MKX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description mohawk homeobox|The protein encoded by this gene is an IRX family-related homeobox protein that may play a role in cell adhesion. Studies in mice suggest that this protein may be a regulator of tendon development. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jun 2011] (NCBI Entrez Gene Database, 283078)
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Genes

335 genes differentially expressed following the MKX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.06816
INSYN1 inhibitory synaptic factor 1 3.06816
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.06816
MISP3 MISP family member 3 3.06816
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.06816
ALOX15 arachidonate 15-lipoxygenase 3.06816
GJA5 gap junction protein, alpha 5, 40kDa 3.06816
PTK6 protein tyrosine kinase 6 3.06816
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.06816
LRRC63 leucine rich repeat containing 63 3.06816
STKLD1 serine/threonine kinase-like domain containing 1 3.06816
ARG1 arginase 1 3.06816
EMP1 epithelial membrane protein 1 3.06816
PSKH2 protein serine kinase H2 3.06816
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.06816
CLCN1 chloride channel, voltage-sensitive 1 3.06816
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 3.06816
CCDC154 coiled-coil domain containing 154 3.06816
CRYAA crystallin, alpha A 3.06816
LRRC25 leucine rich repeat containing 25 3.06816
EDN3 endothelin 3 3.06816
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 3.06816
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 3.06816
LY6G5C lymphocyte antigen 6 complex, locus G5C 3.06816
PCGF3 polycomb group ring finger 3 3.03541
TMOD4 tropomodulin 4 (muscle) 3.03541
SPINK4 serine peptidase inhibitor, Kazal type 4 3.03541
LTB4R2 leukotriene B4 receptor 2 3.03541
THRSP thyroid hormone responsive 3.03541
CPB1 carboxypeptidase B1 (tissue) 3.03541
PRR29 proline rich 29 3.03541
PNMA8B PNMA family member 8B 3.03541
TDRD6 tudor domain containing 6 3.03541
H2BC1 H2B clustered histone 1 3.03541
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.03541
OR2J2 olfactory receptor, family 2, subfamily J, member 2 3.03541
KYNU kynureninase 3.03541
LBHD2 LBH domain containing 2 3.03541
ARSH arylsulfatase family, member H 3.03541
NWD1 NACHT and WD repeat domain containing 1 3.03541
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.03541
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.03541
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.03541
C2ORF78 chromosome 2 open reading frame 78 3.03541
ODAD1 outer dynein arm docking complex subunit 1 3.03541
MRPL23 mitochondrial ribosomal protein L23 3.03541
MYO1G myosin IG 3.03541
PRDM16 PR domain containing 16 3.03541
AVP arginine vasopressin 3.03541
TAS2R13 taste receptor, type 2, member 13 3.03541
MUC22 mucin 22 3.03541
BRICD5 BRICHOS domain containing 5 3.03541
PNOC prepronociceptin 3.03541
FAM81B family with sequence similarity 81, member B 3.03541
LRRC56 leucine rich repeat containing 56 3.03541
HBA2 hemoglobin, alpha 2 3.03541
FAM3D family with sequence similarity 3, member D 3.03541
LOC390937 Ets2 repressor factor-like 3.03541
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.03541
PCDHA5 protocadherin alpha 5 3.03541
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 3.03541
IRF5 interferon regulatory factor 5 3.03541
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 3.03541
CHRD chordin 3.03541
ANXA10 annexin A10 3.03541
CBLN3 cerebellin 3 precursor 3.03541
SPATA22 spermatogenesis associated 22 3.03541
CATSPERD catsper channel auxiliary subunit delta 3.03541
TACSTD2 tumor-associated calcium signal transducer 2 3.03541
AWAT2 acyl-CoA wax alcohol acyltransferase 2 3.03541
DLK2 delta-like 2 homolog (Drosophila) 3.03541
UBL4B ubiquitin-like 4B 3.03541
MEP1B meprin A, beta 3.03541
LOC124901449 uncharacterized LOC124901449 3.03541
PROZ protein Z, vitamin K-dependent plasma glycoprotein 3.03541
TM4SF1 transmembrane 4 L six family member 1 3.03541
TNNI1 troponin I type 1 (skeletal, slow) 3.03541
PRODH2 proline dehydrogenase (oxidase) 2 3.03541
ZFP57 ZFP57 zinc finger protein 3.03541
