MK-8353_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description MK-8353 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the MK-8353_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.289369
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.187055
TXNRD1 thioredoxin reductase 1 0.13556
TPM3 tropomyosin 3 0.105804
ERRFI1 ERBB receptor feedback inhibitor 1 0.101859
YBX3 Y box binding protein 3 0.0994113
KTN1 kinectin 1 (kinesin receptor) 0.0956853
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0872586
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0863822
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0799971
CSDE1 cold shock domain containing E1, RNA-binding 0.0746609
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0732099
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0726367
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0713284
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0683413
NIPBL Nipped-B homolog (Drosophila) 0.0679128
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0675128
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0674996
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0648608
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0641585
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0633183
TFPI2 tissue factor pathway inhibitor 2 0.0621956
COPA coatomer protein complex, subunit alpha 0.0530867
GRAMD1B GRAM domain containing 1B 0.052913
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0512372
JMJD1C jumonji domain containing 1C 0.0500271
GOLGB1 golgin B1 0.0485707
IPO7 importin 7 0.0477876
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0471519
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.046702
XPO1 exportin 1 0.0459363
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0452357
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0450815
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0447001
ZFAND3 zinc finger, AN1-type domain 3 0.0446018
CLTC clathrin, heavy chain (Hc) 0.0441849
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.042183
SPAG9 sperm associated antigen 9 0.0405945
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0402588
CANX calnexin 0.0398395
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0396987
VMP1 vacuole membrane protein 1 0.0396661
AHNAK AHNAK nucleoprotein 0.03835
ENO1 enolase 1, (alpha) 0.0377825
CSNK1A1 casein kinase 1, alpha 1 0.0377342
CRY1 cryptochrome circadian clock 1 0.037699
NF1 neurofibromin 1 0.036721
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0362794
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0356929
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0352974
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0352229
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0348338
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.034793
IL6ST interleukin 6 signal transducer 0.0338438
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0336102
TNPO1 transportin 1 0.0335259
RBM39 RNA binding motif protein 39 0.0335098
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0333607
DST dystonin 0.0333193
ELL2 elongation factor, RNA polymerase II, 2 0.0331574
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0331475
PREPL prolyl endopeptidase-like 0.032938
ADAR adenosine deaminase, RNA-specific 0.0328945
PHF20 PHD finger protein 20 0.0328234
CCND2 cyclin D2 0.0324271
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0323945
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.032036
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0317692
TRIO trio Rho guanine nucleotide exchange factor 0.0315311
MKI67 marker of proliferation Ki-67 0.0308042
STAG2 stromal antigen 2 0.0307102
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0306101
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0303522
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0302722
SFPQ splicing factor proline/glutamine-rich 0.0302219
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0302195
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0299329
KIF5B kinesin family member 5B 0.0296453
SEC31A SEC31 homolog A (S. cerevisiae) 0.0296323
EXOC6B exocyst complex component 6B 0.0295773
SNAP25 synaptosomal-associated protein, 25kDa 0.0291614
YAP1 Yes-associated protein 1 0.0291239
EIF4B eukaryotic translation initiation factor 4B 0.0288107
NUP153 nucleoporin 153kDa 0.0287098
ANXA5 annexin A5 0.0287074
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0285412
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0285119
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0284591
TASOR2 transcription activation suppressor family member 2 0.0284493
MORF4L2 mortality factor 4 like 2 0.028446
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0284126
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0283398
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0281795
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0281184
