| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ML264 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ML264_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.170003 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.166795 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.109634 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0876873 |
| RRM2 | ribonucleotide reductase M2 | 0.0828084 |
| AREG | amphiregulin | 0.0748669 |
| JMJD1C | jumonji domain containing 1C | 0.0611134 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0568963 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0543474 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0536131 |
| INTS6 | integrator complex subunit 6 | 0.0514681 |
| RPS12 | ribosomal protein S12 | 0.0476188 |
| RTN4 | reticulon 4 | 0.0460948 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0457265 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0455451 |
| TPM3 | tropomyosin 3 | 0.0452465 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0444568 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0441087 |
| VMP1 | vacuole membrane protein 1 | 0.0439844 |
| TMEM41B | transmembrane protein 41B | 0.0438823 |
| WWOX | WW domain containing oxidoreductase | 0.0424426 |
| ADIPOR2 | adiponectin receptor 2 | 0.0410607 |
| DENND5A | DENN/MADD domain containing 5A | 0.0405059 |
| PCBP2 | poly(rC) binding protein 2 | 0.0402786 |
| ASPH | aspartate beta-hydroxylase | 0.0392558 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0392087 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0387354 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.038034 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0380279 |
| YAP1 | Yes-associated protein 1 | 0.0380279 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.03802 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0355394 |
| BRD2 | bromodomain containing 2 | 0.0353653 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0352713 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0352 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0351765 |
| RPS2 | ribosomal protein S2 | 0.0347865 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0346819 |
| ANXA1 | annexin A1 | 0.0339906 |
| RPS6 | ribosomal protein S6 | 0.0334743 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.033418 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0330668 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0325688 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0324631 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0322801 |
| ARRDC3 | arrestin domain containing 3 | 0.0322172 |
| LRRC23 | leucine rich repeat containing 23 | 0.0306846 |
| YBX1 | Y box binding protein 1 | 0.0301148 |
| IPO7 | importin 7 | 0.0296748 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0293451 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0288295 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0282637 |
| RPS8 | ribosomal protein S8 | 0.0282588 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0281554 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0276578 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0272666 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0268475 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0264732 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.026227 |
| MCL1 | myeloid cell leukemia 1 | 0.0258907 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0256158 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.02546 |
| HLA-A | major histocompatibility complex, class I, A | 0.0249642 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0248469 |
| GOLGB1 | golgin B1 | 0.0247268 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0246061 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0243784 |
| ATP11A | ATPase, class VI, type 11A | 0.023542 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0235257 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0235173 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0234514 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0231926 |
| CPOX | coproporphyrinogen oxidase | 0.0231123 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0230279 |
| SQSTM1 | sequestosome 1 | 0.0227205 |
| RCOR1 | REST corepressor 1 | 0.0226413 |
| USP53 | ubiquitin specific peptidase 53 | 0.0226187 |
| PRDX1 | peroxiredoxin 1 | 0.0225827 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0224771 |
| PCDH9 | protocadherin 9 | 0.0221428 |
| MAGEA4 | melanoma antigen family A4 | 0.0221352 |
| INTS4 | integrator complex subunit 4 | 0.0219207 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0217141 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0217102 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0217098 |
| SETX | senataxin | 0.0216722 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0213749 |
| ACTG1 | actin gamma 1 | 0.0211326 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0208093 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0204221 |
| CALR | calreticulin | 0.0202773 |
| HOMER1 | homer scaffolding protein 1 | 0.020237 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0202097 |
| GANAB | glucosidase, alpha; neutral AB | 0.0201468 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0201267 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0198076 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0197967 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.019711 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0196178 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0193354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0985177 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0923936 |
| MMP12 | matrix metallopeptidase 12 | -0.0899406 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0772968 |
| CLDN1 | claudin 1 | -0.0770239 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0759195 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0753939 |
| RASAL2 | RAS protein activator like 2 | -0.0628516 |
| PCDH7 | protocadherin 7 | -0.0619279 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0599115 |
| ZNF804A | zinc finger protein 804A | -0.0585375 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0542851 |
| LMO7 | LIM domain 7 | -0.0533681 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0492887 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0487292 |
| SYT1 | synaptotagmin I | -0.0480255 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0477102 |
| DST | dystonin | -0.0466667 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0461799 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0454852 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0451284 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0451151 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0433421 |
| EHBP1 | EH domain binding protein 1 | -0.0421802 |
| TMEM131 | transmembrane protein 131 | -0.042151 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0419657 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0413222 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0403256 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0400202 |
| NEBL | nebulette | -0.0377624 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0372372 |
| H1-0 | H1.0 linker histone | -0.0361747 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0355886 |
| EGFR | epidermal growth factor receptor | -0.034752 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0334782 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0333449 |
| MAP4 | microtubule-associated protein 4 | -0.0331185 |
| AHNAK | AHNAK nucleoprotein | -0.0303999 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0300492 |
| MAP1B | microtubule-associated protein 1B | -0.0295498 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0284529 |
| CDK6 | cyclin-dependent kinase 6 | -0.0280973 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0264367 |
| DTNA | dystrobrevin, alpha | -0.026225 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.02608 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0258958 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.025617 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0253434 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0253038 |
| TENM3 | teneurin transmembrane protein 3 | -0.0249505 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0249041 |
| HMGA1 | high mobility group AT-hook 1 | -0.0243798 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0237538 |
| TMEM123 | transmembrane protein 123 | -0.0233322 |
| THOC2 | THO complex 2 | -0.0230837 |
| TSPAN5 | tetraspanin 5 | -0.0229744 |
| FSTL5 | follistatin-like 5 | -0.022832 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0227861 |
| KIF5B | kinesin family member 5B | -0.022465 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0213806 |
| MGAT4C | MGAT4 family, member C | -0.0212123 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0212034 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0209213 |
| SBF2 | SET binding factor 2 | -0.020907 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0208525 |
| PFN1 | profilin 1 | -0.02079 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0207748 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.020755 |
| CENPF | centromere protein F, 350/400kDa | -0.0206893 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0205895 |
| NF1 | neurofibromin 1 | -0.0202263 |
| RNF13 | ring finger protein 13 | -0.020177 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0201393 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0201349 |
| NSD1 | nuclear receptor binding SET domain protein 1 | -0.0201139 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0200533 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0199963 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0199196 |
| RPS24 | ribosomal protein S24 | -0.0199001 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | -0.0196303 |
| TPD52 | tumor protein D52 | -0.0195755 |
| CMIP | c-Maf inducing protein | -0.019548 |
| AIG1 | androgen-induced 1 | -0.0195332 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0194786 |
| ECT2 | epithelial cell transforming 2 | -0.0192108 |
| CBX3 | chromobox homolog 3 | -0.0189729 |
| WDR43 | WD repeat domain 43 | -0.0188449 |
| XPO1 | exportin 1 | -0.0188248 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0186452 |
| DENND5B | DENN/MADD domain containing 5B | -0.0186119 |
| NRG1 | neuregulin 1 | -0.0185651 |
| OXR1 | oxidation resistance 1 | -0.0184371 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0183121 |
| NEK7 | NIMA-related kinase 7 | -0.0181997 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0180355 |
| RAI14 | retinoic acid induced 14 | -0.0179294 |
| NHSL1 | NHS-like 1 | -0.0178824 |
| IPMK | inositol polyphosphate multikinase | -0.0178646 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0177094 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0177076 |