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.03541
PLIN1 perilipin 1 3.03541
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 3.03541
IGFL3 IGF-like family member 3 3.03541
SCN2B sodium channel, voltage gated, type II beta subunit 3.03541
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 3.03541
CARD14 caspase recruitment domain family, member 14 3.03541
INHBB inhibin, beta B 3.03541
CD5 CD5 molecule 3.03541
COL20A1 collagen, type XX, alpha 1 3.03541
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 3.03541
LMNTD1 lamin tail domain containing 1 3.03541
SIX1 SIX homeobox 1 3.03541
COX8C cytochrome c oxidase subunit VIIIC 3.03541
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 3.03541
GAL3ST2 galactose-3-O-sulfotransferase 2 3.03541
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.03541
TBC1D10C TBC1 domain family, member 10C 3.03541
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.03541
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.03541
FIBIN fin bud initiation factor homolog (zebrafish) 3.03541
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.03541
OR52K1 olfactory receptor, family 52, subfamily K, member 1 3.03541
CHI3L2 chitinase 3-like 2 3.03541
KLHL41 kelch-like family member 41 3.03541
SERTM2 serine rich and transmembrane domain containing 2 3.03541
KLHL1 kelch-like family member 1 3.03541
KRTAP5-10 keratin associated protein 5-10 3.03541
CFAP157 cilia and flagella associated protein 157 3.03541
GSTT4 glutathione S-transferase theta 4 3.03541
CLDN34 claudin 34 3.03541
CSTA cystatin A (stefin A) 3.03541
EFCAB3 EF-hand calcium binding domain 3 3.03541
EFCAB9 EF-hand calcium binding domain 9 3.03541
EHF ets homologous factor 3.03541
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.03541
COL6A5 collagen, type VI, alpha 5 3.03541
CLEC1A C-type lectin domain family 1, member A 3.03541
SPATA31G1 SPATA31 subfamily G member 1 3.03541
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.03541
FAIM2 Fas apoptotic inhibitory molecule 2 3.03541
PPP1R27 protein phosphatase 1, regulatory subunit 27 3.03541
LRRN4 leucine rich repeat neuronal 4 3.03541
ZNF836 zinc finger protein 836 3.03541
STRC stereocilin 3.03541
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3.03541
GSTA3 glutathione S-transferase alpha 3 3.03541
FCRL1 Fc receptor-like 1 3.03541
CDRT15L2 CMT1A duplicated region transcript 15-like 2 3.03541
PRPH peripherin 3.03541
SAMD7 sterile alpha motif domain containing 7 3.03541
UTS2B urotensin 2B 3.03541
VSTM5 V-set and transmembrane domain containing 5 3.03541
LOC124903372 uncharacterized LOC124903372 3.03541
ITGB7 integrin, beta 7 3.03541
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.03541
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.03541
CCDC198 coiled-coil domain containing 198 3.03541
TGM6 transglutaminase 6 3.03541
TMEM150B transmembrane protein 150B 3.03541
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.03541
CBLIF cobalamin binding intrinsic factor 3.03541
PRR15L proline rich 15-like 3.03541
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.03541
LPAR5 lysophosphatidic acid receptor 5 3.03541
SUN3 Sad1 and UNC84 domain containing 3 3.03541
BPIFC BPI fold containing family C 3.03541
PAGE2B P antigen family, member 2B 3.03541
GRAPL GRB2-related adaptor protein-like 3.03541
CLCA1 chloride channel accessory 1 3.03541
KRT15 keratin 15, type I 3.03541
MMP10 matrix metallopeptidase 10 3.03541
ANKRD30A ankyrin repeat domain 30A 3.03541
CHAT choline O-acetyltransferase 3.03541
GPR171 G protein-coupled receptor 171 3.03541
CD22 CD22 molecule 3.03541
TREH trehalase (brush-border membrane glycoprotein) 3.03541
NGB neuroglobin 3.03541
TMEM81 transmembrane protein 81 3.03541
SLC30A6 solute carrier family 30 (zinc transporter), member 6 2.97924
DRC1 dynein regulatory complex subunit 1 2.94152
CFAP100 cilia and flagella associated protein 100 2.94152
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.94152
PARP4 poly (ADP-ribose) polymerase family, member 4 2.90685
TRIM35 tripartite motif containing 35 2.88682
KDSR 3-ketodihydrosphingosine reductase 2.81885
LRRC3B leucine rich repeat containing 3B 2.65543
GMEB1 glucocorticoid modulatory element binding protein 1 2.62163
