MKKS Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description McKusick-Kaufman syndrome|This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013] (NCBI Entrez Gene Database, 8195)
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Genes

299 genes differentially expressed following the MKKS gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TUBB8 tubulin, beta 8 class VIII 2.32175
OTOP2 otopetrin 2 2.32175
OSR2 odd-skipped related transciption factor 2 2.32175
MTMR2 myotubularin related protein 2 2.32175
CRYGA crystallin, gamma A 2.32175
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.32175
C10ORF90 chromosome 10 open reading frame 90 2.32175
IRF5 interferon regulatory factor 5 2.32175
TMEM151A transmembrane protein 151A 2.32175
THBD thrombomodulin 2.32175
RHOXF2 Rhox homeobox family, member 2 2.32175
AKNAD1 AKNA domain containing 1 2.32175
RHOJ ras homolog family member J 2.32175
TES testin LIM domain protein 2.32175
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 2.32175
RASA4 RAS p21 protein activator 4 2.32175
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.32175
MFAP4 microfibrillar-associated protein 4 2.32175
CD80 CD80 molecule 2.32175
MAPK11 mitogen-activated protein kinase 11 2.32175
TSPAN19 tetraspanin 19 2.32175
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 2.32175
STAB2 stabilin 2 2.32175
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.32175
RERGL RERG/RAS-like 2.32175
TMPRSS11F transmembrane protease, serine 11F 2.25097
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.25097
CD93 CD93 molecule 2.25097
CD5 CD5 molecule 2.25097
TUBA3D tubulin, alpha 3d 2.25097
FOXL1 forkhead box L1 2.25097
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.25097
PTPRC protein tyrosine phosphatase, receptor type, C 2.25097
ZNF99 zinc finger protein 99 2.25097
SAA4 serum amyloid A4, constitutive 2.25097
HEXB hexosaminidase B (beta polypeptide) 2.25097
CARD18 caspase recruitment domain family, member 18 2.25097
GJB1 gap junction protein, beta 1, 32kDa 2.25097
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 2.25097
FETUB fetuin B 2.25097
PLCH2 phospholipase C, eta 2 2.25097
CEP295NL CEP295 N-terminal like 2.25097
RPP30 ribonuclease P/MRP 30kDa subunit 2.25097
MUSK muscle, skeletal, receptor tyrosine kinase 2.25097
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.25097
MATR3 matrin 3 2.25097
PDZD9 PDZ domain containing 9 2.25097
NRAP nebulin-related anchoring protein 2.25097
ZNF503 zinc finger protein 503 2.25097
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.25097
ENTHD1 ENTH domain containing 1 2.25097
NANOS2 nanos homolog 2 (Drosophila) 2.25097
CELA3A chymotrypsin-like elastase family, member 3A 2.25097
ABHD16B abhydrolase domain containing 16B 2.25097
PNMA5 paraneoplastic Ma antigen family member 5 2.25097
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.25097
GPR21 G protein-coupled receptor 21 2.25097
MAGEB3 melanoma antigen family B3 2.25097
LOC124901449 uncharacterized LOC124901449 2.25097
GIPC3 GIPC PDZ domain containing family, member 3 2.25097
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.25097
GBP6 guanylate binding protein family, member 6 2.25097
PSPH phosphoserine phosphatase 2.25097
ZAR1 zygote arrest 1 2.25097
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.25097
RD3 retinal degeneration 3 2.25097
FMOD fibromodulin 2.25097
C20ORF202 chromosome 20 open reading frame 202 2.25097
FBH1 F-box DNA helicase 1 2.25097
PMIS2 PMIS2 transmembrane protein 2.25097
GLYATL1B glycine-N-acyltransferase like 1B 2.25097
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.25097
TEX13C TEX13 family member C 2.25097
GARIN6 golgi associated RAB2 interactor family member 6 2.25097
