| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.101245 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0954779 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0898841 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0830232 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0806249 |
| SVIL | supervillin | 0.0700201 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0661207 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0656556 |
| DST | dystonin | 0.0650321 |
| INTS6 | integrator complex subunit 6 | 0.0601436 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0600033 |
| FMNL2 | formin-like 2 | 0.0591564 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.059087 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0556023 |
| PTK2 | protein tyrosine kinase 2 | 0.0534548 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0526681 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0525357 |
| ANGPTL4 | angiopoietin-like 4 | 0.0525304 |
| CD44 | CD44 molecule (Indian blood group) | 0.0511087 |
| AHNAK | AHNAK nucleoprotein | 0.0509013 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0508019 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0501608 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.049966 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0488708 |
| RIGI | RNA sensor RIG-I | 0.0482232 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0474688 |
| CAPRIN2 | caprin family member 2 | 0.0459139 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0454703 |
| HMGA2 | high mobility group AT-hook 2 | 0.0442502 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0442406 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0441246 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0439231 |
| SMAD3 | SMAD family member 3 | 0.0417368 |
| SQSTM1 | sequestosome 1 | 0.041568 |
| EXT1 | exostosin glycosyltransferase 1 | 0.040901 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0408442 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0392692 |
| EMP1 | epithelial membrane protein 1 | 0.0389628 |
| S100A10 | S100 calcium binding protein A10 | 0.0373719 |
| B2M | beta-2-microglobulin | 0.0369938 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0365496 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0364079 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0362646 |
| IL6ST | interleukin 6 signal transducer | 0.0359592 |
| PRSS23 | protease, serine, 23 | 0.0358716 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0356538 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.035455 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0344242 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0341804 |
| RPS12 | ribosomal protein S12 | 0.0340002 |
| SET | SET nuclear proto-oncogene | 0.0331605 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0328467 |
| DSCAM | Down syndrome cell adhesion molecule | 0.032431 |
| ANXA1 | annexin A1 | 0.0317343 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0316058 |
| GPC5 | glypican 5 | 0.0315986 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.031196 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0309763 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0309436 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0308625 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.03065 |
| SKIL | SKI-like proto-oncogene | 0.0305244 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0303115 |
| RIOK3 | RIO kinase 3 | 0.0302696 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0299522 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0298398 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0292179 |
| RPS17 | ribosomal protein S17 | 0.0291355 |
| GOLGB1 | golgin B1 | 0.0289119 |
| ENO1 | enolase 1, (alpha) | 0.0289111 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.028809 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0287577 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0286166 |
| ZNF638 | zinc finger protein 638 | 0.0285423 |
| MSN | moesin | 0.0285277 |
| PRELID2 | PRELI domain containing 2 | 0.0284292 |
| EGFR | epidermal growth factor receptor | 0.0281629 |
| PRR16 | proline rich 16 | 0.0281211 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0279471 |
| AEBP2 | AE binding protein 2 | 0.0277396 |
| PLEK2 | pleckstrin 2 | 0.027174 |
| RAI14 | retinoic acid induced 14 | 0.0269395 |
| POTEF | POTE ankyrin domain family, member F | 0.0268565 |
| CDK6 | cyclin-dependent kinase 6 | 0.0265384 |
| CLDN1 | claudin 1 | 0.0261155 |
| KLF6 | Kruppel-like factor 6 | 0.0257032 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0256413 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.0256179 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0254736 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0253419 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0252663 |
| SETD5 | SET domain containing 5 | 0.0252203 |
| MMP10 | matrix metallopeptidase 10 | 0.0250946 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0249772 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0245711 |
| TJP1 | tight junction protein 1 | 0.0244895 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0242302 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0241981 |
| MED13 | mediator complex subunit 13 | 0.024027 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.023975 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.078607 |
| TMSB10 | thymosin beta 10 | -0.0777926 |
| ANLN | anillin, actin binding protein | -0.044778 |
| DIAPH3 | diaphanous-related formin 3 | -0.042437 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0378878 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0377423 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0375937 |
| SGO2 | shugoshin 2 | -0.0375933 |
| DNER | delta/notch-like EGF repeat containing | -0.0365603 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0362789 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0353042 |
| PTMA | prothymosin, alpha | -0.033608 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0329949 |
| BRCA2 | breast cancer 2, early onset | -0.0306113 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.03058 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.030278 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0302025 |
| TPX2 | TPX2, microtubule-associated | -0.0296039 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0293632 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0282053 |
| MKI67 | marker of proliferation Ki-67 | -0.027928 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0278168 |
| GPC6 | glypican 6 | -0.0274776 |
| KIAA1328 | KIAA1328 | -0.027178 |
| CANX | calnexin | -0.0252354 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0248018 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0242313 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0239824 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0236651 |
| ETV6 | ets variant 6 | -0.0235999 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0235911 |
| PRR11 | proline rich 11 | -0.0233034 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0232969 |
| ATG7 | autophagy related 7 | -0.0232212 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0228707 |
| TUBB | tubulin, beta class I | -0.0227856 |
| RABGAP1 | RAB GTPase activating protein 1 | -0.0225994 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.022486 |
| IGF2 | insulin-like growth factor 2 | -0.0216235 |
| HJURP | Holliday junction recognition protein | -0.0213921 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0213676 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0213625 |
| ATXN2L | ataxin 2-like | -0.0212702 |
| GPR107 | G protein-coupled receptor 107 | -0.0208336 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0207436 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0203722 |
| ECT2 | epithelial cell transforming 2 | -0.0203371 |
| EFNA5 | ephrin-A5 | -0.0202479 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0201946 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0200653 |
| FAF2 | Fas associated factor family member 2 | -0.0199827 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0198088 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0197597 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0196444 |
| RIN2 | Ras and Rab interactor 2 | -0.0193887 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0193776 |
| TTK | TTK protein kinase | -0.0192903 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.019287 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0192379 |
| CENPF | centromere protein F, 350/400kDa | -0.0191684 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0190403 |
| PHF3 | PHD finger protein 3 | -0.0189153 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0188499 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0187572 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0187041 |
| CDK12 | cyclin-dependent kinase 12 | -0.018594 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0185137 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0184718 |
| ATN1 | atrophin 1 | -0.0184302 |
| RPLP0 | ribosomal protein, large, P0 | -0.0183794 |
| RBM39 | RNA binding motif protein 39 | -0.0183496 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0183319 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0182067 |
| SYCP2 | synaptonemal complex protein 2 | -0.0180282 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0177765 |
| SEC23B | Sec23 homolog B (S. cerevisiae) | -0.0176098 |
| VIM | vimentin | -0.0175371 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0173107 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0172508 |
| SOGA1 | suppressor of glucose, autophagy associated 1 | -0.0172371 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.0172149 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | -0.0171613 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0170638 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0170334 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0169721 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0168308 |
| ADAR | adenosine deaminase, RNA-specific | -0.0168265 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0166812 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0166175 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0165643 |
| CLIC1 | chloride intracellular channel 1 | -0.0165363 |
| IFT74 | intraflagellar transport 74 | -0.0165347 |
| TBCK | TBC1 domain containing kinase | -0.0164752 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0163815 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.016346 |
| R3HDM1 | R3H domain containing 1 | -0.0163232 |
| VPS41 | vacuolar protein sorting 41 homolog (S. cerevisiae) | -0.0162896 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0162883 |
| FANCI | Fanconi anemia, complementation group I | -0.0162379 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | -0.0162166 |
