ML264_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description ML264 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the ML264_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.0771634
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0727976
LMO7 LIM domain 7 0.0624176
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0475169
MYO1E myosin IE 0.0393256
AFF1 AF4/FMR2 family, member 1 0.0391098
EXT1 exostosin glycosyltransferase 1 0.0365133
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0359651
GMDS GDP-mannose 4,6-dehydratase 0.0336949
NEBL nebulette 0.0316611
HSPA8 heat shock 70kDa protein 8 0.0269475
ZSWIM6 zinc finger, SWIM-type containing 6 0.0265166
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0261535
PARD3B par-3 family cell polarity regulator beta 0.0249635
TGFBR3 transforming growth factor, beta receptor III 0.024253
WHRN whirlin 0.0227194
MARCHF3 membrane associated ring-CH-type finger 3 0.0225058
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0218521
MUC13 mucin 13, cell surface associated 0.0211588
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0208624
PTPRK protein tyrosine phosphatase, receptor type, K 0.0203684
ATXN1 ataxin 1 0.0200745
CLCN3 chloride channel, voltage-sensitive 3 0.0196228
UNC13B unc-13 homolog B (C. elegans) 0.0191285
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0190131
CRY1 cryptochrome circadian clock 1 0.0183693
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0175069
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0174021
SIK3 SIK family kinase 3 0.0173402
AKAP13 A kinase (PRKA) anchor protein 13 0.0170602
MYO5B myosin VB 0.0168815
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0168379
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0161083
ASPH aspartate beta-hydroxylase 0.0160786
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0160659
CEMIP2 cell migration inducing hyaluronidase 2 0.0159405
EEF2 eukaryotic translation elongation factor 2 0.0159052
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0158994
BTBD9 BTB (POZ) domain containing 9 0.015337
MBNL2 muscleblind-like splicing regulator 2 0.0149462
PDZD8 PDZ domain containing 8 0.014868
VEGFA vascular endothelial growth factor A 0.014172
MED13 mediator complex subunit 13 0.0138265
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0137298
FAM107B family with sequence similarity 107, member B 0.0136592
PGM3 phosphoglucomutase 3 0.0136013
MLF1 myeloid leukemia factor 1 0.0135975
MBNL1 muscleblind-like splicing regulator 1 0.0135119
USP6NL USP6 N-terminal like 0.0133601
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0128799
GLS2 glutaminase 2 (liver, mitochondrial) 0.0127448
APLP2 amyloid beta (A4) precursor-like protein 2 0.0127067
SVIL supervillin 0.012532
GOLGB1 golgin B1 0.0121683
GCLC glutamate-cysteine ligase, catalytic subunit 0.0120942
SAMD4A sterile alpha motif domain containing 4A 0.0120598
PSD3 pleckstrin and Sec7 domain containing 3 0.0119825
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0117513
RC3H1 ring finger and CCCH-type domains 1 0.0117176
GDA guanine deaminase 0.0116688
TPM3 tropomyosin 3 0.0116485
IQGAP1 IQ motif containing GTPase activating protein 1 0.0115373
ARHGAP21 Rho GTPase activating protein 21 0.0115287
RPS18 ribosomal protein S18 0.0114059
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0112657
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0111815
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.011001
CADPS2 Ca++-dependent secretion activator 2 0.0109794
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0105443
PCBP2 poly(rC) binding protein 2 0.0105034
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0104824
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0103706
SGMS2 sphingomyelin synthase 2 0.0103699
ATF6 activating transcription factor 6 0.0101093
ABHD2 abhydrolase domain containing 2 0.0100527
OCLN occludin 0.0100278
RPL3 ribosomal protein L3 0.0099059
ARHGAP42 Rho GTPase activating protein 42 0.00974458
CALR calreticulin 0.00974303
EHF ets homologous factor 0.00970286
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.00966759
HYOU1 hypoxia up-regulated 1 0.00962565
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00962339
PPARD peroxisome proliferator-activated receptor delta 0.00955888
RORA RAR-related orphan receptor A 0.0095275
GRB10 growth factor receptor-bound protein 10 0.00947032
EIF4B eukaryotic translation initiation factor 4B 0.00930882
TMC5 transmembrane channel-like 5 0.00923808
AARS1 alanyl-tRNA synthetase 1 0.0091894
LURAP1L leucine rich adaptor protein 1-like 0.00910924
EGFR epidermal growth factor receptor 0.00910237
EXPH5 exophilin 5 0.00908237
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00906869
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00905458