GARIN4 golgi associated RAB2 interactor family member 4 2.25097
CHCT1 CHD1 helical C-terminal domain containing 1 2.25097
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.25097
CIROP ciliated left-right organizer metallopeptidase 2.25097
CCDC198 coiled-coil domain containing 198 2.25097
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.25097
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.25097
PIWIL3 piwi-like RNA-mediated gene silencing 3 2.25097
CREB3L3 cAMP responsive element binding protein 3-like 3 2.25097
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.25097
SCRT1 scratch family zinc finger 1 2.25097
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.25097
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.25097
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.25097
DNAAF8 dynein axonemal assembly factor 8 2.25097
ZSWIM2 zinc finger, SWIM-type containing 2 2.25097
EXOC3L4 exocyst complex component 3-like 4 2.25097
GSC goosecoid homeobox 2.25097
PROX2 prospero homeobox 2 2.25097
IQCF1 IQ motif containing F1 2.25097
TMEM40 transmembrane protein 40 2.25097
MIOX myo-inositol oxygenase 2.25097
MYPN myopalladin 2.25097
PCDHGC4 protocadherin gamma subfamily C, 4 2.25097
GDF6 growth differentiation factor 6 2.25097
LRRC71 leucine rich repeat containing 71 2.25097
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.25097
TEX101 testis expressed 101 2.25097
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 2.25097
WNT10A wingless-type MMTV integration site family, member 10A 2.25097
KLF1 Kruppel-like factor 1 (erythroid) 2.25097
WFDC1 WAP four-disulfide core domain 1 2.25097
SCX scleraxis basic helix-loop-helix transcription factor 2.25097
CALB2 calbindin 2 2.25097
WDR4 WD repeat domain 4 2.25097
DRD2 dopamine receptor D2 2.25097
ALOXE3 arachidonate lipoxygenase 3 2.25097
ISL2 ISL LIM homeobox 2 2.25097
NOX1 NADPH oxidase 1 2.25097
CPSF4L cleavage and polyadenylation specific factor 4-like 2.25097
POU3F2 POU class 3 homeobox 2 2.25097
TECRL trans-2,3-enoyl-CoA reductase-like 2.25097
WDFY2 WD repeat and FYVE domain containing 2 2.25097
C17ORF107 chromosome 17 open reading frame 107 2.25097
PCDHGB2 protocadherin gamma subfamily B, 2 2.25097
LRRC43 leucine rich repeat containing 43 2.25097
NUP93 nucleoporin 93kDa 2.25097
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.25097
RGCC regulator of cell cycle 2.25097
FBXO47 F-box protein 47 2.25097
CD27 CD27 molecule 2.25097
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.25097
HMGB4 high mobility group box 4 2.25097
NYX nyctalopin 2.25097
ERVV-1 endogenous retrovirus group V, member 1 2.25097
GPR142 G protein-coupled receptor 142 2.25097
ASXL2 additional sex combs like transcriptional regulator 2 2.25097
LAMB1 laminin, beta 1 2.25097
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.25097
CA5A carbonic anhydrase VA, mitochondrial 2.25097
EGR3 early growth response 3 2.25097
MATN1 matrilin 1, cartilage matrix protein 2.25097
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.25097
AICDA activation-induced cytidine deaminase 2.25097
PPIG peptidylprolyl isomerase G (cyclophilin G) 2.25097
FCRL1 Fc receptor-like 1 2.25097
CTSS cathepsin S 2.25097
DAPL1 death associated protein-like 1 2.25097
POTEE POTE ankyrin domain family, member E 2.25097
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.25097
CD34 CD34 molecule 2.25097
KCNU1 potassium channel, subfamily U, member 1 2.25097
ANKK1 ankyrin repeat and kinase domain containing 1 2.25097
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.25097
ETV2 ets variant 2 2.25097
GALR3 galanin receptor 3 2.25097
MRC1 mannose receptor, C type 1 2.25097
