ML264_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ML264_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.163739
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.127199
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.123011
LMO7 LIM domain 7 0.103332
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0967696
INTS6 integrator complex subunit 6 0.0871826
AKAP13 A kinase (PRKA) anchor protein 13 0.0779275
SMAD3 SMAD family member 3 0.0754818
DSCAM Down syndrome cell adhesion molecule 0.0735692
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0628094
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0621768
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0606916
ENO1 enolase 1, (alpha) 0.0577494
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0571116
ASPH aspartate beta-hydroxylase 0.056554
ZNF292 zinc finger protein 292 0.0521962
RPS8 ribosomal protein S8 0.0515452
CANX calnexin 0.051205
B2M beta-2-microglobulin 0.0498048
GOLGA4 golgin A4 0.0497897
MBNL2 muscleblind-like splicing regulator 2 0.0496801
EFNB2 ephrin-B2 0.04766
LCN2 lipocalin 2 0.0472812
HKDC1 hexokinase domain containing 1 0.0464774
CALR calreticulin 0.0453254
SPAG9 sperm associated antigen 9 0.0436599
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0432078
ZSWIM6 zinc finger, SWIM-type containing 6 0.0414897
RPS6 ribosomal protein S6 0.0409253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0406047
FNIP1 folliculin interacting protein 1 0.0401359
GOLGB1 golgin B1 0.0399831
AHI1 Abelson helper integration site 1 0.039977
RPL12 ribosomal protein L12 0.0399393
FNDC3B fibronectin type III domain containing 3B 0.0394286
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0386423
TRIM2 tripartite motif containing 2 0.0384432
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0375587
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0374144
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0372745
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0372341
RPL35A ribosomal protein L35a 0.0369335
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0369279
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0368902
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.036541
RAB1A RAB1A, member RAS oncogene family 0.0365282
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0354869
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0351706
ANKHD1 ankyrin repeat and KH domain containing 1 0.0345007
RAB7A RAB7A, member RAS oncogene family 0.0341345
SEC31A SEC31 homolog A (S. cerevisiae) 0.0335955
GCLC glutamate-cysteine ligase, catalytic subunit 0.0331451
EIF1 eukaryotic translation initiation factor 1 0.0326054
ATXN1 ataxin 1 0.0324856
SIK3 SIK family kinase 3 0.0320191
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0315489
PRRC2C proline-rich coiled-coil 2C 0.0315219
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0314791
SON SON DNA binding protein 0.0311704
MYO1E myosin IE 0.030407
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0301727
PDIA3 protein disulfide isomerase family A, member 3 0.0301341
LDHA lactate dehydrogenase A 0.0301158
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0299454
UFM1 ubiquitin-fold modifier 1 0.0297539
ANXA1 annexin A1 0.0291975
TTC3 tetratricopeptide repeat domain 3 0.0290005
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0289871
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0286203
RPL26 ribosomal protein L26 0.0283499
UBC ubiquitin C 0.0280658
EEF2 eukaryotic translation elongation factor 2 0.0280268
RPL23 ribosomal protein L23 0.027921
SEPTIN9 septin 9 0.0275738
MACC1 metastasis associated in colon cancer 1 0.0275207
BCLAF1 BCL2-associated transcription factor 1 0.0273226
MORF4L2 mortality factor 4 like 2 0.0272824
RPS3 ribosomal protein S3 0.0272573
TMEM65 transmembrane protein 65 0.0270307
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0264029
SUCO SUN domain containing ossification factor 0.0262152
TMED2 transmembrane emp24 domain trafficking protein 2 0.0261452
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0261188
EREG epiregulin 0.0252798
PDIA4 protein disulfide isomerase family A, member 4 0.0252728
AHNAK AHNAK nucleoprotein 0.024797
FTL ferritin, light polypeptide 0.0247678
SLK STE20-like kinase 0.0247235
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0245103
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0245081
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0244912
UBE2H ubiquitin-conjugating enzyme E2H 0.0244177
RPL7 ribosomal protein L7 0.0242218
TM9SF2 transmembrane 9 superfamily member 2 0.0240211
DUSP10 dual specificity phosphatase 10 0.0240127
KMT2C lysine (K)-specific methyltransferase 2C 0.0237896
RPL19 ribosomal protein L19 0.0237142
ANXA2 annexin A2 0.0237024
CALU calumenin 0.0233974
TMED9 transmembrane emp24 protein transport domain containing 9 0.0233865

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.170776
ZMYND8 zinc finger, MYND-type containing 8 -0.114321
