| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.119865 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0796391 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0694861 |
| H1-0 | H1.0 linker histone | 0.0676763 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0663585 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0606058 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0568983 |
| ZNF292 | zinc finger protein 292 | 0.054325 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0533503 |
| RBM39 | RNA binding motif protein 39 | 0.051343 |
| SPAG9 | sperm associated antigen 9 | 0.0510582 |
| FTL | ferritin, light polypeptide | 0.0509847 |
| RYBP | RING1 and YY1 binding protein | 0.0508926 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0504099 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0496977 |
| MATR3 | matrin 3 | 0.0494792 |
| NCKAP1 | NCK-associated protein 1 | 0.0485918 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0463567 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0461018 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0459386 |
| AFDN | afadin, adherens junction formation factor | 0.0446334 |
| RHEB | Ras homolog enriched in brain | 0.0436852 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0430417 |
| DSPP | dentin sialophosphoprotein | 0.0420289 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.041545 |
| GOLGA4 | golgin A4 | 0.0414716 |
| TPX2 | TPX2, microtubule-associated | 0.0405999 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0394041 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0393082 |
| FNBP1L | formin binding protein 1-like | 0.0383536 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0380438 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0378943 |
| XPO1 | exportin 1 | 0.0363692 |
| B2M | beta-2-microglobulin | 0.0357254 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0357204 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0356428 |
| TFG | TRK-fused gene | 0.035295 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0347805 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0341603 |
| USP3 | ubiquitin specific peptidase 3 | 0.0337644 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0334802 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0334699 |
| SUCO | SUN domain containing ossification factor | 0.0332022 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0329926 |
| RBM33 | RNA binding motif protein 33 | 0.0329518 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0325264 |
| ZNF207 | zinc finger protein 207 | 0.0325213 |
| EZR | ezrin | 0.0324647 |
| KIF5B | kinesin family member 5B | 0.0323416 |
| TXNIP | thioredoxin interacting protein | 0.0323008 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0321672 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0321618 |
| CANX | calnexin | 0.0320661 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0319114 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0317958 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0317775 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0317445 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0316772 |
| TES | testin LIM domain protein | 0.0316081 |
| CCNL1 | cyclin L1 | 0.031402 |
| SNX9 | sorting nexin 9 | 0.0313422 |
| MED13L | mediator complex subunit 13-like | 0.0313046 |
| AHNAK | AHNAK nucleoprotein | 0.0308432 |
| HMGB2 | high mobility group box 2 | 0.030711 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0299303 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0293981 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0293877 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.029085 |
| JAK1 | Janus kinase 1 | 0.0287833 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0285145 |
| SEPTIN7 | septin 7 | 0.028114 |
| NOP58 | NOP58 ribonucleoprotein | 0.0281115 |
| ABI1 | abl-interactor 1 | 0.0279429 |
| NEK7 | NIMA-related kinase 7 | 0.0277841 |
| WAC | WW domain containing adaptor with coiled-coil | 0.027744 |
| JMJD1C | jumonji domain containing 1C | 0.0276748 |
| TXNRD1 | thioredoxin reductase 1 | 0.0273706 |
| OGA | O-GlcNAcase | 0.0273385 |
| YAP1 | Yes-associated protein 1 | 0.0272797 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0272605 |
| FAM3C | family with sequence similarity 3, member C | 0.0271906 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0270964 |
| EHF | ets homologous factor | 0.0269107 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0267248 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0263088 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0263041 |
| HBP1 | HMG-box transcription factor 1 | 0.0262645 |
| TOP1 | topoisomerase (DNA) I | 0.0262369 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0261726 |
| NEBL | nebulette | 0.0260665 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.02597 |
| LRRC1 | leucine rich repeat containing 1 | 0.025934 |
| RPL12 | ribosomal protein L12 | 0.0257772 |
| OXR1 | oxidation resistance 1 | 0.025679 |
| TJP1 | tight junction protein 1 | 0.0255479 |
| RND3 | Rho family GTPase 3 | 0.0255054 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0253148 |
| CUL3 | cullin 3 | 0.0251679 |
| MKI67 | marker of proliferation Ki-67 | 0.0250887 |
| NPTN | neuroplastin | 0.0250233 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAML2 | mastermind-like 2 (Drosophila) | -0.17908 |
