MK2206 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/46930998
Similar Terms
Downloads & Tools

Genes

198 proteins with high or low expression in MK2206 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
NRIP1 nuclear receptor interacting protein 1 5.1
APOB apolipoprotein B 3.57
PAH phenylalanine hydroxylase 2.89
NDFIP1 Nedd4 family interacting protein 1 2.22
ITM2C integral membrane protein 2C 2.03
NBR1 neighbor of BRCA1 gene 1 2.02
SLC16A6 solute carrier family 16, member 6 2.0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.98
TMEM59 transmembrane protein 59 1.92
LRP10 low density lipoprotein receptor-related protein 10 1.91
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.8
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.77
SQLE squalene epoxidase 1.75
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.73
FGFBP1 fibroblast growth factor binding protein 1 1.69
NCOA4 nuclear receptor coactivator 4 1.63
TSPAN3 tetraspanin 3 1.62
IDI1 isopentenyl-diphosphate delta isomerase 1 1.61
DEPTOR DEP domain containing MTOR-interacting protein 1.52
MSMO1 methylsterol monooxygenase 1 1.51
ITM2B integral membrane protein 2B 1.47
ACSS2 acyl-CoA synthetase short-chain family member 2 1.43
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 1.42
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.41
FAM122B family with sequence similarity 122B 1.39
PCSK9 proprotein convertase subtilisin/kexin type 9 1.38
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.36
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.32
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.32
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.3
IFNGR1 interferon gamma receptor 1 1.3
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.3
APOE apolipoprotein E 1.3
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.29
TM7SF2 transmembrane 7 superfamily member 2 1.28
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.23
RNF149 ring finger protein 149 1.2
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 1.14
ERG28 ergosterol biosynthesis 28 homolog 1.14
LDLR low density lipoprotein receptor 1.13
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 1.12
DHCR7 7-dehydrocholesterol reductase 1.12
ERBB3 erb-b2 receptor tyrosine kinase 3 1.1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 1.1
SLC38A2 solute carrier family 38, member 2 1.08
FGFR4 fibroblast growth factor receptor 4 1.08
DUSP6 dual specificity phosphatase 6 1.06
LPIN1 lipin 1 1.04
MT2A metallothionein 2A 1.03
MVK mevalonate kinase 1.02
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 1.02
CD63 CD63 molecule 1.01
F2R coagulation factor II (thrombin) receptor 1.01
ACAT2 acetyl-CoA acetyltransferase 2 1.0
BMPR1B bone morphogenetic protein receptor, type IB 0.99
ACVR1B activin A receptor, type IB 0.99
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.98
NDFIP2 Nedd4 family interacting protein 2 0.98
SLC49A4 solute carrier family 49 member 4 0.98
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.96
FDPS farnesyl diphosphate synthase 0.94
RNF145 ring finger protein 145 0.94
WNT16 wingless-type MMTV integration site family, member 16 0.93
IRS2 insulin receptor substrate 2 0.93
DHCR24 24-dehydrocholesterol reductase 0.92
UGCG UDP-glucose ceramide glucosyltransferase 0.92
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 0.91
PRXL2A peroxiredoxin like 2A 0.91
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.91
H1-0 H1.0 linker histone 0.9
ELOVL6 ELOVL fatty acid elongase 6 0.89
GRB7 growth factor receptor-bound protein 7 0.89
SC5D sterol-C5-desaturase 0.88
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 0.88
COQ8A coenzyme Q8A 0.88
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 0.86
GINM1 glycoprotein integral membrane 1 0.86
MVD mevalonate (diphospho) decarboxylase 0.85
AREG amphiregulin 0.83
ABHD3 abhydrolase domain containing 3 0.82
FAR1 fatty acyl CoA reductase 1 0.82
APLP2 amyloid beta (A4) precursor-like protein 2 0.82
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.81
SQSTM1 sequestosome 1 0.81
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.81
FBXL20 F-box and leucine-rich repeat protein 20 0.8
PLPP3 phospholipid phosphatase 3 0.8
TRIB1 tribbles pseudokinase 1 0.79
BCL6 B-cell CLL/lymphoma 6 0.77
MOSPD1 motile sperm domain containing 1 0.77
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.77
TMEM185B transmembrane protein 185B 0.76
SDCBP syndecan binding protein (syntenin) 0.76
TMEM200A transmembrane protein 200A 0.76
SGMS2 sphingomyelin synthase 2 0.76
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.75
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 0.75
AKAP12 A kinase (PRKA) anchor protein 12 0.75
GRN granulin 0.74

