| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ML264 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ML264_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.157992 |
| MT2A | metallothionein 2A | 0.155308 |
| MCL1 | myeloid cell leukemia 1 | 0.141189 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.139511 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.120063 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.115303 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.110839 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0828386 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0801119 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0796036 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0784679 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0769431 |
| ASPH | aspartate beta-hydroxylase | 0.0767092 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0765298 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.075672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0741064 |
| WWOX | WW domain containing oxidoreductase | 0.071177 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0703453 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0692545 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0660009 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0621198 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0611832 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0610582 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0593346 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0590411 |
| FAM107B | family with sequence similarity 107, member B | 0.0586432 |
| PYGL | phosphorylase, glycogen, liver | 0.0558646 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0544609 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0536993 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0513826 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0513071 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0506391 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0505267 |
| RRM2 | ribonucleotide reductase M2 | 0.0502684 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0487833 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0485968 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0481761 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0472542 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0444419 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0443028 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.043492 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0428386 |
| IER3 | immediate early response 3 | 0.0417781 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0414948 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0414494 |
| ATXN1 | ataxin 1 | 0.0413617 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.04114 |
| STC1 | stanniocalcin 1 | 0.0403659 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0398566 |
| BMP6 | bone morphogenetic protein 6 | 0.0390541 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0384459 |
| TPM3 | tropomyosin 3 | 0.0378241 |
| FUS | FUS RNA binding protein | 0.0376353 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0369214 |
| GRAMD1B | GRAM domain containing 1B | 0.0362986 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0360374 |
| RCOR1 | REST corepressor 1 | 0.0358376 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0356542 |
| RPS8 | ribosomal protein S8 | 0.0354305 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0348429 |
| RAD51B | RAD51 paralog B | 0.0346332 |
| SNX14 | sorting nexin 14 | 0.0337128 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0331939 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0331229 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.032553 |
| ITGA6 | integrin, alpha 6 | 0.0323209 |
| CUL3 | cullin 3 | 0.0321825 |
| INTS6 | integrator complex subunit 6 | 0.0317157 |
| CTSL | cathepsin L | 0.031459 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0310487 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0301872 |
| BRD2 | bromodomain containing 2 | 0.0296071 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0295224 |
| CALR | calreticulin | 0.0294736 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0290916 |
| NUMB | numb homolog (Drosophila) | 0.029041 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0289815 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0285325 |
| SFPQ | splicing factor proline/glutamine-rich | 0.028524 |
| KIF5B | kinesin family member 5B | 0.0283072 |
| RPS29 | ribosomal protein S29 | 0.0283069 |
| GOLGB1 | golgin B1 | 0.0282403 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0279475 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0279212 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0277614 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0276497 |
| CANX | calnexin | 0.0274053 |
| CMIP | c-Maf inducing protein | 0.0268894 |
| SERINC3 | serine incorporator 3 | 0.0266971 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0261456 |
| DST | dystonin | 0.0260734 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0260682 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0260439 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0258742 |
| RPS12 | ribosomal protein S12 | 0.0257948 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0257901 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0256996 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0254995 |
| MED13 | mediator complex subunit 13 | 0.0253621 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0252856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.188738 |
| IGF2 | insulin-like growth factor 2 | -0.162044 |
| TMSB10 | thymosin beta 10 | -0.121201 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0954789 |
| HDAC9 | histone deacetylase 9 | -0.0797162 |
| ERBIN | erbb2 interacting protein | -0.0714117 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0627303 |
| VIM | vimentin | -0.0619705 |
| FTL | ferritin, light polypeptide | -0.0607402 |
| POTEF | POTE ankyrin domain family, member F | -0.0552578 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.050677 |
| PFN1 | profilin 1 | -0.0502362 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0475961 |
| S100A6 | S100 calcium binding protein A6 | -0.0465378 |
| RHOA | ras homolog family member A | -0.0422332 |
| BICC1 | BicC family RNA binding protein 1 | -0.0412227 |
| RASAL2 | RAS protein activator like 2 | -0.0376119 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0372112 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0358918 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0351767 |
| TPD52 | tumor protein D52 | -0.0343365 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0339647 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0333904 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0323863 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0321009 |
| WDR43 | WD repeat domain 43 | -0.0319408 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0316443 |
| CHN1 | chimerin 1 | -0.0313471 |
| THBS1 | thrombospondin 1 | -0.0311799 |
| FAM168A | family with sequence similarity 168, member A | -0.0305644 |
| FGB | fibrinogen beta chain | -0.0303103 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0301529 |
| ACTG1 | actin gamma 1 | -0.0300584 |
| DENND4A | DENN/MADD domain containing 4A | -0.0300583 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.029658 |
| UTRN | utrophin | -0.0295964 |
| WBP11 | WW domain binding protein 11 | -0.0288493 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.028752 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0286013 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0285976 |
| USP3 | ubiquitin specific peptidase 3 | -0.0281829 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0281337 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.02799 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0276876 |
| KLF6 | Kruppel-like factor 6 | -0.0270846 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0258184 |
| HMGA1 | high mobility group AT-hook 1 | -0.0256172 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0254862 |
| EGFR | epidermal growth factor receptor | -0.0254367 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0253668 |
| TMEM123 | transmembrane protein 123 | -0.0251518 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0249115 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0249083 |
| RPS21 | ribosomal protein S21 | -0.0247678 |
| AHR | aryl hydrocarbon receptor | -0.0243794 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0243431 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0243116 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0242785 |
| RBM25 | RNA binding motif protein 25 | -0.0239983 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0234934 |
| EYA4 | EYA transcriptional coactivator and phosphatase 4 | -0.0234312 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0231465 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0227613 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0227558 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0226792 |
| TBC1D19 | TBC1 domain family, member 19 | -0.0225459 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0223769 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0223506 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0223174 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0221721 |
| PTEN | phosphatase and tensin homolog | -0.0220885 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0219171 |
| AK1 | adenylate kinase 1 | -0.0218343 |
| ILF2 | interleukin enhancer binding factor 2 | -0.0218079 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0217796 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0215029 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0214756 |
| EFNA5 | ephrin-A5 | -0.02126 |
| RHEB | Ras homolog enriched in brain | -0.0211054 |
| PKM | pyruvate kinase, muscle | -0.0203469 |
| CCNL1 | cyclin L1 | -0.0201088 |
| MTF2 | metal response element binding transcription factor 2 | -0.0200612 |
| PTK2 | protein tyrosine kinase 2 | -0.0199294 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | -0.0199095 |
| RPL34 | ribosomal protein L34 | -0.0198969 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0198827 |
| RPL32 | ribosomal protein L32 | -0.0197997 |
| TES | testin LIM domain protein | -0.019567 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.019364 |
| ARHGAP17 | Rho GTPase activating protein 17 | -0.0192762 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.0191832 |
| ECT2 | epithelial cell transforming 2 | -0.0191178 |
| COG5 | component of oligomeric golgi complex 5 | -0.0191054 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0191037 |
| RBM8A | RNA binding motif protein 8A | -0.0190867 |
| RPL18 | ribosomal protein L18 | -0.0190341 |
| WDR36 | WD repeat domain 36 | -0.0187743 |
| RNF145 | ring finger protein 145 | -0.0187618 |
| TAGLN2 | transgelin 2 | -0.0187484 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.0187399 |
