| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | 0.116738 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0716456 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.067977 |
| EFNA5 | ephrin-A5 | 0.0668479 |
| HMGA2 | high mobility group AT-hook 2 | 0.0634359 |
| FTL | ferritin, light polypeptide | 0.0587899 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0584674 |
| STC2 | stanniocalcin 2 | 0.0565481 |
| PLIN2 | perilipin 2 | 0.0527993 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0516942 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0513567 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.048939 |
| SQSTM1 | sequestosome 1 | 0.0488848 |
| B2M | beta-2-microglobulin | 0.0483513 |
| RPL35A | ribosomal protein L35a | 0.0468364 |
| RAI14 | retinoic acid induced 14 | 0.0450543 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0434487 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0422015 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0392703 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0378192 |
| INTS6 | integrator complex subunit 6 | 0.037535 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0357017 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0348297 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.034763 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0343227 |
| DUSP6 | dual specificity phosphatase 6 | 0.0335012 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0332925 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0329339 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0327967 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0327871 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0326133 |
| RPS8 | ribosomal protein S8 | 0.0316677 |
| GPATCH2L | G patch domain containing 2-like | 0.0313013 |
| RND3 | Rho family GTPase 3 | 0.0309808 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0307162 |
| HLA-B | major histocompatibility complex, class I, B | 0.0305755 |
| ACTG1 | actin gamma 1 | 0.0301935 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0301665 |
| RPL37A | ribosomal protein L37a | 0.0301252 |
| SFTPA2 | surfactant protein A2 | 0.0293767 |
| RPS2 | ribosomal protein S2 | 0.0290682 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0283887 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0282412 |
| GLIS3 | GLIS family zinc finger 3 | 0.0280979 |
| S100A10 | S100 calcium binding protein A10 | 0.0276693 |
| ASPH | aspartate beta-hydroxylase | 0.0269799 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0262097 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0260352 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0254225 |
| LRRC23 | leucine rich repeat containing 23 | 0.0251809 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0251271 |
| EGR1 | early growth response 1 | 0.024264 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0240658 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0237489 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0236876 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0227456 |
| TGFB1 | transforming growth factor, beta 1 | 0.022738 |
| GOLGB1 | golgin B1 | 0.0223701 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0220981 |
| RASAL2 | RAS protein activator like 2 | 0.0215208 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.021017 |
| RPL31 | ribosomal protein L31 | 0.0207405 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0207227 |
| UBAP2 | ubiquitin associated protein 2 | 0.0206877 |
| RPS27 | ribosomal protein S27 | 0.0206001 |
| MYADM | myeloid-associated differentiation marker | 0.020266 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.020158 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0201267 |
| CUX1 | cut-like homeobox 1 | 0.0200286 |
| POU2F2 | POU class 2 homeobox 2 | 0.0198116 |
| ADIPOR2 | adiponectin receptor 2 | 0.0193795 |
| IL6 | interleukin 6 | 0.0189996 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0189608 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0187008 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0185976 |
| TNRC6C | trinucleotide repeat containing 6C | 0.018564 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0184238 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0180757 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0180447 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | 0.0178738 |
| DSTN | destrin (actin depolymerizing factor) | 0.0177891 |
| RPS6 | ribosomal protein S6 | 0.0176379 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0175475 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0175335 |
| TRIP11 | thyroid hormone receptor interactor 11 | 0.0174635 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0171693 |
| CCDC138 | coiled-coil domain containing 138 | 0.0170134 |
| SGMS2 | sphingomyelin synthase 2 | 0.0168085 |
| GPC6 | glypican 6 | 0.0167658 |
| PRSS23 | protease, serine, 23 | 0.0167195 |
| CRY1 | cryptochrome circadian clock 1 | 0.016675 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0164248 |
| ENO1 | enolase 1, (alpha) | 0.016378 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0163401 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0163065 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0162034 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0160743 |
| PALLD | palladin, cytoskeletal associated protein | 0.0160661 |
| S100A9 | S100 calcium binding protein A9 | 0.0158145 |
| MX2 | MX dynamin-like GTPase 2 | 0.015726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.135934 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.118925 |
| UBC | ubiquitin C | -0.109585 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.108619 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.081607 |
| CANX | calnexin | -0.0788472 |
| AHR | aryl hydrocarbon receptor | -0.0748591 |
| OGA | O-GlcNAcase | -0.0726388 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0718352 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0691619 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0670224 |
| RPS27A | ribosomal protein S27a | -0.0662238 |
| SMAD3 | SMAD family member 3 | -0.0613513 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0608215 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0580001 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0546028 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0534564 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0529441 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0525768 |
| RNF145 | ring finger protein 145 | -0.0523664 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0523095 |
| NEK7 | NIMA-related kinase 7 | -0.0518466 |
| OSMR | oncostatin M receptor | -0.0506609 |
| PCBP2 | poly(rC) binding protein 2 | -0.0499773 |
| ZNF292 | zinc finger protein 292 | -0.0496147 |
| ETNK1 | ethanolamine kinase 1 | -0.0495247 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0485968 |
| APP | amyloid beta (A4) precursor protein | -0.0478939 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0469421 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0467806 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0450839 |
| FNBP1 | formin binding protein 1 | -0.0442552 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0437859 |
| SUCO | SUN domain containing ossification factor | -0.043708 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0433104 |
| CENPF | centromere protein F, 350/400kDa | -0.0425527 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0419981 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0415406 |
| CAB39 | calcium binding protein 39 | -0.0411996 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0410862 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.040933 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0408619 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0406914 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0405859 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0402678 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0390113 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0388762 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0387509 |
| TFG | TRK-fused gene | -0.0387414 |
| CDC73 | cell division cycle 73 | -0.0383039 |
| PTMA | prothymosin, alpha | -0.0382952 |
| RBM39 | RNA binding motif protein 39 | -0.0381829 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0380758 |
| S100A6 | S100 calcium binding protein A6 | -0.0380541 |
| RHEB | Ras homolog enriched in brain | -0.0379235 |
| PELO | pelota homolog (Drosophila) | -0.0378313 |
| MKI67 | marker of proliferation Ki-67 | -0.0376206 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0369033 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0364342 |
| COPA | coatomer protein complex, subunit alpha | -0.0364113 |
| HELZ | helicase with zinc finger | -0.0360945 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0359216 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0357978 |
| TMSB10 | thymosin beta 10 | -0.0357844 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0357231 |
| FLNA | filamin A, alpha | -0.0355952 |
| SPAG9 | sperm associated antigen 9 | -0.0355845 |
| PTK2 | protein tyrosine kinase 2 | -0.0346046 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0340998 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0340464 |
| WDR45B | WD repeat domain 45B | -0.0338412 |
| XPO1 | exportin 1 | -0.0336804 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0334989 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0334619 |
| NUP58 | nucleoporin 58 | -0.0329671 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0327851 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0324076 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0319536 |
| SYNJ2 | synaptojanin 2 | -0.031938 |
| CALU | calumenin | -0.0314254 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0313077 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0311963 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0311319 |
| USP3 | ubiquitin specific peptidase 3 | -0.0311198 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0308393 |
| SMOX | spermine oxidase | -0.0307949 |
| TXNRD1 | thioredoxin reductase 1 | -0.0303433 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.0303197 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0301939 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0297935 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0297477 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0297023 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.029616 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0293899 |
| TPR | translocated promoter region, nuclear basket protein | -0.0292929 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0290104 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0289708 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0289224 |
| ZFR | zinc finger RNA binding protein | -0.0287915 |
| FOXO3 | forkhead box O3 | -0.0287489 |
