| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | 0.172622 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.144143 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0785681 |
| GOLGB1 | golgin B1 | 0.0709541 |
| RND3 | Rho family GTPase 3 | 0.0694062 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.064436 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0640097 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0620421 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0603504 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0594494 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0578948 |
| RPS2 | ribosomal protein S2 | 0.0563902 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0550524 |
| B2M | beta-2-microglobulin | 0.0546172 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0545322 |
| ENO1 | enolase 1, (alpha) | 0.0488562 |
| AHNAK | AHNAK nucleoprotein | 0.0471699 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0471629 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0465611 |
| JMJD1C | jumonji domain containing 1C | 0.0451452 |
| ATXN1 | ataxin 1 | 0.0449214 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.044409 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0441525 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.044137 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.043884 |
| SQSTM1 | sequestosome 1 | 0.0420778 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0412299 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0406435 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0405358 |
| ARFGEF3 | ARFGEF family member 3 | 0.0404368 |
| MSN | moesin | 0.0402332 |
| TPM3 | tropomyosin 3 | 0.0401811 |
| CD44 | CD44 molecule (Indian blood group) | 0.0386454 |
| ASPH | aspartate beta-hydroxylase | 0.0385606 |
| FNIP1 | folliculin interacting protein 1 | 0.0375441 |
| NAV2 | neuron navigator 2 | 0.036005 |
| RIGI | RNA sensor RIG-I | 0.0357702 |
| SFTPA2 | surfactant protein A2 | 0.0355699 |
| MYOF | myoferlin | 0.03502 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0346451 |
| VMP1 | vacuole membrane protein 1 | 0.0345327 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0342365 |
| MORF4L2 | mortality factor 4 like 2 | 0.033201 |
| SMAD3 | SMAD family member 3 | 0.0329059 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0320812 |
| VEGFA | vascular endothelial growth factor A | 0.0320811 |
| MX1 | MX dynamin-like GTPase 1 | 0.0319135 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0301444 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0298011 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0295079 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0293553 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0293361 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0290827 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0286621 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0272845 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.0268998 |
| RPS12 | ribosomal protein S12 | 0.0268684 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0267626 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0261751 |
| TNS3 | tensin 3 | 0.0260299 |
| INTS6 | integrator complex subunit 6 | 0.0259316 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0257671 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0256661 |
| AHR | aryl hydrocarbon receptor | 0.025282 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0251981 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0251611 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0250181 |
| ARRDC3 | arrestin domain containing 3 | 0.0249394 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0248999 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0247578 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0237722 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.023704 |
| KYNU | kynureninase | 0.0234051 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0234022 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0231076 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0229716 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0229389 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0225071 |
| DST | dystonin | 0.0224365 |
| BRD2 | bromodomain containing 2 | 0.0223398 |
| TLE4 | transducin-like enhancer of split 4 | 0.0223232 |
| LOXL2 | lysyl oxidase-like 2 | 0.0222463 |
| RPL4 | ribosomal protein L4 | 0.0222305 |
| GPR176 | G protein-coupled receptor 176 | 0.0221172 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0218733 |
| PHF3 | PHD finger protein 3 | 0.0218267 |
| TXNIP | thioredoxin interacting protein | 0.0217897 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0216895 |
| FAM107B | family with sequence similarity 107, member B | 0.0216143 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.021527 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0213692 |
| OPTN | optineurin | 0.021338 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0211867 |
| DUSP10 | dual specificity phosphatase 10 | 0.0211711 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0210287 |
| EZR | ezrin | 0.0209895 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0208705 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0208577 |
| MYADM | myeloid-associated differentiation marker | 0.0207888 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0207872 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.17224 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.156545 |
| TMSB10 | thymosin beta 10 | -0.134127 |
| IER3 | immediate early response 3 | -0.130493 |
| HLA-B | major histocompatibility complex, class I, B | -0.126374 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.111207 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.110164 |
| PTMA | prothymosin, alpha | -0.0992169 |
| FTL | ferritin, light polypeptide | -0.0920482 |
| FN1 | fibronectin 1 | -0.0776616 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0726675 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0707057 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0704672 |
| PGK1 | phosphoglycerate kinase 1 | -0.0653499 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0611279 |
| COL1A1 | collagen, type I, alpha 1 | -0.0596551 |
| GNAS | GNAS complex locus | -0.0596048 |
| RPS24 | ribosomal protein S24 | -0.0577038 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0568014 |
| GLIS3 | GLIS family zinc finger 3 | -0.0554179 |
| FRMD4A | FERM domain containing 4A | -0.0540364 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0528232 |
| ATP13A3 | ATPase type 13A3 | -0.0522799 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0519085 |
| CADM1 | cell adhesion molecule 1 | -0.0518325 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.051211 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0506693 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0485856 |
| RPL35A | ribosomal protein L35a | -0.0463701 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0439279 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.04391 |
| CTSD | cathepsin D | -0.0406373 |
| RPS21 | ribosomal protein S21 | -0.0397555 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0381316 |
| OGA | O-GlcNAcase | -0.0375632 |
| TMSB4X | thymosin beta 4, X-linked | -0.0373311 |
| ADM | adrenomedullin | -0.0369774 |
| QKI | QKI, KH domain containing, RNA binding | -0.035706 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0355973 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0347185 |
| TUBB | tubulin, beta class I | -0.0337082 |
| HMGA1 | high mobility group AT-hook 1 | -0.0336131 |
| CDH13 | cadherin 13 | -0.0332437 |
| RPLP2 | ribosomal protein, large, P2 | -0.0331258 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0327392 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.032736 |
| ACTG1 | actin gamma 1 | -0.0325284 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0324391 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.032377 |
| CAVIN1 | caveolae associated protein 1 | -0.0316962 |
| RPL37A | ribosomal protein L37a | -0.0316683 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0312741 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0312262 |
| CD63 | CD63 molecule | -0.0312233 |
| NRN1 | neuritin 1 | -0.0309461 |
| RPL36A | ribosomal protein L36a | -0.0308393 |
| RPL9 | ribosomal protein L9 | -0.0303096 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0298356 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0293487 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0289025 |
| ZNF292 | zinc finger protein 292 | -0.028434 |
| CTSB | cathepsin B | -0.0281955 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0280375 |
| RPL34 | ribosomal protein L34 | -0.027924 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0276617 |
| SEPTIN7 | septin 7 | -0.0273932 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0272485 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0272412 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0272217 |
| FBXO32 | F-box protein 32 | -0.0271205 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.026506 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0261332 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0261141 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.026009 |
| ANXA2 | annexin A2 | -0.0259554 |
| HLA-A | major histocompatibility complex, class I, A | -0.0259264 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0253658 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0253128 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0250533 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0249515 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0248649 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0247644 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0247162 |
| RPS23 | ribosomal protein S23 | -0.0247048 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0246324 |
| RPLP0 | ribosomal protein, large, P0 | -0.0245977 |
| TMEM123 | transmembrane protein 123 | -0.0245633 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.024225 |
| RAI14 | retinoic acid induced 14 | -0.024211 |
| SRGN | serglycin | -0.0241968 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.024075 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0235528 |
| TMEM263 | transmembrane protein 263 | -0.0235062 |
| PHF21A | PHD finger protein 21A | -0.0234947 |
| RPL11 | ribosomal protein L11 | -0.0231779 |
| RPL19 | ribosomal protein L19 | -0.0230283 |
| RBM39 | RNA binding motif protein 39 | -0.0227324 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0226215 |
| MT2A | metallothionein 2A | -0.0224922 |
| FAM162A | family with sequence similarity 162, member A | -0.0222719 |