| PTMA | prothymosin, alpha | -0.0995164 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0859844 |
| TMSB10 | thymosin beta 10 | -0.0722937 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.063779 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0603008 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0579001 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0572788 |
| NDRG1 | N-myc downstream regulated 1 | -0.0560969 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0551463 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0517324 |
| EHBP1 | EH domain binding protein 1 | -0.0510051 |
| RPL35A | ribosomal protein L35a | -0.0506798 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0492814 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0476736 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0464369 |
| BCL2L1 | BCL2-like 1 | -0.0456976 |
| ITGB4 | integrin, beta 4 | -0.045417 |
| HLA-A | major histocompatibility complex, class I, A | -0.0433768 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0427782 |
| RPL37A | ribosomal protein L37a | -0.0427364 |
| NFIA | nuclear factor I/A | -0.042678 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0399352 |
| EXOC4 | exocyst complex component 4 | -0.0384885 |
| HMGA1 | high mobility group AT-hook 1 | -0.0373155 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0367919 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.036567 |
| HM13 | histocompatibility (minor) 13 | -0.0357116 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0356914 |
| RPS13 | ribosomal protein S13 | -0.0346101 |
| CADPS | Ca++-dependent secretion activator | -0.0334291 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0332009 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0322061 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0317752 |
| RPS6 | ribosomal protein S6 | -0.0317558 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0317167 |
| CUX1 | cut-like homeobox 1 | -0.0314585 |
| RPS12 | ribosomal protein S12 | -0.0311553 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0299912 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0293398 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0292562 |
| RAD51B | RAD51 paralog B | -0.0290675 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0283944 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0278047 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0272772 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | -0.0271619 |
| KRT18 | keratin 18, type I | -0.0268402 |
| RPL9 | ribosomal protein L9 | -0.0266469 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -0.0258716 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0255979 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0252056 |
| CMIP | c-Maf inducing protein | -0.0239913 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0238814 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0236582 |
| KLK10 | kallikrein-related peptidase 10 | -0.0235387 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0230193 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0228972 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0228417 |
| HMGA2 | high mobility group AT-hook 2 | -0.0227718 |
| CCND1 | cyclin D1 | -0.022618 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0223509 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0223373 |
| PKM | pyruvate kinase, muscle | -0.0220744 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.022002 |
| ZFHX3 | zinc finger homeobox 3 | -0.0219123 |
| EGR1 | early growth response 1 | -0.0218825 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0217627 |
| TPM4 | tropomyosin 4 | -0.021617 |
| USP34 | ubiquitin specific peptidase 34 | -0.0215613 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0214737 |
| MSI2 | musashi RNA-binding protein 2 | -0.0212348 |
| DYNC2I1 | dynein 2 intermediate chain 1 | -0.0207742 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0207135 |
| NCOR2 | nuclear receptor corepressor 2 | -0.020691 |
| BMP6 | bone morphogenetic protein 6 | -0.020579 |
| FOSL1 | FOS-like antigen 1 | -0.0203278 |
| IER3 | immediate early response 3 | -0.0203215 |
| CTSD | cathepsin D | -0.0201396 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0199723 |
| S100A6 | S100 calcium binding protein A6 | -0.0195715 |
| CCDC91 | coiled-coil domain containing 91 | -0.019566 |
| RPS3 | ribosomal protein S3 | -0.0195202 |
| STK39 | serine threonine kinase 39 | -0.0191123 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0190247 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0190173 |
| RPS29 | ribosomal protein S29 | -0.0190088 |
| ATP9A | ATPase, class II, type 9A | -0.0189269 |
| TMEM45B | transmembrane protein 45B | -0.0189261 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0189242 |
| S100A2 | S100 calcium binding protein A2 | -0.0188937 |
| SRRM3 | serine/arginine repetitive matrix 3 | -0.0185651 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0185291 |
| STC2 | stanniocalcin 2 | -0.0183899 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0182029 |
| LAMA4 | laminin, alpha 4 | -0.0181596 |
| SCG2 | secretogranin II | -0.0180401 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0180145 |
| THOC2 | THO complex 2 | -0.0179403 |
| ANXA4 | annexin A4 | -0.0178478 |
| DIAPH2 | diaphanous-related formin 2 | -0.0176372 |