GADL1 glutamate decarboxylase-like 1 2.59692
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.59692
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 2.57997
SMS spermine synthase 2.47392
DENND6B DENN/MADD domain containing 6B 2.4555
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 2.42798
PLSCR3 phospholipid scramblase 3 2.42798
SPATA6L spermatogenesis associated 6-like 2.42382
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 2.42382
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.41683
ASS1 argininosuccinate synthase 1 2.41553
CHMP3 charged multivesicular body protein 3 2.4123
MRPL39 mitochondrial ribosomal protein L39 2.41094
ERI1 exoribonuclease 1 2.38768
OTUD6B OTU domain containing 6B 2.31077
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 2.2901
ZNF768 zinc finger protein 768 2.2901
GPR27 G protein-coupled receptor 27 2.2901
MAK16 MAK16 homolog (S. cerevisiae) 2.2901
MINK1 misshapen-like kinase 1 2.2901
FAM117A family with sequence similarity 117, member A 2.2901
CETN2 centrin, EF-hand protein, 2 2.2901
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.28937
BSN bassoon presynaptic cytomatrix protein 2.27137
TIPE1 TNF alpha induced protein 8 like 1 2.27114
C11ORF86 chromosome 11 open reading frame 86 2.27114
BCAS3 breast carcinoma amplified sequence 3 2.25485
ACE angiotensin I converting enzyme 2.21936
SPDYE5 speedy/RINGO cell cycle regulator family member E5 2.19542
EXOC3L2 exocyst complex component 3-like 2 2.1598
RPS28 ribosomal protein S28 2.12105
ZC3H10 zinc finger CCCH-type containing 10 2.11486
ERICH2 glutamate-rich 2 2.11017
PRRX2 paired related homeobox 2 2.09817
LGALS9 lectin, galactoside-binding, soluble, 9 2.08402
SUGP1 SURP and G patch domain containing 1 2.08402
ATP5MG ATP synthase membrane subunit g 2.06647
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.0583
PAOX polyamine oxidase (exo-N4-amino) 2.04782
IFIH1 interferon induced with helicase C domain 1 2.03585
STAB2 stabilin 2 2.03585
SMKR1 small lysine-rich protein 1 2.03585
OR56A1 olfactory receptor, family 56, subfamily A, member 1 2.03585
FAM163B family with sequence similarity 163, member B 2.03585
USP35 ubiquitin specific peptidase 35 2.03585
ANKDD1A ankyrin repeat and death domain containing 1A 2.03585
KCTD19 potassium channel tetramerization domain containing 19 2.03585
IFT122 intraflagellar transport 122 2.03585
ARHGAP18 Rho GTPase activating protein 18 2.03585
TATDN2 TatD DNase domain containing 2 2.03585
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 2.03585
POU2F3 POU class 2 homeobox 3 2.03585
IDO2 indoleamine 2,3-dioxygenase 2 2.03585
CFL1 cofilin 1 (non-muscle) 2.03585
PTX3 pentraxin 3, long 2.03585
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 2.03585
GPR20 G protein-coupled receptor 20 2.03585
PARP10 poly (ADP-ribose) polymerase family, member 10 2.03585
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.01393
CRYM crystallin, mu 2.01393
NUP214 nucleoporin 214kDa 2.00042

decreased expression

Symbol Name Standardized Value
DPPA3 developmental pluripotency associated 3 -3.06816
ACMSD aminocarboxymuconate semialdehyde decarboxylase -3.06816
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -3.06816
GLRA3 glycine receptor, alpha 3 -3.03541
PTGER4 prostaglandin E receptor 4 (subtype EP4) -3.03541
CA3 carbonic anhydrase III -3.03541
RGL4 ral guanine nucleotide dissociation stimulator-like 4 -3.03541
SH2D6 SH2 domain containing 6 -3.03541
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -3.03541
NCAPG2 non-SMC condensin II complex, subunit G2 -3.03541
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -3.03541
TMEM82 transmembrane protein 82 -3.03541
FILIP1 filamin A interacting protein 1 -3.03541
IRX4 iroquois homeobox 4 -3.03541
PRSS27 protease, serine 27 -3.03541
DKK2 dickkopf WNT signaling pathway inhibitor 2 -3.03541
EVPL envoplakin -3.03541
DNAH8 dynein, axonemal, heavy chain 8 -3.03541
IL2RB interleukin 2 receptor, beta -3.03541
MUC20 mucin 20, cell surface associated -3.03541
LRRC43 leucine rich repeat containing 43 -3.03541
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) -3.03541
TULP2 tubby like protein 2 -3.03541
RELN reelin -3.03541
