| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | ML264 perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the ML264_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.154582 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.128989 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0874646 |
| MCL1 | myeloid cell leukemia 1 | 0.0826885 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0783015 |
| KYNU | kynureninase | 0.0762119 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0737699 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0727617 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0710864 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0707159 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0628551 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0585587 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0577641 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0569984 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0551726 |
| INTS6 | integrator complex subunit 6 | 0.0545966 |
| SQSTM1 | sequestosome 1 | 0.0519662 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.050405 |
| FMNL2 | formin-like 2 | 0.0496394 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0463818 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0458946 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0454075 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.04537 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0450328 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0430128 |
| ENO1 | enolase 1, (alpha) | 0.0429005 |
| CANX | calnexin | 0.0427294 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0419282 |
| RPS12 | ribosomal protein S12 | 0.0415798 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0412332 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0411092 |
| EZR | ezrin | 0.0406723 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0405702 |
| DST | dystonin | 0.0402954 |
| CTBP2 | C-terminal binding protein 2 | 0.0391395 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0385124 |
| RPS8 | ribosomal protein S8 | 0.0380999 |
| SMAD2 | SMAD family member 2 | 0.0375517 |
| ANXA1 | annexin A1 | 0.037072 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0363329 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0361867 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0360178 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0349069 |
| CDH13 | cadherin 13 | 0.0348928 |
| PCBP2 | poly(rC) binding protein 2 | 0.0344917 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0338399 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0336158 |
| BMP6 | bone morphogenetic protein 6 | 0.0335277 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0328914 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0327224 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0325214 |
| FAM107B | family with sequence similarity 107, member B | 0.0321406 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0316111 |
| RPS2 | ribosomal protein S2 | 0.0315004 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0309681 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0307894 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0307227 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0303592 |
| PRELID2 | PRELI domain containing 2 | 0.0299013 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0297046 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0296798 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0294357 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0292471 |
| CD44 | CD44 molecule (Indian blood group) | 0.0291352 |
| FNIP1 | folliculin interacting protein 1 | 0.0289307 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0285607 |
| VCL | vinculin | 0.0276917 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0272175 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0271249 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0268939 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0264653 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.026262 |
| OXSR1 | oxidative stress responsive 1 | 0.0262616 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0261163 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0259566 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0258905 |
| RPS17 | ribosomal protein S17 | 0.0258307 |
| ATXN1 | ataxin 1 | 0.0257907 |
| RPL37A | ribosomal protein L37a | 0.0256382 |
| TENM2 | teneurin transmembrane protein 2 | 0.0251731 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0249664 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0247437 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0246956 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0246603 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.024526 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0244731 |
| RPS6 | ribosomal protein S6 | 0.0243768 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.024003 |
| BRD2 | bromodomain containing 2 | 0.023887 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0234731 |
| NDRG1 | N-myc downstream regulated 1 | 0.0234667 |
| FAM168A | family with sequence similarity 168, member A | 0.0232188 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0230528 |
| GOLGB1 | golgin B1 | 0.0222317 |
| RAD51B | RAD51 paralog B | 0.0222302 |
| STC1 | stanniocalcin 1 | 0.0221541 |
| ANXA2 | annexin A2 | 0.02204 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0219604 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0219311 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.021836 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.193883 |
| FN1 | fibronectin 1 | -0.14341 |
| EFNA5 | ephrin-A5 | -0.113244 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.11034 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.10202 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0845238 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0771803 |
| TMSB10 | thymosin beta 10 | -0.0765171 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.075758 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0750897 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0719795 |
| SMYD3 | SET and MYND domain containing 3 | -0.0705711 |
| COL5A2 | collagen, type V, alpha 2 | -0.0675753 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0659934 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0637549 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0577594 |
| NRCAM | neuronal cell adhesion molecule | -0.0556036 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0541312 |
| TXNRD1 | thioredoxin reductase 1 | -0.0535227 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0528474 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0503052 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.050208 |
| GDA | guanine deaminase | -0.0471054 |
| NEK7 | NIMA-related kinase 7 | -0.0470427 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0469541 |
| PTGR1 | prostaglandin reductase 1 | -0.0419065 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0410855 |
| RTN1 | reticulon 1 | -0.038375 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.038025 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0378479 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.037567 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0368997 |
| NCKAP5 | NCK-associated protein 5 | -0.0368913 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0366393 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0363838 |
| OSMR | oncostatin M receptor | -0.0353412 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0346427 |
| RTN4 | reticulon 4 | -0.0335355 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0331539 |
| LAMB1 | laminin, beta 1 | -0.0329589 |
| KIAA0825 | KIAA0825 | -0.0313193 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0312641 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0300129 |
| SRPK2 | SRSF protein kinase 2 | -0.0299483 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0292295 |
| PCBP3 | poly(rC) binding protein 3 | -0.0286655 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0282016 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0279034 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0277831 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0274695 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0273436 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0273333 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0272729 |
| NF1 | neurofibromin 1 | -0.026908 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0269072 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0263932 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0260472 |
| PDE7B | phosphodiesterase 7B | -0.0259382 |
| MFF | mitochondrial fission factor | -0.0256933 |
| CTSC | cathepsin C | -0.0248816 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.024444 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0244432 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.024265 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0239756 |
| AOPEP | aminopeptidase O (putative) | -0.023975 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0239683 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0236294 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0235342 |
| S100A6 | S100 calcium binding protein A6 | -0.0234383 |
| TBC1D19 | TBC1 domain family, member 19 | -0.0234003 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0230962 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0229557 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0227696 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0227481 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.022675 |
| GPRIN3 | GPRIN family member 3 | -0.0224591 |
| FRMD4B | FERM domain containing 4B | -0.0222351 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0221832 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0220912 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.022049 |
| THOC2 | THO complex 2 | -0.0218367 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0216729 |
| PTEN | phosphatase and tensin homolog | -0.0216534 |
| ENAH | enabled homolog (Drosophila) | -0.0215659 |
| CENPF | centromere protein F, 350/400kDa | -0.0214818 |
| RAI1 | retinoic acid induced 1 | -0.0214422 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0212656 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0210234 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0206158 |
| TNPO1 | transportin 1 | -0.020581 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0203986 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0203786 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0203355 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0202169 |
| TCERG1 | transcription elongation regulator 1 | -0.0200971 |
| SRGN | serglycin | -0.0197877 |
| TBXT | T-box transcription factor T | -0.0197656 |
| PLCB4 | phospholipase C, beta 4 | -0.0196108 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0195608 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0193966 |