TMSB4X thymosin beta 4, X-linked 0.00899644
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.00897522
CYSTM1 cysteine-rich transmembrane module containing 1 0.00887222
EPHA4 EPH receptor A4 0.00884187
EIF4A2 eukaryotic translation initiation factor 4A2 0.00877587
MACF1 microtubule-actin crosslinking factor 1 0.00873573

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.260688
TMSB10 thymosin beta 10 -0.1305
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130347
RPS6 ribosomal protein S6 -0.110258
TPT1 tumor protein, translationally-controlled 1 -0.093224
RPL35A ribosomal protein L35a -0.0830623
NPSR1 neuropeptide S receptor 1 -0.0811976
RPS8 ribosomal protein S8 -0.0575162
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0553768
RPS19 ribosomal protein S19 -0.0548281
RPLP1 ribosomal protein, large, P1 -0.0540375
RPL34 ribosomal protein L34 -0.0537155
GPHN gephyrin -0.0526975
RPS24 ribosomal protein S24 -0.0511345
RPL12 ribosomal protein L12 -0.0493899
RPL9 ribosomal protein L9 -0.0455931
RPS3 ribosomal protein S3 -0.044968
ANXA2 annexin A2 -0.0448064
RPLP2 ribosomal protein, large, P2 -0.0443524
RPL23 ribosomal protein L23 -0.0436572
TNS4 tensin 4 -0.0434791
RPL37A ribosomal protein L37a -0.0422716
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0408234
RPLP0 ribosomal protein, large, P0 -0.0406489
ACTG1 actin gamma 1 -0.0386898
RPL11 ribosomal protein L11 -0.0376784
RPS23 ribosomal protein S23 -0.0376445
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0373731
RPL19 ribosomal protein L19 -0.0368279
EPCAM epithelial cell adhesion molecule -0.0364959
RPL26 ribosomal protein L26 -0.0363736
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.035641
RPL36 ribosomal protein L36 -0.0355965
FTL ferritin, light polypeptide -0.0349189
NDRG1 N-myc downstream regulated 1 -0.0347889
S100A10 S100 calcium binding protein A10 -0.0346687
KRT18 keratin 18, type I -0.0342893
PNISR PNN-interacting serine/arginine-rich protein -0.0341547
RPS25 ribosomal protein S25 -0.0338823
RPL31 ribosomal protein L31 -0.033552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0317705
GOLGA4 golgin A4 -0.0316084
HMGA1 high mobility group AT-hook 1 -0.031329
IER3 immediate early response 3 -0.0313259
RPL7A ribosomal protein L7a -0.0311765
FAM13A family with sequence similarity 13, member A -0.0310529
EIF1 eukaryotic translation initiation factor 1 -0.0302466
RPS29 ribosomal protein S29 -0.0296412
RPS12 ribosomal protein S12 -0.0293536
NCOR1 nuclear receptor corepressor 1 -0.0292249
VCL vinculin -0.0290641
AREG amphiregulin -0.0285572
RPL5 ribosomal protein L5 -0.0285176
EIF5B eukaryotic translation initiation factor 5B -0.0281673
NALF1 NALCN channel auxiliary factor 1 -0.0281209
FNBP1L formin binding protein 1-like -0.0279815
H1-0 H1.0 linker histone -0.0278092
RPS21 ribosomal protein S21 -0.0277617
ONECUT3 one cut homeobox 3 -0.0276325
S100A6 S100 calcium binding protein A6 -0.0275218
RPL8 ribosomal protein L8 -0.0274804
RNF43 ring finger protein 43 -0.0274115
GCC2 GRIP and coiled-coil domain containing 2 -0.027405
RPS13 ribosomal protein S13 -0.0266824
RBM39 RNA binding motif protein 39 -0.0265883
NAP1L1 nucleosome assembly protein 1-like 1 -0.026433
PKM pyruvate kinase, muscle -0.0263231
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0262742
RPL13A ribosomal protein L13a -0.0262654
SETD5 SET domain containing 5 -0.0260222
ANKRD11 ankyrin repeat domain 11 -0.0260216
S100A9 S100 calcium binding protein A9 -0.025795
RPL32 ribosomal protein L32 -0.0254062
GARS1 glycyl-tRNA synthetase 1 -0.0253857
RPS14 ribosomal protein S14 -0.0251859
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.024851
S100P S100 calcium binding protein P -0.0248435
CD46 CD46 molecule, complement regulatory protein -0.0248418
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0248107
RPS16 ribosomal protein S16 -0.02476
GNAS GNAS complex locus -0.0247355
WDR45B WD repeat domain 45B -0.0241915
VDAC1 voltage-dependent anion channel 1 -0.0239649
MYL12B myosin, light chain 12B, regulatory -0.0238891
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0238856
RPS27A ribosomal protein S27a -0.0238441
KDM3A lysine (K)-specific demethylase 3A -0.0237618
NF1 neurofibromin 1 -0.0236975
KIF5B kinesin family member 5B -0.0234946
TXNIP thioredoxin interacting protein -0.0234828
FLNB filamin B, beta -0.0230169
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0229619
RPL28 ribosomal protein L28 -0.0227099
RBM25 RNA binding motif protein 25 -0.0226752
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0224486
ARHGAP5 Rho GTPase activating protein 5 -0.0223012
RAB1A RAB1A, member RAS oncogene family -0.0222502
RACK1 receptor for activated C kinase 1 -0.0220145
PRRC2C proline-rich coiled-coil 2C -0.0219562
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0216576