SMIM38 small integral membrane protein 38 -3.03541
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -3.03541
RBM24 RNA binding motif protein 24 -3.03541
MINAR1 membrane integral NOTCH2 associated receptor 1 -3.03541
DRC3 dynein regulatory complex subunit 3 -3.03541
ADRA2A adrenoceptor alpha 2A -3.03541
ZFP92 ZFP92 zinc finger protein -3.03541
ABHD12 abhydrolase domain containing 12 -3.03541
TMPRSS11A transmembrane protease, serine 11A -3.03541
PHLDB2 pleckstrin homology-like domain, family B, member 2 -3.03541
CNTFR ciliary neurotrophic factor receptor -3.03541
TP73 tumor protein p73 -3.03541
ELAVL4 ELAV like neuron-specific RNA binding protein 4 -3.03541
IL4I1 interleukin 4 induced 1 -3.03541
HLF hepatic leukemia factor -3.03541
PRICKLE2 prickle homolog 2 (Drosophila) -2.98643
C19ORF84 chromosome 19 open reading frame 84 -2.94256
SAXO4 stabilizer of axonemal microtubules 4 -2.94152
RNFT1 ring finger protein, transmembrane 1 -2.94152
VCP valosin containing protein -2.94152
SMTNL1 smoothelin-like 1 -2.94152
SPEF2 sperm flagellar 2 -2.94152
MRPL28 mitochondrial ribosomal protein L28 -2.83059
MOXD1 monooxygenase, DBH-like 1 -2.82477
RHBDD3 rhomboid domain containing 3 -2.78325
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -2.7679
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -2.75672
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 -2.70738
DEMA1 DPM1 ER membrane anchor 1 -2.61863
BZW2 basic leucine zipper and W2 domains 2 -2.54255
ZMYM4 zinc finger, MYM-type 4 -2.53865
GALNS galactosamine (N-acetyl)-6-sulfatase -2.50004
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -2.50004
MVK mevalonate kinase -2.47739
AGO2 argonaute RISC catalytic component 2 -2.46543
STAG1 stromal antigen 1 -2.44881
VWA2 von Willebrand factor A domain containing 2 -2.42798
FOSL1 FOS-like antigen 1 -2.42798
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 -2.41354
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.41354
ZDHHC11B zinc finger, DHHC-type containing 11B -2.343
SCRIB scribbled planar cell polarity protein -2.30426
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.30066
LPAR3 lysophosphatidic acid receptor 3 -2.27184
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.25485
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.22576
EVI5L ecotropic viral integration site 5-like -2.22392
PAQR8 progestin and adipoQ receptor family member VIII -2.21936
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.19542
ARSK arylsulfatase family, member K -2.19542
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 -2.19364
EPSTI1 epithelial stromal interaction 1 (breast) -2.1719
BTN3A3 butyrophilin, subfamily 3, member A3 -2.1719
C12ORF42 chromosome 12 open reading frame 42 -2.1719
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.1719
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.1719
TRUB1 TruB pseudouridine (psi) synthase family member 1 -2.16509
STX10 syntaxin 10 -2.16367
GCH1 GTP cyclohydrolase 1 -2.16367
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.13465
IMMT inner membrane protein, mitochondrial -2.12721
CHD9 chromodomain helicase DNA binding protein 9 -2.11486
PLA2R1 phospholipase A2 receptor 1, 180kDa -2.11486
RFX3 regulatory factor X, 3 (influences HLA class II expression) -2.11175
CEP152 centrosomal protein 152kDa -2.11017
UNC119B unc-119 homolog B (C. elegans) -2.09817
POLD4 polymerase (DNA-directed), delta 4, accessory subunit -2.09221
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 -2.08402
SPATA20 spermatogenesis associated 20 -2.07382
C2CD5 C2 calcium-dependent domain containing 5 -2.06647
DZIP1L DAZ interacting zinc finger protein 1-like -2.05362
XXYLT1 xyloside xylosyltransferase 1 -2.05081
SH3GL2 SH3-domain GRB2-like 2 -2.04845
DPP3 dipeptidyl-peptidase 3 -2.04218
UHMK1 U2AF homology motif (UHM) kinase 1 -2.04218
ANAPC13 anaphase promoting complex subunit 13 -2.04218
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.04218
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.04044
LEMD1 LEM domain containing 1 -2.03585
VENTX VENT homeobox -2.00476
NPSR1 neuropeptide S receptor 1 -2.00476
RPGR retinitis pigmentosa GTPase regulator -2.00476
CNR1 cannabinoid receptor 1 (brain) -2.00476