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0279956
CHD4 chromodomain helicase DNA binding protein 4 0.0279734
AKIRIN1 akirin 1 0.0279323
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0278497
DEK DEK proto-oncogene 0.0277457
ADAM17 ADAM metallopeptidase domain 17 0.0276841

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102756
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.100797
TMSB10 thymosin beta 10 -0.0998985
RPL35A ribosomal protein L35a -0.0833937
MCL1 myeloid cell leukemia 1 -0.0822396
RPS3 ribosomal protein S3 -0.0758232
RPL37A ribosomal protein L37a -0.0720493
MT2A metallothionein 2A -0.0629922
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0619856
THSD4 thrombospondin, type I, domain containing 4 -0.0602891
RYR3 ryanodine receptor 3 -0.0571858
TPT1 tumor protein, translationally-controlled 1 -0.056658
RPL9 ribosomal protein L9 -0.0531577
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0529427
EGR1 early growth response 1 -0.0504962
HLA-B major histocompatibility complex, class I, B -0.0492738
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0476225
RPS12 ribosomal protein S12 -0.0436402
RPL31 ribosomal protein L31 -0.0429605
RPS29 ribosomal protein S29 -0.0427179
HMGA2 high mobility group AT-hook 2 -0.0402174
RPL26 ribosomal protein L26 -0.0380293
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0378147
RPL11 ribosomal protein L11 -0.0370366
WSB1 WD repeat and SOCS box containing 1 -0.0365242
RAD51B RAD51 paralog B -0.0354733
RPS10 ribosomal protein S10 -0.0351359
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0348769
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0341848
RPS27A ribosomal protein S27a -0.0317315
RIMS2 regulating synaptic membrane exocytosis 2 -0.0306667
PRELID2 PRELI domain containing 2 -0.0300994
RPS19 ribosomal protein S19 -0.0298381
NTSR1 neurotensin receptor 1 (high affinity) -0.0291983
RPS24 ribosomal protein S24 -0.0289419
FTL ferritin, light polypeptide -0.0286451
RPL36 ribosomal protein L36 -0.0278823
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0270716
RPL13A ribosomal protein L13a -0.0269748
PFN1 profilin 1 -0.0264686
RPL8 ribosomal protein L8 -0.0263005
FLNA filamin A, alpha -0.0262966
RPS15 ribosomal protein S15 -0.0262603
TM4SF1 transmembrane 4 L six family member 1 -0.0260142
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0259369
RPS23 ribosomal protein S23 -0.0256875
KDM4B lysine (K)-specific demethylase 4B -0.0254538
RPLP2 ribosomal protein, large, P2 -0.0254001
IER3 immediate early response 3 -0.0250287
NABP1 nucleic acid binding protein 1 -0.0250081
RPS21 ribosomal protein S21 -0.0234901
EGFR epidermal growth factor receptor -0.0233198
RPS13 ribosomal protein S13 -0.0232125
FMN1 formin 1 -0.0227323
STYK1 serine/threonine/tyrosine kinase 1 -0.0224025
IGF2 insulin-like growth factor 2 -0.0222985
RPS6 ribosomal protein S6 -0.0222779
WWTR1 WW domain containing transcription regulator 1 -0.0221738
EEF2 eukaryotic translation elongation factor 2 -0.0221163
RPL19 ribosomal protein L19 -0.021798
RPL28 ribosomal protein L28 -0.0214441
NEK10 NIMA-related kinase 10 -0.0210505
S100A11 S100 calcium binding protein A11 -0.0208832
NDRG1 N-myc downstream regulated 1 -0.0207304
CUX1 cut-like homeobox 1 -0.0206934
RPS11 ribosomal protein S11 -0.0206723
NCOA7 nuclear receptor coactivator 7 -0.0206022
PARD3 par-3 family cell polarity regulator -0.0203572
HLA-A major histocompatibility complex, class I, A -0.0201248
ATXN1 ataxin 1 -0.0200647
ZBTB20 zinc finger and BTB domain containing 20 -0.0196933
ATG7 autophagy related 7 -0.0196401
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0194544
TBC1D22A TBC1 domain family, member 22A -0.0190732
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0190312
PTMA prothymosin, alpha -0.0188596
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0186616
RPL38 ribosomal protein L38 -0.0186136
POTEF POTE ankyrin domain family, member F -0.0182688
ANGPTL4 angiopoietin-like 4 -0.0181884
SUMF1 sulfatase modifying factor 1 -0.0181179
ITSN1 intersectin 1 (SH3 domain protein) -0.0180447
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.017766
IFI6 interferon, alpha-inducible protein 6 -0.0177574
RPS25 ribosomal protein S25 -0.0174909
VDAC1 voltage-dependent anion channel 1 -0.017431
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.017331
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0173149
S100A10 S100 calcium binding protein A10 -0.0172757
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0172754
RYK receptor-like tyrosine kinase -0.0170015
RPL23 ribosomal protein L23 -0.0169951
RPS8 ribosomal protein S8 -0.0169506
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0167995
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0165149
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0165064
RPL36A ribosomal protein L36a -0.0164907
PLEC plectin -0.0161824
RPL30 ribosomal protein L30 -0.0161526
RPL27 ribosomal protein L27 -0.0161437