| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.212399 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.152843 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.120926 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.113639 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.113272 |
| DST | dystonin | 0.103171 |
| ENO1 | enolase 1, (alpha) | 0.102625 |
| ASPH | aspartate beta-hydroxylase | 0.0988437 |
| POTEF | POTE ankyrin domain family, member F | 0.0922463 |
| AHNAK | AHNAK nucleoprotein | 0.0847109 |
| B2M | beta-2-microglobulin | 0.0827722 |
| NAV2 | neuron navigator 2 | 0.0798428 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0796539 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0766608 |
| SET | SET nuclear proto-oncogene | 0.0724418 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0712147 |
| TPM3 | tropomyosin 3 | 0.0678194 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.063825 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0624412 |
| ERBIN | erbb2 interacting protein | 0.059969 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0580632 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0575433 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0575023 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0574597 |
| PTK2 | protein tyrosine kinase 2 | 0.056377 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0563378 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0563354 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0555256 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0546064 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0542783 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0535378 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0533544 |
| CENPF | centromere protein F, 350/400kDa | 0.0526003 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0525715 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0519585 |
| TXNRD1 | thioredoxin reductase 1 | 0.0515186 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0511961 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0498218 |
| TLE4 | transducin-like enhancer of split 4 | 0.0491696 |
| DIAPH3 | diaphanous-related formin 3 | 0.047472 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0473131 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0453847 |
| FHIT | fragile histidine triad | 0.0453487 |
| ANXA1 | annexin A1 | 0.0435469 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0427937 |
| PKM | pyruvate kinase, muscle | 0.0425258 |
| DTNA | dystrobrevin, alpha | 0.0419616 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0418261 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0413582 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0408981 |
| MSN | moesin | 0.0408077 |
| RIGI | RNA sensor RIG-I | 0.040378 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0398543 |
| CALD1 | caldesmon 1 | 0.0398121 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0396835 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0396757 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0395488 |
| INTS6 | integrator complex subunit 6 | 0.0395019 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0391379 |
| GOLGB1 | golgin B1 | 0.0389032 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0388152 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.038792 |
| PRELID2 | PRELI domain containing 2 | 0.0387591 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0387056 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0384276 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0383588 |
| KRT7 | keratin 7, type II | 0.0380468 |
| SMYD3 | SET and MYND domain containing 3 | 0.0374882 |
| BBX | bobby sox homolog (Drosophila) | 0.036845 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0365998 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0363216 |
| MAP1B | microtubule-associated protein 1B | 0.0363181 |
| ATXN1 | ataxin 1 | 0.0361849 |
| LDHA | lactate dehydrogenase A | 0.0361305 |
| RUNX1 | runt-related transcription factor 1 | 0.0358635 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0353773 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0348112 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0343637 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.034272 |
| CDK6 | cyclin-dependent kinase 6 | 0.0340366 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0338153 |
| RNF213 | ring finger protein 213 | 0.0337712 |
| EGFR | epidermal growth factor receptor | 0.0333104 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0331816 |
| FAM107B | family with sequence similarity 107, member B | 0.0330575 |
| TPM1 | tropomyosin 1 (alpha) | 0.032729 |
| IL6ST | interleukin 6 signal transducer | 0.0323895 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0319317 |
| FNIP1 | folliculin interacting protein 1 | 0.0319029 |
| ANO6 | anoctamin 6 | 0.0318837 |
| DEK | DEK proto-oncogene | 0.0317949 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0317382 |
| RPS6 | ribosomal protein S6 | 0.0310993 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0309836 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0309729 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0309597 |
| VCL | vinculin | 0.0308489 |
| NAV1 | neuron navigator 1 | 0.0308168 |
| PLSCR1 | phospholipid scramblase 1 | 0.0307122 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0304313 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HLA-B | major histocompatibility complex, class I, B | -0.150347 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.147767 |
