ML264_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ML264_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.262108
SVIL supervillin 0.120254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.119114
FAM107B family with sequence similarity 107, member B 0.114394
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107055
TPT1 tumor protein, translationally-controlled 1 0.106766
IGFBP1 insulin-like growth factor binding protein 1 0.0955521
ENO1 enolase 1, (alpha) 0.0955112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0951301
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0920389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0915741
MT2A metallothionein 2A 0.0886408
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0881577
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0810467
EEF2 eukaryotic translation elongation factor 2 0.0771168
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0751449
ASPH aspartate beta-hydroxylase 0.0745269
PDLIM5 PDZ and LIM domain 5 0.0738313
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0731288
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0703136
CANX calnexin 0.0684664
MACF1 microtubule-actin crosslinking factor 1 0.0663926
AHSG alpha-2-HS-glycoprotein 0.065589
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0651258
DSPP dentin sialophosphoprotein 0.0636122
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0618895
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0572834
RPS8 ribosomal protein S8 0.0561867
APLP2 amyloid beta (A4) precursor-like protein 2 0.0560233
GRB10 growth factor receptor-bound protein 10 0.0542206
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0541535
EXT1 exostosin glycosyltransferase 1 0.0525686
SAMD4A sterile alpha motif domain containing 4A 0.0522498
CCL20 chemokine (C-C motif) ligand 20 0.0514718
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0510582
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0491939
MCL1 myeloid cell leukemia 1 0.0487912
INTS6 integrator complex subunit 6 0.0473557
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0472077
RPS12 ribosomal protein S12 0.044749
MBNL2 muscleblind-like splicing regulator 2 0.0438246
DTNA dystrobrevin, alpha 0.0427753
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0415775
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0400778
ATXN1 ataxin 1 0.0396854
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0387786
RPL7 ribosomal protein L7 0.0384818
RPS27A ribosomal protein S27a 0.0378258
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0373241
RPL37A ribosomal protein L37a 0.0370335
PAWR PRKC, apoptosis, WT1, regulator 0.0368372
FOXP1 forkhead box P1 0.0368314
KYNU kynureninase 0.0362587
RPL5 ribosomal protein L5 0.0357997
MYO1E myosin IE 0.0353674
GMDS GDP-mannose 4,6-dehydratase 0.0350243
GCLC glutamate-cysteine ligase, catalytic subunit 0.0349801
TF transferrin 0.0346464
CRY1 cryptochrome circadian clock 1 0.0345295
LDHA lactate dehydrogenase A 0.0340574
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0337269
MYH9 myosin, heavy chain 9, non-muscle 0.0336784
ITGA6 integrin, alpha 6 0.033482
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0332779
DDIT4 DNA-damage-inducible transcript 4 0.0328356
AHNAK AHNAK nucleoprotein 0.0325182
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0323542
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0322891
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0320188
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0315788
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0315442
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0310393
HOOK2 hook microtubule-tethering protein 2 0.0307706
JAK1 Janus kinase 1 0.0298994
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0298058
CLIC4 chloride intracellular channel 4 0.0296967
GOLGB1 golgin B1 0.0296274
FLNB filamin B, beta 0.0292529
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0292369
TLE4 transducin-like enhancer of split 4 0.0292227
NDRG1 N-myc downstream regulated 1 0.0288308
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.028765
STC2 stanniocalcin 2 0.0285801
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0281627
HSPA8 heat shock 70kDa protein 8 0.0281166
TBC1D22A TBC1 domain family, member 22A 0.027827
ACTG1 actin gamma 1 0.0278029
OSBPL8 oxysterol binding protein-like 8 0.0274562
FAM13A family with sequence similarity 13, member A 0.0272288
TNS1 tensin 1 0.0271696
SOD2 superoxide dismutase 2, mitochondrial 0.02709
ZEB1 zinc finger E-box binding homeobox 1 0.0270722
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0268393
HM13 histocompatibility (minor) 13 0.0264313
LMO7 LIM domain 7 0.0262673
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0261388
GOLGA4 golgin A4 0.0257615
EIF4A2 eukaryotic translation initiation factor 4A2 0.0257297
AKAP13 A kinase (PRKA) anchor protein 13 0.0254834
HSPA1A heat shock 70kDa protein 1A 0.0254834

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.197177
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.156976
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.138526
