MKN7 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description A immortal human stomach-derived cell line cell that has the characteristics: c-erbB-2 expressing gastric adenocarcinoma. Differentiated type. (Cell Line Ontology, CLO_0050805)
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Genes

339 gene knockdowns changing fitness of MKN7 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.9054
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 2.67919
RLIM ring finger protein, LIM domain interacting 2.59949
DCLRE1B DNA cross-link repair 1B 2.53952
TMPRSS5 transmembrane protease, serine 5 2.42821
AMDHD2 amidohydrolase domain containing 2 2.29757
HLA-C major histocompatibility complex, class I, C 2.22936
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 2.10845
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.10485
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 2.08854
JMJD1C jumonji domain containing 1C 2.04439
FBXL20 F-box and leucine-rich repeat protein 20 1.92954
AGAP5 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 1.89962
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) 1.88232
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 1.87502
PABPC1 poly(A) binding protein, cytoplasmic 1 1.86494
KRTAP10-5 keratin associated protein 10-5 1.84145
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 1.841
PLS3 plastin 3 1.79889
ZNF623 zinc finger protein 623 1.78895
ZBTB45 zinc finger and BTB domain containing 45 1.74908
ZNF16 zinc finger protein 16 1.74285
FOXD1 forkhead box D1 1.71036
RPS25 ribosomal protein S25 1.68651
SPRED2 sprouty-related, EVH1 domain containing 2 1.65589
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 1.65448
ZBTB25 zinc finger and BTB domain containing 25 1.62561
TMED7 transmembrane emp24 protein transport domain containing 7 1.61623
ZFP36L2 ZFP36 ring finger protein-like 2 1.61525
OR8A1 olfactory receptor, family 8, subfamily A, member 1 1.61128
ZNF124 zinc finger protein 124 1.60683
EID2 EP300 interacting inhibitor of differentiation 2 1.58457
KCNK10 potassium channel, two pore domain subfamily K, member 10 1.58296
PRDM1 PR domain containing 1, with ZNF domain 1.58152
ZNF234 zinc finger protein 234 1.57164
RASA2 RAS p21 protein activator 2 1.56808
GRK5 G protein-coupled receptor kinase 5 1.53172
QRFPR pyroglutamylated RFamide peptide receptor 1.51208
RAP2C RAP2C, member of RAS oncogene family 1.49639
ADI1 acireductone dioxygenase 1 1.48812
COPS5 COP9 signalosome subunit 5 1.46489
AJAP1 adherens junctions associated protein 1 1.45721
H1FX H1 histone family, member X 1.45691
WDSUB1 WD repeat, sterile alpha motif and U-box domain containing 1 1.44779
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 1.44489
RGS16 regulator of G-protein signaling 16 1.44461
CABP4 calcium binding protein 4 1.43262
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 1.40328
RNF24 ring finger protein 24 1.39046
HIST1H3H histone cluster 1, H3h 1.38644
EVX1 even-skipped homeobox 1 1.38534
GPR78 G protein-coupled receptor 78 1.38428
HCAR1 hydroxycarboxylic acid receptor 1 1.37412
ACSL4 acyl-CoA synthetase long-chain family member 4 1.37056
RNF7 ring finger protein 7 1.3665
APAF1 apoptotic peptidase activating factor 1 1.35905
IL16 interleukin 16 1.35006
PRKD1 protein kinase D1 1.34486
SGPP2 sphingosine-1-phosphate phosphatase 2 1.33975
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 1.33517
CSNK2B casein kinase 2, beta polypeptide 1.33062
MAST4 microtubule associated serine/threonine kinase family member 4 1.32359
PSKH2 protein serine kinase H2 1.32283
CERS5 ceramide synthase 5 1.30896
SEC24B SEC24 family member B 1.29419
GSG2 germ cell associated 2 (haspin) 1.29338
GK2 glycerol kinase 2 1.29037
PVRL3 poliovirus receptor-related 3 1.28039
TRPM5 transient receptor potential cation channel, subfamily M, member 5 1.2775
DSG4 desmoglein 4 1.2735
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 1.27007
AP3D1 adaptor-related protein complex 3, delta 1 subunit 1.26774
CTSB cathepsin B 1.26249
UBAC2 UBA domain containing 2 1.25973
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.25848
VPREB1 pre-B lymphocyte 1 1.25402
DERA deoxyribose-phosphate aldolase (putative) 1.24373
GARS glycyl-tRNA synthetase 1.24246
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.23734
LPPR1 lipid phosphate phosphatase-related protein type 1 1.23397
UNC5C unc-5 homolog C (C. elegans) 1.23133
EDAR ectodysplasin A receptor 1.22862
EMX2 empty spiracles homeobox 2 1.22491
CNGB1 cyclic nucleotide gated channel beta 1 1.22489
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 1.22422
ADAM29 ADAM metallopeptidase domain 29 1.22232
LMO7 LIM domain 7 1.22183
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 1.21664
HNF1B HNF1 homeobox B 1.21572
TSTA3 tissue specific transplantation antigen P35B 1.21309
PAN3 PAN3 poly(A) specific ribonuclease subunit 1.2062
GLT8D1 glycosyltransferase 8 domain containing 1 1.20613
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 1.206
WNT1 wingless-type MMTV integration site family, member 1 1.2035
POFUT1 protein O-fucosyltransferase 1 1.2012
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 1.18707
RAB17 RAB17, member RAS oncogene family 1.18136
INSRR insulin receptor-related receptor 1.18113
GGPS1 geranylgeranyl diphosphate synthase 1 1.17798
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1.17656
ZNF595 zinc finger protein 595 1.1726
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2 1.16682
SLC30A1 solute carrier family 30 (zinc transporter), member 1 1.16348
MED19 mediator complex subunit 19 1.1578
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.1508
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 1.15044
PCDHA13 protocadherin alpha 13 1.1417
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 1.14136
RHOA ras homolog family member A 1.14113
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 1.13937
IL17RC interleukin 17 receptor C 1.13804
VANGL1 VANGL planar cell polarity protein 1 1.13397
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 1.13252
CCNDBP1 cyclin D-type binding-protein 1 1.1319
UHMK1 U2AF homology motif (UHM) kinase 1 1.12997
NHLH2 nescient helix loop helix 2 1.12908
RPS29 ribosomal protein S29 1.12833
GPRC5C G protein-coupled receptor, class C, group 5, member C 1.12365
PDLIM5 PDZ and LIM domain 5 1.12139
ING2 inhibitor of growth family, member 2 1.11903
SRCAP Snf2-related CREBBP activator protein 1.11565
MORF4L1 mortality factor 4 like 1 1.11466
MCHR1 melanin-concentrating hormone receptor 1 1.11354
ACSL3 acyl-CoA synthetase long-chain family member 3 1.11268
ZNF714 zinc finger protein 714 1.10655
SCN5A sodium channel, voltage gated, type V alpha subunit 1.10301
ADAM28 ADAM metallopeptidase domain 28 1.10272
RBM19 RNA binding motif protein 19 1.09975
ADCK3 aarF domain containing kinase 3 1.09146
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 1.08806
MINK1 misshapen-like kinase 1 1.08616
ARF5 ADP-ribosylation factor 5 1.085
ZEB2 zinc finger E-box binding homeobox 2 1.07668
MYBBP1A MYB binding protein (P160) 1a 1.07645
DOPEY1 dopey family member 1 1.07437
RBM25 RNA binding motif protein 25 1.06967
PGM3 phosphoglucomutase 3 1.06794
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.06475
RANBP9 RAN binding protein 9 1.06419
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 1.06377
MAX MYC associated factor X 1.06193
C14ORF166 chromosome 14 open reading frame 166 1.06138
ADCK5 aarF domain containing kinase 5 1.05915
ACO1 aconitase 1, soluble 1.05825
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.05548
INSM1 insulinoma-associated 1 1.04927
KLF5 Kruppel-like factor 5 (intestinal) 1.04707
TBX5 T-box 5 1.04325
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 1.03644
CAMK1D calcium/calmodulin-dependent protein kinase ID 1.03427
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 1.03201
LPCAT2 lysophosphatidylcholine acyltransferase 2 1.03147
AGBL3 ATP/GTP binding protein-like 3 1.02967
HSPA14 heat shock 70kDa protein 14 1.02822
DNAH5 dynein, axonemal, heavy chain 5 1.02703
LAD1 ladinin 1 1.02678
CBS cystathionine-beta-synthase 1.02533
RNF145 ring finger protein 145 1.02457
CCDC146 coiled-coil domain containing 146 1.02432
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 1.02397
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 1.01853
C17ORF75 chromosome 17 open reading frame 75 1.01665
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 1.01352
RBM26 RNA binding motif protein 26 1.01002
MAPK9 mitogen-activated protein kinase 9 1.00646
PRDM10 PR domain containing 10 1.00482
TPK1 thiamin pyrophosphokinase 1 1.00384
CDH13 cadherin 13 1.00356
