636
USP6NL USP6 N-terminal like 0.0264832

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.284653
C3 complement component 3 -0.230479
APOB apolipoprotein B -0.205741
IGF2 insulin-like growth factor 2 -0.141744
FN1 fibronectin 1 -0.0847676
GPC3 glypican 3 -0.0830608
ELL2 elongation factor, RNA polymerase II, 2 -0.079001
NKD1 naked cuticle homolog 1 (Drosophila) -0.0636011
TRIM26 tripartite motif containing 26 -0.0579285
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0556522
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0551634
FRMD5 FERM domain containing 5 -0.0514764
LRMDA leucine rich melanocyte differentiation associated -0.0490784
NPAS2 neuronal PAS domain protein 2 -0.0489814
APOA2 apolipoprotein A-II -0.0476161
PDGFB platelet-derived growth factor beta polypeptide -0.047063
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0464977
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0455071
EML4 echinoderm microtubule associated protein like 4 -0.0454688
EHBP1 EH domain binding protein 1 -0.0451458
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0446836
MBNL3 muscleblind-like splicing regulator 3 -0.0428824
RBM39 RNA binding motif protein 39 -0.0426181
ZMYND8 zinc finger, MYND-type containing 8 -0.042358
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0417833
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0415514
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0388817
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0386014
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.037851
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0373079
GPC6 glypican 6 -0.037214
MALT1 MALT1 paracaspase -0.0369028
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0364642
KDM3A lysine (K)-specific demethylase 3A -0.0359815
TM4SF1 transmembrane 4 L six family member 1 -0.0353106
RBM25 RNA binding motif protein 25 -0.0350999
PEG3 paternally expressed 3 -0.0341108
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0339434
TM9SF3 transmembrane 9 superfamily member 3 -0.0324666
ICAM1 intercellular adhesion molecule 1 -0.0316945
PTBP3 polypyrimidine tract binding protein 3 -0.0308335
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0296145
CFB complement factor B -0.029566
SMAD3 SMAD family member 3 -0.0295435
PTPRF protein tyrosine phosphatase, receptor type, F -0.0293112
TPT1 tumor protein, translationally-controlled 1 -0.0292765
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0288351
IGF2R insulin-like growth factor 2 receptor -0.0287686
ITGB5 integrin, beta 5 -0.0282933
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0279595
MYH9 myosin, heavy chain 9, non-muscle -0.0275312
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0274421
RUNX1 runt-related transcription factor 1 -0.027101
PTPRM protein tyrosine phosphatase, receptor type, M -0.0263935
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0261121
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0259092
EPAS1 endothelial PAS domain protein 1 -0.0258208
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0253898
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.02526
HLF hepatic leukemia factor -0.0251527
TGFBI transforming growth factor, beta-induced, 68kDa -0.0251421
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0234399
TMEM123 transmembrane protein 123 -0.0233872
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0231532
FERMT1 fermitin family member 1 -0.0231492
A2M alpha-2-macroglobulin -0.0231327
APOE apolipoprotein E -0.0223685
CHD6 chromodomain helicase DNA binding protein 6 -0.0222684
RRBP1 ribosome binding protein 1 -0.0221517
LARP4B La ribonucleoprotein domain family, member 4B -0.0220693
H1-0 H1.0 linker histone -0.0217206
CRLS1 cardiolipin synthase 1 -0.0213923
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0210968
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0210191
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0207939
STK39 serine threonine kinase 39 -0.0207886
IL4R interleukin 4 receptor -0.0207067
RNF213 ring finger protein 213 -0.0206862
PUM2 pumilio RNA-binding family member 2 -0.0204172
FLNB filamin B, beta -0.0203162
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0202617
ZFHX3 zinc finger homeobox 3 -0.0202064
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.020063
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0200498
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0199621
RSRC2 arginine/serine-rich coiled-coil 2 -0.0197767
CDK19 cyclin-dependent kinase 19 -0.019666
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0194971
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 -0.019422
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0192856
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0192525
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0191699
ITGA1 integrin, alpha 1 -0.019108
CELF1 CUGBP, Elav-like family member 1 -0.0190887
NECTIN2 nectin cell adhesion molecule 2 -0.0189874
CAMTA1 calmodulin binding transcription activator 1 -0.0189072
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.018889
PLAC8 placenta-specific 8 -0.0188213
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0187349
MED13L mediator complex subunit 13-like -0.0186949