| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0938401 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0669262 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0667163 |
| MYO1E | myosin IE | 0.0633352 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0443548 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0397242 |
| LMO7 | LIM domain 7 | 0.0352458 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0336926 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.030932 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0304559 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0303649 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0300089 |
| NEBL | nebulette | 0.0297794 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0297526 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0275656 |
| MED13 | mediator complex subunit 13 | 0.0268544 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0267878 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0260314 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0258321 |
| RPS8 | ribosomal protein S8 | 0.0256119 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0253345 |
| DSPP | dentin sialophosphoprotein | 0.0250154 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.023682 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0233797 |
| SIK3 | SIK family kinase 3 | 0.0227352 |
| B2M | beta-2-microglobulin | 0.022232 |
| CRY1 | cryptochrome circadian clock 1 | 0.022149 |
| ENO1 | enolase 1, (alpha) | 0.021973 |
| MUC13 | mucin 13, cell surface associated | 0.021858 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0209153 |
| GOLGB1 | golgin B1 | 0.0208501 |
| MT2A | metallothionein 2A | 0.020814 |
| FAT1 | FAT atypical cadherin 1 | 0.0207882 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0204599 |
| RPS2 | ribosomal protein S2 | 0.0195278 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0194538 |
| RPL4 | ribosomal protein L4 | 0.018827 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0187482 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0185258 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0179433 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0178261 |
| TPM3 | tropomyosin 3 | 0.0172078 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0167975 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.0164596 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0164419 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0159304 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0159247 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0157313 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0156339 |
| FAM107B | family with sequence similarity 107, member B | 0.0155688 |
| TMC5 | transmembrane channel-like 5 | 0.0155303 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0154021 |
| SGMS2 | sphingomyelin synthase 2 | 0.0153858 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0151406 |
| SVIL | supervillin | 0.0147818 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0142901 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0141943 |
| SPATA13 | spermatogenesis associated 13 | 0.0139999 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0139422 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.013806 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0137813 |
| SON | SON DNA binding protein | 0.0137537 |
| EGFR | epidermal growth factor receptor | 0.0137434 |
| TPM4 | tropomyosin 4 | 0.0136626 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0130612 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0129707 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0129621 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0128262 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.0128215 |
| DSTN | destrin (actin depolymerizing factor) | 0.0126275 |
| INTS6 | integrator complex subunit 6 | 0.0125032 |
| WHRN | whirlin | 0.0124192 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.012349 |
| MT1E | metallothionein 1E | 0.0122313 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0121725 |
| DUSP16 | dual specificity phosphatase 16 | 0.012153 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0120044 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0119853 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0117916 |
| RPL21 | ribosomal protein L21 | 0.0117044 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0116735 |
| RND3 | Rho family GTPase 3 | 0.0116597 |
| ASPH | aspartate beta-hydroxylase | 0.0115328 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0115281 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0114698 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0114668 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0114501 |
| TFF1 | trefoil factor 1 | 0.0114499 |
| HBEGF | heparin-binding EGF-like growth factor | 0.0112695 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0110832 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0110305 |
| ACTG1 | actin gamma 1 | 0.0107874 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0107673 |
| HM13 | histocompatibility (minor) 13 | 0.0107665 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0107565 |
| TRIM2 | tripartite motif containing 2 | 0.0106398 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0105289 |
| RPS6 | ribosomal protein S6 | 0.0105073 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0104611 |
| SMAD2 | SMAD family member 2 | 0.0102615 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112508 |
| PTMA | prothymosin, alpha | -0.0765239 |
| ANXA2 | annexin A2 | -0.060257 |
| NPSR1 | neuropeptide S receptor 1 | -0.056217 |
| TNS4 | tensin 4 | -0.0548046 |
| TMSB10 | thymosin beta 10 | -0.0524068 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0493087 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0469885 |
| FAM13A | family with sequence similarity 13, member A | -0.0418502 |
| NDRG1 | N-myc downstream regulated 1 | -0.0413901 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0412802 |
| GPHN | gephyrin | -0.0406559 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0387082 |
| RNF43 | ring finger protein 43 | -0.037971 |
| EPCAM | epithelial cell adhesion molecule | -0.0379389 |
| FLNB | filamin B, beta | -0.0361364 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0349972 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0345201 |
| MED13L | mediator complex subunit 13-like | -0.0343256 |
| ANKRD11 | ankyrin repeat domain 11 | -0.034085 |
| RBM39 | RNA binding motif protein 39 | -0.0323663 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0313553 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0297496 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0293787 |
| ZNF292 | zinc finger protein 292 | -0.0291113 |
| H1-0 | H1.0 linker histone | -0.0291092 |
| WDR45B | WD repeat domain 45B | -0.0285986 |
| FERMT1 | fermitin family member 1 | -0.0284993 |
| FNBP1L | formin binding protein 1-like | -0.0282522 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0278959 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0278471 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.027687 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0275266 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0272353 |
| RNF145 | ring finger protein 145 | -0.0271398 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0265488 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0263097 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0261411 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0260818 |
| NFIA | nuclear factor I/A | -0.0258094 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0255251 |
| SBF2 | SET binding factor 2 | -0.0254181 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0252387 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0252154 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0250366 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0248275 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0247562 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0245104 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.024503 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0241119 |
| USP3 | ubiquitin specific peptidase 3 | -0.0238687 |
| KRT18 | keratin 18, type I | -0.0237419 |
| CCNY | cyclin Y | -0.0236373 |
| AFDN | afadin, adherens junction formation factor | -0.0233955 |
| S100A6 | S100 calcium binding protein A6 | -0.0230043 |
| SETD5 | SET domain containing 5 | -0.0223575 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0222608 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0220005 |
| NF1 | neurofibromin 1 | -0.021925 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0210934 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0210841 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0210179 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0206603 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0203572 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0202656 |
| COG5 | component of oligomeric golgi complex 5 | -0.0201378 |
| EXOC1 | exocyst complex component 1 | -0.0201316 |
| HMGA1 | high mobility group AT-hook 1 | -0.0201208 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0198869 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0197995 |
| PIGR | polymeric immunoglobulin receptor | -0.0197646 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0197333 |
| OLA1 | Obg-like ATPase 1 | -0.0196241 |
| KRT8 | keratin 8, type II | -0.0196115 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0195774 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0195012 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0194925 |
| OGA | O-GlcNAcase | -0.0193458 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0192807 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0192478 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0188603 |
| ITGB4 | integrin, beta 4 | -0.0187899 |
| MSI2 | musashi RNA-binding protein 2 | -0.0187346 |
| RLF | rearranged L-myc fusion | -0.0185718 |
| S100P | S100 calcium binding protein P | -0.0184389 |
| RFX7 | regulatory factor X, 7 | -0.018373 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0183692 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0183506 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0182433 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0182116 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0181867 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0180107 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0178583 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0177327 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.01773 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0176836 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0175925 |
| WDFY3 | WD repeat and FYVE domain containing 3 | -0.0175923 |
| INSIG1 | insulin induced gene 1 | -0.0174842 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0174313 |
