| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | MK-8353 perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the MK-8353_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.177083 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.144418 |
| ASPH | aspartate beta-hydroxylase | 0.105654 |
| INTS6 | integrator complex subunit 6 | 0.0968776 |
| WWOX | WW domain containing oxidoreductase | 0.0772283 |
| NAV2 | neuron navigator 2 | 0.0696248 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0677459 |
| ENO1 | enolase 1, (alpha) | 0.0663914 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0646326 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0645824 |
| AHNAK | AHNAK nucleoprotein | 0.064485 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0630226 |
| RPS2 | ribosomal protein S2 | 0.0603408 |
| RAD51B | RAD51 paralog B | 0.0602683 |
| VCL | vinculin | 0.0593427 |
| CDK6 | cyclin-dependent kinase 6 | 0.0582641 |
| DSPP | dentin sialophosphoprotein | 0.0574003 |
| RPS8 | ribosomal protein S8 | 0.0570571 |
| RPS12 | ribosomal protein S12 | 0.0565011 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0558468 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0551294 |
| SET | SET nuclear proto-oncogene | 0.0532291 |
| TNS3 | tensin 3 | 0.0520184 |
| EXOC4 | exocyst complex component 4 | 0.0511943 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0482933 |
| DST | dystonin | 0.0473389 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0471607 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0468797 |
| EZR | ezrin | 0.0468386 |
| SERINC5 | serine incorporator 5 | 0.046099 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0456285 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0445503 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0439772 |
| TPM3 | tropomyosin 3 | 0.0436738 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0424609 |
| YAP1 | Yes-associated protein 1 | 0.0423342 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0422012 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0421614 |
| SMAD3 | SMAD family member 3 | 0.0417785 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0403379 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0400441 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0395729 |
| COBL | cordon-bleu WH2 repeat protein | 0.0393925 |
| SIK3 | SIK family kinase 3 | 0.0382346 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0376667 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0375354 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0373832 |
| UBAP2 | ubiquitin associated protein 2 | 0.0368512 |
| DIAPH2 | diaphanous-related formin 2 | 0.0367632 |
| BPTF | bromodomain PHD finger transcription factor | 0.0356314 |
| SPATA13 | spermatogenesis associated 13 | 0.0350345 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0349498 |
| EGFR | epidermal growth factor receptor | 0.0347207 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0342924 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0339292 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0335429 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0334648 |
| GSPT1 | G1 to S phase transition 1 | 0.0333687 |
| CDH13 | cadherin 13 | 0.032917 |
| HDAC4 | histone deacetylase 4 | 0.0328321 |
| LMO7 | LIM domain 7 | 0.0327379 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0325704 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0324263 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0322718 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0322225 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0321708 |
| EHBP1 | EH domain binding protein 1 | 0.031839 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0314998 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0311918 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0310167 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0309455 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0309001 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0308037 |
| RPL4 | ribosomal protein L4 | 0.0305544 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0305248 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0303587 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0301785 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0299908 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0295872 |
| SQSTM1 | sequestosome 1 | 0.0293689 |
| MED13 | mediator complex subunit 13 | 0.029339 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0293057 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0292487 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0291311 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.029001 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0289653 |
| MYO1E | myosin IE | 0.0285898 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0283176 |
| MT2A | metallothionein 2A | 0.028265 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0279437 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0278685 |
| RCOR1 | REST corepressor 1 | 0.0278266 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0278174 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0276863 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0275804 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0272554 |
| CD44 | CD44 molecule (Indian blood group) | 0.0272489 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0271196 |
| MCC | mutated in colorectal cancers | 0.0270945 |
| SVIL | supervillin | 0.0269687 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.137264 |
| KRT18 | keratin 18, type I | -0.101751 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.093269 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0905982 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0697999 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0609188 |
| H1-0 | H1.0 linker histone | -0.0576149 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0545109 |
| HMGA1 | high mobility group AT-hook 1 | -0.0542095 |
| RPS24 | ribosomal protein S24 | -0.0540914 |
| KRT8 | keratin 8, type II | -0.0514832 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0513501 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.050666 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0472155 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0466511 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0433625 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0423842 |
| RPLP0 | ribosomal protein, large, P0 | -0.0409051 |
| DIAPH3 | diaphanous-related formin 3 | -0.0393914 |
| OXR1 | oxidation resistance 1 | -0.0392945 |
| OGA | O-GlcNAcase | -0.0389459 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0384272 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0375955 |
| RPS21 | ribosomal protein S21 | -0.0371877 |
| RBM39 | RNA binding motif protein 39 | -0.0364537 |
| ZNF292 | zinc finger protein 292 | -0.0361674 |
| THOC2 | THO complex 2 | -0.0359125 |
| MIS18BP1 | MIS18 binding protein 1 | -0.035722 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0356696 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0352875 |
| USP3 | ubiquitin specific peptidase 3 | -0.0352633 |
| S100A6 | S100 calcium binding protein A6 | -0.0351012 |
| PTMA | prothymosin, alpha | -0.0343764 |
| RPL34 | ribosomal protein L34 | -0.0337108 |
| WDR45B | WD repeat domain 45B | -0.0331769 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0329624 |
| NDRG1 | N-myc downstream regulated 1 | -0.0325697 |
| RPLP1 | ribosomal protein, large, P1 | -0.0323692 |
| CDK8 | cyclin-dependent kinase 8 | -0.0323296 |
| RPL36A | ribosomal protein L36a | -0.031754 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0317307 |
| KRT19 | keratin 19, type I | -0.0313734 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0312705 |
| ANLN | anillin, actin binding protein | -0.031212 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0310973 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0310915 |
| GNAS | GNAS complex locus | -0.0307801 |
| GOLGA4 | golgin A4 | -0.0307467 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0307175 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0304947 |
| RPL35A | ribosomal protein L35a | -0.0304793 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0304564 |
| MORF4L2 | mortality factor 4 like 2 | -0.0304532 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.030379 |
| PFN1 | profilin 1 | -0.0298307 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0296148 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0295616 |
| MATR3 | matrin 3 | -0.0295375 |
| CCDC82 | coiled-coil domain containing 82 | -0.0294445 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0293676 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0286004 |
| TMEM41B | transmembrane protein 41B | -0.0283456 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0282944 |
| CEP95 | centrosomal protein 95kDa | -0.0282703 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0281318 |
| MT1X | metallothionein 1X | -0.0280203 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0279775 |
| ANXA2 | annexin A2 | -0.0279707 |
| SBF2 | SET binding factor 2 | -0.0277795 |
| NF1 | neurofibromin 1 | -0.0273796 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.027065 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0269726 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0269663 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0269063 |
| RPL19 | ribosomal protein L19 | -0.0267667 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0266882 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0266406 |
| RPL13A | ribosomal protein L13a | -0.0265456 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0264686 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.026448 |
| MTF2 | metal response element binding transcription factor 2 | -0.0261288 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0261259 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0258496 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.025585 |
| ACTG1 | actin gamma 1 | -0.025222 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0251815 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0251566 |
| STK4 | serine/threonine kinase 4 | -0.0250634 |
| IER3 | immediate early response 3 | -0.0249188 |
| RPL12 | ribosomal protein L12 | -0.024541 |
| COG5 | component of oligomeric golgi complex 5 | -0.0245225 |
| RLF | rearranged L-myc fusion | -0.0244875 |
| RPL27A | ribosomal protein L27a | -0.0241751 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0239738 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0239724 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0239418 |
| PGK1 | phosphoglycerate kinase 1 | -0.0238735 |
| RPL11 | ribosomal protein L11 | -0.0238095 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0238022 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0237347 |