low expression

Symbol Name Standardized Value
DNAH5 dynein, axonemal, heavy chain 5 -2.18
TMEM97 transmembrane protein 97 -1.48
VAV1 vav 1 guanine nucleotide exchange factor -1.24
TTLL4 tubulin tyrosine ligase-like family member 4 -1.18
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 -1.16
FBXO31 F-box protein 31 -0.86
CLN5 ceroid-lipofuscinosis, neuronal 5 -0.86
CCND3 cyclin D3 -0.86
CDC20 cell division cycle 20 -0.77
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -0.77
CCN3 cellular communication network factor 3 -0.76
ZFP90 ZFP90 zinc finger protein -0.75
MOCS2 molybdenum cofactor synthesis 2 -0.74
PLK1 polo-like kinase 1 -0.74
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -0.74
DONSON downstream neighbor of SON -0.72
CCNB1 cyclin B1 -0.72
SMIM26 small integral membrane protein 26 -0.72
ARL16 ADP-ribosylation factor-like 16 -0.7
ZNF503 zinc finger protein 503 -0.67
DIPK1B divergent protein kinase domain 1B -0.67
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -0.66
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.66
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.66
MAGEA12 melanoma antigen family A12 -0.65
KDM6B lysine (K)-specific demethylase 6B -0.64
SESN2 sestrin 2 -0.64
ARHGAP19 Rho GTPase activating protein 19 -0.64
CENPE centromere protein E, 312kDa -0.63
KNSTRN kinetochore-localized astrin/SPAG5 binding protein -0.62
TRIM16 tripartite motif containing 16 -0.62
CILP2 cartilage intermediate layer protein 2 -0.62
RAP1GAP RAP1 GTPase activating protein -0.61
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.61
AEN apoptosis enhancing nuclease -0.61
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) -0.6
SDC1 syndecan 1 -0.6
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.6
ZNF724 zinc finger protein 724 -0.59
CDKN3 cyclin-dependent kinase inhibitor 3 -0.59
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.59
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.58
EHF ets homologous factor -0.57
ZNF414 zinc finger protein 414 -0.57
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -0.57
ZNF175 zinc finger protein 175 -0.57
SPAG5 sperm associated antigen 5 -0.56
CYTH1 cytohesin 1 -0.56
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.56
UBE2S ubiquitin-conjugating enzyme E2S -0.56
ENO1 enolase 1, (alpha) -0.55
AURKA aurora kinase A -0.55
ZUP1 zinc finger containing ubiquitin peptidase 1 -0.54
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -0.54
NIPA2 non imprinted in Prader-Willi/Angelman syndrome 2 -0.54
KLK6 kallikrein-related peptidase 6 -0.54
MYNN myoneurin -0.54
CCNF cyclin F -0.54
TCF3 transcription factor 3 -0.54
STK17B serine/threonine kinase 17b -0.53
FBXO44 F-box protein 44 -0.53
RRM2 ribonucleotide reductase M2 -0.53
BORA bora, aurora kinase A activator -0.53
MINDY4 MINDY lysine 48 deubiquitinase 4 -0.52
OIP5 Opa interacting protein 5 -0.52
SPNS1 spinster homolog 1 (Drosophila) -0.52
ODC1 ornithine decarboxylase 1 -0.52
ZWINT ZW10 interacting kinetochore protein -0.51
PSAT1 phosphoserine aminotransferase 1 -0.51
TOB2 transducer of ERBB2, 2 -0.51
ZNF296 zinc finger protein 296 -0.51
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.51
SAPCD2 suppressor APC domain containing 2 -0.51
SPDL1 spindle apparatus coiled-coil protein 1 -0.5
MIS18A MIS18 kinetochore protein A -0.5
AAGAB alpha- and gamma-adaptin binding protein -0.5
NES nestin -0.5
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.5
C1ORF112 chromosome 1 open reading frame 112 -0.5
CCNB2 cyclin B2 -0.5
CCDC138 coiled-coil domain containing 138 -0.5
CYTH3 cytohesin 3 -0.49
ARSG arylsulfatase G -0.49
BCL2L12 BCL2-like 12 (proline rich) -0.49
CUEDC2 CUE domain containing 2 -0.49
KIF2C kinesin family member 2C -0.49
ZCCHC2 zinc finger, CCHC domain containing 2 -0.49
SACK1D scaffolding CK1 anchoring protein D -0.49
PTTG1 pituitary tumor-transforming 1 -0.48
DBF4 DBF4 zinc finger -0.48
GMDS GDP-mannose 4,6-dehydratase -0.48
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.47
KNL1 kinetochore scaffold 1 -0.47
BMP1 bone morphogenetic protein 1 -0.47
PROCR protein C receptor, endothelial -0.47
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.47
FAM86B2 family with sequence similarity 86, member B2 -0.47
HSF2 heat shock transcription factor 2 -0.47
FLCN folliculin -0.47