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0969014
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.085021
LYZ lysozyme -0.0799317
RIGI RNA sensor RIG-I -0.078142
STS steroid sulfatase (microsomal), isozyme S -0.0688611
MX1 MX dynamin-like GTPase 1 -0.0682676
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.067825
RNF213 ring finger protein 213 -0.067187
RABGAP1L RAB GTPase activating protein 1-like -0.0599496
NPSR1 neuropeptide S receptor 1 -0.055083
SP100 SP100 nuclear antigen -0.0506137
PLSCR1 phospholipid scramblase 1 -0.0497414
ITGA6 integrin, alpha 6 -0.048301
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0471048
SSH2 slingshot protein phosphatase 2 -0.0468675
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0468071
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0467898
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0467686
TSHZ2 teashirt zinc finger homeobox 2 -0.0465166
MX2 MX dynamin-like GTPase 2 -0.0452353
EGR1 early growth response 1 -0.0449421
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0436317
ARHGAP26 Rho GTPase activating protein 26 -0.0435386
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0430252
XAF1 XIAP associated factor 1 -0.0423906
MAML2 mastermind-like 2 (Drosophila) -0.0419894
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.041071
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0398231
PHF3 PHD finger protein 3 -0.0391756
C6ORF132 chromosome 6 open reading frame 132 -0.0380607
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0378682
NCOA7 nuclear receptor coactivator 7 -0.037767
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0369118
MUC13 mucin 13, cell surface associated -0.0366014
TRIO trio Rho guanine nucleotide exchange factor -0.0357174
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0356525
ATP10B ATPase, class V, type 10B -0.0353923
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0345215
PMP22 peripheral myelin protein 22 -0.0339833
GMDS GDP-mannose 4,6-dehydratase -0.0324484
MUC20 mucin 20, cell surface associated -0.032291
PRKCA protein kinase C, alpha -0.0320364
TMEM62 transmembrane protein 62 -0.0304111
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0302911
BICRAL BICRA like chromatin remodeling complex associated protein -0.0296467
IFIH1 interferon induced with helicase C domain 1 -0.0291984
ZNFX1 zinc finger, NFX1-type containing 1 -0.0286935
NKD1 naked cuticle homolog 1 (Drosophila) -0.0284789
PRSS3 protease, serine, 3 -0.0275299
OASL 2'-5'-oligoadenylate synthetase-like -0.0267986
MECOM MDS1 and EVI1 complex locus -0.0260458
IGF1R insulin-like growth factor 1 receptor -0.0259596
LAP3 leucine aminopeptidase 3 -0.0258304
DGKH diacylglycerol kinase, eta -0.0256311
PRKCE protein kinase C, epsilon -0.024847
TC2N tandem C2 domains, nuclear -0.024709
ITGA1 integrin, alpha 1 -0.024188
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0240432
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0240404
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0239991
TNS4 tensin 4 -0.0238072
SAMD9 sterile alpha motif domain containing 9 -0.0231433
CD2AP CD2-associated protein -0.0231279
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.022793
SAMD12 sterile alpha motif domain containing 12 -0.0225217
NT5C2 5'-nucleotidase, cytosolic II -0.0223802
IGFBP3 insulin-like growth factor binding protein 3 -0.0221189
ATP11A ATPase, class VI, type 11A -0.0221043
PTGR1 prostaglandin reductase 1 -0.0218881
SAMHD1 SAM domain and HD domain 1 -0.0218403
PCED1B PC-esterase domain containing 1B -0.0216738
TFRC transferrin receptor -0.0216109
ANXA4 annexin A4 -0.0216073
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0215828
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0215479
NCKAP5 NCK-associated protein 5 -0.021521
JUP junction plakoglobin -0.0214307
CCND3 cyclin D3 -0.0214193
ITGB4 integrin, beta 4 -0.0211997
USP18 ubiquitin specific peptidase 18 -0.0207813
USP54 ubiquitin specific peptidase 54 -0.0206869
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.020625
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.020285
MAP2K6 mitogen-activated protein kinase kinase 6 -0.0199699
IFI16 interferon, gamma-inducible protein 16 -0.0196429
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -0.0194862
GCC2 GRIP and coiled-coil domain containing 2 -0.0193545
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0192763
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0192682
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0191061
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0189641
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0189333
APOL1 apolipoprotein L, 1 -0.0189095
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0184317
SLC38A1 solute carrier family 38, member 1 -0.0177067
NECTIN2 nectin cell adhesion molecule 2 -0.0176927
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0175333
CDC42SE2 CDC42 small effector 2 -0.0174601