MKNK2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description MAP kinase interacting serine/threonine kinase 2|This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2872)
Similar Terms
Downloads & Tools

Genes

283 genes differentially expressed following the MKNK2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLEC4C C-type lectin domain family 4, member C 2.98731
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.98731
HCRT hypocretin (orexin) neuropeptide precursor 2.98731
CDCP2 CUB domain containing protein 2 2.98731
PADI6 peptidyl arginine deiminase, type VI 2.98731
SRL sarcalumenin 2.98731
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.98731
PLET1 placenta expressed transcript 1 2.98731
LRRC31 leucine rich repeat containing 31 2.98731
ZIC4 Zic family member 4 2.98731
GTSF1 gametocyte specific factor 1 2.98731
CFAP54 cilia and flagella associated 54 2.98731
CCDC27 coiled-coil domain containing 27 2.98731
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.98731
SCEL sciellin 2.98731
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 2.98731
CCNA1 cyclin A1 2.98731
LHFPL7 LHFPL tetraspan subfamily member 7 2.98731
SQOR sulfide quinone oxidoreductase 2.98731
WEE2 WEE1 homolog 2 (S. pombe) 2.98731
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.98731
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.98731
GSC2 goosecoid homeobox 2 2.98731
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.98731
FAM187B family with sequence similarity 187, member B 2.89495
CELA3B chymotrypsin-like elastase family, member 3B 2.89495
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.89495
AGTR1 angiotensin II receptor, type 1 2.89495
PTPRH protein tyrosine phosphatase, receptor type, H 2.89495
DNASE1L2 deoxyribonuclease I-like 2 2.89495
INHBC inhibin, beta C 2.89495
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 2.89495
FBXL8 F-box and leucine-rich repeat protein 8 2.89495
VTN vitronectin 2.89495
CD19 CD19 molecule 2.89495
GSTM5 glutathione S-transferase mu 5 2.89495
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.89495
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene) 2.89495
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2.89495
BFSP2 beaded filament structural protein 2, phakinin 2.89495
IGFL3 IGF-like family member 3 2.89495
SHD Src homology 2 domain containing transforming protein D 2.89495
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.89495
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.89495
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.89495
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.89495
BIRC7 baculoviral IAP repeat containing 7 2.89495
SLC23A3 solute carrier family 23, member 3 2.89495
FABP4 fatty acid binding protein 4, adipocyte 2.89495
MYO1A myosin IA 2.89495
TYRP1 tyrosinase-related protein 1 2.89495
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.89495
LRRC53 leucine rich repeat containing 53 2.89495
PDILT protein disulfide isomerase-like, testis expressed 2.89495
TMPRSS4 transmembrane protease, serine 4 2.89495
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G 2.89495
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.89495
PKD2L1 polycystic kidney disease 2-like 1 2.89495
FIMP1 fertilization-influencing membrane protein 1 2.89495
ADGRG7 adhesion G protein-coupled receptor G7 2.89495
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.89495
LTB4R2 leukotriene B4 receptor 2 2.89495
AVPR1A arginine vasopressin receptor 1A 2.89495
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.89495
CBY2 chibby family member 2 2.89495
NFILZ NFIL3 like basic leucine zipper 2.89495
GLYATL1B glycine-N-acyltransferase like 1B 2.89495
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.89495
CFAP97D2 CFAP97 domain containing 2 2.89495
PRR20G proline rich 20G 2.89495
ADRB1 adrenoceptor beta 1 2.89495
SAG S-antigen; retina and pineal gland (arrestin) 2.89495
ADAM30 ADAM metallopeptidase domain 30 2.89495
SYCP2 synaptonemal complex protein 2 2.89495
SLC22A14 solute carrier family 22, member 14 2.89495
ISM2 isthmin 2 2.89495
ACTL10 actin-like 10 2.89495
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.89495
MAGEB1 melanoma antigen family B1 2.89495
EDAR ectodysplasin A receptor 2.89495
CHRD chordin 2.89495
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.89495
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.89495
TLR9 toll-like receptor 9 2.89495
PGLYRP2 peptidoglycan recognition protein 2 2.89495
OR2D3 olfactory receptor, family 2, subfamily D, member 3 2.89495
RNF183 ring finger protein 183 2.89495
ZNF705A zinc finger protein 705A 2.89495
LOC124906892 uncharacterized LOC124906892 2.89495