DGKG diacylglycerol kinase, gamma 90kDa 1.00289
GPR119 G protein-coupled receptor 119 1.00062

decreased fitness

Symbol Name Standardized Value
PGK2 phosphoglycerate kinase 2 -2.69879
CIITA class II, major histocompatibility complex, transactivator -2.6137
DHRS13 dehydrogenase/reductase (SDR family) member 13 -2.53012
MRC2 mannose receptor, C type 2 -2.42401
TLR5 toll-like receptor 5 -2.37246
RHOG ras homolog family member G -2.26968
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.26173
HCAR2 hydroxycarboxylic acid receptor 2 -2.23562
CAPN2 calpain 2, (m/II) large subunit -2.20562
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 -2.07549
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.05892
PRSS30P protease, serine, 30, pseudogene -2.05725
SYT1 synaptotagmin I -2.04265
EGFR epidermal growth factor receptor -1.96514
EFCAB2 EF-hand calcium binding domain 2 -1.9241
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A -1.86286
GAMT guanidinoacetate N-methyltransferase -1.81737
INHBB inhibin, beta B -1.79752
HAND2 heart and neural crest derivatives expressed 2 -1.79695
TSHZ2 teashirt zinc finger homeobox 2 -1.77618
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 -1.76767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -1.73841
CCNB1 cyclin B1 -1.73629
CPA1 carboxypeptidase A1 (pancreatic) -1.73512
TONSL tonsoku-like, DNA repair protein -1.73137
ZNF563 zinc finger protein 563 -1.6895
KCTD8 potassium channel tetramerization domain containing 8 -1.68126
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -1.64998
HIST1H2AG histone cluster 1, H2ag -1.64695
PARP6 poly (ADP-ribose) polymerase family, member 6 -1.63784
MMP13 matrix metallopeptidase 13 -1.6088
BATF2 basic leucine zipper transcription factor, ATF-like 2 -1.60386
MPL MPL proto-oncogene, thrombopoietin receptor -1.5914
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -1.57774
GUSBP4 glucuronidase, beta pseudogene 4 -1.57343
CCR10 chemokine (C-C motif) receptor 10 -1.56949
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -1.56807
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -1.56291
ELAVL1 ELAV like RNA binding protein 1 -1.55377
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -1.54969
TNS1 tensin 1 -1.54262
TWIST1 twist family bHLH transcription factor 1 -1.53062
LARGE like-glycosyltransferase -1.51575
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -1.49947
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -1.48992
PRKCSH protein kinase C substrate 80K-H -1.48531
ZFP36L1 ZFP36 ring finger protein-like 1 -1.47732
AKAP9 A kinase (PRKA) anchor protein 9 -1.46825
HLA-DRB3 major histocompatibility complex, class II, DR beta 3 -1.46241
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -1.46236
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) -1.45949
TUBB8 tubulin, beta 8 class VIII -1.4565
GZMM granzyme M (lymphocyte met-ase 1) -1.44846
FNDC3B fibronectin type III domain containing 3B -1.43307
ZNF610 zinc finger protein 610 -1.40415
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma -1.39242
FBXO5 F-box protein 5 -1.38818
CDK2 cyclin-dependent kinase 2 -1.3695
H3F3C H3 histone, family 3C -1.35522
PM20D1 peptidase M20 domain containing 1 -1.34917
PDCD6IP programmed cell death 6 interacting protein -1.34822
KIR2DS2 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 -1.3288
HIST1H2AB histone cluster 1, H2ab -1.32278
FBN2 fibrillin 2 -1.32212
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 -1.31962
CHEK2 checkpoint kinase 2 -1.31618
FUS FUS RNA binding protein -1.31406
RAD9A RAD9 homolog A (S. pombe) -1.31224
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -1.31044
PKN3 protein kinase N3 -1.30995
NR0B2 nuclear receptor subfamily 0, group B, member 2 -1.30558
ZBTB22 zinc finger and BTB domain containing 22 -1.29272
CNGA3 cyclic nucleotide gated channel alpha 3 -1.28583
NEUROG2 neurogenin 2 -1.28452
LCK LCK proto-oncogene, Src family tyrosine kinase -1.27779
TTK TTK protein kinase -1.27257
SCRT1 scratch family zinc finger 1 -1.2619
WDR33 WD repeat domain 33 -1.26047
TRAF3 TNF receptor-associated factor 3 -1.26011
PAQR3 progestin and adipoQ receptor family member III -1.25725
GBA glucosidase, beta, acid -1.24821
ZFYVE16 zinc finger, FYVE domain containing 16 -1.23925
PRPF3 pre-mRNA processing factor 3 -1.23077
