| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the MK-8353_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.220383 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.217522 |
| TXNRD1 | thioredoxin reductase 1 | 0.111507 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0976035 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0975171 |
| EZR | ezrin | 0.0847185 |
| AHNAK | AHNAK nucleoprotein | 0.0806702 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0771341 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0711276 |
| CANX | calnexin | 0.0709231 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0680978 |
| EREG | epiregulin | 0.0669357 |
| TXNIP | thioredoxin interacting protein | 0.0666522 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.058942 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0584343 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.055744 |
| EMP1 | epithelial membrane protein 1 | 0.0547866 |
| SPAG9 | sperm associated antigen 9 | 0.0533517 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0520802 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0511122 |
| GOLGB1 | golgin B1 | 0.0483516 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0468677 |
| JMJD1C | jumonji domain containing 1C | 0.0458648 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0449108 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0443723 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0429831 |
| MYOF | myoferlin | 0.0428131 |
| JUN | jun proto-oncogene | 0.0426142 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0422561 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0420868 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0411144 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0398944 |
| CALR | calreticulin | 0.0395279 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0385985 |
| SEC24A | SEC24 family member A | 0.038425 |
| RAI1 | retinoic acid induced 1 | 0.0379769 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.036485 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0364837 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.03648 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0357103 |
| ENO1 | enolase 1, (alpha) | 0.0354672 |
| HDLBP | high density lipoprotein binding protein | 0.0350255 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0345061 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0335509 |
| MORF4L2 | mortality factor 4 like 2 | 0.0330704 |
| KLF6 | Kruppel-like factor 6 | 0.0323938 |
| TPM3 | tropomyosin 3 | 0.0321881 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0310724 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0309436 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0305896 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0303884 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0296258 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.028425 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0278584 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0277006 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0275655 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0275574 |
| SQSTM1 | sequestosome 1 | 0.0275502 |
| RPS2 | ribosomal protein S2 | 0.0273093 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0269627 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.026547 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0263914 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0259343 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0256299 |
| SUCO | SUN domain containing ossification factor | 0.0256194 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0254796 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0253686 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0252306 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0251386 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.025112 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0250985 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0249349 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0247364 |
| CALU | calumenin | 0.0244836 |
| COPA | coatomer protein complex, subunit alpha | 0.0244753 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0242227 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0241898 |
| DST | dystonin | 0.024177 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0238171 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0232825 |
| RPL4 | ribosomal protein L4 | 0.0231437 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0230692 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0229522 |
| ARRDC3 | arrestin domain containing 3 | 0.0229442 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0227421 |
| MT1E | metallothionein 1E | 0.0222403 |
| GOLGA4 | golgin A4 | 0.0221641 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0220565 |
| TOP1 | topoisomerase (DNA) I | 0.0218338 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0217614 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0216351 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0216169 |
| SETX | senataxin | 0.0213926 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0212484 |
| SVIL | supervillin | 0.0212084 |
| KIF5B | kinesin family member 5B | 0.0208631 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0206584 |
| RPS8 | ribosomal protein S8 | 0.0205895 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0205016 |
| ATF3 | activating transcription factor 3 | 0.0204025 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.147198 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.141653 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.130733 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.108531 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0902055 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0893885 |
| CADM2 | cell adhesion molecule 2 | -0.085807 |
| TMSB10 | thymosin beta 10 | -0.083041 |
| HLA-B | major histocompatibility complex, class I, B | -0.0793327 |
| EHBP1 | EH domain binding protein 1 | -0.073781 |
| RAD51B | RAD51 paralog B | -0.0687354 |
| RPL35A | ribosomal protein L35a | -0.0638381 |
| MT2A | metallothionein 2A | -0.0616002 |
| TNS3 | tensin 3 | -0.0591013 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0590638 |
| CD44 | CD44 molecule (Indian blood group) | -0.0586364 |
| COL5A2 | collagen, type V, alpha 2 | -0.0552022 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.052811 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0518617 |
| EXOC4 | exocyst complex component 4 | -0.0516371 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0510355 |
| PTK2 | protein tyrosine kinase 2 | -0.0494743 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0445301 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0436252 |
| PTMA | prothymosin, alpha | -0.0435759 |
| DNER | delta/notch-like EGF repeat containing | -0.0425302 |
| DPH6 | diphthamine biosynthesis 6 | -0.0421203 |
| EFNA5 | ephrin-A5 | -0.0420029 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0414646 |
| RPL37A | ribosomal protein L37a | -0.0412387 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0405969 |
| RNF213 | ring finger protein 213 | -0.0401533 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0401214 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0401146 |
| RUNX1 | runt-related transcription factor 1 | -0.0394179 |
| RPL26 | ribosomal protein L26 | -0.0382027 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0370262 |
| RPS12 | ribosomal protein S12 | -0.0366383 |
| TGM2 | transglutaminase 2 | -0.035725 |
| PRELID2 | PRELI domain containing 2 | -0.0353302 |
| HLA-A | major histocompatibility complex, class I, A | -0.0347362 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0344776 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0337057 |
| EPHA4 | EPH receptor A4 | -0.0331006 |
| TPRG1 | tumor protein p63 regulated 1 | -0.0320197 |
| PODXL | podocalyxin-like | -0.0311254 |
| PDE10A | phosphodiesterase 10A | -0.0309769 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0292742 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0288719 |
| RIGI | RNA sensor RIG-I | -0.0288598 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0284088 |
| NEK10 | NIMA-related kinase 10 | -0.0277119 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0276695 |
| CMIP | c-Maf inducing protein | -0.0272443 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.026733 |
| RPS19 | ribosomal protein S19 | -0.0266043 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0265738 |
| WDR27 | WD repeat domain 27 | -0.0264953 |
| RPL9 | ribosomal protein L9 | -0.0264383 |
| HPCAL1 | hippocalcin-like 1 | -0.026192 |
| LOXL2 | lysyl oxidase-like 2 | -0.0260057 |
| POTEF | POTE ankyrin domain family, member F | -0.0259136 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0257808 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0256696 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0256651 |
| RPL31 | ribosomal protein L31 | -0.0256497 |
| LMNTD1 | lamin tail domain containing 1 | -0.025305 |
| RPS10 | ribosomal protein S10 | -0.0247132 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0245712 |
| HMGA1 | high mobility group AT-hook 1 | -0.0242072 |
| MT1X | metallothionein 1X | -0.0241987 |
| PLSCR1 | phospholipid scramblase 1 | -0.0240871 |
| CCDC91 | coiled-coil domain containing 91 | -0.0239759 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0237314 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | -0.0236287 |
| FTL | ferritin, light polypeptide | -0.0234933 |
| PMP22 | peripheral myelin protein 22 | -0.0234332 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0232306 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0230698 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0226634 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0226553 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0225552 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0225141 |
| RPS3 | ribosomal protein S3 | -0.0224236 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.0221965 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0220636 |
| RPS29 | ribosomal protein S29 | -0.0219487 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0218521 |
| FLNB | filamin B, beta | -0.0217521 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0216181 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0215658 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0212502 |
| FOXN3 | forkhead box N3 | -0.0211445 |
| RPS13 | ribosomal protein S13 | -0.0210255 |
| TANGO6 | transport and golgi organization 6 homolog (Drosophila) | -0.0209966 |
| RPL36 | ribosomal protein L36 | -0.0208923 |
| FMNL2 | formin-like 2 | -0.0208593 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0207112 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0206338 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0205342 |