TRIM55 tripartite motif containing 55 2.89495
APOF apolipoprotein F 2.89495
PHACTR3 phosphatase and actin regulator 3 2.89495
HCAR1 hydroxycarboxylic acid receptor 1 2.89495
TEX19 testis expressed 19 2.89495
SIRPD signal-regulatory protein delta 2.89495
LRRC15 leucine rich repeat containing 15 2.89495
TBC1D28 TBC1 domain family, member 28 2.89495
ALOX15B arachidonate 15-lipoxygenase, type B 2.89495
ROM1 retinal outer segment membrane protein 1 2.89495
IL9R interleukin 9 receptor 2.89495
ITGB6 integrin, beta 6 2.89495
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.89495
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 2.89495
GTF2A1L general transcription factor IIA, 1-like 2.89495
KLK12 kallikrein-related peptidase 12 2.89495
CLEC18C C-type lectin domain family 18, member C 2.89495
CBX8 chromobox homolog 8 2.89495
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.89495
SPATA4 spermatogenesis associated 4 2.89495
THBD thrombomodulin 2.89495
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.89495
CRYBB2 crystallin, beta B2 2.89495
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.89495
DQX1 DEAQ box RNA-dependent ATPase 1 2.89495
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.89495
POLN polymerase (DNA directed) nu 2.89495
KLK11 kallikrein-related peptidase 11 2.89495
NT5C1B 5'-nucleotidase, cytosolic IB 2.89495
CHAT choline O-acetyltransferase 2.89495
IL26 interleukin 26 2.89495
IL27 interleukin 27 2.89495
MROH2A maestro heat-like repeat family member 2A 2.89495
KLHL10 kelch-like family member 10 2.89495
ASCL5 achaete-scute family bHLH transcription factor 5 2.89495
PASD1 PAS domain containing 1 2.89495
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.89495
G6PC2 glucose-6-phosphatase, catalytic, 2 2.89495
DSPP dentin sialophosphoprotein 2.89495
NPR3 natriuretic peptide receptor 3 2.89495
C22ORF31 chromosome 22 open reading frame 31 2.89495
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.89495
TAS2R46 taste receptor, type 2, member 46 2.89495
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 2.89495
TRPM3 transient receptor potential cation channel, subfamily M, member 3 2.89495
TRPM6 transient receptor potential cation channel, subfamily M, member 6 2.89495
MYADML2 myeloid-associated differentiation marker-like 2 2.89495
TSPAN19 tetraspanin 19 2.89495
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 2.89495
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.89495
TEX38 testis expressed 38 2.89495
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.89495
PTK6 protein tyrosine kinase 6 2.84302
VCX3B variable charge, X-linked 3B 2.83479
SPA17 sperm autoantigenic protein 17 2.70764
STX6 syntaxin 6 2.64734
SACK1F scaffolding CK1 anchoring protein F 2.5861
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 2.56259
MCFD2 multiple coagulation factor deficiency 2 2.48968
FN3KRP fructosamine 3 kinase related protein 2.47643
SP140L SP140 nuclear body protein-like 2.42748
WARS1 tryptophanyl-tRNA synthetase 1 2.42543
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2.41153
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.38746
CNTN6 contactin 6 2.37979
CDON cell adhesion associated, oncogene regulated 2.37638
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.36661
USH1G Usher syndrome 1G (autosomal recessive) 2.36228
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2.3448
INSC inscuteable homolog (Drosophila) 2.33658
RHD Rh blood group, D antigen 2.32973
CEP97 centrosomal protein 97kDa 2.31386
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.29531
S1PR1 sphingosine-1-phosphate receptor 1 2.29531
ATXN7L2 ataxin 7-like 2 2.29531
PRR14L proline rich 14-like 2.28153
TRIB2 tribbles pseudokinase 2 2.28008
PLD1 phospholipase D1, phosphatidylcholine-specific 2.27384
RANBP9 RAN binding protein 9 2.23535
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.21778
RNASE6 ribonuclease, RNase A family, k6 2.21502
SLC46A2 solute carrier family 46, member 2 2.21502
ZNF33A zinc finger protein 33A 2.21502
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 2.20423
TUBA4A tubulin, alpha 4a 2.20423
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 2.20038
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 2.17029
CHPF2 chondroitin polymerizing factor 2 2.16046
BORCS5 BLOC-1 related complex subunit 5 2.15663
GPR173 G protein-coupled receptor 173 2.14829
TNRC18 trinucleotide repeat containing 18 2.13512
JOSD2 Josephin domain containing 2 2.13512
ARHGAP28 Rho GTPase activating protein 28 2.13267
NUP160 nucleoporin 160kDa 2.11408
ZNF749 zinc finger protein 749 2.11208
ZNF713 zinc finger protein 713 2.10235
FBXO6 F-box protein 6 2.09682
DGKZ diacylglycerol kinase, zeta 2.07679