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.120312
IGF2 insulin-like growth factor 2 -0.119837
C3 complement component 3 -0.111718
LRMDA leucine rich melanocyte differentiation associated -0.109515
FNDC3B fibronectin type III domain containing 3B -0.101882
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0896041
EML4 echinoderm microtubule associated protein like 4 -0.0849693
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.080881
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0754093
GPC6 glypican 6 -0.0701858
MAML2 mastermind-like 2 (Drosophila) -0.0641393
NPAS2 neuronal PAS domain protein 2 -0.0624681
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0612978
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0597586
NKD1 naked cuticle homolog 1 (Drosophila) -0.0597227
EHBP1 EH domain binding protein 1 -0.0590446
MBNL3 muscleblind-like splicing regulator 3 -0.0541242
ELL2 elongation factor, RNA polymerase II, 2 -0.0528732
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0520718
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0520158
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0504703
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0504456
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0495169
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0494714
SLC38A2 solute carrier family 38, member 2 -0.0493379
ZMYND8 zinc finger, MYND-type containing 8 -0.0483052
OSMR oncostatin M receptor -0.0459626
TRIM26 tripartite motif containing 26 -0.0444949
SOX5 SRY (sex determining region Y)-box 5 -0.0443689
EGR1 early growth response 1 -0.0435156
PTPRM protein tyrosine phosphatase, receptor type, M -0.0425415
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.040463
MALT1 MALT1 paracaspase -0.0395819
PDGFB platelet-derived growth factor beta polypeptide -0.0390129
TMEM123 transmembrane protein 123 -0.0384703
RBM25 RNA binding motif protein 25 -0.0377701
GPC3 glypican 3 -0.0377153
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0375929
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0370293
HLF hepatic leukemia factor -0.0369545
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0366763
MTUS1 microtubule associated tumor suppressor 1 -0.036337
CRLS1 cardiolipin synthase 1 -0.0359118
DNAH17 dynein, axonemal, heavy chain 17 -0.0347614
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0346994
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0339899
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0339663
LYZ lysozyme -0.0318308
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0317563
PTCHD4 patched domain containing 4 -0.0314272
MRTFA myocardin related transcription factor A -0.0311727
PTBP3 polypyrimidine tract binding protein 3 -0.0307042
APOA2 apolipoprotein A-II -0.0306452
PERP PERP, TP53 apoptosis effector -0.0305097
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0304261
CP ceruloplasmin (ferroxidase) -0.0301265
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0299173
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0297127
RRBP1 ribosome binding protein 1 -0.0294663
PATJ PATJ crumbs cell polarity complex component -0.0293629
CFB complement factor B -0.0291763
RBM39 RNA binding motif protein 39 -0.0288503
FAM135A family with sequence similarity 135, member A -0.0287827
SESTD1 SEC14 and spectrin domains 1 -0.0286626
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0285873
TMEM51 transmembrane protein 51 -0.0279307
PEG10 paternally expressed 10 -0.0272861
ITGA1 integrin, alpha 1 -0.0272808
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0272241
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0268784
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 -0.0263663
NCOA7 nuclear receptor coactivator 7 -0.0258686
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.0252717
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0252388
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0247611
GDF15 growth differentiation factor 15 -0.0243728
ZFHX3 zinc finger homeobox 3 -0.0242256
DNAAF9 dynein axonemal assembly factor 9 -0.0240703
PHF21A PHD finger protein 21A -0.0239165
MAPK14 mitogen-activated protein kinase 14 -0.0238073
TTC28 tetratricopeptide repeat domain 28 -0.0237321
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0233639
H1-0 H1.0 linker histone -0.0232957
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0232406
CHD6 chromodomain helicase DNA binding protein 6 -0.0231132
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0230784
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.022678
APOE apolipoprotein E -0.0226302
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0225652
SOS1 son of sevenless homolog 1 (Drosophila) -0.0217248
LMCD1 LIM and cysteine-rich domains 1 -0.0216964
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0215869
ARID4B AT rich interactive domain 4B (RBP1-like) -0.021354
CALD1 caldesmon 1 -0.0209749
MALRD1 MAM and LDL receptor class A domain containing 1 -0.0208943
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0208902
DOK6 docking protein 6 -0.0208696