| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the MK-8353_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.201504 |
| B2M | beta-2-microglobulin | 0.119733 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.105678 |
| MT2A | metallothionein 2A | 0.0887321 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0875384 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0798287 |
| CALR | calreticulin | 0.0723088 |
| PRELID2 | PRELI domain containing 2 | 0.0691565 |
| ARRDC3 | arrestin domain containing 3 | 0.0662229 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0636072 |
| AHNAK | AHNAK nucleoprotein | 0.05999 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0591723 |
| ENO1 | enolase 1, (alpha) | 0.0560438 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0541525 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0520008 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0517011 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0516253 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0505973 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0492244 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0485631 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0480465 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.047477 |
| FAM13A | family with sequence similarity 13, member A | 0.0459651 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0458353 |
| IL6 | interleukin 6 | 0.0447485 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0444517 |
| UBC | ubiquitin C | 0.0444334 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0442793 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0440824 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0439078 |
| CD44 | CD44 molecule (Indian blood group) | 0.0423988 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0422731 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0413555 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0408582 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0407173 |
| SDC4 | syndecan 4 | 0.0405186 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0403713 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0403363 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.040262 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0401766 |
| CANX | calnexin | 0.0398723 |
| LDHA | lactate dehydrogenase A | 0.0398016 |
| FAM107B | family with sequence similarity 107, member B | 0.0393051 |
| CDK6 | cyclin-dependent kinase 6 | 0.0387213 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0380867 |
| SRP54 | signal recognition particle 54kDa | 0.0376503 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0375523 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0373333 |
| GOLGB1 | golgin B1 | 0.0370474 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0369073 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0368958 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0367982 |
| AHR | aryl hydrocarbon receptor | 0.0360478 |
| HYOU1 | hypoxia up-regulated 1 | 0.0360053 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0356573 |
| LMNA | lamin A/C | 0.0353592 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0347767 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0345219 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0344634 |
| TPM3 | tropomyosin 3 | 0.0341032 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0339 |
| IL6ST | interleukin 6 signal transducer | 0.0338996 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0337834 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0333496 |
| IRF1 | interferon regulatory factor 1 | 0.0330091 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0329786 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0329245 |
| EFNA5 | ephrin-A5 | 0.0324123 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0321385 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0321249 |
| STK10 | serine/threonine kinase 10 | 0.0321048 |
| ECE1 | endothelin converting enzyme 1 | 0.031884 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0314585 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0314266 |
| ANO6 | anoctamin 6 | 0.0314048 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.031199 |
| MKI67 | marker of proliferation Ki-67 | 0.0308432 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0306932 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0306631 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0304271 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0302227 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0300918 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0297688 |
| CDK19 | cyclin-dependent kinase 19 | 0.0297567 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0295346 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0294812 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0294193 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0290766 |
| FTO | fat mass and obesity associated | 0.0290618 |
| TOP1 | topoisomerase (DNA) I | 0.0288792 |
| SQSTM1 | sequestosome 1 | 0.0287195 |
| ANLN | anillin, actin binding protein | 0.0282896 |
| ITM2B | integral membrane protein 2B | 0.0280325 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0279462 |
| VMP1 | vacuole membrane protein 1 | 0.0279232 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0279195 |
| HLA-B | major histocompatibility complex, class I, B | 0.0277825 |
| RBM39 | RNA binding motif protein 39 | 0.0276273 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0273876 |
| YBX1 | Y box binding protein 1 | 0.0273089 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.216313 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.10751 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0960057 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0739505 |
| COL6A3 | collagen, type VI, alpha 3 | -0.062316 |
| TNS3 | tensin 3 | -0.0568628 |
| VCL | vinculin | -0.0549571 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0547621 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0546837 |
| TMSB10 | thymosin beta 10 | -0.0531867 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0426074 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0417338 |
| CALD1 | caldesmon 1 | -0.0367952 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0363186 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0363112 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0356491 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0350474 |
| COL1A2 | collagen, type I, alpha 2 | -0.0345906 |
| FRMD4A | FERM domain containing 4A | -0.0342813 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0337876 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0334328 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0333816 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0331616 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.0331047 |
| NAV1 | neuron navigator 1 | -0.0330428 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.032357 |
| S100A6 | S100 calcium binding protein A6 | -0.0321585 |
| RPL9 | ribosomal protein L9 | -0.031709 |
| KAZN | kazrin, periplakin interacting protein | -0.0316325 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0313676 |
| RAD50 | RAD50 homolog (S. cerevisiae) | -0.0307308 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.030344 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0288311 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0285306 |
| MAP4 | microtubule-associated protein 4 | -0.0271938 |
| OXR1 | oxidation resistance 1 | -0.0267657 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0265657 |
| COL1A1 | collagen, type I, alpha 1 | -0.0261353 |
| UTRN | utrophin | -0.026013 |
| UBQLN1 | ubiquilin 1 | -0.0258343 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0255673 |
| FLNA | filamin A, alpha | -0.0253682 |
| CDK13 | cyclin-dependent kinase 13 | -0.0253635 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0253548 |
| FBN1 | fibrillin 1 | -0.0251976 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.025128 |
| TUBA1C | tubulin, alpha 1c | -0.0250436 |
| PDZRN3 | PDZ domain containing ring finger 3 | -0.0249592 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0247864 |
| SEC24D | SEC24 family member D | -0.0245189 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0244491 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0242164 |
| COL5A1 | collagen, type V, alpha 1 | -0.0240129 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0239319 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0237926 |
| N4BP1 | NEDD4 binding protein 1 | -0.0237696 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.0236965 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0234332 |
| RPL12 | ribosomal protein L12 | -0.023378 |
| CDH13 | cadherin 13 | -0.0233703 |
| HMGA2 | high mobility group AT-hook 2 | -0.0232989 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0232582 |
| RNF145 | ring finger protein 145 | -0.0228851 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0226366 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0226236 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | -0.0224433 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0223705 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0222825 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0222394 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0222061 |
| SIL1 | SIL1 nucleotide exchange factor | -0.0221832 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0220131 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0219142 |
| MTPN | myotrophin | -0.0216898 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0215467 |
| RPL27A | ribosomal protein L27a | -0.0214985 |
| HDLBP | high density lipoprotein binding protein | -0.0214942 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0214246 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | -0.0213162 |
| RAB10 | RAB10, member RAS oncogene family | -0.0212026 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.021148 |
| ROS1 | ROS proto-oncogene 1 , receptor tyrosine kinase | -0.0211236 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0211022 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0210925 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0210351 |
| ZFR | zinc finger RNA binding protein | -0.0210186 |
| RUNX2 | runt-related transcription factor 2 | -0.0208748 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | -0.0207665 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0206818 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0205701 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0204264 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0204152 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.020225 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0199841 |
| PRKCA | protein kinase C, alpha | -0.0199285 |
| TCF20 | transcription factor 20 (AR1) | -0.0198339 |
| RPS13 | ribosomal protein S13 | -0.0197483 |
| SP100 | SP100 nuclear antigen | -0.0196763 |
| RPL34 | ribosomal protein L34 | -0.0195912 |
| FNBP4 | formin binding protein 4 | -0.01953 |