EFCAB7 EF-hand calcium binding domain 7 2.07679
DMAC2L distal membrane arm assembly component 2 like 2.05812
SUGCT succinyl-CoA:glutarate-CoA transferase 2.05557
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 2.04129
FXYD1 FXYD domain containing ion transport regulator 1 2.0385
TMEM260 transmembrane protein 260 2.0385
RND3 Rho family GTPase 3 2.03532
AURKA aurora kinase A 2.00709

decreased expression

Symbol Name Standardized Value
FAM216B family with sequence similarity 216, member B -2.96643
MYT1L myelin transcription factor 1-like -2.96643
SPEF2 sperm flagellar 2 -2.96643
REP15 RAB15 effector protein -2.89495
PROX1 prospero homeobox 1 -2.89495
RANBP17 RAN binding protein 17 -2.89495
ZNF221 zinc finger protein 221 -2.89495
YPEL4 yippee-like 4 (Drosophila) -2.89495
IFITM10 interferon induced transmembrane protein 10 -2.89495
OTOF otoferlin -2.89495
VWC2L von Willebrand factor C domain containing protein 2-like -2.89495
PCDHGA9 protocadherin gamma subfamily A, 9 -2.89495
ECSIT ECSIT signalling integrator -2.89495
PTCD3 pentatricopeptide repeat domain 3 -2.89495
DPF3 D4, zinc and double PHD fingers, family 3 -2.89495
SYNPO2L synaptopodin 2-like -2.89495
CATSPERD catsper channel auxiliary subunit delta -2.89495
COX8C cytochrome c oxidase subunit VIIIC -2.89495
HAPLN2 hyaluronan and proteoglycan link protein 2 -2.89495
ZNF773 zinc finger protein 773 -2.89495
EXOC3L1 exocyst complex component 3-like 1 -2.89495
LOC107986837 uncharacterized LOC107986837 -2.89495
MAGEB17 melanoma antigen family B17 -2.89495
VXN vexin -2.89495
ALPK2 alpha-kinase 2 -2.89495
SFRP5 secreted frizzled-related protein 5 -2.89495
RRM1 ribonucleotide reductase M1 -2.89495
TTC9B tetratricopeptide repeat domain 9B -2.89495
OAZ3 ornithine decarboxylase antizyme 3 -2.89495
GOLGA6A golgin A6 family, member A -2.89495
FCRLB Fc receptor-like B -2.89495
RIN1 Ras and Rab interactor 1 -2.89495
GRK4 G protein-coupled receptor kinase 4 -2.89495
CFAP410 cilia and flagella associated protein 410 -2.89495
SBDS Shwachman-Bodian-Diamond syndrome -2.89495
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -2.89495
DYDC1 DPY30 domain containing 1 -2.89495
PDE11A phosphodiesterase 11A -2.78127
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.78127
SLC45A4 solute carrier family 45, member 4 -2.76902
CRTAC1 cartilage acidic protein 1 -2.72378
EIF3F eukaryotic translation initiation factor 3, subunit F -2.69887
HCK HCK proto-oncogene, Src family tyrosine kinase -2.59593
MMD2 monocyte to macrophage differentiation-associated 2 -2.58876
ACBD3 acyl-CoA binding domain containing 3 -2.51799
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase -2.47923
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.47643
IL1RAP interleukin 1 receptor accessory protein -2.47643
MEX3B mex-3 RNA binding family member B -2.40264
CHD9NB CHD9 neighbor -2.38537
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.36478
MID2 midline 2 -2.32973
PAQR6 progestin and adipoQ receptor family member VI -2.32973
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.32973
CCDC74B coiled-coil domain containing 74B -2.30935
FHIT fragile histidine triad -2.28153
CLSTN1 calsyntenin 1 -2.28153
VIPR1 vasoactive intestinal peptide receptor 1 -2.25043
PANX2 pannexin 2 -2.21514
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.20423
WBP11 WW domain binding protein 11 -2.20423
EML1 echinoderm microtubule associated protein like 1 -2.20229
COASY CoA synthase -2.19808
PGBD2 piggyBac transposable element derived 2 -2.19808
UPK1B uroplakin 1B -2.19808
SPDYA speedy/RINGO cell cycle regulator family member A -2.19808
EXO5 exonuclease 5 -2.18732
ZNF442 zinc finger protein 442 -2.18732
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.17004
SCN4B sodium channel, voltage gated, type IV beta subunit -2.16736
VWDE von Willebrand factor D and EGF domains -2.13512
COPRS coordinator of PRMT5, differentiation stimulator -2.13267
HARBI1 harbinger transposase derived 1 -2.11038
KLK14 kallikrein-related peptidase 14 -2.11038
MYO10 myosin X -2.10627
ZNF267 zinc finger protein 267 -2.10627
ELP6 elongator acetyltransferase complex subunit 6 -2.10627
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.10272
C3 complement component 3 -2.10235
D2HGDH D-2-hydroxyglutarate dehydrogenase -2.09682
PRKG1 protein kinase, cGMP-dependent, type I -2.07679
ZNF287 zinc finger protein 287 -2.07679
SOX8 SRY (sex determining region Y)-box 8 -2.07659
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) -2.05191
CEP89 centrosomal protein 89kDa -2.04129
MAP2K6 mitogen-activated protein kinase kinase 6 -2.0385
RAB3A RAB3A, member RAS oncogene family -2.0343
MTA2 metastasis associated 1 family, member 2 -2.01673