| FTL | ferritin, light polypeptide | -0.0703839 |
| FN1 | fibronectin 1 | -0.068773 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0645095 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0581505 |
| HLA-C | major histocompatibility complex, class I, C | -0.0572877 |
| MT2A | metallothionein 2A | -0.054696 |
| MT1X | metallothionein 1X | -0.0467988 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0462838 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0446396 |
| TMSB10 | thymosin beta 10 | -0.0411658 |
| CTSD | cathepsin D | -0.0388478 |
| GLIS3 | GLIS family zinc finger 3 | -0.0383272 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0376622 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0340902 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0336681 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0322327 |
| SCFD2 | sec1 family domain containing 2 | -0.030305 |
| NDRG1 | N-myc downstream regulated 1 | -0.0300108 |
| ARF1 | ADP-ribosylation factor 1 | -0.0282488 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0276243 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0275562 |
| ARF4 | ADP-ribosylation factor 4 | -0.0266052 |
| TMEM263 | transmembrane protein 263 | -0.0264063 |
| GNAS | GNAS complex locus | -0.0263602 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0260131 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0258945 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0255646 |
| OSMR | oncostatin M receptor | -0.0255375 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0254454 |
| FLNA | filamin A, alpha | -0.0253462 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0249009 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0238304 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0234056 |
| EGR1 | early growth response 1 | -0.0227587 |
| ZXDC | ZXD family zinc finger C | -0.0224012 |
| CDK17 | cyclin-dependent kinase 17 | -0.0223589 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0220196 |
| HLA-A | major histocompatibility complex, class I, A | -0.0219075 |
| RPLP2 | ribosomal protein, large, P2 | -0.0214788 |
| CEP95 | centrosomal protein 95kDa | -0.0212494 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0211831 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0211403 |
| S100A6 | S100 calcium binding protein A6 | -0.0208108 |
| GOLGA3 | golgin A3 | -0.0207387 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0205483 |
| GOLT1B | golgi transport 1B | -0.0205181 |
| WDR45B | WD repeat domain 45B | -0.0199718 |
| FLNB | filamin B, beta | -0.0195026 |
| ATP13A3 | ATPase type 13A3 | -0.0193626 |
| TMEM41B | transmembrane protein 41B | -0.0190912 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0190371 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0187661 |
| LOX | lysyl oxidase | -0.018397 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0182843 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0182312 |
| CALU | calumenin | -0.0181996 |
| H1-0 | H1.0 linker histone | -0.0181001 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.017731 |
| PTMA | prothymosin, alpha | -0.0177053 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0176435 |
| SRP54 | signal recognition particle 54kDa | -0.0175466 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0175319 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0171646 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0171536 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0171457 |
| SMAP1 | small ArfGAP 1 | -0.0170922 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0170914 |
| EDF1 | endothelial differentiation-related factor 1 | -0.0170778 |
| TUBB | tubulin, beta class I | -0.0166264 |
| SEC22B | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) | -0.016539 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0164284 |
| TMEM39A | transmembrane protein 39A | -0.0163159 |
| RBM25 | RNA binding motif protein 25 | -0.0159482 |
| COL5A1 | collagen, type V, alpha 1 | -0.0158188 |
| HYCC2 | hyccin PI4KA lipid kinase complex subunit 2 | -0.0156471 |
| POSTN | periostin, osteoblast specific factor | -0.0156084 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0155083 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0154689 |
| ACTN4 | actinin, alpha 4 | -0.0154645 |
| RPS21 | ribosomal protein S21 | -0.0154019 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0153204 |
| HM13 | histocompatibility (minor) 13 | -0.0151201 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0151179 |
| CAVIN1 | caveolae associated protein 1 | -0.0151023 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.014941 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0148451 |
| IER3 | immediate early response 3 | -0.0148173 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.0148049 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0147115 |
| ZFR | zinc finger RNA binding protein | -0.0146718 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0146027 |
| RPL26 | ribosomal protein L26 | -0.0145699 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0144326 |
| RPL35A | ribosomal protein L35a | -0.0143303 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.0141712 |
| GPR107 | G protein-coupled receptor 107 | -0.014159 |
| FRMD4A | FERM domain containing 4A | -0.0140844 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0140406 |
