MKNK2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description MAP kinase interacting serine/threonine kinase 2|This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011] (NCBI Entrez Gene Database, 2872)
External Link http://www.ncbi.nlm.nih.gov/gene/2872
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45 interacting proteins for MKNK2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
BMPR1B bone morphogenetic protein receptor, type IB
CCDC8 coiled-coil domain containing 8
CNBP CCHC-type zinc finger, nucleic acid binding protein
CUL2 cullin 2
EEF2 eukaryotic translation elongation factor 2
EIF4E eukaryotic translation initiation factor 4E
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
IQGAP1 IQ motif containing GTPase activating protein 1
LRRK2 leucine-rich repeat kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK3 mitogen-activated protein kinase 3
MAPK6 mitogen-activated protein kinase 6
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKSL1 MARCKS-like 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MKNK1 MAP kinase interacting serine/threonine kinase 1
NEB nebulin
NRF1 nuclear respiratory factor 1
OBSL1 obscurin-like 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
RBX1 ring-box 1, E3 ubiquitin protein ligase
RPL7A ribosomal protein L7a
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRP1B ribosomal RNA processing 1B
SFPQ splicing factor proline/glutamine-rich
SPRY2 sprouty homolog 2 (Drosophila)
SRPK1 SRSF protein kinase 1
TCEAL1 transcription elongation factor A (SII)-like 1
TGFBR1 transforming growth factor, beta receptor 1
UBC ubiquitin C
USP11 ubiquitin specific peptidase 11
VBP1 von Hippel-Lindau binding protein 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase