ML264_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ML264_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.110041
TLE4 transducin-like enhancer of split 4 0.0833925
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0738704
FMN1 formin 1 0.0705846
THSD4 thrombospondin, type I, domain containing 4 0.0620214
MEIS2 Meis homeobox 2 0.0588246
NALF1 NALCN channel auxiliary factor 1 0.0584778
DST dystonin 0.0535547
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0500088
FAM107B family with sequence similarity 107, member B 0.0496292
ZSWIM6 zinc finger, SWIM-type containing 6 0.0493316
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0479895
ZMIZ1 zinc finger, MIZ-type containing 1 0.0439551
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0435033
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0434307
LPP LIM domain containing preferred translocation partner in lipoma 0.0432251
VMP1 vacuole membrane protein 1 0.0426786
MED13 mediator complex subunit 13 0.0426292
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.042312
COL1A1 collagen, type I, alpha 1 0.0379477
EEF2 eukaryotic translation elongation factor 2 0.0379095
SYT1 synaptotagmin I 0.0354148
HSPA8 heat shock 70kDa protein 8 0.0348802
AMOTL1 angiomotin like 1 0.0347662
SLIT2 slit homolog 2 (Drosophila) 0.0345626
ANTXR1 anthrax toxin receptor 1 0.0336331
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0333846
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.03323
TPST1 tyrosylprotein sulfotransferase 1 0.0330702
SEPTIN9 septin 9 0.0327431
SMYD3 SET and MYND domain containing 3 0.0318658
PSD3 pleckstrin and Sec7 domain containing 3 0.0315352
EXT1 exostosin glycosyltransferase 1 0.0311362
PTPRK protein tyrosine phosphatase, receptor type, K 0.0311014
B2M beta-2-microglobulin 0.0310329
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0309809
DNM3 dynamin 3 0.0300613
FAM13A family with sequence similarity 13, member A 0.0296013
WAC WW domain containing adaptor with coiled-coil 0.029499
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0289889
PRKCA protein kinase C, alpha 0.0289694
FERMT2 fermitin family member 2 0.0289538
PTPRD protein tyrosine phosphatase, receptor type, D 0.0285727
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0285489
HELZ helicase with zinc finger 0.0283749
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0279204
KMT2C lysine (K)-specific methyltransferase 2C 0.0276174
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0270804
PDZRN3 PDZ domain containing ring finger 3 0.0270584
PCBP3 poly(rC) binding protein 3 0.0269437
THBS1 thrombospondin 1 0.0265584
ADAR adenosine deaminase, RNA-specific 0.0265355
RPL23 ribosomal protein L23 0.0262986
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0260653
STK38L serine/threonine kinase 38 like 0.0259622
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0258559
SPAG9 sperm associated antigen 9 0.0258231
TUFT1 tuftelin 1 0.0257524
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0257459
PTPRE protein tyrosine phosphatase, receptor type, E 0.0257192
MYH9 myosin, heavy chain 9, non-muscle 0.0254962
CSNK1A1 casein kinase 1, alpha 1 0.0253896
DNMBP dynamin binding protein 0.0251214
PRRC2C proline-rich coiled-coil 2C 0.0250345
CTNND1 catenin (cadherin-associated protein), delta 1 0.0246729
SLC38A2 solute carrier family 38, member 2 0.0240756
RIGI RNA sensor RIG-I 0.0240743
TPM4 tropomyosin 4 0.0239704
AHNAK AHNAK nucleoprotein 0.0237815
NPAS2 neuronal PAS domain protein 2 0.0236326
NBAS neuroblastoma amplified sequence 0.0233785
COL3A1 collagen, type III, alpha 1 0.0233575
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0230383
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0230275
GPATCH8 G patch domain containing 8 0.0229583
RPL26 ribosomal protein L26 0.0229072
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.022898
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0228304
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224899
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0223784
PABPC1 poly(A) binding protein, cytoplasmic 1 0.022376
RPS8 ribosomal protein S8 0.0223731
FNBP1 formin binding protein 1 0.0223478
CALD1 caldesmon 1 0.0221725
IGF1R insulin-like growth factor 1 receptor 0.0220675
PCM1 pericentriolar material 1 0.0219255
MYO6 myosin VI 0.0216216
RAD51B RAD51 paralog B 0.0215361
MX1 MX dynamin-like GTPase 1 0.0214555
ZMYM2 zinc finger, MYM-type 2 0.0213735
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0213296
MEF2A myocyte enhancer factor 2A 0.021252
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0212107
KLHL13 kelch-like family member 13 0.0211698
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0210325
TRA2A transformer 2 alpha homolog (Drosophila) 0.0207502
LSAMP limbic system-associated membrane protein 0.0207226
HAND2 heart and neural crest derivatives expressed 2 0.0206764
INTS6 integrator complex subunit 6 0.0206529
TRIP12 thyroid hormone receptor interactor 12 0.0205746

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.247345
IGF2 insulin-like growth factor 2 -0.175086
GPC5 glypican 5 -0.0550673
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0493783
FRMD4A FERM domain containing 4A -0.0311691
NDRG1 N-myc downstream regulated 1 -0.0308926
IGFBP3 insulin-like growth factor binding protein 3 -0.0282815
CEMIP cell migration inducing protein, hyaluronan binding -0.0278815
PDIA3 protein disulfide isomerase family A, member 3 -0.0266077
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0236346
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0227513
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0225744
PLAT plasminogen activator, tissue -0.0221555
GARS1 glycyl-tRNA synthetase 1 -0.0216705
PCDH9 protocadherin 9 -0.0209935
MAML2 mastermind-like 2 (Drosophila) -0.020918
ITPRID2 ITPR interacting domain containing 2 -0.020786
ANKRD17 ankyrin repeat domain 17 -0.020706
PLCB4 phospholipase C, beta 4 -0.0206599
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0198531
CADM2 cell adhesion molecule 2 -0.0196962
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0189595
NRG1 neuregulin 1 -0.0189006
GDF15 growth differentiation factor 15 -0.0187729
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0187658
RPLP0 ribosomal protein, large, P0 -0.0184966
SETD5 SET domain containing 5 -0.0181862
CUX1 cut-like homeobox 1 -0.017552
ACACA acetyl-CoA carboxylase alpha -0.0168707
ASPH aspartate beta-hydroxylase -0.016641
ESYT2 extended synaptotagmin-like protein 2 -0.0166171
SCG2 secretogranin II -0.0165219
IARS1 isoleucyl-tRNA synthetase 1 -0.0163041
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0162513
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0161692
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0160781
NREP neuronal regeneration related protein -0.0160168
AFF3 AF4/FMR2 family, member 3 -0.0160131
RPTOR regulatory associated protein of MTOR, complex 1 -0.015883
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0154496
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0150651
COL4A5 collagen, type IV, alpha 5 -0.0148054
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0146687
TOX thymocyte selection-associated high mobility group box -0.0146217
DLG1 discs, large homolog 1 (Drosophila) -0.0145113
DEK DEK proto-oncogene -0.0144539
H1-0 H1.0 linker histone -0.0143135
DLC1 DLC1 Rho GTPase activating protein -0.014226
PTPRM protein tyrosine phosphatase, receptor type, M -0.014076
RANBP17 RAN binding protein 17 -0.0137884
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0137005
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0133647
PCDH11Y protocadherin 11 Y-linked -0.01335
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0132516
RNF145 ring finger protein 145 -0.0131732
IGFBP4 insulin-like growth factor binding protein 4 -0.0131722
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0131385
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.013037
TBC1D19 TBC1 domain family, member 19 -0.0127415
COPA coatomer protein complex, subunit alpha -0.0127283
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.0126823
RPS24 ribosomal protein S24 -0.0122373
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0122176
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0121911
KATNBL1 katanin p80 subunit B-like 1 -0.0120883
ACLY ATP citrate lyase -0.0120375
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -0.0120224
PRAME preferentially expressed antigen in melanoma -0.0120042
DENND1A DENN/MADD domain containing 1A -0.0119697
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0119671
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0119562
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0118806
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0118767
TIMP2 TIMP metallopeptidase inhibitor 2 -0.01183
KIF26A kinesin family member 26A -0.0118289
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0117561
ERRFI1 ERBB receptor feedback inhibitor 1 -0.011755
HM13 histocompatibility (minor) 13 -0.0116761
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0115943
RNF149 ring finger protein 149 -0.0115295
SRRM2 serine/arginine repetitive matrix 2 -0.011498
CEP57 centrosomal protein 57kDa -0.011477
ATM ATM serine/threonine kinase -0.0114263
NAMPT nicotinamide phosphoribosyltransferase -0.0112973
RPS5 ribosomal protein S5 -0.0112669
KDM6B lysine (K)-specific demethylase 6B -0.0112632
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0112538
SEC61G Sec61 gamma subunit -0.0112397
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0112262
KCNIP4 Kv channel interacting protein 4 -0.0110371
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0110362
RTN4 reticulon 4 -0.0110001
BTG1 B-cell translocation gene 1, anti-proliferative -0.0109951
U2SURP U2 snRNP-associated SURP domain containing -0.01099
DPYSL2 dihydropyrimidinase-like 2 -0.0109454
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0108424
GHR growth hormone receptor -0.0108062
STC1 stanniocalcin 1 -0.0107843
RHOBTB3 Rho-related BTB domain containing 3 -0.0107779
SUGCT succinyl-CoA:glutarate-CoA transferase -0.0106743