LGALS2 lectin, galactoside-binding, soluble, 2 2.25097
LGI1 leucine-rich, glioma inactivated 1 2.25097
NPIPA8 nuclear pore complex interacting protein family, member A8 2.25097
GNRH2 gonadotropin-releasing hormone 2 2.25097
LGALS4 lectin, galactoside-binding, soluble, 4 2.25097
MUC22 mucin 22 2.25097
RTN4R reticulon 4 receptor 2.25097
KIAA2012 KIAA2012 2.25097
C9ORF152 chromosome 9 open reading frame 152 2.25097
GRAPL GRB2-related adaptor protein-like 2.25097
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.25097
PADI1 peptidyl arginine deiminase, type I 2.25097
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.25097
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.25097
PAIP2 poly(A) binding protein interacting protein 2 2.25097
CREB5 cAMP responsive element binding protein 5 2.25097
PKD2L1 polycystic kidney disease 2-like 1 2.25097
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.25097
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.25097
EDDM3A epididymal protein 3A 2.25097
ZPBP2 zona pellucida binding protein 2 2.25097
TREML1 triggering receptor expressed on myeloid cells-like 1 2.25097
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 2.22957
EBPL emopamil binding protein-like 2.20553
CHD7 chromodomain helicase DNA binding protein 7 2.19735
ZCCHC10 zinc finger, CCHC domain containing 10 2.16931
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.16868
SPP1 secreted phosphoprotein 1 2.16851
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 2.16851
RNF41 ring finger protein 41, E3 ubiquitin protein ligase 2.16043
POU3F1 POU class 3 homeobox 1 2.15311
TCF4 transcription factor 4 2.14983
CCDC107 coiled-coil domain containing 107 2.14842
GPR141 G protein-coupled receptor 141 2.14842
ZNF487 zinc finger protein 487 2.14684
MEGF9 multiple EGF-like-domains 9 2.14684
FBXO15 F-box protein 15 2.13952
PDIA4 protein disulfide isomerase family A, member 4 2.13818
DNAI7 dynein axonemal intermediate chain 7 2.12817
ACTN4 actinin, alpha 4 2.12517
MPPE1 metallophosphoesterase 1 2.11726
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.10849
STIM1 stromal interaction molecule 1 2.10849
RRM2 ribonucleotide reductase M2 2.06573
PTGES2 prostaglandin E synthase 2 2.05276
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 2.05055
ANK2 ankyrin 2, neuronal 2.00914

decreased expression

Symbol Name Standardized Value
TAFA1 TAFA chemokine like family member 1 -2.32175
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) -2.32175
QPRT quinolinate phosphoribosyltransferase -2.32175
UBOX5 U-box domain containing 5 -2.26239
OSMR oncostatin M receptor -2.25611
MYH15 myosin, heavy chain 15 -2.25097
PXDC1 PX domain containing 1 -2.25097
METTL9 methyltransferase like 9 -2.25097
EBI3 Epstein-Barr virus induced 3 -2.25097
SETD7 SET domain containing (lysine methyltransferase) 7 -2.25097
RBM39 RNA binding motif protein 39 -2.25097
PDPK1 3-phosphoinositide dependent protein kinase 1 -2.25097
POPDC3 popeye domain containing 3 -2.25097
SP4 Sp4 transcription factor -2.25097
PCDHB2 protocadherin beta 2 -2.25097
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.25097
MIDN midnolin -2.25097
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 -2.25097
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C -2.25097
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 -2.25097
ERLIN1 ER lipid raft associated 1 -2.25097
ELAC1 elaC ribonuclease Z 1 -2.25097
TAS2R30 taste receptor, type 2, member 30 -2.25097
CDKL5 cyclin-dependent kinase-like 5 -2.25097
PRDM6 PR domain containing 6 -2.25097
LYG2 lysozyme G-like 2 -2.25097
TMEM238L transmembrane protein 238 like -2.25097
CCDC134 coiled-coil domain containing 134 -2.25097
EPHA10 EPH receptor A10 -2.25097
