MK-8353_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-8353 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-8353_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.167777
MBNL2 muscleblind-like splicing regulator 2 0.167579
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.114827
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0950279
MAML2 mastermind-like 2 (Drosophila) 0.0925397
ANXA1 annexin A1 0.0913456
PTPRK protein tyrosine phosphatase, receptor type, K 0.0901954
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0804654
FGFR2 fibroblast growth factor receptor 2 0.0800415
ZSWIM6 zinc finger, SWIM-type containing 6 0.0674891
FNDC3B fibronectin type III domain containing 3B 0.0664325
MBNL1 muscleblind-like splicing regulator 1 0.0638957
KLF5 Kruppel-like factor 5 (intestinal) 0.0633771
GDA guanine deaminase 0.063341
AKAP13 A kinase (PRKA) anchor protein 13 0.0622538
SIK3 SIK family kinase 3 0.0603261
ERRFI1 ERBB receptor feedback inhibitor 1 0.0596088
COBL cordon-bleu WH2 repeat protein 0.0591785
KLHL29 kelch-like family member 29 0.0587495
LCN2 lipocalin 2 0.0564227
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0555242
ATXN1 ataxin 1 0.0550443
APLP2 amyloid beta (A4) precursor-like protein 2 0.054923
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0547352
MACC1 metastasis associated in colon cancer 1 0.0531157
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0526333
ITGA6 integrin, alpha 6 0.0506688
CDK6 cyclin-dependent kinase 6 0.0499
VMP1 vacuole membrane protein 1 0.0496922
EZR ezrin 0.0492188
ENO1 enolase 1, (alpha) 0.048759
SLC38A2 solute carrier family 38, member 2 0.047941
FNIP1 folliculin interacting protein 1 0.0469646
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0465348
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0463045
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.045542
FRMD5 FERM domain containing 5 0.0452077
ARHGAP32 Rho GTPase activating protein 32 0.0434376
EXT1 exostosin glycosyltransferase 1 0.0434149
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.04332
EMP1 epithelial membrane protein 1 0.0417904
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0413686
AREG amphiregulin 0.0409295
DSPP dentin sialophosphoprotein 0.040639
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0405315
ZCCHC7 zinc finger, CCHC domain containing 7 0.0404008
VEGFA vascular endothelial growth factor A 0.0401174
RUNX1 runt-related transcription factor 1 0.0401126
RASEF RAS and EF-hand domain containing 0.0400485
RPS6 ribosomal protein S6 0.0396584
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0395224
ESYT2 extended synaptotagmin-like protein 2 0.0388155
NCEH1 neutral cholesterol ester hydrolase 1 0.0385464
GCLC glutamate-cysteine ligase, catalytic subunit 0.0374057
PDLIM5 PDZ and LIM domain 5 0.0370756
MYO1E myosin IE 0.0366659
TJP1 tight junction protein 1 0.0359817
SET SET nuclear proto-oncogene 0.0355327
DOCK5 dedicator of cytokinesis 5 0.0351162
INTS6 integrator complex subunit 6 0.0347593
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.034726
ASPH aspartate beta-hydroxylase 0.0346916
AHR aryl hydrocarbon receptor 0.0344033
EFNA5 ephrin-A5 0.0342609
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0340919
HDAC9 histone deacetylase 9 0.0333971
CDK13 cyclin-dependent kinase 13 0.0332441
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0328349
EPS8 epidermal growth factor receptor pathway substrate 8 0.0322264
SEC31A SEC31 homolog A (S. cerevisiae) 0.0322226
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0321004
GMDS GDP-mannose 4,6-dehydratase 0.0320248
HKDC1 hexokinase domain containing 1 0.0318389
LURAP1L leucine rich adaptor protein 1-like 0.0314438
NUPR1 nuclear protein, transcriptional regulator, 1 0.0311872
GOLGB1 golgin B1 0.0309908
FTH1 ferritin, heavy polypeptide 1 0.0309162
DST dystonin 0.0308181
CATSPERB catsper channel auxiliary subunit beta 0.0307057
DIAPH2 diaphanous-related formin 2 0.0304599
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0302339
MYOF myoferlin 0.0298309
LPP LIM domain containing preferred translocation partner in lipoma 0.0295465
ARHGAP29 Rho GTPase activating protein 29 0.029423
SLTM SAFB-like, transcription modulator 0.0292993
BACE2 beta-site APP-cleaving enzyme 2 0.0292564
ANKRD11 ankyrin repeat domain 11 0.0288509
POF1B premature ovarian failure, 1B 0.0288209
BAIAP2L1 BAI1-associated protein 2-like 1 0.0282576
SNX9 sorting nexin 9 0.0281084
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0280525
MTUS1 microtubule associated tumor suppressor 1 0.0280345
RPS8 ribosomal protein S8 0.0278791
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.027861
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0276665
AGR3 anterior gradient 3 0.0274408
GRB10 growth factor receptor-bound protein 10 0.0274278
MCU mitochondrial calcium uniporter 0.02741
FTL ferritin, light polypeptide 0.0270422
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0270356

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.155994
