| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.103 |
| CD44 | CD44 molecule (Indian blood group) | 0.0974082 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0613285 |
| EZR | ezrin | 0.0602895 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0578186 |
| B2M | beta-2-microglobulin | 0.0577161 |
| SIK3 | SIK family kinase 3 | 0.0552799 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0533318 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0507091 |
| ANXA1 | annexin A1 | 0.0455107 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0450159 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0443868 |
| TXNIP | thioredoxin interacting protein | 0.0395889 |
| GOLGB1 | golgin B1 | 0.0392619 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0374506 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0371655 |
| LMO7 | LIM domain 7 | 0.0361939 |
| EMP1 | epithelial membrane protein 1 | 0.0355219 |
| TPM3 | tropomyosin 3 | 0.0347786 |
| JMJD1C | jumonji domain containing 1C | 0.0320989 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0304587 |
| RPS2 | ribosomal protein S2 | 0.0290009 |
| CLU | clusterin | 0.0286954 |
| YBX3 | Y box binding protein 3 | 0.0285609 |
| FAM107B | family with sequence similarity 107, member B | 0.0278846 |
| DIAPH1 | diaphanous-related formin 1 | 0.0270673 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0265019 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0261582 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0256295 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.025603 |
| MT2A | metallothionein 2A | 0.0255322 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0253428 |
| DSTN | destrin (actin depolymerizing factor) | 0.0248965 |
| MT1E | metallothionein 1E | 0.0247113 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0238525 |
| SGMS2 | sphingomyelin synthase 2 | 0.0232357 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0230207 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.022878 |
| MEF2A | myocyte enhancer factor 2A | 0.022864 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0228366 |
| ARRDC3 | arrestin domain containing 3 | 0.0216089 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0214113 |
| TMEM67 | transmembrane protein 67 | 0.0200005 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0198373 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0198262 |
| SIK2 | salt-inducible kinase 2 | 0.0198165 |
| MYOF | myoferlin | 0.0193528 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0192777 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0189275 |
| VMP1 | vacuole membrane protein 1 | 0.0188104 |
| SPAG9 | sperm associated antigen 9 | 0.0187169 |
| SMAD3 | SMAD family member 3 | 0.0185611 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0183931 |
| NRG1 | neuregulin 1 | 0.017342 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0170877 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0169639 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.016823 |
| MX1 | MX dynamin-like GTPase 1 | 0.0165986 |
| RUNX1 | runt-related transcription factor 1 | 0.0164855 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0164339 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0162628 |
| FOXO1 | forkhead box O1 | 0.016102 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0160907 |
| MLF1 | myeloid leukemia factor 1 | 0.0159992 |
| SEPTIN9 | septin 9 | 0.0159365 |
| IRS2 | insulin receptor substrate 2 | 0.0159011 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0156752 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0155474 |
| TXNRD1 | thioredoxin reductase 1 | 0.0154611 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0153923 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.01538 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0152728 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0152361 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0151683 |
| MYADM | myeloid-associated differentiation marker | 0.0150675 |
| CRY1 | cryptochrome circadian clock 1 | 0.0150301 |
| SON | SON DNA binding protein | 0.0149511 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0149251 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0147611 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0147204 |
| FAT1 | FAT atypical cadherin 1 | 0.0147082 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0145653 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.0144004 |
| ANO6 | anoctamin 6 | 0.0143039 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0142301 |
| FTL | ferritin, light polypeptide | 0.0140579 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0139844 |
| EGR1 | early growth response 1 | 0.0139052 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0138787 |
| SLK | STE20-like kinase | 0.0136335 |
| SIRT1 | sirtuin 1 | 0.0135615 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0135415 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0134575 |
| WHRN | whirlin | 0.0134188 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0133944 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0133571 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0132935 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0132294 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.013202 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0131818 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.189949 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.187605 |
| FLNB | filamin B, beta | -0.0892272 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0698537 |
| MTSS1 | metastasis suppressor 1 | -0.0647926 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0606956 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0562456 |
| SULF1 | sulfatase 1 | -0.0553998 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0533557 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0512559 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0510626 |
| PODXL | podocalyxin-like | -0.0507806 |
| PTMA | prothymosin, alpha | -0.0507124 |
| NDRG1 | N-myc downstream regulated 1 | -0.0499577 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0499334 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.04915 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0483934 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0431147 |
| TMSB10 | thymosin beta 10 | -0.0423568 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0403975 |
| STC1 | stanniocalcin 1 | -0.0381422 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0381169 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0366648 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0360266 |
| CALB1 | calbindin 1, 28kDa | -0.0345326 |
| LDHA | lactate dehydrogenase A | -0.0339362 |
| THBD | thrombomodulin | -0.0339178 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0329508 |
| RAI14 | retinoic acid induced 14 | -0.0328735 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0326864 |
| IGF2 | insulin-like growth factor 2 | -0.0313469 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0308282 |
| RPS21 | ribosomal protein S21 | -0.0302613 |
| PRSS23 | protease, serine, 23 | -0.0302141 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0297796 |
| INTS6 | integrator complex subunit 6 | -0.0294272 |
| RPS3 | ribosomal protein S3 | -0.0288929 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0287348 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0286382 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0269924 |
| GNAS | GNAS complex locus | -0.0269116 |
| NAV2 | neuron navigator 2 | -0.0257762 |
| LAMC2 | laminin, gamma 2 | -0.0253741 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.025276 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0251834 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0251474 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0247082 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0243512 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0239302 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0234494 |
| RPL26 | ribosomal protein L26 | -0.023218 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0228275 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0228125 |
| SMYD3 | SET and MYND domain containing 3 | -0.022516 |
| FNIP1 | folliculin interacting protein 1 | -0.0220579 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0217907 |
| PLS3 | plastin 3 | -0.0216812 |
| AHNAK | AHNAK nucleoprotein | -0.0212762 |
| CDK13 | cyclin-dependent kinase 13 | -0.021123 |
| C4BPB | complement component 4 binding protein, beta | -0.0210035 |
| CALU | calumenin | -0.0206348 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0205319 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0203754 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0202736 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0201885 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0200514 |
| PLEC | plectin | -0.0199913 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0199836 |
| DSG2 | desmoglein 2 | -0.0199341 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0196687 |
| EGFR | epidermal growth factor receptor | -0.0196667 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0196648 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0195892 |
| CDK6 | cyclin-dependent kinase 6 | -0.0195582 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0195136 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0195065 |
| H1-0 | H1.0 linker histone | -0.0194479 |
| MECOM | MDS1 and EVI1 complex locus | -0.0187275 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0186589 |
| OSBPL6 | oxysterol binding protein-like 6 | -0.018534 |
| CLIC4 | chloride intracellular channel 4 | -0.0183824 |
| AOPEP | aminopeptidase O (putative) | -0.0181531 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0180734 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0180389 |
| HLA-E | major histocompatibility complex, class I, E | -0.0179767 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0177917 |
| RPL35A | ribosomal protein L35a | -0.0177877 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.017349 |
| RPS13 | ribosomal protein S13 | -0.0173214 |
| ITGB4 | integrin, beta 4 | -0.0172994 |
| RPL30 | ribosomal protein L30 | -0.0172942 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0171983 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.017156 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0169888 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0167458 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0166003 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0165486 |
| RPS27A | ribosomal protein S27a | -0.0165427 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0164477 |
| HMGA1 | high mobility group AT-hook 1 | -0.0162116 |