SLX4IP SLX4 interacting protein -2.25097
ADGRD2 adhesion G protein-coupled receptor D2 -2.25097
DRC3 dynein regulatory complex subunit 3 -2.25097
TMEM254 transmembrane protein 254 -2.25097
TNS1-AS1 TNS1 antisense RNA 1 -2.25097
TASOR2 transcription activation suppressor family member 2 -2.25097
SAPCD1 suppressor APC domain containing 1 -2.25097
GRM6 glutamate receptor, metabotropic 6 -2.25097
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -2.25097
FAM240C family with sequence similarity 240 member C -2.25097
SMAD9 SMAD family member 9 -2.25097
INTS15 integrator complex subunit 15 -2.23372
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.22105
ZNF680 zinc finger protein 680 -2.20023
CHD9NB CHD9 neighbor -2.19582
KIAA1614 KIAA1614 -2.19582
CD46 CD46 molecule, complement regulatory protein -2.19321
CCDC120 coiled-coil domain containing 120 -2.16868
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.16851
TACC2 transforming, acidic coiled-coil containing protein 2 -2.14842
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) -2.14842
IRGQ immunity-related GTPase family, Q -2.14842
FAM186A family with sequence similarity 186, member A -2.13818
CCDC13 coiled-coil domain containing 13 -2.13818
HEATR9 HEAT repeat containing 9 -2.13818
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 -2.13818
ZAN zonadhesin (gene/pseudogene) -2.13818
LOC122526780 uncharacterized LOC122526780 -2.13818
DUSP9 dual specificity phosphatase 9 -2.13818
SRL sarcalumenin -2.13818
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -2.13818
NBPF20 neuroblastoma breakpoint family, member 20 -2.13818
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.13818
SLC51B solute carrier family 51, beta subunit -2.13818
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.13818
STMND1 stathmin domain containing 1 -2.13818
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 -2.13818
DUSP26 dual specificity phosphatase 26 (putative) -2.13818
FNDC8 fibronectin type III domain containing 8 -2.13818
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.13818
SV2C synaptic vesicle glycoprotein 2C -2.13818
KLHL41 kelch-like family member 41 -2.13818
CAMK2G calcium/calmodulin-dependent protein kinase II gamma -2.13818
F2RL3 coagulation factor II (thrombin) receptor-like 3 -2.13818
FBXL22 F-box and leucine-rich repeat protein 22 -2.13818
KRT17 keratin 17, type I -2.13818
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.13818
ARSI arylsulfatase family, member I -2.13818
SERF1A small EDRK-rich factor 1A (telomeric) -2.13818
CORO6 coronin 6 -2.13818
ADAMTSL2 ADAMTS-like 2 -2.13818
HIC1 hypermethylated in cancer 1 -2.13818
PKD1L1 polycystic kidney disease 1 like 1 -2.13818
TMC6 transmembrane channel-like 6 -2.13063
CASZ1 castor zinc finger 1 -2.12172
TFB1M transcription factor B1, mitochondrial -2.11715
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.11715
PCSK9 proprotein convertase subtilisin/kexin type 9 -2.11194
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide -2.10534
THEM4 thioesterase superfamily member 4 -2.09309
RPA1 replication protein A1, 70kDa -2.06573
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -2.05902
SAP25 Sin3A-associated protein, 25kDa -2.05276
COL6A6 collagen, type VI, alpha 6 -2.05276
LRATD2 LRAT domain containing 2 -2.05055
ELP4 elongator acetyltransferase complex subunit 4 -2.05055
DAZAP1 DAZ associated protein 1 -2.04906
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.04328
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.02619
PKNOX1 PBX/knotted 1 homeobox 1 -2.00914
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 -2.00683
FAM162A family with sequence similarity 162, member A -2.00296