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.152303
NPSR1 neuropeptide S receptor 1 -0.126101
CEMIP cell migration inducing protein, hyaluronan binding -0.115909
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.114626
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0995144
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0915742
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0845509
S100A6 S100 calcium binding protein A6 -0.0840916
KRT18 keratin 18, type I -0.0785201
TMSB10 thymosin beta 10 -0.0779768
H1-0 H1.0 linker histone -0.0743788
KRT8 keratin 8, type II -0.0640068
LOC112694756 uncharaterized LOC112694756 -0.0553373
PRSS3 protease, serine, 3 -0.0550034
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0520332
INSIG1 insulin induced gene 1 -0.0516588
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0505716
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.050162
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0466491
RRBP1 ribosome binding protein 1 -0.0462845
S100A10 S100 calcium binding protein A10 -0.0453256
ACACA acetyl-CoA carboxylase alpha -0.0451811
ITGB4 integrin, beta 4 -0.0438077
ACTN4 actinin, alpha 4 -0.0434006
MUC17 mucin 17, cell surface associated -0.0430565
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0402413
HLA-C major histocompatibility complex, class I, C -0.0392615
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0390111
GPX2 glutathione peroxidase 2 -0.0387449
TPT1 tumor protein, translationally-controlled 1 -0.0383702
JUP junction plakoglobin -0.0382763
PDIA4 protein disulfide isomerase family A, member 4 -0.0375589
TRIM31 tripartite motif containing 31 -0.0361869
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.035487
FLNB filamin B, beta -0.035103
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0339299
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0323954
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0312986
ANXA2 annexin A2 -0.0312394
AVL9 AVL9 homolog (S. cerevisiase) -0.0305617
KRT19 keratin 19, type I -0.0303531
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0298414
FASN fatty acid synthase -0.0296001
KRT17 keratin 17, type I -0.0292091
EPCAM epithelial cell adhesion molecule -0.0290164
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0289273
NECTIN2 nectin cell adhesion molecule 2 -0.028846
TUBB4B tubulin, beta 4B class IVb -0.0281709
MSMO1 methylsterol monooxygenase 1 -0.027718
TMPRSS4 transmembrane protease, serine 4 -0.0276338
HLA-E major histocompatibility complex, class I, E -0.0275576
RNF43 ring finger protein 43 -0.0274091
KLK10 kallikrein-related peptidase 10 -0.0273036
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0268362
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0264536
ALDOC aldolase C, fructose-bisphosphate -0.0262327
ACTG1 actin gamma 1 -0.0257682
GNAS GNAS complex locus -0.0256479
LPIN1 lipin 1 -0.025595
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0254107
TNRC18 trinucleotide repeat containing 18 -0.025388
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0252212
TMEM45B transmembrane protein 45B -0.0250237
ABHD17C abhydrolase domain containing 17C -0.024778
KDM3A lysine (K)-specific demethylase 3A -0.024702
HYOU1 hypoxia up-regulated 1 -0.0246953
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0241049
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0234798
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0232395
CALR calreticulin -0.0227314
LAMB3 laminin, beta 3 -0.0225416
PRRC2C proline-rich coiled-coil 2C -0.0224238
GSTP1 glutathione S-transferase pi 1 -0.0222567
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0222241
KLF3 Kruppel-like factor 3 (basic) -0.0218506
MUC1 mucin 1, cell surface associated -0.0215545
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0215489
CLINT1 clathrin interactor 1 -0.0214218
ARF1 ADP-ribosylation factor 1 -0.0212894
PPARG peroxisome proliferator-activated receptor gamma -0.0209634
MYL12B myosin, light chain 12B, regulatory -0.0205448
PRRC2B proline-rich coiled-coil 2B -0.0203952
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.0202017
SMC4 structural maintenance of chromosomes 4 -0.0200835
NPC1 Niemann-Pick disease, type C1 -0.0200622
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0198637
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.0198355
HLA-B major histocompatibility complex, class I, B -0.0197
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0195592
RPS24 ribosomal protein S24 -0.0195495
CEP95 centrosomal protein 95kDa -0.0195085
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0194559
BHLHE40 basic helix-loop-helix family, member e40 -0.0194362
FDPS farnesyl diphosphate synthase -0.0191544
CTSE cathepsin E -0.0189584
FGFBP1 fibroblast growth factor binding protein 1 -0.0187803
TC2N tandem C2 domains, nuclear -0.018721
SHB Src homology 2 domain containing adaptor protein B -0.0186316
CD46 CD46 molecule, complement regulatory protein -0.0185038