| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SW48 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.179813 |
| LAMA4 | laminin, alpha 4 | 0.135752 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.133921 |
| EGFR | epidermal growth factor receptor | 0.129485 |
| RCOR1 | REST corepressor 1 | 0.118694 |
| ACTG1 | actin gamma 1 | 0.093356 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0914126 |
| EMP1 | epithelial membrane protein 1 | 0.0911153 |
| EGR1 | early growth response 1 | 0.0864772 |
| AHNAK | AHNAK nucleoprotein | 0.0863535 |
| ANXA2 | annexin A2 | 0.0816876 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0798084 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0771835 |
| ITPKC | inositol-trisphosphate 3-kinase C | 0.0754316 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0737077 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0730939 |
| SNX9 | sorting nexin 9 | 0.0715072 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0710784 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0693788 |
| FLOT1 | flotillin 1 | 0.0684301 |
| HMGA2 | high mobility group AT-hook 2 | 0.068422 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0676475 |
| LAMC2 | laminin, gamma 2 | 0.0671635 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.06692 |
| DSPP | dentin sialophosphoprotein | 0.0638407 |
| SGMS2 | sphingomyelin synthase 2 | 0.0637496 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0622083 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0618812 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0614218 |
| ITGA6 | integrin, alpha 6 | 0.0612785 |
| TPM4 | tropomyosin 4 | 0.0609793 |
| ATXN1 | ataxin 1 | 0.0604446 |
| VCL | vinculin | 0.059625 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0588281 |
| NUP50 | nucleoporin 50kDa | 0.0574717 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0564171 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0546173 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0533931 |
| EZR | ezrin | 0.0529726 |
| CANX | calnexin | 0.0520313 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0511381 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.0508504 |
| EXOC4 | exocyst complex component 4 | 0.0505336 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0501225 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0494764 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0491137 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0483402 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0477906 |
| ABR | active BCR-related | 0.0474734 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0461836 |
| SEPTIN9 | septin 9 | 0.0452182 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0450468 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0449291 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0434908 |
| FHL2 | four and a half LIM domains 2 | 0.0421016 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.041446 |
| MYO5B | myosin VB | 0.0413757 |
| SET | SET nuclear proto-oncogene | 0.0385679 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0385377 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0384185 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.038261 |
| POTEF | POTE ankyrin domain family, member F | 0.0382493 |
| RPL4 | ribosomal protein L4 | 0.0381669 |
| CD9 | CD9 molecule | 0.0373328 |
| PERP | PERP, TP53 apoptosis effector | 0.0369639 |
| FRAS1 | Fraser extracellular matrix complex subunit 1 | 0.0367807 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0360967 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0345214 |
| BPTF | bromodomain PHD finger transcription factor | 0.0340505 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.033914 |
| LMO7 | LIM domain 7 | 0.0336479 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0334669 |
| CDCP1 | CUB domain containing protein 1 | 0.033402 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0333633 |
| KLF6 | Kruppel-like factor 6 | 0.0333223 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0333161 |
| ENO1 | enolase 1, (alpha) | 0.0332564 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0332552 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0325462 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0324834 |
| DSC3 | desmocollin 3 | 0.0324638 |
| LAMB3 | laminin, beta 3 | 0.0323579 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.032258 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0320178 |
| CUX1 | cut-like homeobox 1 | 0.03149 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0314396 |
| HOMER1 | homer scaffolding protein 1 | 0.0312258 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0308498 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.0307965 |
| EFNB2 | ephrin-B2 | 0.0306545 |
| DOCK5 | dedicator of cytokinesis 5 | 0.03043 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0301605 |
| TRAF3 | TNF receptor-associated factor 3 | 0.0301045 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0300716 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0299967 |
| GATAD2A | GATA zinc finger domain containing 2A | 0.0299243 |
| SCFD1 | sec1 family domain containing 1 | 0.0297879 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0295233 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0294975 |
| FHIT | fragile histidine triad | 0.0292016 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0975389 |
