| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/44246499 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in ML-265 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 1.87 |
| MT1X | metallothionein 1X | 1.65 |
| MT1E | metallothionein 1E | 1.55 |
| ZNF160 | zinc finger protein 160 | 1.53 |
| MT1L | metallothionein 1L (gene/pseudogene) | 1.5 |
| MT1F | metallothionein 1F | 1.36 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.89 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | 0.61 |
| MED22 | mediator complex subunit 22 | 0.55 |
| RGN | regucalcin | 0.52 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.51 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | 0.48 |
| ZIC2 | Zic family member 2 | 0.47 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.46 |
| ZNF444 | zinc finger protein 444 | 0.46 |
| LRRC45 | leucine rich repeat containing 45 | 0.45 |
| FANCM | Fanconi anemia, complementation group M | 0.45 |
| GPN3 | GPN-loop GTPase 3 | 0.43 |
| RARG | retinoic acid receptor, gamma | 0.41 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.39 |
| DUS4L | dihydrouridine synthase 4-like (S. cerevisiae) | 0.38 |
| MRPS18C | mitochondrial ribosomal protein S18C | 0.37 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.37 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | 0.37 |
| ZNF655 | zinc finger protein 655 | 0.37 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.37 |
| RASSF7 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 | 0.37 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.36 |
| CD82 | CD82 molecule | 0.35 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | 0.34 |
| SLC25A39 | solute carrier family 25, member 39 | 0.33 |
| USP19 | ubiquitin specific peptidase 19 | 0.33 |
| VIM | vimentin | 0.32 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.32 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.31 |
| BMP4 | bone morphogenetic protein 4 | 0.3 |
| GIGYF1 | GRB10 interacting GYF protein 1 | 0.3 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.3 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | 0.3 |
| EPN3 | epsin 3 | 0.29 |
| DMAC2L | distal membrane arm assembly component 2 like | 0.29 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.29 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.28 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.28 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.28 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.28 |
| HRH1 | histamine receptor H1 | 0.28 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.28 |
| UBL3 | ubiquitin-like 3 | 0.27 |
| PUSL1 | pseudouridylate synthase-like 1 | 0.27 |
| M1AP | meiosis 1 associated protein | 0.27 |
| TMEM183B | transmembrane protein 183B | 0.27 |
| GCH1 | GTP cyclohydrolase 1 | 0.27 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.27 |
| RGS3 | regulator of G-protein signaling 3 | 0.27 |
| CDC42EP2 | CDC42 effector protein (Rho GTPase binding) 2 | 0.27 |
| ARHGEF26 | Rho guanine nucleotide exchange factor (GEF) 26 | 0.26 |
| ISCA2 | iron-sulfur cluster assembly 2 | 0.26 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | 0.26 |
| CNKSR1 | connector enhancer of kinase suppressor of Ras 1 | 0.26 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.26 |
| SATB1 | SATB homeobox 1 | 0.26 |
| HAS3 | hyaluronan synthase 3 | 0.26 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.25 |
| NEBL | nebulette | 0.25 |
| ZNF431 | zinc finger protein 431 | 0.25 |
| SOCS2 | suppressor of cytokine signaling 2 | 0.25 |
| DUOX1 | dual oxidase 1 | 0.25 |
| ZNF700 | zinc finger protein 700 | 0.25 |
| PDCD2 | programmed cell death 2 | 0.25 |
| SP4 | Sp4 transcription factor | 0.24 |
| ZNF274 | zinc finger protein 274 | 0.24 |
| MRPL55 | mitochondrial ribosomal protein L55 | 0.24 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.24 |
| ABHD13 | abhydrolase domain containing 13 | 0.24 |
| MAP3K11 | mitogen-activated protein kinase kinase kinase 11 | 0.24 |
| ZNF629 | zinc finger protein 629 | 0.24 |
| SIAH2 | siah E3 ubiquitin protein ligase 2 | 0.23 |
| IRF2 | interferon regulatory factor 2 | 0.23 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.23 |
| TRIM41 | tripartite motif containing 41 | 0.23 |
| ZNF664 | zinc finger protein 664 | 0.23 |
| NRP1 | neuropilin 1 | 0.23 |
| CDC42SE2 | CDC42 small effector 2 | 0.22 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | 0.22 |
| C12ORF4 | chromosome 12 open reading frame 4 | 0.22 |
| SFT2D3 | SFT2 domain containing 3 | 0.22 |
| TRMT2B | tRNA methyltransferase 2 homolog B (S. cerevisiae) | 0.22 |
| TYW5 | tRNA-yW synthesizing protein 5 | 0.22 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | 0.22 |
| CASKIN1 | CASK interacting protein 1 | 0.22 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 0.22 |
| ENTPD5 | ectonucleoside triphosphate diphosphohydrolase 5 | 0.22 |
| RABAC1 | Rab acceptor 1 (prenylated) | 0.22 |
| ZSWIM7 | zinc finger, SWIM-type containing 7 | 0.22 |
| TMCO6 | transmembrane and coiled-coil domains 6 | 0.22 |
| RWDD2B | RWD domain containing 2B | 0.22 |
| ENO1 | enolase 1, (alpha) | 0.22 |
| ADGRL1 | adhesion G protein-coupled receptor L1 | 0.22 |