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 -1.22479
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -1.22378
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -1.21664
RET ret proto-oncogene -1.21392
COL4A2 collagen, type IV, alpha 2 -1.21092
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -1.21076
NAE1 NEDD8 activating enzyme E1 subunit 1 -1.20438
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -1.19527
MSC musculin -1.1947
CAPS2 calcyphosine 2 -1.17492
UIMC1 ubiquitin interaction motif containing 1 -1.17322
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -1.17096
PCDHGA11 protocadherin gamma subfamily A, 11 -1.16864
PPARG peroxisome proliferator-activated receptor gamma -1.15842
ILK integrin-linked kinase -1.15791
CHD2 chromodomain helicase DNA binding protein 2 -1.15243
OAZ1 ornithine decarboxylase antizyme 1 -1.15032
UBE2L3 ubiquitin-conjugating enzyme E2L 3 -1.14977
SHOX2 short stature homeobox 2 -1.14975
AEBP1 AE binding protein 1 -1.14789
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -1.14762
NCAPD2 non-SMC condensin I complex, subunit D2 -1.14612
WNT9B wingless-type MMTV integration site family, member 9B -1.14173
L3MBTL1 l(3)mbt-like 1 (Drosophila) -1.13597
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -1.12912
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -1.12774
ST7 suppression of tumorigenicity 7 -1.12287
YES1 YES proto-oncogene 1, Src family tyrosine kinase -1.12239
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) -1.11687
FBXW11 F-box and WD repeat domain containing 11 -1.11553
YAP1 Yes-associated protein 1 -1.11161
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 -1.11112
FOXM1 forkhead box M1 -1.10652
SLC35B1 solute carrier family 35, member B1 -1.09995
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 -1.09988
NCOR1 nuclear receptor corepressor 1 -1.09795
SYT7 synaptotagmin VII -1.09766
F11R F11 receptor -1.09724
SEPT3 septin 3 -1.09532
DCLK3 doublecortin-like kinase 3 -1.09387
CFD complement factor D (adipsin) -1.0919
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -1.09071
SRBD1 S1 RNA binding domain 1 -1.08763
EN2 engrailed homeobox 2 -1.08613
CPA2 carboxypeptidase A2 (pancreatic) -1.08385
GTF2A1 general transcription factor IIA, 1, 19/37kDa -1.07803
PEBP4 phosphatidylethanolamine-binding protein 4 -1.07795
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -1.07759
MAP2 microtubule-associated protein 2 -1.0768
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -1.07442
ZNF22 zinc finger protein 22 -1.07179
AGPS alkylglycerone phosphate synthase -1.07171
IFT57 intraflagellar transport 57 -1.06687
ARSJ arylsulfatase family, member J -1.06607
RAB23 RAB23, member RAS oncogene family -1.06465
PHKG1 phosphorylase kinase, gamma 1 (muscle) -1.06203
NACA2 nascent polypeptide-associated complex alpha subunit 2 -1.06203
POU2F2 POU class 2 homeobox 2 -1.05615
NOS2 nitric oxide synthase 2, inducible -1.05392
AADAT aminoadipate aminotransferase -1.05098
IL7 interleukin 7 -1.04811
FDPS farnesyl diphosphate synthase -1.04489
COMT catechol-O-methyltransferase -1.04477
UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus -1.04392
GSS glutathione synthetase -1.04073
BST1 bone marrow stromal cell antigen 1 -1.03848
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 -1.03611
SLC10A5 solute carrier family 10, member 5 -1.03588
MCM2 minichromosome maintenance complex component 2 -1.03352
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -1.02836
RGN regucalcin -1.0281
IFNA17 interferon, alpha 17 -1.0278
PMPCB peptidase (mitochondrial processing) beta -1.02687
SLU7 SLU7 splicing factor homolog (S. cerevisiae) -1.02026
NRGN neurogranin (protein kinase C substrate, RC3) -1.01962
UBR1 ubiquitin protein ligase E3 component n-recognin 1 -1.01949
CCNA2 cyclin A2 -1.01923
PPP1R10 protein phosphatase 1, regulatory subunit 10 -1.01911
TGFBR3 transforming growth factor, beta receptor III -1.01674
RAX2 retina and anterior neural fold homeobox 2 -1.01647
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -1.01413
ARF1 ADP-ribosylation factor 1 -1.01294
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -1.0094
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase -1.00419
PRKCI protein kinase C, iota -1.00263
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -1.00232