| RNF43 | ring finger protein 43 | -0.0727642 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0681315 |
| RPL35A | ribosomal protein L35a | -0.0676551 |
| TMSB10 | thymosin beta 10 | -0.0623277 |
| TOP1 | topoisomerase (DNA) I | -0.0576071 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0482621 |
| MT2A | metallothionein 2A | -0.0476173 |
| RPS24 | ribosomal protein S24 | -0.047082 |
| GOLGA4 | golgin A4 | -0.0466391 |
| RBM25 | RNA binding motif protein 25 | -0.0459551 |
| NDRG1 | N-myc downstream regulated 1 | -0.0446326 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0419246 |
| RPL26 | ribosomal protein L26 | -0.0373017 |
| RUNX2 | runt-related transcription factor 2 | -0.0369322 |
| TXNRD1 | thioredoxin reductase 1 | -0.0368914 |
| COG5 | component of oligomeric golgi complex 5 | -0.0346362 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0343882 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0332868 |
| HLA-B | major histocompatibility complex, class I, B | -0.0332312 |
| USP3 | ubiquitin specific peptidase 3 | -0.0328863 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0325305 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | -0.0324058 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | -0.0319505 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0314845 |
| LRP8 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | -0.0314194 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0309811 |
| RPS29 | ribosomal protein S29 | -0.0305454 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0300323 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0293534 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0292897 |
| RPL37A | ribosomal protein L37a | -0.0291095 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0288655 |
| RPL11 | ribosomal protein L11 | -0.0285907 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.028263 |
| RPS13 | ribosomal protein S13 | -0.0271693 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0271605 |
| MSI2 | musashi RNA-binding protein 2 | -0.027151 |
| RFX7 | regulatory factor X, 7 | -0.0268811 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0268105 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.026793 |
| RBM39 | RNA binding motif protein 39 | -0.0267405 |
| RPL36 | ribosomal protein L36 | -0.0261948 |
| NFIA | nuclear factor I/A | -0.0261458 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0254964 |
| WDR43 | WD repeat domain 43 | -0.0252883 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0249628 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0245403 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0240235 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0237626 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0237275 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0234144 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0233558 |
| RPL9 | ribosomal protein L9 | -0.0231419 |
| FAM3C | family with sequence similarity 3, member C | -0.0231297 |
| AOPEP | aminopeptidase O (putative) | -0.0230387 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0230294 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0226298 |
| OGA | O-GlcNAcase | -0.022486 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0224034 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0222832 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0222181 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0221432 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0219358 |
| AREG | amphiregulin | -0.0216722 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0213987 |
| MAP4 | microtubule-associated protein 4 | -0.0213625 |
| RNF145 | ring finger protein 145 | -0.0211463 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0210576 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0208206 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0207543 |
| RPL13A | ribosomal protein L13a | -0.0205787 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0205182 |
| RPS21 | ribosomal protein S21 | -0.0204643 |
| RPS3 | ribosomal protein S3 | -0.0204541 |
| WDR45B | WD repeat domain 45B | -0.0203623 |
| USP24 | ubiquitin specific peptidase 24 | -0.0203531 |
| XPO7 | exportin 7 | -0.0201821 |
| NGLY1 | N-glycanase 1 | -0.0200841 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0199527 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0199373 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0197043 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0196874 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0193508 |
| NBAS | neuroblastoma amplified sequence | -0.0193183 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | -0.0192138 |
| SEC24D | SEC24 family member D | -0.0188994 |
| ELP2 | elongator acetyltransferase complex subunit 2 | -0.0187609 |
| VPS36 | vacuolar protein sorting 36 homolog (S. cerevisiae) | -0.0187156 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0186525 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0185258 |
| GDF15 | growth differentiation factor 15 | -0.0185089 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0183914 |
| SLMAP | sarcolemma associated protein | -0.0182634 |
| NEMF | nuclear export mediator factor | -0.018255 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0180782 |
| S100A9 | S100 calcium binding protein A9 | -0.0180563 |
| OXR1 | oxidation resistance 1 | -0.0179834 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0178478 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0178185 |