| C16ORF72 | chromosome 16 open reading frame 72 | 0.21 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | -1.5 |
| MINDY4 | MINDY lysine 48 deubiquitinase 4 | -0.86 |
| TMEM41A | transmembrane protein 41A | -0.65 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.63 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.6 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.6 |
| ASB7 | ankyrin repeat and SOCS box containing 7 | -0.58 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.58 |
| CNTRL | centriolin | -0.51 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.51 |
| PMF1 | polyamine-modulated factor 1 | -0.5 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.49 |
| NECTIN1 | nectin cell adhesion molecule 1 | -0.47 |
| IL6ST | interleukin 6 signal transducer | -0.46 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.46 |
| DENND3 | DENN/MADD domain containing 3 | -0.44 |
| TNNC2 | troponin C type 2 (fast) | -0.44 |
| MAGEB1 | melanoma antigen family B1 | -0.42 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.42 |
| GSTO2 | glutathione S-transferase omega 2 | -0.41 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.41 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.38 |
| NUDT7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | -0.38 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.37 |
| POP5 | processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) | -0.36 |
| POLQ | polymerase (DNA directed), theta | -0.36 |
| VASN | vasorin | -0.36 |
| ELFN1 | extracellular leucine-rich repeat and fibronectin type III domain containing 1 | -0.35 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.35 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.35 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.35 |
| AMPD1 | adenosine monophosphate deaminase 1 | -0.35 |
| CASZ1 | castor zinc finger 1 | -0.34 |
| SOAT1 | sterol O-acyltransferase 1 | -0.34 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.34 |
| MIER2 | mesoderm induction early response 1, family member 2 | -0.34 |
| RMI2 | RecQ mediated genome instability 2 | -0.33 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | -0.33 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.32 |
| FAM122A | family with sequence similarity 122A | -0.32 |
| ABHD17A | abhydrolase domain containing 17A | -0.32 |
| FBXO41 | F-box protein 41 | -0.31 |
| RTN2 | reticulon 2 | -0.3 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.3 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.3 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | -0.3 |
| RCAN1 | regulator of calcineurin 1 | -0.3 |
| IL10RB | interleukin 10 receptor, beta | -0.3 |
| SPHK2 | sphingosine kinase 2 | -0.3 |
| CORO2B | coronin, actin binding protein, 2B | -0.3 |
| MXRA7 | matrix-remodelling associated 7 | -0.29 |
| TMEM173 | transmembrane protein 173 | -0.29 |
| C5 | complement component 5 | -0.29 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.29 |
| TMEM179B | transmembrane protein 179B | -0.29 |
| PUM2 | pumilio RNA-binding family member 2 | -0.28 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.28 |
| ACTBL2 | actin, beta-like 2 | -0.28 |
| TMEM184C | transmembrane protein 184C | -0.28 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.28 |
| TPM4 | tropomyosin 4 | -0.28 |
| PALM | paralemmin | -0.28 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.27 |
| HPX | hemopexin | -0.27 |
| EPHA5 | EPH receptor A5 | -0.27 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.27 |
| TRERF1 | transcriptional regulating factor 1 | -0.27 |
| ZBED8 | zinc finger, BED-type containing 8 | -0.27 |
| MED19 | mediator complex subunit 19 | -0.27 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.26 |
| PEX5 | peroxisomal biogenesis factor 5 | -0.26 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.26 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.26 |
| FADS1 | fatty acid desaturase 1 | -0.26 |
| FITM2 | fat storage-inducing transmembrane protein 2 | -0.26 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.25 |
| IRF5 | interferon regulatory factor 5 | -0.25 |
| ZNF174 | zinc finger protein 174 | -0.25 |
| COBL | cordon-bleu WH2 repeat protein | -0.25 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.25 |
| C4BPA | complement component 4 binding protein, alpha | -0.25 |
| BORCS6 | BLOC-1 related complex subunit 6 | -0.24 |
| MCL1 | myeloid cell leukemia 1 | -0.24 |
| ZNF250 | zinc finger protein 250 | -0.24 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.24 |
| TMEM231 | transmembrane protein 231 | -0.24 |
| ATP9A | ATPase, class II, type 9A | -0.24 |
| BANF1 | barrier to autointegration factor 1 | -0.24 |
| MYO7B | myosin VIIB | -0.24 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.23 |
| FGB | fibrinogen beta chain | -0.23 |
| ANKRD36C | ankyrin repeat domain 36C | -0.23 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.23 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | -0.23 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -0.23 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.23 |
| BCL7B | B-cell CLL/lymphoma 7B | -0.22 |
| CENPH | centromere protein H | -0.22 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | -0.22 |
| ANGPTL4 | angiopoietin-like 4 | -0.22 |
